ZA200107157B - 4-Heterocyclysulfonamidyl-6-methoxy-5-(2-methoxy-phenoxy)-2-pyridyl-pyrimidine derivatives, their preparation and use as endothel in receptor antagonists. - Google Patents

4-Heterocyclysulfonamidyl-6-methoxy-5-(2-methoxy-phenoxy)-2-pyridyl-pyrimidine derivatives, their preparation and use as endothel in receptor antagonists. Download PDF

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Publication number
ZA200107157B
ZA200107157B ZA200107157A ZA200107157A ZA200107157B ZA 200107157 B ZA200107157 B ZA 200107157B ZA 200107157 A ZA200107157 A ZA 200107157A ZA 200107157 A ZA200107157 A ZA 200107157A ZA 200107157 B ZA200107157 B ZA 200107157B
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ZA
South Africa
Prior art keywords
methoxy
phenoxy
compound
pyridine
pyrimidin
Prior art date
Application number
ZA200107157A
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English (en)
Inventor
Breu Volker Neidhardt Werner
Peter Weiss
Philippe Coassolo
Sebastien Roux
Original Assignee
Hoffmann La Roche
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Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ZA200107157B publication Critical patent/ZA200107157B/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Neurosurgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
ZA200107157A 1999-03-03 2001-08-29 4-Heterocyclysulfonamidyl-6-methoxy-5-(2-methoxy-phenoxy)-2-pyridyl-pyrimidine derivatives, their preparation and use as endothel in receptor antagonists. ZA200107157B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99104306 1999-03-03

Publications (1)

Publication Number Publication Date
ZA200107157B true ZA200107157B (en) 2002-11-29

Family

ID=8237697

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200107157A ZA200107157B (en) 1999-03-03 2001-08-29 4-Heterocyclysulfonamidyl-6-methoxy-5-(2-methoxy-phenoxy)-2-pyridyl-pyrimidine derivatives, their preparation and use as endothel in receptor antagonists.

Country Status (30)

Country Link
US (2) US6417360B1 (fr)
EP (1) EP1185525B1 (fr)
JP (1) JP3488203B2 (fr)
KR (1) KR100478798B1 (fr)
CN (1) CN1342158B (fr)
AR (1) AR044720A1 (fr)
AT (1) ATE353325T1 (fr)
AU (1) AU756738B2 (fr)
BR (1) BR0008717A (fr)
CA (1) CA2364906C (fr)
CY (1) CY1108002T1 (fr)
CZ (1) CZ300324B6 (fr)
DE (1) DE60033280T2 (fr)
DK (1) DK1185525T3 (fr)
ES (1) ES2280198T3 (fr)
HK (1) HK1044943B (fr)
HR (1) HRP20010630B1 (fr)
HU (1) HUP0200080A3 (fr)
ID (1) ID30484A (fr)
IL (1) IL145051A0 (fr)
MA (1) MA26776A1 (fr)
NO (1) NO320809B1 (fr)
NZ (1) NZ513671A (fr)
PL (1) PL198815B1 (fr)
PT (1) PT1185525E (fr)
RS (1) RS50109B (fr)
RU (1) RU2201928C1 (fr)
TR (1) TR200102562T2 (fr)
WO (1) WO2000052007A1 (fr)
ZA (1) ZA200107157B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY140724A (en) 2000-07-21 2010-01-15 Actelion Pharmaceuticals Ltd Novel arylethene-sulfonamides
US20020184047A1 (en) * 2001-04-03 2002-12-05 Plotnick Michael A. Universal ad queue
EP1454625A1 (fr) * 2003-03-06 2004-09-08 Speedel Development AG Pyridylsulfonamidyl-pyrimidines pour le traitement des néphropaties diabétiques
EP1595880A1 (fr) * 2004-05-13 2005-11-16 Speedel Pharma AG Formes crystallines d'un pyridinylsulphonamide et leur utilisation comme antagonistes du récepteur de l'endothéline
BRPI0615794A2 (pt) * 2005-09-12 2011-05-24 Speedel Pharma Ag piridilsulfonamidil-pirimidinas para a prevenção de falha de enxerto de vaso sangüìneo
BRPI0709950A2 (pt) * 2006-04-13 2011-08-02 Actelion Pharmaceuticals Ltd uso de bosentan na preparação de um medicamento para o tratamento de fibrose pulmonar idiopática em estágio precoce e uso de antagonista do receptor endotelin
EP1938812A1 (fr) * 2006-12-22 2008-07-02 Speedel Pharma AG Composition pharmaceutique utilisant aliskiren et avosentan
WO2010011868A2 (fr) * 2008-07-23 2010-01-28 Auspex Pharmaceuticals Modulateurs de pyridine sulfonamide du récepteur a de l'endothéline
CA2975260C (fr) 2015-01-29 2024-05-21 Signal Pharmaceuticals Llc Isotopologues de 2-(tert-butylamino)-4-((1r,3r,4r) -3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide
KR101936054B1 (ko) 2017-06-23 2019-01-11 한국과학기술연구원 항염증 활성을 가지는 6-페녹시피리미딘 유도체, 이의 제조방법 및 이를 활성성분으로 하는 약학 조성물
WO2023111299A1 (fr) 2021-12-17 2023-06-22 Idorsia Pharmaceuticals Ltd Sel disodique de clazosentan, sa préparation et compositions pharmaceutiques le comprenant

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5837708A (en) 1994-11-25 1998-11-17 Hoffmann-La Roche Inc. Sulphonamides
CA2162630C (fr) 1994-11-25 2007-05-01 Volker Breu Sulfonamides
CN1064965C (zh) * 1994-11-25 2001-04-25 弗·哈夫曼-拉罗切有限公司 新的磺酰胺类化合物及其作为药物的用途
TW313568B (fr) * 1994-12-20 1997-08-21 Hoffmann La Roche
EP0897914B1 (fr) 1997-08-19 2004-05-26 F. Hoffmann-La Roche Ag Procédé pour la préparation de pyridines 2,5-disubstitués
TWI284642B (en) * 1999-01-18 2007-08-01 Hoffmann La Roche Novel heterocyclic sulfonamides

Also Published As

Publication number Publication date
RU2201928C1 (ru) 2003-04-10
NO320809B1 (no) 2006-01-30
EP1185525B1 (fr) 2007-02-07
KR20010102480A (ko) 2001-11-15
ATE353325T1 (de) 2007-02-15
MA26776A1 (fr) 2004-12-20
JP3488203B2 (ja) 2004-01-19
TR200102562T2 (tr) 2002-02-21
US6417360B1 (en) 2002-07-09
CY1108002T1 (el) 2013-09-04
CA2364906C (fr) 2006-01-10
KR100478798B1 (ko) 2005-03-24
PL198815B1 (pl) 2008-07-31
CZ20013108A3 (cs) 2002-02-13
HK1044943B (zh) 2013-03-22
US20020137933A1 (en) 2002-09-26
IL145051A0 (en) 2002-06-30
PL351794A1 (en) 2003-06-16
EP1185525A1 (fr) 2002-03-13
AU3161100A (en) 2000-09-21
NO20014224D0 (no) 2001-08-31
HUP0200080A3 (en) 2003-01-28
CA2364906A1 (fr) 2000-09-08
HRP20010630A2 (en) 2002-08-31
HRP20010630B1 (en) 2010-08-31
DK1185525T3 (da) 2007-06-04
HUP0200080A2 (en) 2002-06-29
ID30484A (id) 2001-12-13
AU756738B2 (en) 2003-01-23
AR044720A1 (es) 2005-10-05
PT1185525E (pt) 2007-05-31
YU62801A (sh) 2004-07-15
HK1044943A1 (fr) 2002-11-08
US6521631B2 (en) 2003-02-18
WO2000052007A1 (fr) 2000-09-08
BR0008717A (pt) 2001-12-26
RU2001126348A (ru) 2004-03-20
CZ300324B6 (cs) 2009-04-22
CN1342158B (zh) 2012-06-06
NZ513671A (en) 2003-04-29
NO20014224L (no) 2001-08-31
DE60033280T2 (de) 2007-11-22
RS50109B (sr) 2009-03-25
DE60033280D1 (de) 2007-03-22
ES2280198T3 (es) 2007-09-16
CN1342158A (zh) 2002-03-27
JP2002538156A (ja) 2002-11-12

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