ZA200203612B - Preparation of a macrocyclic lactone. - Google Patents
Preparation of a macrocyclic lactone. Download PDFInfo
- Publication number
- ZA200203612B ZA200203612B ZA200203612A ZA200203612A ZA200203612B ZA 200203612 B ZA200203612 B ZA 200203612B ZA 200203612 A ZA200203612 A ZA 200203612A ZA 200203612 A ZA200203612 A ZA 200203612A ZA 200203612 B ZA200203612 B ZA 200203612B
- Authority
- ZA
- South Africa
- Prior art keywords
- formula
- compound
- microorganism
- streptomyces
- cells
- Prior art date
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- PQZTVWVYCLIIJY-UHFFFAOYSA-N diethyl(propyl)amine Chemical group CCCN(CC)CC PQZTVWVYCLIIJY-UHFFFAOYSA-N 0.000 description 1
- 125000005442 diisocyanate group Chemical group 0.000 description 1
- GCKZANITAMOIAR-XWVCPFKXSA-N dsstox_cid_14566 Chemical class [O-]C(=O)C1=CC=CC=C1.C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H]([NH2+]C)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 GCKZANITAMOIAR-XWVCPFKXSA-N 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 229960000555 fenyramidol Drugs 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000001640 fractional crystallisation Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 150000002484 inorganic compounds Chemical class 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 239000011147 inorganic material Substances 0.000 description 1
- 108010090785 inulinase Proteins 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 125000004491 isohexyl group Chemical group C(CCC(C)C)* 0.000 description 1
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000000555 isopropenyl group Chemical group [H]\C([H])=C(\*)C([H])([H])[H] 0.000 description 1
- ZBKFYXZXZJPWNQ-UHFFFAOYSA-N isothiocyanate group Chemical group [N-]=C=S ZBKFYXZXZJPWNQ-UHFFFAOYSA-N 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000007483 microbial process Effects 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- ZUHZZVMEUAUWHY-UHFFFAOYSA-N n,n-dimethylpropan-1-amine Chemical compound CCCN(C)C ZUHZZVMEUAUWHY-UHFFFAOYSA-N 0.000 description 1
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 210000003463 organelle Anatomy 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- RVTZCBVAJQQJTK-UHFFFAOYSA-N oxygen(2-);zirconium(4+) Chemical compound [O-2].[O-2].[Zr+4] RVTZCBVAJQQJTK-UHFFFAOYSA-N 0.000 description 1
- 229940055729 papain Drugs 0.000 description 1
- 235000019834 papain Nutrition 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 229960000292 pectin Drugs 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000005373 porous glass Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 210000001938 protoplast Anatomy 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 210000004215 spore Anatomy 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 229960004418 trolamine Drugs 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- 229910001928 zirconium oxide Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
- C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9926887.2A GB9926887D0 (en) | 1999-11-12 | 1999-11-12 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200203612B true ZA200203612B (en) | 2003-02-26 |
Family
ID=10864471
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200203612A ZA200203612B (en) | 1999-11-12 | 2002-05-07 | Preparation of a macrocyclic lactone. |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6808903B1 (fr) |
| EP (1) | EP1228078B1 (fr) |
| JP (1) | JP3671003B2 (fr) |
| KR (1) | KR20020063890A (fr) |
| CN (2) | CN100519574C (fr) |
| AR (1) | AR026411A1 (fr) |
| AT (1) | ATE240340T1 (fr) |
| AU (1) | AU763109B2 (fr) |
| BR (1) | BR0015489B1 (fr) |
| CA (1) | CA2388824A1 (fr) |
| CZ (1) | CZ20021616A3 (fr) |
| DE (1) | DE60002751T2 (fr) |
| DK (1) | DK1228078T3 (fr) |
| ES (1) | ES2199883T3 (fr) |
| GB (1) | GB9926887D0 (fr) |
| HK (1) | HK1051204A1 (fr) |
| HU (1) | HUP0204437A3 (fr) |
| IL (2) | IL149369A0 (fr) |
| MX (1) | MXPA02004512A (fr) |
| PL (1) | PL354894A1 (fr) |
| PT (1) | PT1228078E (fr) |
| RU (1) | RU2234511C2 (fr) |
| WO (1) | WO2001036434A1 (fr) |
| ZA (1) | ZA200203612B (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030068788A1 (en) * | 2001-05-16 | 2003-04-10 | Buckel Thomas Gunther | Methods and compositions for making emamectin |
| AU2006100665A4 (en) * | 2006-07-06 | 2006-09-07 | Wyeth | Biocatalytic oxidation process and use thereof |
| CN109485683A (zh) * | 2018-11-27 | 2019-03-19 | 齐鲁晟华制药有限公司 | 一种含氟系列阿维菌素衍生物及其制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE434277B (sv) * | 1976-04-19 | 1984-07-16 | Merck & Co Inc | Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis |
| US4427663A (en) * | 1982-03-16 | 1984-01-24 | Merck & Co., Inc. | 4"-Keto-and 4"-amino-4"-deoxy avermectin compounds and substituted amino derivatives thereof |
| US4874749A (en) * | 1987-07-31 | 1989-10-17 | Merck & Co., Inc. | 4"-Deoxy-4-N-methylamino avermectin Bla/Blb |
| US5030622A (en) * | 1989-06-02 | 1991-07-09 | Merck & Co., Inc. | Avermectin derivatives |
| IL98599A (en) * | 1990-06-28 | 1995-06-29 | Merck & Co Inc | Stable salts of "4-deoxy-" 4-epi-methylamino abramectin and insecticides containing them |
| TW344649B (en) * | 1995-04-05 | 1998-11-11 | Novartis Ag | Pesticidal composition |
-
1999
- 1999-11-12 GB GBGB9926887.2A patent/GB9926887D0/en not_active Ceased
-
2000
- 2000-11-09 AR ARP000105911A patent/AR026411A1/es unknown
- 2000-11-10 US US10/129,853 patent/US6808903B1/en not_active Expired - Fee Related
- 2000-11-10 IL IL14936900A patent/IL149369A0/xx active IP Right Grant
- 2000-11-10 DE DE60002751T patent/DE60002751T2/de not_active Expired - Lifetime
- 2000-11-10 ES ES00977526T patent/ES2199883T3/es not_active Expired - Lifetime
- 2000-11-10 CA CA002388824A patent/CA2388824A1/fr not_active Abandoned
- 2000-11-10 WO PCT/EP2000/011139 patent/WO2001036434A1/fr not_active Application Discontinuation
- 2000-11-10 RU RU2002113754/04A patent/RU2234511C2/ru not_active IP Right Cessation
- 2000-11-10 EP EP00977526A patent/EP1228078B1/fr not_active Expired - Lifetime
- 2000-11-10 DK DK00977526T patent/DK1228078T3/da active
- 2000-11-10 HU HU0204437A patent/HUP0204437A3/hu unknown
- 2000-11-10 BR BRPI0015489-0A patent/BR0015489B1/pt not_active IP Right Cessation
- 2000-11-10 AT AT00977526T patent/ATE240340T1/de not_active IP Right Cessation
- 2000-11-10 KR KR1020027006098A patent/KR20020063890A/ko not_active Application Discontinuation
- 2000-11-10 PL PL00354894A patent/PL354894A1/xx not_active Application Discontinuation
- 2000-11-10 CZ CZ20021616A patent/CZ20021616A3/cs unknown
- 2000-11-10 PT PT00977526T patent/PT1228078E/pt unknown
- 2000-11-10 JP JP2001538923A patent/JP3671003B2/ja not_active Expired - Fee Related
- 2000-11-10 CN CNB2004100074552A patent/CN100519574C/zh not_active Expired - Fee Related
- 2000-11-10 AU AU15209/01A patent/AU763109B2/en not_active Ceased
- 2000-11-10 MX MXPA02004512A patent/MXPA02004512A/es active IP Right Grant
- 2000-11-10 CN CNB008155402A patent/CN1165542C/zh not_active Expired - Fee Related
-
2002
- 2002-04-25 IL IL149369A patent/IL149369A/en not_active IP Right Cessation
- 2002-05-07 ZA ZA200203612A patent/ZA200203612B/en unknown
-
2003
- 2003-05-16 HK HK03103469A patent/HK1051204A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IL149369A0 (en) | 2002-11-10 |
| US6808903B1 (en) | 2004-10-26 |
| CZ20021616A3 (cs) | 2002-07-17 |
| CN1523116A (zh) | 2004-08-25 |
| CA2388824A1 (fr) | 2001-05-25 |
| IL149369A (en) | 2007-07-04 |
| HUP0204437A2 (hu) | 2003-04-28 |
| DE60002751D1 (de) | 2003-06-18 |
| MXPA02004512A (es) | 2002-09-02 |
| AU1520901A (en) | 2001-05-30 |
| AU763109B2 (en) | 2003-07-10 |
| RU2002113754A (ru) | 2004-01-20 |
| ATE240340T1 (de) | 2003-05-15 |
| BR0015489A (pt) | 2002-06-25 |
| PL354894A1 (en) | 2004-03-22 |
| PT1228078E (pt) | 2003-09-30 |
| CN100519574C (zh) | 2009-07-29 |
| CN1165542C (zh) | 2004-09-08 |
| RU2234511C2 (ru) | 2004-08-20 |
| BR0015489B1 (pt) | 2012-11-27 |
| EP1228078A1 (fr) | 2002-08-07 |
| DK1228078T3 (da) | 2003-09-15 |
| HUP0204437A3 (en) | 2005-05-30 |
| ES2199883T3 (es) | 2004-03-01 |
| KR20020063890A (ko) | 2002-08-05 |
| CN1390226A (zh) | 2003-01-08 |
| WO2001036434A1 (fr) | 2001-05-25 |
| HK1051204A1 (en) | 2003-07-25 |
| DE60002751T2 (de) | 2004-02-26 |
| EP1228078B1 (fr) | 2003-05-14 |
| JP3671003B2 (ja) | 2005-07-13 |
| AR026411A1 (es) | 2003-02-12 |
| GB9926887D0 (en) | 2000-01-12 |
| JP2003514542A (ja) | 2003-04-22 |
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