RS49983B - Postupak dobijanja 3-acil-indola - Google Patents

Postupak dobijanja 3-acil-indola

Info

Publication number
RS49983B
RS49983B YUP-535/00A YUP53500A RS49983B RS 49983 B RS49983 B RS 49983B YU P53500 A YUP53500 A YU P53500A RS 49983 B RS49983 B RS 49983B
Authority
RS
Serbia
Prior art keywords
fluoro
c6alkyl
alkyl
formula
preparation
Prior art date
Application number
YUP-535/00A
Other languages
English (en)
Inventor
Francis Jolyon Perkins
Original Assignee
Pfizer Inc.,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc., filed Critical Pfizer Inc.,
Publication of YU53500A publication Critical patent/YU53500A/sh
Publication of RS49983B publication Critical patent/RS49983B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms

Abstract

Postupak za dobijanje jedinjenja formule (I) gde je R= C1-C6alkil, C1-C6alkoksi, C3-C7cikloalki] ili aril po potrebi supstituisan sa jednim ili više hidroksi, C1-C6alkil, Ci-C4alkoksi, f1uoro, f1uoro(C1-C4)alkil i fluoror(C1-C4)alkoksi i X je vodonik ili jedan ili više supstituenata nezavisno odabranih od cijano, halogena, nitro, C1-C6alkil, C1-C6alkoksi, C3-C7cikloalkil i aril po potreb supstituisan jednim ili više cijano, halogen, nitro, C1-C4alkil, C1-C4alkoksi, f1uoro(C1-C4)alkil i f1uoro(C1-C4)alkoksi; ili gde je R, N-karboksibenzil-2-pirolidillil i X je S-bromo; naznačen time, što obuhvata odvojeno i simultano dodavanje li mešani rastvor indola formule (II) gde je X kao što je prethodno definisano; (i) rastvor sadrži halogenid kiseline formule RCOCl gde je R kao što je prethodno definisano; i (ii) rastvor sadrži alkil ili aril magnezijum halogenid tako da su (a) rastvori (i) i (ii) dodati odvojeno kako bi se izbeglo njihovo međusobno reagovanje; i (b) su rastvori (i) i (ii) dodati u ekvivalentnom mol.irnom odnosu. Prijava sadrži još 10 patentnih zahteva.
YUP-535/00A 1999-10-01 2000-08-29 Postupak dobijanja 3-acil-indola RS49983B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9923314.0A GB9923314D0 (en) 1999-10-01 1999-10-01 Acylation process

Publications (2)

Publication Number Publication Date
YU53500A YU53500A (sh) 2003-02-28
RS49983B true RS49983B (sr) 2008-09-29

Family

ID=10861993

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-535/00A RS49983B (sr) 1999-10-01 2000-08-29 Postupak dobijanja 3-acil-indola

Country Status (25)

Country Link
US (2) US6441192B1 (sr)
EP (1) EP1088817B1 (sr)
JP (1) JP3374125B2 (sr)
KR (1) KR100365458B1 (sr)
CN (1) CN1142140C (sr)
AR (1) AR035993A1 (sr)
AT (1) ATE233238T1 (sr)
AU (1) AU778663B2 (sr)
BR (1) BR0004578A (sr)
CA (1) CA2322346C (sr)
CZ (1) CZ297897B6 (sr)
DE (1) DE60001477T2 (sr)
DK (1) DK1088817T3 (sr)
ES (1) ES2188482T3 (sr)
GB (1) GB9923314D0 (sr)
HK (1) HK1034970A1 (sr)
HU (1) HUP0003862A3 (sr)
ID (1) ID27404A (sr)
IL (1) IL138691A (sr)
PL (1) PL342875A1 (sr)
RS (1) RS49983B (sr)
RU (1) RU2197480C2 (sr)
TR (1) TR200002834A2 (sr)
TW (1) TWI265923B (sr)
ZA (1) ZA200005216B (sr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9923314D0 (en) * 1999-10-01 1999-12-08 Pfizer Ltd Acylation process
US6927296B2 (en) 2003-07-23 2005-08-09 Pfizer Inc. Process
IT1393700B1 (it) * 2009-04-22 2012-05-08 F S I Fabbrica Italiana Sint Sintesi di 3-{[(2r)-1-metilpirrolidin-2-il]metil}-5-[2-(fenilsulfonil)etil]-1h-indolo
WO2011024039A1 (en) * 2009-08-25 2011-03-03 Ramesh Babu Potluri Synthesis of novel 5-(2-(phenylsulfonyl)ethyl)-1h-indole derivatives
WO2011089614A1 (en) 2010-01-19 2011-07-28 Sms Pharmaceuticals Limited PROCESS FOR PREPARING ELETRIPTAN HYDROBROMIDE HAVING α-FORM
AU2021215709A1 (en) 2020-02-04 2022-09-01 Mindset Pharma Inc. 3-pyrrolidine-indole derivatives as serotonergic psychedelic agents for the treatment of CNS disorders

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU574383B2 (en) * 1983-09-28 1988-07-07 Nippon Zoki Pharmaceutical Co., Ltd. Acylindole derivatives
JPS625012A (ja) * 1985-06-28 1987-01-12 Chugai Ro Kogyo Kaisha Ltd 排熱回収バ−ナ
US5545644A (en) 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
US5559246A (en) 1990-10-15 1996-09-24 Pfizer Inc. Indole derivatives
US5559129A (en) 1990-10-15 1996-09-24 Pfizer Inc Indole derivatives
AU651637B2 (en) * 1990-10-15 1994-07-28 Pfizer Inc. Indole derivatives
US5578612A (en) 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
US5607951A (en) 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
JPH05154271A (ja) * 1991-12-05 1993-06-22 Mitsubishi Heavy Ind Ltd 連続式水洗機
GB9207930D0 (en) * 1992-04-10 1992-05-27 Pfizer Ltd Indoles
JPH064167A (ja) * 1992-06-18 1994-01-14 Nec Corp ディスク媒体障害の復旧方式
GB9417310D0 (en) 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
FR2735774B1 (fr) * 1995-06-21 1997-09-12 Sanofi Sa Utilisation de composes agonistes du recepteur cb2 humain pour la preparation de medicaments immunomodulateurs, nouveaux composes agonistes du recepteur cb2 et les compositions pharmaceutiques les contenant
US5998462A (en) * 1996-12-16 1999-12-07 Allelix Biopharmaceuticals Inc. 5-alkyl indole compounds
JPH10195048A (ja) * 1997-01-17 1998-07-28 Sumitomo Chem Co Ltd ３−（ニトロベンゾイル）インドール誘導体の製造法
EA002174B1 (ru) 1997-07-03 2002-02-28 Пфайзер Инк. Фармацевтические композиции, содержащие гемисульфат элетриптана и кофеин
GB9923314D0 (en) * 1999-10-01 1999-12-08 Pfizer Ltd Acylation process

Also Published As

Publication number Publication date
JP2001131146A (ja) 2001-05-15
ATE233238T1 (de) 2003-03-15
AU778663B2 (en) 2004-12-16
CZ20003572A3 (cs) 2002-05-15
DK1088817T3 (da) 2003-04-22
BR0004578A (pt) 2001-05-29
US6914145B2 (en) 2005-07-05
EP1088817A3 (en) 2001-08-29
HUP0003862A2 (hu) 2001-12-28
IL138691A (en) 2005-03-20
CN1290697A (zh) 2001-04-11
CN1142140C (zh) 2004-03-17
US20020188138A1 (en) 2002-12-12
TWI265923B (en) 2006-11-11
HU0003862D0 (en) 2000-12-28
JP3374125B2 (ja) 2003-02-04
AR035993A1 (es) 2004-08-04
CA2322346A1 (en) 2001-04-01
TR200002834A2 (tr) 2001-04-20
YU53500A (sh) 2003-02-28
EP1088817B1 (en) 2003-02-26
IL138691A0 (en) 2001-10-31
DE60001477D1 (de) 2003-04-03
CA2322346C (en) 2004-08-10
ES2188482T3 (es) 2003-07-01
ID27404A (id) 2001-04-05
CZ297897B6 (cs) 2007-04-25
AU5951100A (en) 2001-04-05
GB9923314D0 (en) 1999-12-08
HK1034970A1 (en) 2001-11-09
ZA200005216B (en) 2002-03-28
HUP0003862A3 (en) 2002-02-28
KR100365458B1 (ko) 2002-12-18
PL342875A1 (en) 2001-04-09
DE60001477T2 (de) 2003-08-28
RU2197480C2 (ru) 2003-01-27
KR20010050785A (ko) 2001-06-25
US6441192B1 (en) 2002-08-27
EP1088817A2 (en) 2001-04-04

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