YU73001A - Derivati karbaminske kiseline i njihova primena kao liganada metabotropnih glutamat receptora - Google Patents

Derivati karbaminske kiseline i njihova primena kao liganada metabotropnih glutamat receptora

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Publication number
YU73001A
YU73001A YU73001A YUP73001A YU73001A YU 73001 A YU73001 A YU 73001A YU 73001 A YU73001 A YU 73001A YU P73001 A YUP73001 A YU P73001A YU 73001 A YU73001 A YU 73001A
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YU
Yugoslavia
Prior art keywords
acid derivatives
carbamic acid
receptor ligands
glutamate receptor
metabotropic glutamate
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YU73001A
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English (en)
Inventor
Konrad Bleicher
Vincent Mutel
Eric Vieira
Jurgen Wichmann
Thomas Johannes Woltering
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F.Hoffmann-La Roche Ag.
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Application filed by F.Hoffmann-La Roche Ag. filed Critical F.Hoffmann-La Roche Ag.
Publication of YU73001A publication Critical patent/YU73001A/sh

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Abstract

Ovaj pronalazak se odnosi na jedinjenja formule (I) gde X označava O, S ili dva vodonikova atoma koja ne čine most; A1/A2 označava, nezavisno jedno od drugog, fenil ili 6-člani heterocikl koji sadrži 1 ili 2 azotova atoma; B je grupa formule (A), gde Y označava -O-, -S- ili vezu, Z označava -O-ili -S-; ili B je 5-člana heterociklična grupa formula (a, b, c ili d). Ova jedinjenja se mogu koristiti kao ligandi metabotropnih grutamat receptora u kontroli ili prevenciji akutnih i/ili hroničnih neuroloških poremećaja.
YU73001A 1999-04-20 2000-04-19 Derivati karbaminske kiseline i njihova primena kao liganada metabotropnih glutamat receptora YU73001A (sh)

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EP99107843 1999-04-20

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US (2) US6462198B1 (sh)
EP (1) EP1171423B1 (sh)
JP (1) JP3751825B2 (sh)
KR (1) KR100497889B1 (sh)
CN (1) CN1228337C (sh)
AR (1) AR029626A1 (sh)
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AU (1) AU776344B2 (sh)
BR (1) BR0009885A (sh)
CA (1) CA2367368C (sh)
CO (1) CO5160347A1 (sh)
CZ (1) CZ20013736A3 (sh)
DE (1) DE60017376T2 (sh)
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NO (1) NO20015064L (sh)
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PE (1) PE20010039A1 (sh)
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SI (1) SI1171423T1 (sh)
TR (1) TR200103010T2 (sh)
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WO (1) WO2000063166A1 (sh)
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Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0005700D0 (en) * 2000-03-09 2000-05-03 Glaxo Group Ltd Therapy
IT1318636B1 (it) * 2000-07-21 2003-08-27 Roberto Pellicciari Derivati dell'acido 2- o 3- tenoico ad attivita' antagonista deirecettori del glutammato.
AU2003298195B8 (en) * 2002-12-23 2009-04-23 F. Hoffmann-La Roche Ag Oxazoles as mGluR1 enhancer
RU2006106920A (ru) 2003-08-06 2007-09-20 Синомикс Инк. (Us) Гетеро-олигомерные вкусовые рецепторы t1r, клеточные линии, которые экспрессируют указанные рецепторы и вкусовые соединения
EP1653952A4 (en) * 2003-08-06 2007-04-04 Pfizer Prod Inc OXAZOLE COMPOUNDS FOR THE TREATMENT OF NEURODEEGENERATIVE DISORDER
JP2007504255A (ja) * 2003-09-06 2007-03-01 バーテックス ファーマシューティカルズ インコーポレイテッド Atp結合カセットトランスポーターの調節因子
US20050222227A1 (en) * 2004-04-01 2005-10-06 Pfizer Inc Oxazole-amine compounds for the treatment of neurodegenerative disorders
CA2597134C (en) 2005-02-04 2015-05-26 Senomyx, Inc. Compounds comprising linked heteroaryl moieties and their use as novel umami flavor modifiers, tastants and taste enhancers for comestible compositions
TW200715993A (en) 2005-06-15 2007-05-01 Senomyx Inc Bis-aromatic amides and their uses as sweet flavor modifiers, tastants, and taste enhancers
DK3235811T3 (en) 2006-04-21 2018-11-12 Senomyx Inc PROCEDURE FOR THE PREPARATION OF OXALAMIDS
CA2670116C (en) 2006-11-22 2015-03-10 Seaside Therapeutics, Llc Methods of treating mental retardation, down's syndrome, fragile x syndrome and autism
US20080262066A1 (en) * 2007-04-20 2008-10-23 Green Cross Corporation Azole Derivatives as Cannabinoid CB1 Receptor Antagonists
EP2178858B1 (en) 2007-08-02 2011-12-28 Recordati Ireland Limited Novel heterocyclic compounds as mglu5 antagonists
EP2093234A1 (en) 2008-02-08 2009-08-26 Nutrinova Nutrition Specialties & Food Ingredients GmbH Oligopeptides for use as taste modulators
TWI429404B (zh) 2008-03-03 2014-03-11 Senomyx Inc 異山梨醇衍生物及彼等作為風味改良劑、促味劑及促味增強劑之用途
WO2010089119A1 (en) 2009-02-04 2010-08-12 Recordati Ireland Limited Heterocyclic derivatives as m-glu5 antagonists
US20120028931A1 (en) 2009-09-14 2012-02-02 Recordati Ireland Limited Heterocyclic m-glu5 antagonists
WO2011109398A2 (en) 2010-03-02 2011-09-09 President And Fellows Of Harvard College Methods and compositions for treatment of angelman syndrome and autism spectrum disorders
US20110294879A1 (en) 2010-05-28 2011-12-01 Xenoport, Inc. Method of treatment of fragile x syndrome, down's syndrome, autism and related disorders
SG186107A1 (en) * 2010-07-09 2013-01-30 Recordati Ireland Ltd Novel spiroheterocyclic compounds as mglu5 antagonists
US20120016021A1 (en) 2010-07-15 2012-01-19 Xenoport, Inc. Methods of treating fragile x syndrome, down's syndrome, autism and related disorders
WO2012054724A1 (en) 2010-10-21 2012-04-26 Massachusetts Institute Of Technology Methods of treating seizure disorders
UA116524C2 (uk) 2011-03-29 2018-04-10 Іммуноджен, Інк. Спосіб одержання кон'югата антитіло-майтансиноїд
MY171008A (en) 2011-03-29 2019-09-23 Immunogen Inc Preparation of maytansinoid antibody conjugates by a one-step process
RU2661083C2 (ru) 2012-10-04 2018-07-11 Иммуноджен, Инк. Использование пвдф-мембраны для очистки конъюгатов клеточно-связывающий агент - цитотоксический агент
CA2966932A1 (en) 2014-11-19 2016-05-26 Immunogen, Inc. Process for preparing cell-binding agent-cytotoxic agent conjugates
WO2017121693A1 (de) 2016-01-15 2017-07-20 Bayer Pharma Aktiengesellschaft Substituierte thiazol- und thiadiazolamide und ihre verwendung
EP3411077A1 (en) 2016-02-05 2018-12-12 ImmunoGen, Inc. Efficient process for preparing cell-binding agent-cytotoxic agent conjugates
AU2017311691B2 (en) 2016-08-18 2021-12-02 Vidac Pharma Ltd. Piperazine derivatives, pharmaceutical compositions and methods of use thereof
JPWO2022050427A1 (sh) * 2020-09-07 2022-03-10

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5073566A (en) * 1989-11-30 1991-12-17 Eli Lilly And Company Angiotensin ii antagonist 1,3-imidazoles and use thereas
GB9626151D0 (en) 1996-12-17 1997-02-05 Lilly Industries Ltd Pharmaceutical compounds

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DE60017376T2 (de) 2006-03-02
WO2000063166A1 (en) 2000-10-26
CA2367368C (en) 2009-09-01
PE20010039A1 (es) 2001-01-29
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BR0009885A (pt) 2002-01-22
IL145665A (en) 2005-09-25
KR100497889B1 (ko) 2005-06-29
ZA200107837B (en) 2002-12-23
NZ514487A (en) 2004-01-30
CZ20013736A3 (cs) 2002-03-13
NO20015064D0 (no) 2001-10-18
AU4749200A (en) 2000-11-02
US6596743B2 (en) 2003-07-22
MA26781A1 (fr) 2004-12-20
US6462198B1 (en) 2002-10-08
CA2367368A1 (en) 2000-10-26
CN1347406A (zh) 2002-05-01
DE60017376D1 (de) 2005-02-17
JP2002542229A (ja) 2002-12-10
KR20010108518A (ko) 2001-12-07
ES2234601T3 (es) 2005-07-01
AU776344B2 (en) 2004-09-02
HUP0201005A2 (hu) 2002-07-29
JP3751825B2 (ja) 2006-03-01
AR029626A1 (es) 2003-07-10
RU2248349C2 (ru) 2005-03-20
PT1171423E (pt) 2005-05-31
CN1228337C (zh) 2005-11-23
IL145665A0 (en) 2002-06-30
SI1171423T1 (en) 2005-06-30
NO20015064L (no) 2001-10-18
TR200103010T2 (tr) 2002-05-21
HUP0201005A3 (en) 2004-12-28
US20020091150A1 (en) 2002-07-11
TW593241B (en) 2004-06-21
MY126586A (en) 2006-10-31
ATE286875T1 (de) 2005-01-15
EP1171423A1 (en) 2002-01-16
HK1045683B (zh) 2006-02-03
HK1045683A1 (en) 2002-12-06
HRP20010761A2 (en) 2002-12-31
CO5160347A1 (es) 2002-05-30
PL352825A1 (en) 2003-09-08

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