AR035993A1 - Procedimiento de acilacion de indoles - Google Patents

Procedimiento de acilacion de indoles

Info

Publication number
AR035993A1
AR035993A1 ARP000105126A ARP000105126A AR035993A1 AR 035993 A1 AR035993 A1 AR 035993A1 AR P000105126 A ARP000105126 A AR P000105126A AR P000105126 A ARP000105126 A AR P000105126A AR 035993 A1 AR035993 A1 AR 035993A1
Authority
AR
Argentina
Prior art keywords
alkyl
alkoxy
fluoro
formula
cyano
Prior art date
Application number
ARP000105126A
Other languages
English (en)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of AR035993A1 publication Critical patent/AR035993A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un procedimiento para preparar un compuesto de fórmula (1), en la que: R = alquilo C1-6, alcoxi C1-6, cicloalquilo C3-7, o arilo opcionalmente sustituido por uno o más de hidroxi, alquilo C1-4, alcoxi C1-4, fluoro, fluoro(alquilo C1-4) y fluoro(alcoxi C1-4); y X es hidrógeno o uno o más sustituyentes seleccionados independientemente de ciano, halógeno, nitro, alquilo C1-6, alcoxi C1-6, cicloalquilo C3-7, y arilo opcionalmente sustituido por uno o más de ciano, halógeno, nitro, alquilo C1-4, alcoxi C1-4, fluoro(alquilo C1-4) y fluoro(alcoxi C1-4); o donde R es N-carboxibencil-2-pirrolidinil y X es 5-bromo; que comprende anadir por separado y de forma simultánea a una solución agitada de indol de fórmula (2) en la que X es como se ha definido antes: (a) una solución que contiene un cloruro de ácido de fórmula RCOCl, siendo R como se ha definido antes; y (ii) una solución de contiene un haluro de alquil- o aril-magnesio, de tal forma que (a) las soluciones (i) y (ii) se anaden con una separación suficiente para evitar que reaccionen entre sí; y (b) las soluciones (i) y (ii) se anaden a velocidades equivalentes de adición molar.
ARP000105126A 1999-10-01 2000-09-28 Procedimiento de acilacion de indoles AR035993A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9923314.0A GB9923314D0 (en) 1999-10-01 1999-10-01 Acylation process

Publications (1)

Publication Number Publication Date
AR035993A1 true AR035993A1 (es) 2004-08-04

Family

ID=10861993

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000105126A AR035993A1 (es) 1999-10-01 2000-09-28 Procedimiento de acilacion de indoles

Country Status (25)

Country Link
US (2) US6441192B1 (es)
EP (1) EP1088817B1 (es)
JP (1) JP3374125B2 (es)
KR (1) KR100365458B1 (es)
CN (1) CN1142140C (es)
AR (1) AR035993A1 (es)
AT (1) ATE233238T1 (es)
AU (1) AU778663B2 (es)
BR (1) BR0004578A (es)
CA (1) CA2322346C (es)
CZ (1) CZ297897B6 (es)
DE (1) DE60001477T2 (es)
DK (1) DK1088817T3 (es)
ES (1) ES2188482T3 (es)
GB (1) GB9923314D0 (es)
HK (1) HK1034970A1 (es)
HU (1) HUP0003862A3 (es)
ID (1) ID27404A (es)
IL (1) IL138691A (es)
PL (1) PL342875A1 (es)
RS (1) RS49983B (es)
RU (1) RU2197480C2 (es)
TR (1) TR200002834A2 (es)
TW (1) TWI265923B (es)
ZA (1) ZA200005216B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9923314D0 (en) * 1999-10-01 1999-12-08 Pfizer Ltd Acylation process
US6927296B2 (en) 2003-07-23 2005-08-09 Pfizer Inc. Process
IT1393700B1 (it) * 2009-04-22 2012-05-08 F S I Fabbrica Italiana Sint Sintesi di 3-{[(2r)-1-metilpirrolidin-2-il]metil}-5-[2-(fenilsulfonil)etil]-1h-indolo
WO2011024039A1 (en) * 2009-08-25 2011-03-03 Ramesh Babu Potluri Synthesis of novel 5-(2-(phenylsulfonyl)ethyl)-1h-indole derivatives
US8754239B2 (en) 2010-01-19 2014-06-17 Sms Pharmaceuticals Limited Process for preparing eletriptan hydrobromide having α-form
AU2021215709A1 (en) 2020-02-04 2022-09-01 Mindset Pharma Inc. 3-pyrrolidine-indole derivatives as serotonergic psychedelic agents for the treatment of CNS disorders

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU574383B2 (en) * 1983-09-28 1988-07-07 Nippon Zoki Pharmaceutical Co., Ltd. Acylindole derivatives
JPS625012A (ja) * 1985-06-28 1987-01-12 Chugai Ro Kogyo Kaisha Ltd 排熱回収バ−ナ
US5559246A (en) 1990-10-15 1996-09-24 Pfizer Inc. Indole derivatives
US5578612A (en) 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
US5545644A (en) 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
US5559129A (en) 1990-10-15 1996-09-24 Pfizer Inc Indole derivatives
US5607951A (en) 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
AU651637B2 (en) * 1990-10-15 1994-07-28 Pfizer Inc. Indole derivatives
JPH05154271A (ja) * 1991-12-05 1993-06-22 Mitsubishi Heavy Ind Ltd 連続式水洗機
GB9207930D0 (en) * 1992-04-10 1992-05-27 Pfizer Ltd Indoles
JPH064167A (ja) * 1992-06-18 1994-01-14 Nec Corp ディスク媒体障害の復旧方式
GB9417310D0 (en) 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
FR2735774B1 (fr) * 1995-06-21 1997-09-12 Sanofi Sa Utilisation de composes agonistes du recepteur cb2 humain pour la preparation de medicaments immunomodulateurs, nouveaux composes agonistes du recepteur cb2 et les compositions pharmaceutiques les contenant
US5998462A (en) * 1996-12-16 1999-12-07 Allelix Biopharmaceuticals Inc. 5-alkyl indole compounds
JPH10195048A (ja) * 1997-01-17 1998-07-28 Sumitomo Chem Co Ltd ３−（ニトロベンゾイル）インドール誘導体の製造法
WO1999001135A1 (en) 1997-07-03 1999-01-14 Pfizer Limited Pharmaceutical compositions containing eletriptan hemisulphate and caffeine
GB9923314D0 (en) * 1999-10-01 1999-12-08 Pfizer Ltd Acylation process

Also Published As

Publication number Publication date
CZ20003572A3 (cs) 2002-05-15
RU2197480C2 (ru) 2003-01-27
JP3374125B2 (ja) 2003-02-04
ES2188482T3 (es) 2003-07-01
PL342875A1 (en) 2001-04-09
TWI265923B (en) 2006-11-11
KR100365458B1 (ko) 2002-12-18
AU5951100A (en) 2001-04-05
US6914145B2 (en) 2005-07-05
ATE233238T1 (de) 2003-03-15
EP1088817B1 (en) 2003-02-26
IL138691A (en) 2005-03-20
HU0003862D0 (en) 2000-12-28
CA2322346A1 (en) 2001-04-01
BR0004578A (pt) 2001-05-29
ID27404A (id) 2001-04-05
EP1088817A2 (en) 2001-04-04
AU778663B2 (en) 2004-12-16
CN1142140C (zh) 2004-03-17
KR20010050785A (ko) 2001-06-25
HUP0003862A2 (hu) 2001-12-28
TR200002834A2 (tr) 2001-04-20
DK1088817T3 (da) 2003-04-22
ZA200005216B (en) 2002-03-28
HK1034970A1 (en) 2001-11-09
CZ297897B6 (cs) 2007-04-25
DE60001477T2 (de) 2003-08-28
RS49983B (sr) 2008-09-29
JP2001131146A (ja) 2001-05-15
GB9923314D0 (en) 1999-12-08
DE60001477D1 (de) 2003-04-03
EP1088817A3 (en) 2001-08-29
US6441192B1 (en) 2002-08-27
CN1290697A (zh) 2001-04-11
YU53500A (sh) 2003-02-28
CA2322346C (en) 2004-08-10
US20020188138A1 (en) 2002-12-12
IL138691A0 (en) 2001-10-31
HUP0003862A3 (en) 2002-02-28

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Legal Events

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