IL152388A0 - Use of substituted acryloyl distamycin derivatives in the treatment of tumors associated with high levels of glutathione - Google Patents

Use of substituted acryloyl distamycin derivatives in the treatment of tumors associated with high levels of glutathione

Info

Publication number
IL152388A0
IL152388A0 IL15238801A IL15238801A IL152388A0 IL 152388 A0 IL152388 A0 IL 152388A0 IL 15238801 A IL15238801 A IL 15238801A IL 15238801 A IL15238801 A IL 15238801A IL 152388 A0 IL152388 A0 IL 152388A0
Authority
IL
Israel
Prior art keywords
glutathione
treatment
high levels
tumors associated
distamycin derivatives
Prior art date
Application number
IL15238801A
Other languages
English (en)
Original Assignee
Pharmacia Italia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Italia Spa filed Critical Pharmacia Italia Spa
Publication of IL152388A0 publication Critical patent/IL152388A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
IL15238801A 2000-05-08 2001-04-19 Use of substituted acryloyl distamycin derivatives in the treatment of tumors associated with high levels of glutathione IL152388A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0011059.3A GB0011059D0 (en) 2000-05-08 2000-05-08 Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione
PCT/EP2001/004470 WO2001085144A2 (en) 2000-05-08 2001-04-19 Use of substituted acryloyl distamycin derivatives in the treatment of tumors associated with high levels of glutathione

Publications (1)

Publication Number Publication Date
IL152388A0 true IL152388A0 (en) 2003-05-29

Family

ID=9891173

Family Applications (2)

Application Number Title Priority Date Filing Date
IL15238801A IL152388A0 (en) 2000-05-08 2001-04-19 Use of substituted acryloyl distamycin derivatives in the treatment of tumors associated with high levels of glutathione
IL152388A IL152388A (en) 2000-05-08 2002-10-21 Use of Transformed Derivatives of Acrylolyl Distamycin in the Manufacture of Medicinal Products for the Treatment of Tumors Associated with High Glutathione Concentration

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL152388A IL152388A (en) 2000-05-08 2002-10-21 Use of Transformed Derivatives of Acrylolyl Distamycin in the Manufacture of Medicinal Products for the Treatment of Tumors Associated with High Glutathione Concentration

Country Status (29)

Country Link
US (1) US7030089B2 (de)
EP (1) EP1280527B1 (de)
JP (1) JP2003532669A (de)
KR (1) KR100776184B1 (de)
CN (1) CN1258362C (de)
AR (1) AR029518A1 (de)
AT (1) ATE300944T1 (de)
AU (2) AU2001260227B2 (de)
BR (1) BR0110628A (de)
CA (1) CA2409664C (de)
CZ (1) CZ300791B6 (de)
DE (1) DE60112423T2 (de)
DK (1) DK1280527T3 (de)
EA (1) EA007506B1 (de)
EE (1) EE200200605A (de)
ES (1) ES2244618T3 (de)
GB (1) GB0011059D0 (de)
HK (1) HK1054193B (de)
HU (1) HUP0301882A2 (de)
IL (2) IL152388A0 (de)
MX (1) MXPA02010962A (de)
NO (1) NO20025303D0 (de)
NZ (1) NZ522234A (de)
PL (1) PL201289B1 (de)
PT (1) PT1280527E (de)
SK (1) SK286501B6 (de)
TW (1) TWI284643B (de)
WO (1) WO2001085144A2 (de)
ZA (1) ZA200208531B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0011059D0 (en) 2000-05-08 2000-06-28 Pharmacia & Upjohn Spa Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione
GB0015446D0 (en) * 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites
GB0015447D0 (en) * 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
GB0016447D0 (en) 2000-07-04 2000-08-23 Pharmacia & Upjohn Spa Process for preparing distamycin derivatives
IT1318696B1 (it) 2000-09-15 2003-08-27 Pharmacia & Upjohn Spa Coniugati di glutatione con derivati della distamicina ad attivita'antitumorale.
US6969592B2 (en) 2001-09-26 2005-11-29 Pharmacia Italia S.P.A. Method for predicting the sensitivity to chemotherapy
EP1490053B1 (de) * 2002-04-02 2008-01-09 NERVIANO MEDICAL SCIENCES S.r.l. Kombinierte tumortherapie auf der basis von distamycin-acryloyl derivaten und radiotherapie
PT3362056T (pt) * 2015-10-15 2021-04-22 Advanced Biodesign Compostos de aminotioléster ou seus sais farmaceuticamente aceitáveis, para utilização no tratamento de cancro

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT387013B (de) 1985-07-16 1988-11-25 Erba Farmitalia Verfahren zur herstellung von poly-4-aminopyrrol -2-carboxamidoderivaten
GB8612218D0 (en) 1986-05-20 1986-06-25 Erba Farmitalia Site specific alkylating agents
EP0265719B1 (de) 1986-10-07 1991-03-06 Boehringer Mannheim Italia S.P.A. Pharmazeutische Zusammensetzungen mit antineoplastischer Wirkung
GB8906709D0 (en) * 1989-03-23 1989-05-10 Creighton Andrew M Acryloyl substituted pyrrole derivatives
JP2919867B2 (ja) 1989-09-27 1999-07-19 千寿製薬株式会社 抗腫瘍剤
IT1272234B (it) 1994-05-02 1997-06-16 Consiglio Nazionale Ricerche Derivati glutationici delle antracicline e procedimento per ottenerli.
GB9416005D0 (en) * 1994-08-08 1994-09-28 Erba Carlo Spa Peptidic compounds analogous to distamycin a and process for their preparation
US5880097A (en) 1996-01-04 1999-03-09 Terrapin Techologies, Inc. Tethered prodrugs
JP2000503999A (ja) 1996-02-02 2000-04-04 フアルマシア・エ・アツプジヨン・エツセ・ピー・アー ジスタマイシン誘導体、その調製方法、および抗腫瘍および抗ウイルス剤としてのその使用
GB9610079D0 (en) 1996-05-14 1996-07-17 Pharmacia Spa Distamycin deriratives process for preparing them and their use as antitumor and antiviral agents
GB9615692D0 (en) 1996-07-25 1996-09-04 Pharmacia Spa Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
GB9623522D0 (en) 1996-11-11 1997-01-08 Pharmacia & Upjohn Spa Benzoheterocycle distamycin derivatives process for preparing them and their use as antitumour and antiviral agents
GB9727524D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Synergistic antitumor composition containing a biologically active ureido compound
GB9806692D0 (en) * 1998-03-27 1998-05-27 Pharmacia & Upjohn Spa Benzoheterocyclic distamycin derivatives, process for preparing them and their use as antitumour agents
GB9806689D0 (en) * 1998-03-27 1998-05-27 Pharmacia & Upjohn Spa Acryloyl derivatives analogous to distamycin,process for preparing them,and their use as antitumour and antiviral agents
GB9816652D0 (en) 1998-07-30 1998-09-30 Pharmacia & Upjohn Spa Sulfurated distamycin derivatives process for preparing them and their use as antitumor agents
GB9816653D0 (en) 1998-07-30 1998-09-30 Pharmacia & Upjohn Spa Oxidised sulfurated distamycin derivatives process for preparing them and their use as antitumor agents
GB9928703D0 (en) * 1999-12-03 2000-02-02 Pharmacia & Upjohn Spa Acryloyl peptidic derivatives,process for their preparation and their use as antitumour agents
GB0011059D0 (en) 2000-05-08 2000-06-28 Pharmacia & Upjohn Spa Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione

Also Published As

Publication number Publication date
CZ300791B6 (cs) 2009-08-12
BR0110628A (pt) 2003-03-18
MXPA02010962A (es) 2003-03-27
CA2409664C (en) 2010-01-12
SK16002002A3 (sk) 2003-04-01
JP2003532669A (ja) 2003-11-05
PT1280527E (pt) 2005-10-31
AU6022701A (en) 2001-11-20
US20030207794A1 (en) 2003-11-06
CA2409664A1 (en) 2001-11-15
DE60112423D1 (de) 2005-09-08
SK286501B6 (sk) 2008-11-06
EP1280527B1 (de) 2005-08-03
PL365831A1 (en) 2005-01-10
CN1258362C (zh) 2006-06-07
EE200200605A (et) 2004-04-15
KR20030019371A (ko) 2003-03-06
PL201289B1 (pl) 2009-03-31
EA007506B1 (ru) 2006-10-27
AU2001260227B2 (en) 2005-10-27
EA200201184A1 (ru) 2003-04-24
CZ20023629A3 (cs) 2003-03-12
NZ522234A (en) 2004-09-24
IL152388A (en) 2008-04-13
ES2244618T3 (es) 2005-12-16
WO2001085144A2 (en) 2001-11-15
HUP0301882A2 (hu) 2003-09-29
HK1054193A1 (en) 2003-11-21
HK1054193B (zh) 2007-02-02
ATE300944T1 (de) 2005-08-15
CN1427719A (zh) 2003-07-02
NO20025303L (no) 2002-11-05
WO2001085144A3 (en) 2002-05-16
EP1280527A2 (de) 2003-02-05
KR100776184B1 (ko) 2007-11-16
GB0011059D0 (en) 2000-06-28
DE60112423T2 (de) 2006-05-24
AR029518A1 (es) 2003-07-02
TWI284643B (en) 2007-08-01
DK1280527T3 (da) 2005-10-17
US7030089B2 (en) 2006-04-18
ZA200208531B (en) 2003-10-22
NO20025303D0 (no) 2002-11-05

Similar Documents

Publication Publication Date Title
HUP0300746A3 (en) Proline derivatives and use thereof as drugs
AU2001277754A1 (en) Proline derivatives and use thereof as drugs
AU2001249967A1 (en) Composition and methods for tissue preservation
IL155071A0 (en) Glucopyranosyloxybenzylbenzene derivatives and medical compositions containing the same
AR028622A1 (es) Derivados de tropano utiles en terapia
HK1053124A1 (en) Substituted quinazoline derivatives and their use as inhibitors
GB0016787D0 (en) Compounds useful in therapy
AU6989800A (en) Diamino-1,2,4-triazole-carboxylic and derivatives as gsk-3 inhibitors
CA2387873A1 (en) Nordihydroguaiaretic derivatives for use in treatment of tumors
IL150219A0 (en) Mulch composition and methods for the preparation and use thereof
AU2001244355A1 (en) Heterobiarylsulphonamides and their use as pde 7 inhibitors
GB0004167D0 (en) 1-piperidinyl-propan-2-ol derivatives and their use as therapeutic agents
HUP0203961A3 (en) 3-phenoxy-1-phenyl acetylene derivatives and their use as herbicedes
HUP0300480A3 (en) 2-acyl indol derivatives and their use as anti-tumour agents
AU2001283285A1 (en) Antimicrobial composition and methods of use in the treatment of disease
HUP0301773A3 (en) Apomorphine derivatives and methods for their use
ZA200210278B (en) 3-azabicyclo(3.1.0)hexane derivatives useful in therapy.
IL158254A0 (en) Indolinones, substituted in position 6, and their use as kinase inhibitors
IL152388A0 (en) Use of substituted acryloyl distamycin derivatives in the treatment of tumors associated with high levels of glutathione
ZA200210316B (en) Composition and its therapeutic use.
AU2002243363A1 (en) Use of aziridino-compounds in the treatment of immune dysfunctions
AU5464901A (en) Dichloropyridyl- and dichloroisothiazolyl-thiocarboxamides and their use as microbicides
HUP0301334A3 (en) Combined compositions against tumors comprising substituted acryloyl distamycin derivatives, taxanes and/or antimetabolited
AU2001276252A1 (en) The novel propanedione derivatives and their use as polymerizable uv-absorbent
CA2481005A1 (en) Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and radiotherapy

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed