ZA200305118B - Pharmaceutically activity piperidine derivatives. - Google Patents
Pharmaceutically activity piperidine derivatives. Download PDFInfo
- Publication number
- ZA200305118B ZA200305118B ZA200305118A ZA200305118A ZA200305118B ZA 200305118 B ZA200305118 B ZA 200305118B ZA 200305118 A ZA200305118 A ZA 200305118A ZA 200305118 A ZA200305118 A ZA 200305118A ZA 200305118 B ZA200305118 B ZA 200305118B
- Authority
- ZA
- South Africa
- Prior art keywords
- compound
- piperidinetriol
- hydroxymethyl
- phenylmethoxy
- methyl
- Prior art date
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- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
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- C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
Landscapes
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| WO2001097829A2 (en) * | 2000-06-19 | 2001-12-27 | Genzyme Corporation | Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases |
| ES2271548T3 (es) * | 2002-03-13 | 2007-04-16 | Unither Pharmaceuticals, Inc. | Enfoque no hormonal de anticoncepcion masculina. |
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| EP1554245B1 (de) * | 2002-07-17 | 2012-09-26 | Actelion Pharmaceuticals Ltd. | Piperidintriolderivate als inhibitoren von glycosylceramidsynthase |
| GB0313677D0 (en) | 2003-06-13 | 2003-07-16 | Oxford Glycosciences Uk Ltd | Novel compound |
| GB0313678D0 (en) * | 2003-06-13 | 2003-07-16 | Oxford Glycosciences Uk Ltd | Novel compounds |
| EP1528056A1 (de) * | 2003-10-29 | 2005-05-04 | Academisch Ziekenhuis bij de Universiteit van Amsterdam | Deoxynojirimycin Derivate und ihre Verwendung als Glukosesylceramidase-Inhibitoren |
| EP1680112B1 (de) * | 2003-10-29 | 2010-12-15 | Genzyme Corporation | N-(5-adamantane-1-yl-methoxy-pentyl)desoxynojirimycin oder eines pharmazeutischen salzes davon zur verwendung bei der behandlung der insulinresistenz |
| GB0400812D0 (en) * | 2004-01-14 | 2004-02-18 | Celltech R&D Ltd | Novel compounds |
| WO2005092334A2 (en) * | 2004-03-25 | 2005-10-06 | David Priestman | Use of n-substituted imino sugars for appetite suppression |
| US20070248591A1 (en) * | 2004-09-08 | 2007-10-25 | Takeda Pharmaceutical Company Limited | Preventive/Therapeutic Drug for Arteriosclerosis |
| EP1811991B1 (de) | 2004-11-10 | 2018-11-07 | Genzyme Corporation | Behandlung von Typ 2 Diabetes mit Inhibitoren der Glycosphigolipid-Synthese |
| EP2923699B1 (de) | 2006-05-09 | 2018-06-20 | Genzyme Corporation | Verfahren zur behandlung von krankhafter fettleber durch hemmung der glucosphingolipid-synthese |
| US8975280B2 (en) | 2006-05-24 | 2015-03-10 | The Chancellor, Masters And Scholars Of The University Of Oxford | Deoxynojirimycin and D-arabinitol analogs and methods of using |
| GB0614947D0 (en) * | 2006-07-27 | 2006-09-06 | Isis Innovation | Epitope reduction therapy |
| US8097728B2 (en) * | 2007-04-30 | 2012-01-17 | Philadelphia Health & Education Corporation | Iminosugar compounds with antiflavirus activity |
| EP2594564B1 (de) | 2007-05-31 | 2016-09-28 | Genzyme Corporation | Glukosylceramid-Synthase-Hemmer vom 2-Acylaminpropanol-Typ |
| BRPI0817864A2 (pt) | 2007-10-05 | 2012-12-25 | Genzyme Corp | uso de um composto derivado de ceramida |
| CA2731685A1 (en) | 2008-07-28 | 2010-02-04 | Genzyme Corporation | Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease |
| WO2010039256A1 (en) * | 2008-10-03 | 2010-04-08 | Genzyme Corporation | 2-acylaminopropoanol-type glucosylceramide synthase inhibitors |
| EP3608330B1 (de) | 2008-12-16 | 2022-11-09 | Genzyme Corporation | Synthetische zwischenprodukte zur verwendung zur herstellung von oligosaccharid-protein-konjugate |
| CA2753195C (en) | 2009-02-23 | 2015-06-02 | United Therapeutics Corporation | Iminosugars and methods of treating viral diseases |
| EP2400843B1 (de) * | 2009-02-24 | 2015-11-11 | United Therapeutics Corporation | Iminozucker und verfahren zur behandlung von arenaviridae-erkrankungen |
| EP2440205B1 (de) * | 2009-06-12 | 2014-08-27 | United Therapeutics Corporation | Iminozucker zur verwendung in der behandlung von bunyaviralen und togaviralen erkrankungen |
| BR112012004676A2 (pt) * | 2009-09-04 | 2019-09-24 | United Therapeutics Corp | método de tratar infecções orotomixovirais. |
| CN105748476A (zh) * | 2009-09-04 | 2016-07-13 | 联合治疗公司 | 亚氨基糖以及治疗丝状病毒性疾病的方法 |
| WO2011028781A1 (en) * | 2009-09-04 | 2011-03-10 | United Therapeutics Corporation | Methods of treating poxviral infections |
| EP2509598A1 (de) * | 2009-12-07 | 2012-10-17 | The Chancellor, Masters And Scholars Of The University Of Oxford | N-substituierte deoxynojirimycinverbindungen zur hemmung von osteoklastogenese und/oder oesteoklastenaktivierung |
| ES2371398B1 (es) * | 2010-06-04 | 2013-05-20 | Bioglane, S.L.N.E. | Uso de un iminoazúcar como inhibidor de la adherencia a células epiteliales. |
| EP2394667A1 (de) * | 2010-06-10 | 2011-12-14 | Laboratorios Del Dr. Esteve, S.A. | Vektoren und Sequenzen zur Behandlung von Erkrankungen |
| US20140350049A1 (en) | 2011-11-29 | 2014-11-27 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and pharmaceutical compositions for the treatment of darier disease |
| JP2016513729A (ja) | 2013-03-15 | 2016-05-16 | ユニザー ヴィロロジー，エルエルシー | 抗菌化合物 |
| JP2016517887A (ja) * | 2013-05-02 | 2016-06-20 | ザ チャンセラー，マスターズ アンド スカラーズ オブ ザ ユニバーシティ オブ オックスフォード | イミノ糖を使用した糖脂質阻害 |
| MX2019014427A (es) | 2017-06-01 | 2020-02-05 | Idorsia Pharmaceuticals Ltd | Forma cristalina de n-butildeoxigalactonojirimicina. |
| WO2020193746A1 (en) | 2019-03-28 | 2020-10-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the survival of patients suffering from melanoma |
| EP3966199A4 (de) * | 2019-05-10 | 2023-02-01 | Alectos Therapeutics Inc. | Nichtlysosomale glucosylceramidase-inhibitoren und verwendungen davon |
| AU2021269232A1 (en) * | 2020-05-07 | 2022-12-08 | Alectos Therapeutics Inc. | Non-lysosomal glucosylceramidase inhibitors and uses thereof |
| PE20231423A1 (es) * | 2020-05-07 | 2023-09-13 | Alectos Therapeutics Inc | Inhibidores de glucosilceramidasa no lisosomal y los usos de los mismos |
| EP4201403A1 (de) | 2021-12-21 | 2023-06-28 | Som Innovation Biotech, S.L. | Verbindungen tirapazamin und quazinon zur verwendung bei der behandlung von gm2-gangliosidosen |
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| NO154918C (no) * | 1977-08-27 | 1987-01-14 | Bayer Ag | Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin. |
| DE3007078A1 (de) * | 1980-02-26 | 1981-09-10 | Bayer Ag, 5090 Leverkusen | Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel sowie in der tierernaehrung |
| DE3024901A1 (de) | 1980-07-01 | 1982-01-28 | Bayer Ag, 5090 Leverkusen | Herbizide mittel auf basis von piperidin-derivaten |
| DE3247615A1 (de) * | 1982-12-23 | 1984-07-05 | Hoechst Ag, 6230 Frankfurt | Substituierte phenylsulfonyloxybenzimidazolcarbaminate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| DE3737523A1 (de) * | 1987-11-05 | 1989-05-18 | Bayer Ag | Verwendung von substituierten hydroxypiperidinen als antivirale mittel |
| US5003072A (en) * | 1988-11-03 | 1991-03-26 | G. D. Searle & Co. | 1,5-dideoxy-1,5-imino-D-glucitol derivatives |
| JPH02306962A (ja) | 1989-05-19 | 1990-12-20 | Meiji Seika Kaisha Ltd | 新規ｎ―置換―１―デオキシノジリマイシン誘導体及びそれを含有する癌細胞転移抑制剤 |
| JPH0324057A (ja) | 1989-06-22 | 1991-02-01 | Tosoh Corp | ポリヒドロキシピペリジン類及びその製造法 |
| CA2065446A1 (en) | 1989-09-07 | 1991-03-08 | Yoshiaki Yoshikuni | Antiviral drug |
| EP0536402A4 (en) | 1990-06-29 | 1993-05-12 | Nippon Shinyaku Company, Limited | Piperidine derivative |
| US5276120A (en) * | 1991-05-30 | 1994-01-04 | The Scripps Research Institute | Process for forming omega-deuxy-azasugars |
| ATE318910T1 (de) | 1993-05-05 | 2006-03-15 | Roche Diagnostics Gmbh | Cholesterinoxidase aus brevibacterium sterolicum |
| US6291657B1 (en) | 1993-05-13 | 2001-09-18 | Monsanto Company | Deoxygalactonojirimycin derivatives |
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| HUP0003362A3 (en) * | 1997-05-06 | 2001-04-28 | Novo Nordisk As | Piperidine derivatives and pharmaceutical compositions containing them |
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| WO2000056334A1 (en) | 1999-03-19 | 2000-09-28 | The Trustees Of Boston College | Use of imino sugars for anti-tumor therapy |
| GB9909064D0 (en) | 1999-04-20 | 1999-06-16 | Oxford Glycosciences Uk Ltd | Therapies |
| GB0100889D0 (en) | 2001-01-12 | 2001-02-21 | Oxford Glycosciences Uk Ltd | Compounds |
| AU6050600A (en) * | 1999-07-26 | 2001-02-13 | G.D. Searle & Co. | Use of long-chain n-alkyl derivates of deoxynojirimycin and a glucocerebrosidaseenzyme for the manufacture of medicament for the treatment of glycolipid storag e diseases |
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| DE60037664T2 (de) * | 1999-08-10 | 2008-12-24 | The Chancellor, Masters And Scholars Of The University Of Oxford | Langkettige n-alkyl verbindungen und deren oxa-derivate zur verwendung als anitvirale mittel |
| ES2271548T3 (es) * | 2002-03-13 | 2007-04-16 | Unither Pharmaceuticals, Inc. | Enfoque no hormonal de anticoncepcion masculina. |
| AU2003246942B2 (en) * | 2002-07-17 | 2009-06-25 | Idorsia Pharmaceuticals Ltd | Piperidinetriol derivatives as inhibitors of glycosylceramide synthase |
| EP1554245B1 (de) | 2002-07-17 | 2012-09-26 | Actelion Pharmaceuticals Ltd. | Piperidintriolderivate als inhibitoren von glycosylceramidsynthase |
| GB0313677D0 (en) * | 2003-06-13 | 2003-07-16 | Oxford Glycosciences Uk Ltd | Novel compound |
| GB0313678D0 (en) | 2003-06-13 | 2003-07-16 | Oxford Glycosciences Uk Ltd | Novel compounds |
| GB0400812D0 (en) | 2004-01-14 | 2004-02-18 | Celltech R&D Ltd | Novel compounds |
-
2001
- 2001-01-12 GB GBGB0100889.5A patent/GB0100889D0/en not_active Ceased
-
2002
- 2002-01-11 RU RU2003124756/04A patent/RU2279425C2/ru active
- 2002-01-11 CN CNB028062264A patent/CN1267420C/zh not_active Expired - Lifetime
- 2002-01-11 ES ES02729458T patent/ES2304439T3/es not_active Expired - Lifetime
- 2002-01-11 MX MXPA03006185A patent/MXPA03006185A/es active IP Right Grant
- 2002-01-11 AT AT02729458T patent/ATE389635T1/de active
- 2002-01-11 EP EP02729458A patent/EP1362031B1/de not_active Expired - Lifetime
- 2002-01-11 DE DE60225671T patent/DE60225671T2/de not_active Expired - Lifetime
- 2002-01-11 HU HU0303891A patent/HU229428B1/hu unknown
- 2002-01-11 CA CA2433675A patent/CA2433675C/en not_active Expired - Lifetime
- 2002-01-11 AU AU2002219363A patent/AU2002219363B2/en not_active Expired
- 2002-01-11 KR KR1020037009309A patent/KR100879651B1/ko active IP Right Grant
- 2002-01-11 IL IL15687302A patent/IL156873A0/xx active IP Right Grant
- 2002-01-11 WO PCT/GB2002/000106 patent/WO2002055498A1/en active IP Right Grant
- 2002-01-11 JP JP2002556170A patent/JP4313572B2/ja not_active Expired - Lifetime
- 2002-01-11 PT PT02729458T patent/PT1362031E/pt unknown
- 2002-01-11 BR BRPI0206433-2 patent/BRPI0206433B8/pt not_active IP Right Cessation
-
2003
- 2003-07-01 ZA ZA200305118A patent/ZA200305118B/en unknown
- 2003-07-11 US US10/618,165 patent/US20040097551A1/en not_active Abandoned
-
2005
- 2005-08-03 US US11/196,153 patent/US8729099B2/en not_active Expired - Lifetime
-
2014
- 2014-04-07 US US14/246,879 patent/US9199935B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1496351A (zh) | 2004-05-12 |
| BRPI0206433B8 (pt) | 2021-05-25 |
| RU2279425C2 (ru) | 2006-07-10 |
| DE60225671T2 (de) | 2009-04-16 |
| KR20030081383A (ko) | 2003-10-17 |
| JP4313572B2 (ja) | 2009-08-12 |
| CA2433675C (en) | 2011-03-22 |
| CA2433675A1 (en) | 2002-07-18 |
| EP1362031B1 (de) | 2008-03-19 |
| HUP0303891A3 (en) | 2010-01-28 |
| IL156873A0 (en) | 2004-02-08 |
| AU2002219363B2 (en) | 2007-11-01 |
| US20040097551A1 (en) | 2004-05-20 |
| US20060074107A1 (en) | 2006-04-06 |
| ES2304439T3 (es) | 2008-10-16 |
| PT1362031E (pt) | 2008-06-12 |
| US8729099B2 (en) | 2014-05-20 |
| BR0206433A (pt) | 2003-12-30 |
| EP1362031A1 (de) | 2003-11-19 |
| US9199935B2 (en) | 2015-12-01 |
| RU2003124756A (ru) | 2005-01-10 |
| MXPA03006185A (es) | 2004-12-03 |
| WO2002055498A1 (en) | 2002-07-18 |
| ATE389635T1 (de) | 2008-04-15 |
| GB0100889D0 (en) | 2001-02-21 |
| BRPI0206433B1 (pt) | 2020-01-07 |
| HU229428B1 (en) | 2013-12-30 |
| HUP0303891A2 (hu) | 2004-03-29 |
| US20140303208A1 (en) | 2014-10-09 |
| DE60225671D1 (de) | 2008-04-30 |
| JP2004517869A (ja) | 2004-06-17 |
| CN1267420C (zh) | 2006-08-02 |
| KR100879651B1 (ko) | 2009-01-20 |
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