YU53991A - Dobijanje beta-ketoestara koji se upotrebljavaju za pripremanje hinolon antibiotika - Google Patents

Dobijanje beta-ketoestara koji se upotrebljavaju za pripremanje hinolon antibiotika

Info

Publication number
YU53991A
YU53991A YU53991A YU53991A YU53991A YU 53991 A YU53991 A YU 53991A YU 53991 A YU53991 A YU 53991A YU 53991 A YU53991 A YU 53991A YU 53991 A YU53991 A YU 53991A
Authority
YU
Yugoslavia
Prior art keywords
preparation
formula
imidazolyl
fluoro
chloro
Prior art date
Application number
YU53991A
Other languages
English (en)
Inventor
B. O'neill
F.R. Busch
R.S. Lehner
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of YU53991A publication Critical patent/YU53991A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/716—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Abstract

DOBIJANJE BETA-KETOESTARA KOJI SE UPOTREBLJAVAJU ZA PRIPREMANJE HINOLON ANTIBIOTIKA, opisan je postupak za dobijanje jedinjenja formule u kojoj Q je C-H ili N; R1 je C1 do C4 alkil, benzil ili p-nitrobenzil i X i Y su nezavisno odabrani od fluoro ili hloro postupak koji obuhvata reakciju jedinjenje formule u kojoj Q je C-H ili N; i X i Y su nezavisno odabrani od fluoro i hloro; i Z je fluoro, hloro, 1-imidazolil ili supstituisani 1-imidazolil, pri čemu 1-imidazolil grupa je supstituisana sa jednim ili dva supstituenta nezavisno odabrani od C1 do C4 alkila sa jedinjenjem formule gde M je zemnoalkalni metil, Cu ili Mn, n je 2, Vp- gde p je 1 ili 2 je anion formule V (a) ili dianion formule V(b) i R1 je C1 do C6 alkil ili paranitrobenzil, pod uslovom što kada Z je 1-imidazolil ili supstituisani 1-imidazolil, M je magnezijum, bakar ili mangan i pod uslovom što kada Z je fluoro, hloro ili bromo, Vp- je dianion formule V(b).
YU53991A 1990-03-27 1991-03-26 Dobijanje beta-ketoestara koji se upotrebljavaju za pripremanje hinolon antibiotika YU53991A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50015590A 1990-03-27 1990-03-27

Publications (1)

Publication Number Publication Date
YU53991A true YU53991A (sh) 1993-11-16

Family

ID=23988274

Family Applications (1)

Application Number Title Priority Date Filing Date
YU53991A YU53991A (sh) 1990-03-27 1991-03-26 Dobijanje beta-ketoestara koji se upotrebljavaju za pripremanje hinolon antibiotika

Country Status (22)

Country Link
US (1) US5380860A (sh)
EP (1) EP0449445A3 (sh)
JP (1) JPH0648990A (sh)
KR (1) KR930005059B1 (sh)
CN (1) CN1041083C (sh)
AU (1) AU617066B1 (sh)
BR (1) BR9101188A (sh)
CA (1) CA2039306C (sh)
EG (1) EG19607A (sh)
FI (1) FI911465A (sh)
HU (1) HUT56826A (sh)
IE (1) IE910991A1 (sh)
IL (1) IL97617A (sh)
MY (1) MY108069A (sh)
NO (1) NO911229L (sh)
NZ (1) NZ237555A (sh)
PH (1) PH30994A (sh)
PL (1) PL289582A1 (sh)
PT (1) PT97130B (sh)
RU (1) RU2058977C1 (sh)
YU (1) YU53991A (sh)
ZA (1) ZA912263B (sh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6043092A (en) * 1996-03-18 2000-03-28 University Of Pittsburgh Cell culture media for mammalian cells
KR100372563B1 (ko) * 1996-12-16 2003-11-20 주식회사 엘지생명과학 퀴놀론계항생제중간체인베타-케토에스테르유도체의제조방법
KR100484386B1 (ko) * 2000-10-04 2005-04-22 경동제약 주식회사 알킬2-[2,3,5-트리플루오로-4-(4-메틸-1-피페라지닐)]벤조일-3(ｓ)-(1-히드록시프로피-2-닐아미노)아크릴레이트의 제조방법
KR100589966B1 (ko) * 2001-10-15 2006-06-15 주식회사 엘지생명과학 베타-케토에스테르 화합물의 제조방법
KR100843125B1 (ko) * 2005-09-16 2008-07-02 주식회사 엘지생명과학 베타-케토에스테르 화합물의 제조방법
JP4790809B2 (ja) * 2005-09-16 2011-10-12 エルジー・ライフ・サイエンシーズ・リミテッド β−ケトエステル化合物の製造方法
US20080139574A1 (en) 2006-11-30 2008-06-12 Cadila Healthcare Limited Novel quinoline derivatives
RU2558932C1 (ru) * 2014-05-22 2015-08-10 Открытое Акционерное Общество "Татхимфармпрепараты" Фармацевтическая композиция моксифлоксацина и способ ее приготовления

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4014919A (en) * 1974-03-01 1977-03-29 The Dow Chemical Company Process for preparing methyl jasmonate and related compounds
DE3142854A1 (de) * 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3420798A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-(3-aryl-l-piperazinyl)- sowie 7-(3-cyclohexyl-l-piperazinyl)-3-chinoloncarbonsaeuren
DE3426482A1 (de) * 1984-07-18 1986-01-30 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von halogenierten aroylessigestern
DE3508816A1 (de) * 1985-01-10 1986-07-10 Bayer Ag, 5090 Leverkusen 6,7-disubstituierte 1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphtyridin-3-carbonsaeuren
JPH0629246B2 (ja) * 1985-02-18 1994-04-20 富山化学工業株式会社 ２−（５−フルオロニコチノイル）酢酸誘導体およびその塩
AT392789B (de) * 1985-01-23 1991-06-10 Toyama Chemical Co Ltd Verfahren zur herstellung von 1-substituierten aryl-1,4-dihydro-4-oxonaphthyridinderivaten
IL82401A0 (en) * 1986-05-06 1987-11-30 Merrell Dow Pharma Dopamine beta hydroxy-lase inhibiting imidazole derivatives and pharmaceutical compositions containing them
FI88506C (fi) * 1986-07-04 1993-05-25 Chemie Linz Gmbh Foerfarande foer framstaellning av farmaceutiskt anvaendbar 7-diazabicykloalkyl-6-fluor-1-(2,4-difluorfenyl)-1,4-dihydro-4-oxo-kinolin-3-karboxylsyra eller karboxylsyraester
DE3641343A1 (de) * 1986-12-03 1988-06-16 Hoechst Ag Carbamoylimidazol-derivate, verfahren zu ihrer herstellung und ihre verwendung als fungizide
ES2074047T3 (es) * 1987-08-14 1995-09-01 Asahi Glass Co Ltd Compuestos de benzoilo fluorados.
US4833270A (en) * 1987-12-21 1989-05-23 American Cyanamid Company Process for preparing 2-chloro-4,5-difluorobenzoic acid
JPH0228178A (ja) * 1988-04-23 1990-01-30 Toyama Chem Co Ltd 新規なピリドンカルボン酸誘導体およびその塩並びにそれらの製造法
EP0342849A3 (en) * 1988-05-19 1990-03-14 Pfizer Inc. Intermediates for preparing 1,4-dihydro-4-oxo-quinoline-3-carboxylic acid esters
JPH0225462A (ja) * 1988-06-06 1990-01-26 Eli Lilly & Co β―ラクタム抗生物質の製造法およびその中間体
US4883270A (en) * 1989-02-09 1989-11-28 Maag Henry H Four-bar variable-resistance frontal calf developing machine
WO1991002526A1 (en) * 1989-08-16 1991-03-07 Pfizer Inc. Azabicyclo quinolone carboxylic acids

Also Published As

Publication number Publication date
FI911465A0 (fi) 1991-03-26
CA2039306C (en) 1999-01-26
NO911229L (no) 1991-09-30
EP0449445A2 (en) 1991-10-02
CN1041083C (zh) 1998-12-09
HUT56826A (en) 1991-10-28
US5380860A (en) 1995-01-10
FI911465A (fi) 1991-09-28
PH30994A (en) 1997-12-23
BR9101188A (pt) 1991-11-05
KR930005059B1 (ko) 1993-06-15
CN1055177A (zh) 1991-10-09
NZ237555A (en) 1993-08-26
PL289582A1 (en) 1992-06-01
RU2058977C1 (ru) 1996-04-27
PT97130A (pt) 1991-11-29
NO911229D0 (no) 1991-03-26
AU617066B1 (en) 1991-11-14
EG19607A (en) 1995-07-27
MY108069A (en) 1996-08-15
IL97617A (en) 1998-08-16
IL97617A0 (en) 1992-06-21
JPH0648990A (ja) 1994-02-22
CA2039306A1 (en) 1991-09-28
ZA912263B (en) 1992-11-25
IE910991A1 (en) 1991-10-09
PT97130B (pt) 1999-02-26
KR920018007A (ko) 1992-10-21
EP0449445A3 (en) 1993-08-25

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