ZA200107157B - 4-Heterocyclysulfonamidyl-6-methoxy-5-(2-methoxy-phenoxy)-2-pyridyl-pyrimidine derivatives, their preparation and use as endothel in receptor antagonists. - Google Patents
4-Heterocyclysulfonamidyl-6-methoxy-5-(2-methoxy-phenoxy)-2-pyridyl-pyrimidine derivatives, their preparation and use as endothel in receptor antagonists. Download PDFInfo
- Publication number
- ZA200107157B ZA200107157B ZA200107157A ZA200107157A ZA200107157B ZA 200107157 B ZA200107157 B ZA 200107157B ZA 200107157 A ZA200107157 A ZA 200107157A ZA 200107157 A ZA200107157 A ZA 200107157A ZA 200107157 B ZA200107157 B ZA 200107157B
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- South Africa
- Prior art keywords
- methoxy
- phenoxy
- compound
- pyridine
- pyrimidin
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- 230000002455 vasospastic effect Effects 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Neurosurgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Child & Adolescent Psychology (AREA)
- Ophthalmology & Optometry (AREA)
- Obesity (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99104306 | 1999-03-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200107157B true ZA200107157B (en) | 2002-11-29 |
Family
ID=8237697
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200107157A ZA200107157B (en) | 1999-03-03 | 2001-08-29 | 4-Heterocyclysulfonamidyl-6-methoxy-5-(2-methoxy-phenoxy)-2-pyridyl-pyrimidine derivatives, their preparation and use as endothel in receptor antagonists. |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US6417360B1 (fr) |
| EP (1) | EP1185525B1 (fr) |
| JP (1) | JP3488203B2 (fr) |
| KR (1) | KR100478798B1 (fr) |
| CN (1) | CN1342158B (fr) |
| AR (1) | AR044720A1 (fr) |
| AT (1) | ATE353325T1 (fr) |
| AU (1) | AU756738B2 (fr) |
| BR (1) | BR0008717A (fr) |
| CA (1) | CA2364906C (fr) |
| CY (1) | CY1108002T1 (fr) |
| CZ (1) | CZ300324B6 (fr) |
| DE (1) | DE60033280T2 (fr) |
| DK (1) | DK1185525T3 (fr) |
| ES (1) | ES2280198T3 (fr) |
| HK (1) | HK1044943B (fr) |
| HR (1) | HRP20010630B1 (fr) |
| HU (1) | HUP0200080A3 (fr) |
| ID (1) | ID30484A (fr) |
| IL (1) | IL145051A0 (fr) |
| MA (1) | MA26776A1 (fr) |
| NO (1) | NO320809B1 (fr) |
| NZ (1) | NZ513671A (fr) |
| PL (1) | PL198815B1 (fr) |
| PT (1) | PT1185525E (fr) |
| RS (1) | RS50109B (fr) |
| RU (1) | RU2201928C1 (fr) |
| TR (1) | TR200102562T2 (fr) |
| WO (1) | WO2000052007A1 (fr) |
| ZA (1) | ZA200107157B (fr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY140724A (en) | 2000-07-21 | 2010-01-15 | Actelion Pharmaceuticals Ltd | Novel arylethene-sulfonamides |
| US20020184047A1 (en) * | 2001-04-03 | 2002-12-05 | Plotnick Michael A. | Universal ad queue |
| EP1454625A1 (fr) * | 2003-03-06 | 2004-09-08 | Speedel Development AG | Pyridylsulfonamidyl-pyrimidines pour le traitement des néphropaties diabétiques |
| EP1595880A1 (fr) * | 2004-05-13 | 2005-11-16 | Speedel Pharma AG | Formes crystallines d'un pyridinylsulphonamide et leur utilisation comme antagonistes du récepteur de l'endothéline |
| JP2009507890A (ja) * | 2005-09-12 | 2009-02-26 | シュペーデル・ファルマ・アーゲー | 血管移植片機能不全の予防のためのピリジルスルホンアミジル−ピリミジン類 |
| RU2435585C2 (ru) * | 2006-04-13 | 2011-12-10 | Актелион Фармасьютиклз Лтд | Антагонисты рецептора эндотелина, предназначенные для ранней стадии идиопатического фиброза легких |
| EP1938812A1 (fr) * | 2006-12-22 | 2008-07-02 | Speedel Pharma AG | Composition pharmaceutique utilisant aliskiren et avosentan |
| US20100093758A1 (en) * | 2008-07-23 | 2010-04-15 | Auspex Pharmaceuticals, Inc. | Pyridine sulfonamide modulators of endothelin-a receptor |
| WO2016123291A1 (fr) | 2015-01-29 | 2016-08-04 | Signal Pharmaceuticals, Llc | Isotopologues de 2-(tert-butylamino)-4-((1r,3r,4r) -3-hydroxy-4-méthylcyclohexylamino)-pyrimidine-5-carboxamide |
| KR101936054B1 (ko) | 2017-06-23 | 2019-01-11 | 한국과학기술연구원 | 항염증 활성을 가지는 6-페녹시피리미딘 유도체, 이의 제조방법 및 이를 활성성분으로 하는 약학 조성물 |
| TW202329952A (zh) | 2021-12-17 | 2023-08-01 | 瑞士商愛杜西亞製藥有限公司 | 克拉生坦(clazosentan)二鈉鹽之製備方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2162630C (fr) | 1994-11-25 | 2007-05-01 | Volker Breu | Sulfonamides |
| CN1064965C (zh) * | 1994-11-25 | 2001-04-25 | 弗·哈夫曼-拉罗切有限公司 | 新的磺酰胺类化合物及其作为药物的用途 |
| US5837708A (en) | 1994-11-25 | 1998-11-17 | Hoffmann-La Roche Inc. | Sulphonamides |
| TW313568B (fr) * | 1994-12-20 | 1997-08-21 | Hoffmann La Roche | |
| ATE267808T1 (de) | 1997-08-19 | 2004-06-15 | Hoffmann La Roche | Verfahren zur herstellung von 2,5- disubstituierten pyridinen |
| TWI284642B (en) * | 1999-01-18 | 2007-08-01 | Hoffmann La Roche | Novel heterocyclic sulfonamides |
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2000
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- 2000-02-28 CZ CZ20013108A patent/CZ300324B6/cs not_active IP Right Cessation
- 2000-02-28 CA CA002364906A patent/CA2364906C/fr not_active Expired - Lifetime
- 2000-02-28 PT PT00909263T patent/PT1185525E/pt unknown
- 2000-02-28 IL IL14505100A patent/IL145051A0/xx not_active IP Right Cessation
- 2000-02-28 KR KR10-2001-7011184A patent/KR100478798B1/ko not_active IP Right Cessation
- 2000-02-28 EP EP00909263A patent/EP1185525B1/fr not_active Expired - Lifetime
- 2000-02-28 DE DE60033280T patent/DE60033280T2/de not_active Expired - Lifetime
- 2000-02-28 TR TR2001/02562T patent/TR200102562T2/xx unknown
- 2000-02-28 PL PL351794A patent/PL198815B1/pl unknown
- 2000-02-28 DK DK00909263T patent/DK1185525T3/da active
- 2000-02-28 JP JP2000602233A patent/JP3488203B2/ja not_active Expired - Lifetime
- 2000-02-28 AT AT00909263T patent/ATE353325T1/de active
- 2000-02-28 ES ES00909263T patent/ES2280198T3/es not_active Expired - Lifetime
- 2000-02-28 BR BR0008717-3A patent/BR0008717A/pt not_active IP Right Cessation
- 2000-02-28 ID IDW00200101897A patent/ID30484A/id unknown
- 2000-02-28 RS YUP-628/01A patent/RS50109B/sr unknown
- 2000-02-28 AU AU31611/00A patent/AU756738B2/en not_active Ceased
- 2000-02-28 CN CN008043582A patent/CN1342158B/zh not_active Expired - Lifetime
- 2000-02-28 WO PCT/EP2000/001660 patent/WO2000052007A1/fr active IP Right Grant
- 2000-02-28 RU RU2001126348/04A patent/RU2201928C1/ru not_active IP Right Cessation
- 2000-02-28 NZ NZ513671A patent/NZ513671A/xx not_active IP Right Cessation
- 2000-02-28 HU HU0200080A patent/HUP0200080A3/hu unknown
- 2000-03-02 AR ARP000100921A patent/AR044720A1/es active IP Right Grant
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2001
- 2001-08-28 HR HR20010630A patent/HRP20010630B1/xx not_active IP Right Cessation
- 2001-08-29 ZA ZA200107157A patent/ZA200107157B/en unknown
- 2001-08-31 NO NO20014224A patent/NO320809B1/no not_active IP Right Cessation
- 2001-09-03 MA MA26313A patent/MA26776A1/fr unknown
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2002
- 2002-03-08 US US10/094,126 patent/US6521631B2/en not_active Expired - Lifetime
- 2002-08-27 HK HK02106318.0A patent/HK1044943B/zh not_active IP Right Cessation
-
2007
- 2007-03-08 CY CY20071100324T patent/CY1108002T1/el unknown
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