ZA200102590B - Bacterial strains for the production of 2-keto-L-gulonic acid. - Google Patents
Bacterial strains for the production of 2-keto-L-gulonic acid. Download PDFInfo
- Publication number
- ZA200102590B ZA200102590B ZA200102590A ZA200102590A ZA200102590B ZA 200102590 B ZA200102590 B ZA 200102590B ZA 200102590 A ZA200102590 A ZA 200102590A ZA 200102590 A ZA200102590 A ZA 200102590A ZA 200102590 B ZA200102590 B ZA 200102590B
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- ZA
- South Africa
- Prior art keywords
- strain
- nrrl
- adm
- culture
- sorbose
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/58—Aldonic, ketoaldonic or saccharic acids
- C12P7/60—2-Ketogulonic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
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Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US9986098P | 1998-09-11 | 1998-09-11 |
Publications (1)
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ZA200102590B true ZA200102590B (en) | 2001-10-02 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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ZA200102590A ZA200102590B (en) | 1998-09-11 | 2001-03-29 | Bacterial strains for the production of 2-keto-L-gulonic acid. |
Country Status (10)
Country | Link |
---|---|
US (4) | US6316231B1 (fr) |
EP (1) | EP1112344A2 (fr) |
JP (1) | JP2002525068A (fr) |
KR (1) | KR20010075047A (fr) |
CN (1) | CN1317042A (fr) |
AU (1) | AU762825B2 (fr) |
BR (1) | BR9913563A (fr) |
CA (1) | CA2342299A1 (fr) |
WO (1) | WO2000015827A2 (fr) |
ZA (1) | ZA200102590B (fr) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5834231A (en) | 1996-10-24 | 1998-11-10 | Archer Daniels Midland Co. | Bacterial strains and use thereof in fermentation process for 2-keto-L-gulonic acid production |
AU762825B2 (en) | 1998-09-11 | 2003-07-03 | Archer-Daniels-Midland Company | Bacterial strains for the production of 2-keto-L-gulonic acid |
AU2001251324A1 (en) | 2000-04-05 | 2001-10-23 | Archer-Daniels-Midland Company | An endogenous ketogulonigenium plasmid |
AU2001253162A1 (en) | 2000-04-05 | 2001-10-23 | Archer-Daniels-Midland Company | Ketogulonigenium shuttle vectors |
WO2001077348A2 (fr) | 2000-04-05 | 2001-10-18 | Archer-Daniels-Midland Company | Plasmides endogenes de $m(f)i$m(g)ketogulonigenium$m(f)/i$m(g) |
FR2820973B1 (fr) | 2001-02-19 | 2003-05-23 | Oreal | Composition comportant de la vitamine c preparee durant l'application, utilisation d'enzymes pour la formation de vitamine c a usage topique et procede de traitement cosmetique |
EP1716240B1 (fr) * | 2004-01-30 | 2010-06-02 | DSM IP Assets B.V. | Production microbienne de vitamine c |
SI2147105T1 (sl) | 2007-05-02 | 2013-08-30 | Merial Limited | DNA-plazmidi z izboljšano ekspresijo in stabilnostjo |
EP4258060A3 (fr) | 2015-02-27 | 2024-03-20 | Canon Kabushiki Kaisha | Unité de tambour, cartouche et élément de couplage |
CN108949846A (zh) * | 2018-08-01 | 2018-12-07 | 安徽新熙盟生物科技有限公司 | 一种高密度发酵提高pqq产率的方法 |
CN114317332B (zh) * | 2021-12-16 | 2024-03-08 | 上海海洋大学 | 一种好氧光合细菌及其应用 |
Family Cites Families (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2421611A (en) | 1945-05-04 | 1947-06-03 | Byron E Gray | Preparation of 2-keto gulonic acid and its salts |
US3043274A (en) | 1959-10-19 | 1962-07-10 | Robert C Quackenbush | Pneumatic hand tool |
US3043749A (en) | 1960-07-28 | 1962-07-10 | Pfizer & Co C | Preparation of 2-keto-l-gulonic acid |
US3234105A (en) | 1962-09-20 | 1966-02-08 | Takeda Chemical Industries Ltd | Method for producing 2-keto-lgulonic acid |
JPS41160Y1 (fr) | 1963-01-21 | 1966-01-07 | ||
JPS41159Y1 (fr) | 1963-02-26 | 1966-01-07 | ||
JPS415907Y1 (fr) | 1963-11-30 | 1966-03-28 | ||
US3907639A (en) | 1972-08-31 | 1975-09-23 | Hoffmann La Roche | Method for producing 2-keto-L-gulonic acid |
US3912592A (en) | 1974-05-06 | 1975-10-14 | Hoffmann La Roche | Method for producing L-sorbosone |
JPS5852273B2 (ja) | 1974-10-02 | 1983-11-21 | 東京電力株式会社 | ランダムデ−タハツセイホウシキ |
SU526660A1 (ru) | 1975-01-24 | 1976-08-30 | Институт Микробиологии И Вирусологии Ан Казахской Сср | Штамм N 806-продуцент 2 кето- гулоной кислоты |
JPS59113896A (ja) * | 1982-12-17 | 1984-06-30 | Ube Ind Ltd | ピロロキノリンキノンの製造方法 |
JPS60251895A (ja) | 1984-05-29 | 1985-12-12 | Ube Ind Ltd | ピロロキノリンキノンの製造方法 |
EP0206471B1 (fr) * | 1985-04-24 | 1992-10-14 | Mitsubishi Gas Chemical Company, Inc. | Procédé de production de la pyrrolo-quinoléine quinone |
US5344768A (en) | 1985-04-24 | 1994-09-06 | Mitsubishi Gas Chemical Co., Inc. | Process for the preparation of pyrrolo-quinoline quinone |
DE3684533D1 (de) * | 1985-08-28 | 1992-04-30 | Hoffmann La Roche | Verfahren zur herstellung von ketogulonsaeure. |
GB8521359D0 (en) | 1985-08-28 | 1985-10-02 | Hoffmann La Roche | Fermentation process |
DK171869B1 (da) | 1985-10-22 | 1997-07-21 | Takeda Chemical Industries Ltd | Fremgangsmåde til fremstilling af 2-keto-L-gulonsyre samt biologisk ren mikroorganismekultur til anvendelse ved fremgangsmåden |
DK617386A (da) | 1985-12-26 | 1987-06-27 | Takeda Chemical Industries Ltd | Fremgangsmaade til fremstilling af 2-keto-d-glucarsyre |
JP2574661B2 (ja) | 1986-06-05 | 1997-01-22 | 武田薬品工業株式会社 | 2−ケト−l−グロン酸生成菌 |
US4933289A (en) | 1986-06-05 | 1990-06-12 | Takeda Chemical Industries, Ltd. | Biologically pure cultures of Pseudomonas sorbosoxidans useful for producing 2-keto-L-gulonic acid |
JPH0795957B2 (ja) | 1986-06-05 | 1995-10-18 | 武田薬品工業株式会社 | 2−ケト−l−グロン酸の製造法 |
US5082785A (en) | 1987-01-30 | 1992-01-21 | Hoffmann-La Roche Inc. | Biosynthesis of 2 keto-l-gulonic acid |
US4935359A (en) | 1987-02-07 | 1990-06-19 | Institute Of Microbiology | Fermentation process |
US4945048A (en) | 1987-05-23 | 1990-07-31 | Takeda Chemical Industries, Ltd. | Process for producing L-sorbose by subculture of seed |
US4877735A (en) | 1987-06-19 | 1989-10-31 | Takeda Chemical Industries, Ltd. | Process for producing 2-keto-L-gulonic acid |
DK173507B1 (da) | 1988-09-30 | 2001-01-15 | Hoffmann La Roche | Fremgangsmåde til fremstilling af 2-keto-L-gulonsyre |
US5399496A (en) | 1989-02-02 | 1995-03-21 | Hoffman-Laroche Inc. | DNA shuttle vectors for E. coli, Gluconobacter, and Acetobacter |
JPH03294281A (ja) * | 1989-11-13 | 1991-12-25 | Mitsubishi Gas Chem Co Inc | オキサゾピロロキノリン類の製造法 |
RU2102481C1 (ru) | 1991-06-13 | 1998-01-20 | Ф.Хоффманн-Ля Рош, Аг | Способ получения 2-кето-l-гулоновой кислоты или ее соли |
CN1081470A (zh) | 1992-07-18 | 1994-02-02 | 北京制药工业研究所 | 提高产2-酮-l-古龙酸混合细菌转化活力的方法 |
US5437989A (en) | 1992-12-30 | 1995-08-01 | Hoffmann-La Roche Inc. | Alcohol/aldehyde dehydrogenase from Gluconobacter oxydans DSM 4025 FERM BP-3812 |
US5580782A (en) | 1993-03-08 | 1996-12-03 | Bio-Polymer Research Co., Ltd. | Acetic acid bacterium, plasmid derived from said bacterium and shuttle vectors constructed with said plasmid |
JPH0767673A (ja) | 1993-07-09 | 1995-03-14 | Takeda Chem Ind Ltd | 2−ケト−l−グロン酸の製造方法 |
JPH08245702A (ja) * | 1995-03-13 | 1996-09-24 | Denichi Mizuno | 高分子量リポポリサッカライド |
US5997881A (en) * | 1995-11-22 | 1999-12-07 | University Of Maryland, Baltimore | Method of making non-pyrogenic lipopolysaccharide or A |
DE69740092D1 (de) | 1996-09-19 | 2011-02-10 | Dsm Ip Assets Bv | Alkohol-Aldehyd-Deshydrogenasen |
US5834231A (en) * | 1996-10-24 | 1998-11-10 | Archer Daniels Midland Co. | Bacterial strains and use thereof in fermentation process for 2-keto-L-gulonic acid production |
US5846789A (en) | 1996-12-10 | 1998-12-08 | Council Of Scientific And Industrial Research | Process for preparing nontoxic lipopolysaccharides from acidiphilium species |
BR9806934A (pt) * | 1997-01-31 | 2000-05-02 | Fujisawa Pharmaceutical Co | Método para produzir um óxido, meio de cultura e óxido |
US5893683A (en) | 1997-04-29 | 1999-04-13 | Ingersoll Cutting Tool Company | Indexable insert router |
CA2239802A1 (fr) | 1997-08-21 | 1999-02-21 | F. Hoffmann-La Roche Ag | Gene de la d-sorbitol-deshydrogenase |
JP2000050869A (ja) | 1998-08-11 | 2000-02-22 | Ajinomoto Co Inc | グルコノバクター属細菌由来プラスミド及びベクター |
AU762825B2 (en) | 1998-09-11 | 2003-07-03 | Archer-Daniels-Midland Company | Bacterial strains for the production of 2-keto-L-gulonic acid |
PL341895A1 (en) | 1999-08-12 | 2001-02-26 | Ajinomoto Kk | Plasmide autonomously replicable in corynebacter bacteria |
-
1999
- 1999-09-10 AU AU58181/99A patent/AU762825B2/en not_active Ceased
- 1999-09-10 WO PCT/US1999/020642 patent/WO2000015827A2/fr not_active Application Discontinuation
- 1999-09-10 US US09/393,665 patent/US6316231B1/en not_active Expired - Fee Related
- 1999-09-10 BR BR9913563-9A patent/BR9913563A/pt not_active Application Discontinuation
- 1999-09-10 EP EP99945610A patent/EP1112344A2/fr not_active Withdrawn
- 1999-09-10 CA CA002342299A patent/CA2342299A1/fr not_active Abandoned
- 1999-09-10 JP JP2000570354A patent/JP2002525068A/ja not_active Withdrawn
- 1999-09-10 CN CN99810778A patent/CN1317042A/zh active Pending
- 1999-09-10 KR KR1020017003159A patent/KR20010075047A/ko not_active Application Discontinuation
-
2000
- 2000-11-28 US US09/722,427 patent/US6562584B1/en not_active Expired - Fee Related
- 2000-11-28 US US09/722,320 patent/US6511820B1/en not_active Expired - Fee Related
- 2000-11-28 US US09/722,514 patent/US6506583B1/en not_active Expired - Fee Related
-
2001
- 2001-03-29 ZA ZA200102590A patent/ZA200102590B/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN1317042A (zh) | 2001-10-10 |
AU5818199A (en) | 2000-04-03 |
JP2002525068A (ja) | 2002-08-13 |
WO2000015827A2 (fr) | 2000-03-23 |
BR9913563A (pt) | 2001-05-22 |
AU762825B2 (en) | 2003-07-03 |
WO2000015827A3 (fr) | 2000-07-06 |
US6511820B1 (en) | 2003-01-28 |
EP1112344A2 (fr) | 2001-07-04 |
CA2342299A1 (fr) | 2000-03-23 |
US6562584B1 (en) | 2003-05-13 |
US6316231B1 (en) | 2001-11-13 |
US6506583B1 (en) | 2003-01-14 |
KR20010075047A (ko) | 2001-08-09 |
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