ZA200300110B - Pharmaceutical compositions containing tobramycin and xanthan gum. - Google Patents
Pharmaceutical compositions containing tobramycin and xanthan gum. Download PDFInfo
- Publication number
- ZA200300110B ZA200300110B ZA200300110A ZA200300110A ZA200300110B ZA 200300110 B ZA200300110 B ZA 200300110B ZA 200300110 A ZA200300110 A ZA 200300110A ZA 200300110 A ZA200300110 A ZA 200300110A ZA 200300110 B ZA200300110 B ZA 200300110B
- Authority
- ZA
- South Africa
- Prior art keywords
- xanthan gum
- composition
- tobramycin
- agents
- solution
- Prior art date
Links
- 229920001285 xanthan gum Polymers 0.000 title claims description 35
- 239000000230 xanthan gum Substances 0.000 title claims description 34
- 229940082509 xanthan gum Drugs 0.000 title claims description 34
- 235000010493 xanthan gum Nutrition 0.000 title claims description 34
- NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 title claims description 29
- 229960000707 tobramycin Drugs 0.000 title claims description 28
- 239000008194 pharmaceutical composition Substances 0.000 title description 4
- 239000000203 mixture Substances 0.000 claims description 53
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid group Chemical group S(O)(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- 239000008213 purified water Substances 0.000 claims description 8
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical group OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims description 7
- 229960000281 trometamol Drugs 0.000 claims description 7
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 4
- 229930195725 Mannitol Natural products 0.000 claims description 4
- 239000006172 buffering agent Substances 0.000 claims description 4
- 239000004615 ingredient Substances 0.000 claims description 4
- 239000000594 mannitol Substances 0.000 claims description 4
- 235000010355 mannitol Nutrition 0.000 claims description 4
- 239000003002 pH adjusting agent Substances 0.000 claims description 4
- KHSLHYAUZSPBIU-UHFFFAOYSA-M benzododecinium bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 KHSLHYAUZSPBIU-UHFFFAOYSA-M 0.000 claims description 3
- 229940073464 benzododecinium bromide Drugs 0.000 claims description 3
- 239000003755 preservative agent Substances 0.000 claims description 3
- 239000013543 active substance Substances 0.000 claims description 2
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims description 2
- 239000004327 boric acid Substances 0.000 claims description 2
- 239000003974 emollient agent Substances 0.000 claims description 2
- 239000000314 lubricant Substances 0.000 claims description 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 2
- 229920000053 polysorbate 80 Polymers 0.000 claims description 2
- 229940068968 polysorbate 80 Drugs 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- 239000003381 stabilizer Substances 0.000 claims description 2
- 239000004094 surface-active agent Substances 0.000 claims description 2
- 229960002645 boric acid Drugs 0.000 claims 1
- 235000010338 boric acid Nutrition 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 229960001855 mannitol Drugs 0.000 claims 1
- 229940032330 sulfuric acid Drugs 0.000 claims 1
- 239000000243 solution Substances 0.000 description 19
- 238000009472 formulation Methods 0.000 description 18
- 238000003756 stirring Methods 0.000 description 15
- 239000011550 stock solution Substances 0.000 description 10
- 238000000034 method Methods 0.000 description 4
- 238000001556 precipitation Methods 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 2
- 239000003732 agents acting on the eye Substances 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229940023490 ophthalmic product Drugs 0.000 description 2
- 238000010935 polish filtration Methods 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 238000011146 sterile filtration Methods 0.000 description 2
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 1
- 235000019766 L-Lysine Nutrition 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 description 1
- 241000140476 Rice stripe necrosis virus Species 0.000 description 1
- 235000002911 Salvia sclarea Nutrition 0.000 description 1
- 244000182022 Salvia sclarea Species 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940124350 antibacterial drug Drugs 0.000 description 1
- 229960005475 antiinfective agent Drugs 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- -1 but not limited to Substances 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 229940003380 geodon Drugs 0.000 description 1
- 238000003760 magnetic stirring Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000011045 prefiltration Methods 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229940035275 tobrex Drugs 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- MVWVFYHBGMAFLY-UHFFFAOYSA-N ziprasidone Chemical compound C1=CC=C2C(N3CCN(CC3)CCC3=CC=4CC(=O)NC=4C=C3Cl)=NSC2=C1 MVWVFYHBGMAFLY-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Ophthalmology & Optometry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22166000P | 2000-07-28 | 2000-07-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200300110B true ZA200300110B (en) | 2004-01-21 |
Family
ID=22828757
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200300110A ZA200300110B (en) | 2000-07-28 | 2003-01-06 | Pharmaceutical compositions containing tobramycin and xanthan gum. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6352978B1 (zh) |
| EP (1) | EP1305033B1 (zh) |
| CN (1) | CN1218689C (zh) |
| AR (1) | AR029965A1 (zh) |
| AT (1) | ATE279927T1 (zh) |
| AU (1) | AU2001270593A1 (zh) |
| BR (1) | BR0112787B1 (zh) |
| CA (1) | CA2414737C (zh) |
| CO (1) | CO5300418A1 (zh) |
| DE (1) | DE60106619T2 (zh) |
| DK (1) | DK1305033T3 (zh) |
| ES (1) | ES2225573T3 (zh) |
| MX (1) | MXPA03000813A (zh) |
| PL (1) | PL199321B1 (zh) |
| PT (1) | PT1305033E (zh) |
| TW (1) | TWI282278B (zh) |
| WO (1) | WO2002009724A1 (zh) |
| ZA (1) | ZA200300110B (zh) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4948176B2 (ja) * | 2004-09-28 | 2012-06-06 | 千寿製薬株式会社 | キサンタンガムおよびアミノ酸を含有する眼科用組成物 |
| US7795316B1 (en) | 2007-12-19 | 2010-09-14 | Alcon Research, Ltd. | Topical ophthalmic compositions containing tobramycin and dexamethasone |
| TWI495469B (zh) | 2008-06-09 | 2015-08-11 | Alcon Res Ltd | 含有氟喹諾酮抗生素藥物之經改良藥學組成物 |
| JP5728082B2 (ja) * | 2010-06-23 | 2015-06-03 | アルコン リサーチ， リミテッド | トブラマイシンおよびデキサメタゾンを含む局所用眼用懸濁液 |
| EP2704726B1 (en) | 2011-05-04 | 2018-10-31 | Trustees of Boston University | Proton-motive force stimulation to potentiate aminoglycoside antibiotics against persistent bacteria |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3700451A (en) | 1970-04-06 | 1972-10-24 | Itek Corp | Gelable and gelled compositions |
| US3944427A (en) | 1970-04-06 | 1976-03-16 | Itek Corporation | Gelable and gelled compositions |
| US3784712A (en) | 1970-12-23 | 1974-01-08 | Gen Foods Corp | Gum gelling system xanthan-tara dessert gel |
| CA1070629A (en) | 1975-11-10 | 1980-01-29 | Allen I. Laskin | Process for modifying biopolymers |
| US4135979A (en) | 1976-08-24 | 1979-01-23 | Merck & Co., Inc. | Treatment of xanthan gum to improve clarity |
| US4136177A (en) | 1977-01-31 | 1979-01-23 | American Home Products Corp. | Xanthan gum therapeutic compositions |
| US4136173A (en) | 1977-01-31 | 1979-01-23 | American Home Products Corp. | Mixed xanthan gum and locust beam gum therapeutic compositions |
| US4136178A (en) | 1977-01-31 | 1979-01-23 | American Home Products Corp. | Locust bean gum therapeutic compositions |
| GB8318403D0 (en) | 1983-07-07 | 1983-08-10 | Sutherland I W | Gel-forming polysaccharides |
| FR2551087B1 (fr) | 1983-08-30 | 1986-03-21 | Rhone Poulenc Spec Chim | Procede de traitement d'une solution de polysaccharide et son utilisation |
| DE3335593A1 (de) | 1983-09-30 | 1985-04-11 | Diamalt AG, 8000 München | Gelier- und verdickungsmittel auf der basis von cassia-galactomannanen |
| US4717713A (en) | 1983-10-31 | 1988-01-05 | Research Corporation | Controlled release liquid pharmaceutical |
| US4708861A (en) | 1984-02-15 | 1987-11-24 | The Liposome Company, Inc. | Liposome-gel compositions |
| FR2588189B1 (fr) | 1985-10-03 | 1988-12-02 | Merck Sharp & Dohme | Composition pharmaceutique de type a transition de phase liquide-gel |
| US4647470A (en) | 1985-11-27 | 1987-03-03 | Merck & Co., Inc. | Low-acetyl gellan gum blends |
| FR2618333B1 (fr) | 1987-07-20 | 1990-07-13 | Merck Sharp & Dohme | Composition pharmaceutique et/ou cosmetique a usage topique contenant de la gomme rhamsam |
| US5192535A (en) | 1988-02-08 | 1993-03-09 | Insite Vision Incorporated | Ophthalmic suspensions |
| US4814160A (en) | 1988-03-01 | 1989-03-21 | Colgate-Palmolive Company | Non-bleeding striped dentifrice |
| US5234957A (en) | 1991-02-27 | 1993-08-10 | Noven Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
| US5446070A (en) | 1991-02-27 | 1995-08-29 | Nover Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
| US5149694A (en) | 1988-03-09 | 1992-09-22 | Alcon Laboratories, Inc. | Combination of tobramycin and dexamethasone for topical ophthalmic use |
| DE3843416A1 (de) | 1988-12-23 | 1990-06-28 | Wolff Walsrode Ag | Xanthan mit verbesserter loeslichkeit und verfahren zur herstellung |
| CA2021414C (en) | 1989-07-25 | 2004-09-28 | Daniel H. Doherty | Genetic control of acetylation and pyruvylation of xanthan gum |
| US5461081A (en) | 1989-09-28 | 1995-10-24 | Alcon Laboratories, Inc. | Topical ophthalmic pharmaceutical vehicles |
| FR2653021A1 (fr) | 1989-10-17 | 1991-04-19 | Merck Sharp & Dohme | Composition ophtalmique aqueuse liquide a transition de phase liquide-gel. |
| JP2594486B2 (ja) | 1991-01-15 | 1997-03-26 | アルコン ラボラトリーズ インコーポレイテッド | 局所的眼薬組成物 |
| JP2536806B2 (ja) * | 1991-03-27 | 1996-09-25 | アルコン ラボラトリーズ インコーポレイテッド | ゲル化多糖類と微粉砕された薬剤担体とを組み合わせた局部眼科用組成物 |
| US5212162A (en) | 1991-03-27 | 1993-05-18 | Alcon Laboratories, Inc. | Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions |
| ATE162081T1 (de) | 1991-09-17 | 1998-01-15 | Alcon Lab Inc | Chinolan-antibiotika und polystyrolsulfonat enthaltende zusammensetzungen |
| US5192802A (en) | 1991-09-25 | 1993-03-09 | Mcneil-Ppc, Inc. | Bioadhesive pharmaceutical carrier |
| US5318780A (en) | 1991-10-30 | 1994-06-07 | Mediventures Inc. | Medical uses of in situ formed gels |
| US5473062A (en) | 1992-10-29 | 1995-12-05 | Takeda Chemical Industries, Ltd. | Process for producing purified xanthan gum |
| JP3228315B2 (ja) | 1993-04-23 | 2001-11-12 | 信越化学工業株式会社 | キサンタンガムの汚染生菌数を減少させる方法 |
| EP0757555A4 (en) | 1994-01-14 | 1999-04-07 | Lee Shahinian Jr | METHOD FOR LONG-LASTING AND EXTENDED CORNEAL ANALGESIA |
| US5422116A (en) | 1994-02-18 | 1995-06-06 | Ciba-Geigy Corporation | Liquid ophthalmic sustained release delivery system |
| KR100374098B1 (ko) | 1994-04-08 | 2003-06-09 | 아트릭스 라보라토리스, 인코포레이션 | 조절된방출이식편형성에적합한액체전달조성물 |
| US5523301A (en) | 1994-08-05 | 1996-06-04 | Merck & Co., Inc. | Optic nerve health |
| ATE208186T1 (de) | 1994-08-30 | 2001-11-15 | Alcon Lab Inc | Thermisch gelierende trägerstoffe zur arzneistoffabgabe, die zelluloseether enthalten |
| US5972326A (en) | 1995-04-18 | 1999-10-26 | Galin; Miles A. | Controlled release of pharmaceuticals in the anterior chamber of the eye |
| FR2742336B1 (fr) | 1995-12-19 | 1998-03-06 | Chauvin Lab Sa | Collyre destine notamment au traitement de l'oeil sec |
| SE9603480L (sv) | 1996-09-23 | 1998-03-24 | Johan Carlfors | Beredningsform för svårlösliga läkemedel |
| FR2754712B1 (fr) | 1996-10-17 | 1999-09-03 | Merck Sharp Dohme Chibret Lab | Compositions ophtalmiques |
| US5888493A (en) | 1996-12-05 | 1999-03-30 | Sawaya; Assad S. | Ophthalmic aqueous gel formulation and related methods |
| JP2002501533A (ja) | 1997-05-30 | 2002-01-15 | メルク エンド カンパニー インコーポレーテッド | 高眼圧症治療のための眼科用組成物 |
| KR20010013377A (ko) * | 1997-06-04 | 2001-02-26 | 데이비드 엠 모이어 | 마일드한 잔류성 항균 조성물 |
| AU740874B2 (en) | 1997-06-26 | 2001-11-15 | Merck & Co., Inc. | Method for optimizing retinal and optic nerve health |
| ES2203103T3 (es) * | 1998-04-07 | 2004-04-01 | Alcon Manufacturing Ltd. | Composiciones oftalmicas gelificantes que contienen goma xantana. |
| US6174524B1 (en) * | 1999-03-26 | 2001-01-16 | Alcon Laboratories, Inc. | Gelling ophthalmic compositions containing xanthan gum |
| US6297337B1 (en) * | 1999-05-19 | 2001-10-02 | Pmd Holdings Corp. | Bioadhesive polymer compositions |
-
2001
- 2001-06-26 PT PT01949437T patent/PT1305033E/pt unknown
- 2001-06-26 EP EP01949437A patent/EP1305033B1/en not_active Expired - Lifetime
- 2001-06-26 PL PL365154A patent/PL199321B1/pl unknown
- 2001-06-26 AU AU2001270593A patent/AU2001270593A1/en not_active Abandoned
- 2001-06-26 DE DE60106619T patent/DE60106619T2/de not_active Expired - Lifetime
- 2001-06-26 MX MXPA03000813A patent/MXPA03000813A/es active IP Right Grant
- 2001-06-26 AT AT01949437T patent/ATE279927T1/de active
- 2001-06-26 BR BRPI0112787-0A patent/BR0112787B1/pt not_active IP Right Cessation
- 2001-06-26 ES ES01949437T patent/ES2225573T3/es not_active Expired - Lifetime
- 2001-06-26 WO PCT/EP2001/007267 patent/WO2002009724A1/en active IP Right Grant
- 2001-06-26 DK DK01949437T patent/DK1305033T3/da active
- 2001-06-26 CA CA002414737A patent/CA2414737C/en not_active Expired - Fee Related
- 2001-06-26 CN CNB018135285A patent/CN1218689C/zh not_active Expired - Fee Related
- 2001-07-11 US US09/902,844 patent/US6352978B1/en not_active Expired - Fee Related
- 2001-07-12 TW TW090117057A patent/TWI282278B/zh not_active IP Right Cessation
- 2001-07-23 AR ARP010103512A patent/AR029965A1/es unknown
- 2001-07-25 CO CO01060485A patent/CO5300418A1/es not_active Application Discontinuation
-
2003
- 2003-01-06 ZA ZA200300110A patent/ZA200300110B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CO5300418A1 (es) | 2003-07-31 |
| US6352978B1 (en) | 2002-03-05 |
| DE60106619T2 (de) | 2005-03-17 |
| TWI282278B (en) | 2007-06-11 |
| BR0112787B1 (pt) | 2013-03-05 |
| PT1305033E (pt) | 2005-01-31 |
| AR029965A1 (es) | 2003-07-23 |
| WO2002009724A1 (en) | 2002-02-07 |
| BR0112787A (pt) | 2003-09-09 |
| DE60106619D1 (de) | 2004-11-25 |
| ATE279927T1 (de) | 2004-11-15 |
| AU2001270593A1 (en) | 2002-02-13 |
| ES2225573T3 (es) | 2005-03-16 |
| PL199321B1 (pl) | 2008-09-30 |
| CN1218689C (zh) | 2005-09-14 |
| CA2414737A1 (en) | 2002-02-07 |
| MXPA03000813A (es) | 2005-08-16 |
| DK1305033T3 (da) | 2005-01-31 |
| CA2414737C (en) | 2009-01-06 |
| EP1305033A1 (en) | 2003-05-02 |
| PL365154A1 (en) | 2004-12-27 |
| US20020035088A1 (en) | 2002-03-21 |
| CN1444482A (zh) | 2003-09-24 |
| EP1305033B1 (en) | 2004-10-20 |
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