ZA200208531B - Use of substituted acryloyl distamycin derivatives in the treatment of tumors associated with high levels of glutathione. - Google Patents
Use of substituted acryloyl distamycin derivatives in the treatment of tumors associated with high levels of glutathione. Download PDFInfo
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- ZA200208531B ZA200208531B ZA200208531A ZA200208531A ZA200208531B ZA 200208531 B ZA200208531 B ZA 200208531B ZA 200208531 A ZA200208531 A ZA 200208531A ZA 200208531 A ZA200208531 A ZA 200208531A ZA 200208531 B ZA200208531 B ZA 200208531B
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- South Africa
- Prior art keywords
- amino
- methyl
- pyrrol
- carbonyl
- formula
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Classifications
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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Landscapes
- Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0011059.3A GB0011059D0 (en) | 2000-05-08 | 2000-05-08 | Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione |
Publications (1)
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| ZA200208531B true ZA200208531B (en) | 2003-10-22 |
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| ZA200208531A ZA200208531B (en) | 2000-05-08 | 2002-10-22 | Use of substituted acryloyl distamycin derivatives in the treatment of tumors associated with high levels of glutathione. |
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| Country | Link |
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| US (1) | US7030089B2 (de) |
| EP (1) | EP1280527B1 (de) |
| JP (1) | JP2003532669A (de) |
| KR (1) | KR100776184B1 (de) |
| CN (1) | CN1258362C (de) |
| AR (1) | AR029518A1 (de) |
| AT (1) | ATE300944T1 (de) |
| AU (2) | AU2001260227B2 (de) |
| BR (1) | BR0110628A (de) |
| CA (1) | CA2409664C (de) |
| CZ (1) | CZ300791B6 (de) |
| DE (1) | DE60112423T2 (de) |
| DK (1) | DK1280527T3 (de) |
| EA (1) | EA007506B1 (de) |
| EE (1) | EE200200605A (de) |
| ES (1) | ES2244618T3 (de) |
| GB (1) | GB0011059D0 (de) |
| HK (1) | HK1054193B (de) |
| HU (1) | HUP0301882A2 (de) |
| IL (2) | IL152388A0 (de) |
| MX (1) | MXPA02010962A (de) |
| NO (1) | NO20025303D0 (de) |
| NZ (1) | NZ522234A (de) |
| PL (1) | PL201289B1 (de) |
| PT (1) | PT1280527E (de) |
| SK (1) | SK286501B6 (de) |
| TW (1) | TWI284643B (de) |
| WO (1) | WO2001085144A2 (de) |
| ZA (1) | ZA200208531B (de) |
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| GB0011059D0 (en) | 2000-05-08 | 2000-06-28 | Pharmacia & Upjohn Spa | Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione |
| GB0015446D0 (en) * | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites |
| GB0015447D0 (en) * | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents |
| GB0016447D0 (en) | 2000-07-04 | 2000-08-23 | Pharmacia & Upjohn Spa | Process for preparing distamycin derivatives |
| IT1318696B1 (it) | 2000-09-15 | 2003-08-27 | Pharmacia & Upjohn Spa | Coniugati di glutatione con derivati della distamicina ad attivita'antitumorale. |
| US6969592B2 (en) | 2001-09-26 | 2005-11-29 | Pharmacia Italia S.P.A. | Method for predicting the sensitivity to chemotherapy |
| EP1490053B1 (de) * | 2002-04-02 | 2008-01-09 | NERVIANO MEDICAL SCIENCES S.r.l. | Kombinierte tumortherapie auf der basis von distamycin-acryloyl derivaten und radiotherapie |
| PT3362056T (pt) * | 2015-10-15 | 2021-04-22 | Advanced Biodesign | Compostos de aminotioléster ou seus sais farmaceuticamente aceitáveis, para utilização no tratamento de cancro |
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| AT387013B (de) | 1985-07-16 | 1988-11-25 | Erba Farmitalia | Verfahren zur herstellung von poly-4-aminopyrrol -2-carboxamidoderivaten |
| GB8612218D0 (en) | 1986-05-20 | 1986-06-25 | Erba Farmitalia | Site specific alkylating agents |
| EP0265719B1 (de) | 1986-10-07 | 1991-03-06 | Boehringer Mannheim Italia S.P.A. | Pharmazeutische Zusammensetzungen mit antineoplastischer Wirkung |
| GB8906709D0 (en) * | 1989-03-23 | 1989-05-10 | Creighton Andrew M | Acryloyl substituted pyrrole derivatives |
| JP2919867B2 (ja) | 1989-09-27 | 1999-07-19 | 千寿製薬株式会社 | 抗腫瘍剤 |
| IT1272234B (it) | 1994-05-02 | 1997-06-16 | Consiglio Nazionale Ricerche | Derivati glutationici delle antracicline e procedimento per ottenerli. |
| GB9416005D0 (en) * | 1994-08-08 | 1994-09-28 | Erba Carlo Spa | Peptidic compounds analogous to distamycin a and process for their preparation |
| US5880097A (en) | 1996-01-04 | 1999-03-09 | Terrapin Techologies, Inc. | Tethered prodrugs |
| JP2000503999A (ja) | 1996-02-02 | 2000-04-04 | フアルマシア・エ・アツプジヨン・エツセ・ピー・アー | ジスタマイシン誘導体、その調製方法、および抗腫瘍および抗ウイルス剤としてのその使用 |
| GB9610079D0 (en) | 1996-05-14 | 1996-07-17 | Pharmacia Spa | Distamycin deriratives process for preparing them and their use as antitumor and antiviral agents |
| GB9615692D0 (en) | 1996-07-25 | 1996-09-04 | Pharmacia Spa | Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents |
| GB9623522D0 (en) | 1996-11-11 | 1997-01-08 | Pharmacia & Upjohn Spa | Benzoheterocycle distamycin derivatives process for preparing them and their use as antitumour and antiviral agents |
| GB9727524D0 (en) | 1997-12-31 | 1998-02-25 | Pharmacia & Upjohn Spa | Synergistic antitumor composition containing a biologically active ureido compound |
| GB9806692D0 (en) * | 1998-03-27 | 1998-05-27 | Pharmacia & Upjohn Spa | Benzoheterocyclic distamycin derivatives, process for preparing them and their use as antitumour agents |
| GB9806689D0 (en) * | 1998-03-27 | 1998-05-27 | Pharmacia & Upjohn Spa | Acryloyl derivatives analogous to distamycin,process for preparing them,and their use as antitumour and antiviral agents |
| GB9816652D0 (en) | 1998-07-30 | 1998-09-30 | Pharmacia & Upjohn Spa | Sulfurated distamycin derivatives process for preparing them and their use as antitumor agents |
| GB9816653D0 (en) | 1998-07-30 | 1998-09-30 | Pharmacia & Upjohn Spa | Oxidised sulfurated distamycin derivatives process for preparing them and their use as antitumor agents |
| GB9928703D0 (en) * | 1999-12-03 | 2000-02-02 | Pharmacia & Upjohn Spa | Acryloyl peptidic derivatives,process for their preparation and their use as antitumour agents |
| GB0011059D0 (en) | 2000-05-08 | 2000-06-28 | Pharmacia & Upjohn Spa | Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione |
-
2000
- 2000-05-08 GB GBGB0011059.3A patent/GB0011059D0/en not_active Ceased
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2001
- 2001-04-19 AT AT01933856T patent/ATE300944T1/de not_active IP Right Cessation
- 2001-04-19 CZ CZ20023629A patent/CZ300791B6/cs not_active IP Right Cessation
- 2001-04-19 CA CA002409664A patent/CA2409664C/en not_active Expired - Fee Related
- 2001-04-19 WO PCT/EP2001/004470 patent/WO2001085144A2/en active IP Right Grant
- 2001-04-19 BR BR0110628-7A patent/BR0110628A/pt not_active Application Discontinuation
- 2001-04-19 EA EA200201184A patent/EA007506B1/ru not_active IP Right Cessation
- 2001-04-19 EE EEP200200605A patent/EE200200605A/xx unknown
- 2001-04-19 KR KR1020027015026A patent/KR100776184B1/ko not_active IP Right Cessation
- 2001-04-19 CN CNB018092039A patent/CN1258362C/zh not_active Expired - Fee Related
- 2001-04-19 MX MXPA02010962A patent/MXPA02010962A/es active IP Right Grant
- 2001-04-19 JP JP2001581798A patent/JP2003532669A/ja not_active Abandoned
- 2001-04-19 PL PL365831A patent/PL201289B1/pl not_active IP Right Cessation
- 2001-04-19 US US10/258,620 patent/US7030089B2/en not_active Expired - Fee Related
- 2001-04-19 AU AU2001260227A patent/AU2001260227B2/en not_active Ceased
- 2001-04-19 HU HUP0301882 patent/HUP0301882A2/hu unknown
- 2001-04-19 DE DE60112423T patent/DE60112423T2/de not_active Expired - Lifetime
- 2001-04-19 EP EP01933856A patent/EP1280527B1/de not_active Expired - Lifetime
- 2001-04-19 DK DK01933856T patent/DK1280527T3/da active
- 2001-04-19 NZ NZ522234A patent/NZ522234A/en unknown
- 2001-04-19 PT PT01933856T patent/PT1280527E/pt unknown
- 2001-04-19 AU AU6022701A patent/AU6022701A/xx active Pending
- 2001-04-19 SK SK1600-2002A patent/SK286501B6/sk not_active IP Right Cessation
- 2001-04-19 IL IL15238801A patent/IL152388A0/xx active IP Right Grant
- 2001-04-19 ES ES01933856T patent/ES2244618T3/es not_active Expired - Lifetime
- 2001-05-03 TW TW090110601A patent/TWI284643B/zh active
- 2001-05-07 AR ARP010102143A patent/AR029518A1/es unknown
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2002
- 2002-10-21 IL IL152388A patent/IL152388A/en not_active IP Right Cessation
- 2002-10-22 ZA ZA200208531A patent/ZA200208531B/en unknown
- 2002-11-05 NO NO20025303A patent/NO20025303D0/no unknown
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2003
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