AR035993A1 - Procedimiento de acilacion de indoles - Google Patents
Procedimiento de acilacion de indolesInfo
- Publication number
- AR035993A1 AR035993A1 ARP000105126A ARP000105126A AR035993A1 AR 035993 A1 AR035993 A1 AR 035993A1 AR P000105126 A ARP000105126 A AR P000105126A AR P000105126 A ARP000105126 A AR P000105126A AR 035993 A1 AR035993 A1 AR 035993A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkoxy
- fluoro
- formula
- cyano
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un procedimiento para preparar un compuesto de fórmula (1), en la que: R = alquilo C1-6, alcoxi C1-6, cicloalquilo C3-7, o arilo opcionalmente sustituido por uno o más de hidroxi, alquilo C1-4, alcoxi C1-4, fluoro, fluoro(alquilo C1-4) y fluoro(alcoxi C1-4); y X es hidrógeno o uno o más sustituyentes seleccionados independientemente de ciano, halógeno, nitro, alquilo C1-6, alcoxi C1-6, cicloalquilo C3-7, y arilo opcionalmente sustituido por uno o más de ciano, halógeno, nitro, alquilo C1-4, alcoxi C1-4, fluoro(alquilo C1-4) y fluoro(alcoxi C1-4); o donde R es N-carboxibencil-2-pirrolidinil y X es 5-bromo; que comprende anadir por separado y de forma simultánea a una solución agitada de indol de fórmula (2) en la que X es como se ha definido antes: (a) una solución que contiene un cloruro de ácido de fórmula RCOCl, siendo R como se ha definido antes; y (ii) una solución de contiene un haluro de alquil- o aril-magnesio, de tal forma que (a) las soluciones (i) y (ii) se anaden con una separación suficiente para evitar que reaccionen entre sí; y (b) las soluciones (i) y (ii) se anaden a velocidades equivalentes de adición molar.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9923314.0A GB9923314D0 (en) | 1999-10-01 | 1999-10-01 | Acylation process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR035993A1 true AR035993A1 (es) | 2004-08-04 |
Family
ID=10861993
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000105126A AR035993A1 (es) | 1999-10-01 | 2000-09-28 | Procedimiento de acilacion de indoles |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US6441192B1 (es) |
| EP (1) | EP1088817B1 (es) |
| JP (1) | JP3374125B2 (es) |
| KR (1) | KR100365458B1 (es) |
| CN (1) | CN1142140C (es) |
| AR (1) | AR035993A1 (es) |
| AT (1) | ATE233238T1 (es) |
| AU (1) | AU778663B2 (es) |
| BR (1) | BR0004578A (es) |
| CA (1) | CA2322346C (es) |
| CZ (1) | CZ297897B6 (es) |
| DE (1) | DE60001477T2 (es) |
| DK (1) | DK1088817T3 (es) |
| ES (1) | ES2188482T3 (es) |
| GB (1) | GB9923314D0 (es) |
| HK (1) | HK1034970A1 (es) |
| HU (1) | HUP0003862A3 (es) |
| ID (1) | ID27404A (es) |
| IL (1) | IL138691A (es) |
| PL (1) | PL342875A1 (es) |
| RS (1) | RS49983B (es) |
| RU (1) | RU2197480C2 (es) |
| TR (1) | TR200002834A2 (es) |
| TW (1) | TWI265923B (es) |
| ZA (1) | ZA200005216B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9923314D0 (en) * | 1999-10-01 | 1999-12-08 | Pfizer Ltd | Acylation process |
| US6927296B2 (en) | 2003-07-23 | 2005-08-09 | Pfizer Inc. | Process |
| IT1393700B1 (it) * | 2009-04-22 | 2012-05-08 | F S I Fabbrica Italiana Sint | Sintesi di 3-{[(2r)-1-metilpirrolidin-2-il]metil}-5-[2-(fenilsulfonil)etil]-1h-indolo |
| WO2011024039A1 (en) * | 2009-08-25 | 2011-03-03 | Ramesh Babu Potluri | Synthesis of novel 5-(2-(phenylsulfonyl)ethyl)-1h-indole derivatives |
| US8754239B2 (en) | 2010-01-19 | 2014-06-17 | Sms Pharmaceuticals Limited | Process for preparing eletriptan hydrobromide having α-form |
| EP4100403A4 (en) | 2020-02-04 | 2024-01-03 | Mindset Pharma Inc. | 3-PYRROLIDINE-INDOLE DERIVATIVES AS SEROTONINERGIC PSYCHEDELIC AGENTS FOR THE TREATMENT OF CNS DISORDERS |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU574383B2 (en) * | 1983-09-28 | 1988-07-07 | Nippon Zoki Pharmaceutical Co., Ltd. | Acylindole derivatives |
| JPS625012A (ja) * | 1985-06-28 | 1987-01-12 | Chugai Ro Kogyo Kaisha Ltd | 排熱回収バ−ナ |
| US5578612A (en) | 1990-10-15 | 1996-11-26 | Pfizer Inc. | Indole derivatives |
| US5607951A (en) | 1990-10-15 | 1997-03-04 | Pfizer Inc | Indole derivatives |
| US5559129A (en) | 1990-10-15 | 1996-09-24 | Pfizer Inc | Indole derivatives |
| US5559246A (en) | 1990-10-15 | 1996-09-24 | Pfizer Inc. | Indole derivatives |
| RO111767B1 (ro) * | 1990-10-15 | 1997-01-30 | Pfizer | Derivati de indol, procedee si intermediari pentru prepararea acestora, compozitii farmaceutice si metoda pentru tratarea unor afectiuni |
| US5545644A (en) | 1990-10-15 | 1996-08-13 | Pfizer Inc. | Indole derivatives |
| JPH05154271A (ja) * | 1991-12-05 | 1993-06-22 | Mitsubishi Heavy Ind Ltd | 連続式水洗機 |
| GB9207930D0 (en) * | 1992-04-10 | 1992-05-27 | Pfizer Ltd | Indoles |
| JPH064167A (ja) * | 1992-06-18 | 1994-01-14 | Nec Corp | ディスク媒体障害の復旧方式 |
| GB9417310D0 (en) | 1994-08-27 | 1994-10-19 | Pfizer Ltd | Therapeutic agents |
| FR2735774B1 (fr) * | 1995-06-21 | 1997-09-12 | Sanofi Sa | Utilisation de composes agonistes du recepteur cb2 humain pour la preparation de medicaments immunomodulateurs, nouveaux composes agonistes du recepteur cb2 et les compositions pharmaceutiques les contenant |
| US5998462A (en) * | 1996-12-16 | 1999-12-07 | Allelix Biopharmaceuticals Inc. | 5-alkyl indole compounds |
| JPH10195048A (ja) * | 1997-01-17 | 1998-07-28 | Sumitomo Chem Co Ltd | ３−（ニトロベンゾイル）インドール誘導体の製造法 |
| US6166025A (en) | 1997-07-03 | 2000-12-26 | Pfizer Inc. | Pharmaceutical compositions containing eletriptran hemisulphate and caffeine |
| GB9923314D0 (en) * | 1999-10-01 | 1999-12-08 | Pfizer Ltd | Acylation process |
-
1999
- 1999-10-01 GB GBGB9923314.0A patent/GB9923314D0/en not_active Ceased
-
2000
- 2000-07-06 TW TW089113439A patent/TWI265923B/zh not_active IP Right Cessation
- 2000-08-29 RS YUP-535/00A patent/RS49983B/sr unknown
- 2000-09-18 DE DE60001477T patent/DE60001477T2/de not_active Expired - Fee Related
- 2000-09-18 ES ES00308123T patent/ES2188482T3/es not_active Expired - Lifetime
- 2000-09-18 DK DK00308123T patent/DK1088817T3/da active
- 2000-09-18 AT AT00308123T patent/ATE233238T1/de not_active IP Right Cessation
- 2000-09-18 EP EP00308123A patent/EP1088817B1/en not_active Expired - Lifetime
- 2000-09-20 AU AU59511/00A patent/AU778663B2/en not_active Ceased
- 2000-09-25 IL IL13869100A patent/IL138691A/xx not_active IP Right Cessation
- 2000-09-25 US US09/669,318 patent/US6441192B1/en not_active Expired - Fee Related
- 2000-09-26 CN CNB001290053A patent/CN1142140C/zh not_active Expired - Fee Related
- 2000-09-27 CZ CZ20003572A patent/CZ297897B6/cs not_active IP Right Cessation
- 2000-09-28 ID IDP20000835D patent/ID27404A/id unknown
- 2000-09-28 AR ARP000105126A patent/AR035993A1/es active IP Right Grant
- 2000-09-28 ZA ZA200005216A patent/ZA200005216B/xx unknown
- 2000-09-29 CA CA002322346A patent/CA2322346C/en not_active Expired - Fee Related
- 2000-09-29 HU HU0003862A patent/HUP0003862A3/hu unknown
- 2000-09-29 TR TR2000/02834A patent/TR200002834A2/xx unknown
- 2000-09-29 RU RU2000124801/04A patent/RU2197480C2/ru not_active IP Right Cessation
- 2000-09-29 PL PL00342875A patent/PL342875A1/xx unknown
- 2000-09-30 KR KR1020000057607A patent/KR100365458B1/ko not_active IP Right Cessation
- 2000-10-02 BR BR0004578-0A patent/BR0004578A/pt not_active IP Right Cessation
- 2000-10-02 JP JP2000301623A patent/JP3374125B2/ja not_active Expired - Fee Related
-
2001
- 2001-08-15 HK HK01105720A patent/HK1034970A1/xx not_active IP Right Cessation
-
2002
- 2002-07-17 US US10/197,111 patent/US6914145B2/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |