ZA200107255B - 4-Oxo-4,7-dihydro-theino[2,3-b]pyridine-5-carboxamides as antiviral agents. - Google Patents

4-Oxo-4,7-dihydro-theino[2,3-b]pyridine-5-carboxamides as antiviral agents. Download PDF

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Publication number
ZA200107255B
ZA200107255B ZA200107255A ZA200107255A ZA200107255B ZA 200107255 B ZA200107255 B ZA 200107255B ZA 200107255 A ZA200107255 A ZA 200107255A ZA 200107255 A ZA200107255 A ZA 200107255A ZA 200107255 B ZA200107255 B ZA 200107255B
Authority
ZA
South Africa
Prior art keywords
chlorobenzyl
pyridine
carboxamide
dihydrothieno
oxo
Prior art date
Application number
ZA200107255A
Other languages
English (en)
Inventor
Mark E Schnute
Michele M Cudahy
Allen Scott
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of ZA200107255B publication Critical patent/ZA200107255B/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA200107255A 1999-03-09 2001-08-31 4-Oxo-4,7-dihydro-theino[2,3-b]pyridine-5-carboxamides as antiviral agents. ZA200107255B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12366099P 1999-03-09 1999-03-09

Publications (1)

Publication Number Publication Date
ZA200107255B true ZA200107255B (en) 2002-12-02

Family

ID=22410054

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200107255A ZA200107255B (en) 1999-03-09 2001-08-31 4-Oxo-4,7-dihydro-theino[2,3-b]pyridine-5-carboxamides as antiviral agents.

Country Status (25)

Country Link
US (2) US6239142B1 (cs)
EP (1) EP1159279B1 (cs)
JP (1) JP2002539130A (cs)
KR (1) KR20010102543A (cs)
CN (1) CN1347417A (cs)
AT (1) ATE226208T1 (cs)
AU (1) AU759875B2 (cs)
BR (1) BR0008804A (cs)
CA (1) CA2366609A1 (cs)
CZ (1) CZ20013028A3 (cs)
DE (1) DE60000611T2 (cs)
DK (1) DK1159279T3 (cs)
EA (1) EA003607B1 (cs)
ES (1) ES2184705T3 (cs)
HK (1) HK1045518A1 (cs)
HU (1) HUP0200324A3 (cs)
IL (1) IL145005A0 (cs)
NO (1) NO20014363L (cs)
NZ (1) NZ513758A (cs)
PL (1) PL350651A1 (cs)
PT (1) PT1159279E (cs)
SK (1) SK12582001A3 (cs)
TW (1) TWI222451B (cs)
WO (1) WO2000053610A2 (cs)
ZA (1) ZA200107255B (cs)

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US6730682B2 (en) 2000-07-12 2004-05-04 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
US6559145B2 (en) 2000-07-12 2003-05-06 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
US6562822B2 (en) 2000-07-12 2003-05-13 Pharmacia & Upjohn Company Heterocyle carboxamides as antiviral agents
US7638522B2 (en) 2001-08-13 2009-12-29 Janssen Pharmaceutica N.V. Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino] benzonitrile
US8101629B2 (en) 2001-08-13 2012-01-24 Janssen Pharmaceutica N.V. Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
JO3429B1 (ar) 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
WO2003020729A1 (en) * 2001-08-30 2003-03-13 Pharmacia & Upjohn Company 4-THIOXO-4,7-DIHYDRO-THIENO[2,3-b]PYRIDINE-5-CARBOXAMIDES AS ANT IVIRAL AGENTS
WO2003020728A1 (en) 2001-08-30 2003-03-13 Pharmacia & Upjohn Company 4-THIOXO-4,7-DIHYDRO-THIENO[2,3-b]PYRIDINE-5-CARBOTHIOAMIDES AS ANTIVIRAL AGENTS
WO2003053944A1 (en) * 2001-12-20 2003-07-03 Osi Pharmaceuticals, Inc. Pancreatic lipase inhibitor compounds, their synthesis and use
AR038117A1 (es) * 2002-01-14 2004-12-29 Upjohn Co Agentes antivirales derivados de la 4- oxo-4,7 -dihidrofuro [2,3-b]piridin-5-carboxamida
AR038118A1 (es) * 2002-01-14 2004-12-29 Upjohn Co Compuestos derivados de la bencinamida del acido 7-oxo-4,7-dihidrotien[2,3-b[piridin-6-carboxilico 3-sustituido que son utiles como antivirales
AR038294A1 (es) * 2002-01-14 2005-01-12 Upjohn Co Oxotieno(3,2-b)piridincarboxamidas como agentes antivirales
US20030212271A1 (en) * 2002-04-22 2003-11-13 Allen Scott Trifluoroacetic acid process to prepare [2,3-B]pyridine intermediates
EA007953B1 (ru) 2002-08-09 2007-02-27 Янссен Фармацевтика Н.В. Способы получения 4-[[4-[[4-(2-цианоэтенил)-2,6-диметилфенил]амино]-2-пиримидинил]амино]бензонитрила
US20040102473A1 (en) * 2002-08-30 2004-05-27 Wathen Michael W. Method of preventing or treating atherosclerosis or restenosis
US20040176366A1 (en) * 2002-08-30 2004-09-09 Wathen Michael W Method of preventing or treating atherosclerosis or restenosis
AU2003262947A1 (en) * 2002-08-30 2004-03-19 Pharmacia And Upjohn Company Method of preventing or treating atherosclerosis or restenosis
WO2004019940A1 (en) * 2002-08-30 2004-03-11 Pharmacia & Upjohn Company Method of preventing or treating atherosclerosis or restenosis
US20040116464A1 (en) * 2002-09-04 2004-06-17 Schnute Mark E. Aryl-ethanolamine derivatives as antiviral agents
WO2004106345A2 (en) * 2002-09-04 2004-12-09 Pharmacia & Upjohn Company Heteroaryl-ethanolamine derivatives as antiviral agents
WO2004022567A1 (en) * 2002-09-04 2004-03-18 Pharmacia & Upjohn Company Llc Heteroaryl-ethanolamine derivatives as antiviral agents
WO2004022566A1 (en) * 2002-09-04 2004-03-18 Pharmacia & Upjohn Company Llc 4-OXO-4,7-DIHYDROTHIENO[2,3-b]PYRIDINE-5-CARBOXAMIDES AS ANTIVIRAL AGENTS
WO2005003140A1 (en) * 2003-07-02 2005-01-13 Pharmacia & Upjohn Company Llc 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides as antiviral agents
JP2007532615A (ja) * 2004-04-13 2007-11-15 アステックス、セラピューティックス、リミテッド 医薬化合物
SE0401578D0 (sv) 2004-06-18 2004-06-18 Active Biotech Ab Novel compounds
WO2006093518A2 (en) * 2004-06-25 2006-09-08 Apath, Llc Thienyl compounds for treating virus-related conditions
EP2400845B1 (en) 2009-02-27 2017-02-22 Siga Technologies, Inc. Thienopyridine derivatives for the treatment and prevention of dengue virus infections
WO2017143041A1 (en) 2016-02-16 2017-08-24 Vanderbilt University Positive allosteric modulators of the muscarinic acetylcholine receptor m1
US10899759B2 (en) 2016-09-30 2021-01-26 Vanderbilt University Positive allosteric modulators of the muscarinic acetylcholine receptor M1
EP3849979A1 (en) 2018-09-12 2021-07-21 Novartis AG Antiviral pyridopyrazinedione compounds
EP4034537A1 (en) 2019-09-26 2022-08-03 Novartis AG Antiviral pyrazolopyridinone compounds
CN115073489B (zh) * 2021-03-15 2023-11-28 同济大学 一种噻吩骈吡啶酮类化合物、制备方法及一种抗真菌药物
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Also Published As

Publication number Publication date
US20020006937A1 (en) 2002-01-17
KR20010102543A (ko) 2001-11-15
SK12582001A3 (sk) 2002-02-05
BR0008804A (pt) 2002-04-16
EA200100955A1 (ru) 2002-02-28
US6495683B2 (en) 2002-12-17
DE60000611D1 (en) 2002-11-21
HUP0200324A2 (en) 2002-06-29
TWI222451B (en) 2004-10-21
ATE226208T1 (de) 2002-11-15
WO2000053610A3 (en) 2001-01-25
WO2000053610A2 (en) 2000-09-14
CA2366609A1 (en) 2000-09-14
NO20014363L (no) 2001-11-08
CZ20013028A3 (cs) 2002-03-13
AU3516200A (en) 2000-09-28
EP1159279A2 (en) 2001-12-05
DE60000611T2 (de) 2003-06-26
AU759875B2 (en) 2003-05-01
CN1347417A (zh) 2002-05-01
NZ513758A (en) 2001-09-28
PL350651A1 (en) 2003-01-27
EA003607B1 (ru) 2003-06-26
JP2002539130A (ja) 2002-11-19
US6239142B1 (en) 2001-05-29
NO20014363D0 (no) 2001-09-07
ES2184705T3 (es) 2003-04-16
IL145005A0 (en) 2002-06-30
HK1045518A1 (zh) 2002-11-29
HUP0200324A3 (en) 2003-07-28
PT1159279E (pt) 2003-02-28
DK1159279T3 (da) 2003-02-17
EP1159279B1 (en) 2002-10-16

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