ZA200103010B - Method of conversion of interferon isoforms and products thereof. - Google Patents
Method of conversion of interferon isoforms and products thereof. Download PDFInfo
- Publication number
- ZA200103010B ZA200103010B ZA200103010A ZA200103010A ZA200103010B ZA 200103010 B ZA200103010 B ZA 200103010B ZA 200103010 A ZA200103010 A ZA 200103010A ZA 200103010 A ZA200103010 A ZA 200103010A ZA 200103010 B ZA200103010 B ZA 200103010B
- Authority
- ZA
- South Africa
- Prior art keywords
- protein
- isoform
- pyruvate
- adjunct
- solution
- Prior art date
Links
- 102000001708 Protein Isoforms Human genes 0.000 title claims description 98
- 108010029485 Protein Isoforms Proteins 0.000 title claims description 98
- 238000000034 method Methods 0.000 title claims description 60
- 238000006243 chemical reaction Methods 0.000 title description 57
- 102000014150 Interferons Human genes 0.000 title description 7
- 108010050904 Interferons Proteins 0.000 title description 7
- 229940079322 interferon Drugs 0.000 title description 7
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 claims description 52
- 239000011701 zinc Substances 0.000 claims description 20
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- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 13
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- YPZRWBKMTBYPTK-BJDJZHNGSA-N glutathione disulfide Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@H](C(=O)NCC(O)=O)CSSC[C@@H](C(=O)NCC(O)=O)NC(=O)CC[C@H](N)C(O)=O YPZRWBKMTBYPTK-BJDJZHNGSA-N 0.000 description 1
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- 108010055511 interferon alfa-2c Proteins 0.000 description 1
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- 239000003605 opacifier Substances 0.000 description 1
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- 210000001236 prokaryotic cell Anatomy 0.000 description 1
- ALDITMKAAPLVJK-UHFFFAOYSA-N prop-1-ene;hydrate Chemical group O.CC=C ALDITMKAAPLVJK-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19054298A | 1998-11-12 | 1998-11-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200103010B true ZA200103010B (en) | 2002-07-11 |
Family
ID=22701766
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200103010A ZA200103010B (en) | 1998-11-12 | 2001-04-11 | Method of conversion of interferon isoforms and products thereof. |
Country Status (27)
| Country | Link |
|---|---|
| EP (2) | EP1894944B1 (no) |
| JP (3) | JP4468585B2 (no) |
| KR (1) | KR100922454B1 (no) |
| CN (2) | CN101255188A (no) |
| AR (1) | AR023906A1 (no) |
| AT (2) | ATE476445T1 (no) |
| AU (1) | AU766309B2 (no) |
| BR (1) | BR9915257A (no) |
| CA (1) | CA2348739C (no) |
| CY (2) | CY1110444T1 (no) |
| CZ (2) | CZ303110B6 (no) |
| DE (2) | DE69942655D1 (no) |
| DK (2) | DK1894944T3 (no) |
| ES (2) | ES2315019T3 (no) |
| HK (2) | HK1112746A1 (no) |
| HU (1) | HU228265B1 (no) |
| ID (1) | ID28552A (no) |
| IL (2) | IL142546A0 (no) |
| NO (2) | NO329483B1 (no) |
| NZ (1) | NZ511074A (no) |
| PL (2) | PL200274B1 (no) |
| PT (2) | PT1894944E (no) |
| SI (2) | SI1129111T1 (no) |
| SK (2) | SK287564B6 (no) |
| TW (1) | TW577894B (no) |
| WO (1) | WO2000029440A1 (no) |
| ZA (1) | ZA200103010B (no) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU228265B1 (en) * | 1998-11-12 | 2013-02-28 | Merck Sharp & Dohme | Methods of conversion of interferon isoforms and products thereof |
| WO2010075159A1 (en) | 2008-12-23 | 2010-07-01 | Schering Corporation | Purification of recombinantly produced interferon |
| WO2021212220A1 (en) * | 2020-04-20 | 2021-10-28 | Altum Pharmaceuticals Inc. | Recombinant interferon |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3165463D1 (en) | 1980-01-08 | 1984-09-20 | Biogen Nv | Dna sequences, recombinant dna molecules and processes for producing human interferon-alpha like polypeptides |
| US4530901A (en) | 1980-01-08 | 1985-07-23 | Biogen N.V. | Recombinant DNA molecules and their use in producing human interferon-like polypeptides |
| US4315852A (en) | 1980-11-26 | 1982-02-16 | Schering Corporation | Extraction of interferon from bacteria |
| US4364863A (en) * | 1980-12-29 | 1982-12-21 | Schering Corporation | Extraction of interferon from bacteria |
| EP0082481B2 (en) | 1981-12-23 | 1990-09-12 | Schering Corporation | Stabilised alpha-interferon formulations and their preparation |
| DE3515336C2 (de) * | 1985-04-27 | 1994-01-20 | Boehringer Ingelheim Int | Verfahren zur Herstellung und Reinigung von â-Interferon |
| US4847079A (en) | 1985-07-29 | 1989-07-11 | Schering Corporation | Biologically stable interferon compositions comprising thimerosal |
| US4732683A (en) | 1986-12-02 | 1988-03-22 | Biospectrum, Inc. | Purification method for alpha interferon |
| US4765903A (en) | 1987-10-06 | 1988-08-23 | Interferon Sciences, Inc. | Purification of monomeric interferon |
| US5272135A (en) | 1991-03-01 | 1993-12-21 | Chiron Ophthalmics, Inc. | Method for the stabilization of methionine-containing polypeptides |
| AU648214B2 (en) * | 1991-12-31 | 1994-04-14 | Lucky Limited | Recombinant gene coding for human alpha interferon and expression vector thereof, etc. |
| DE69522492T2 (de) * | 1994-04-09 | 2002-05-23 | Hoffmann La Roche | Verfahren zur Herstellung von Alpha-Interferon |
| US5766582A (en) | 1994-10-11 | 1998-06-16 | Schering Corporation | Stable, aqueous alfa interferon solution formulations |
| HU228265B1 (en) * | 1998-11-12 | 2013-02-28 | Merck Sharp & Dohme | Methods of conversion of interferon isoforms and products thereof |
-
1999
- 1999-10-05 HU HU0104113A patent/HU228265B1/hu unknown
- 1999-10-05 KR KR1020017005227A patent/KR100922454B1/ko not_active IP Right Cessation
- 1999-10-05 DE DE69942655T patent/DE69942655D1/de not_active Expired - Lifetime
- 1999-10-05 WO PCT/US1999/020900 patent/WO2000029440A1/en active Application Filing
- 1999-10-05 PL PL348162A patent/PL200274B1/pl not_active IP Right Cessation
- 1999-10-05 AT AT07122953T patent/ATE476445T1/de active
- 1999-10-05 AU AU63870/99A patent/AU766309B2/en not_active Ceased
- 1999-10-05 SI SI9931022T patent/SI1129111T1/sl unknown
- 1999-10-05 EP EP07122953A patent/EP1894944B1/en not_active Expired - Lifetime
- 1999-10-05 TW TW088117149A patent/TW577894B/zh not_active IP Right Cessation
- 1999-10-05 DE DE69939657T patent/DE69939657D1/de not_active Expired - Lifetime
- 1999-10-05 JP JP2000582425A patent/JP4468585B2/ja not_active Expired - Fee Related
- 1999-10-05 ES ES99951431T patent/ES2315019T3/es not_active Expired - Lifetime
- 1999-10-05 NZ NZ511074A patent/NZ511074A/en not_active IP Right Cessation
- 1999-10-05 PT PT07122953T patent/PT1894944E/pt unknown
- 1999-10-05 CA CA2348739A patent/CA2348739C/en not_active Expired - Fee Related
- 1999-10-05 SK SK5003-2010A patent/SK287564B6/sk not_active IP Right Cessation
- 1999-10-05 EP EP99951431A patent/EP1129111B1/en not_active Expired - Lifetime
- 1999-10-05 CN CNA2008100866846A patent/CN101255188A/zh active Pending
- 1999-10-05 AR ARP990105037A patent/AR023906A1/es active IP Right Grant
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