YU46547B - 1,4-dihidropiridini i postupak za njihovo dobijanje - Google Patents
1,4-dihidropiridini i postupak za njihovo dobijanjeInfo
- Publication number
- YU46547B YU46547B YU147088A YU147088A YU46547B YU 46547 B YU46547 B YU 46547B YU 147088 A YU147088 A YU 147088A YU 147088 A YU147088 A YU 147088A YU 46547 B YU46547 B YU 46547B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- dihydropyridines
- obtaining
- picolyl
- thienylmethyl
- fluorobenzyl
- Prior art date
Links
- -1 3-picolyl Chemical group 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000004176 4-fluorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])* 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP87401799A EP0302980B1 (fr) | 1987-08-03 | 1987-08-03 | 1,4-Dihydropyridines, leur procédé de préparation et leur application comme médicaments |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU147088A YU147088A (en) | 1990-04-30 |
| YU46547B true YU46547B (sh) | 1993-11-16 |
Family
ID=8198243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU147088A YU46547B (sh) | 1987-08-03 | 1988-07-29 | 1,4-dihidropiridini i postupak za njihovo dobijanje |
Country Status (34)
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5242933A (en) * | 1990-07-10 | 1993-09-07 | Adir Et Compagnie | Piperidine, tetrahydropyridine and pyrrolidine compounds |
| EP0854721B1 (en) * | 1995-08-02 | 2001-10-24 | Smithkline Beecham Corporation | Endothelin receptor antagonists |
| RU2168987C2 (ru) * | 1997-04-15 | 2001-06-20 | Санкт-Петербургская Государственная Химико-Фармацевтическая Академия | Гипотензивное средство |
| RU2155036C2 (ru) * | 1998-11-11 | 2000-08-27 | Азад Зияд Оглы Абышев | Средство для лечения ишемической болезни сердца |
| IT1304513B1 (it) * | 1998-12-30 | 2001-03-19 | Endura Spa | Processo per la sintesi di 5-(alfa-idrossialchil)benzo(1,3)diossoli. |
| AU4688301A (en) * | 2000-04-11 | 2001-10-23 | Sankyo Co | Stabilized pharmaceutical compositions containing calcium channel blockers |
| RU2187303C2 (ru) * | 2000-10-12 | 2002-08-20 | Азад Зияд Оглы Абышев | Способ получения таблеток диуманкала - forte по 0,01 г |
| PL375713A1 (en) | 2002-08-19 | 2005-12-12 | Pfizer Products Inc. | Combination therapy for hyperproliferative diseases |
| KR20070054644A (ko) * | 2004-07-26 | 2007-05-29 | 액테리온 파마슈티칼 리미티드 | 미립자 제형으로 흡입된 일로프로스트에 의한 폐고혈압의치료 |
| US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
| WO2007050783A2 (en) * | 2005-10-26 | 2007-05-03 | Asahi Kasei Pharma Corporation | Fasudil in combination therapies for the treatment of pulmonary arterial hypertension |
| EP2351569B1 (en) | 2005-10-26 | 2012-08-22 | Asahi Kasei Pharma Corporation | Fasudil in combination therapies for the treatment of pulmonary arterial hypertension |
| US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| TW200736245A (en) * | 2005-11-29 | 2007-10-01 | Sankyo Co | Acid addition salts of optically active dihydropyridine derivatives |
| TW200806648A (en) * | 2005-11-29 | 2008-02-01 | Sankyo Co | Acid addition salts of dihydropyridine derivatives |
| US7919506B2 (en) | 2006-03-10 | 2011-04-05 | Pfizer Inc. | Dibenzyl amine compounds and derivatives |
| EP2094643B1 (en) | 2006-12-01 | 2012-02-29 | Bristol-Myers Squibb Company | N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases |
| WO2012037665A1 (en) | 2010-09-24 | 2012-03-29 | Oral Delivery Technology Ltd. | Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions |
| WO2014170786A1 (en) | 2013-04-17 | 2014-10-23 | Pfizer Inc. | N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases |
| WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
| HUE069590T2 (hu) | 2019-01-18 | 2025-03-28 | Astrazeneca Ab | PCSK9-gátló 6'-[[(1s,3s)-3-[[5-(difluormetoxi)-2-pirimidinil]amino]ciklopentil]amino][1(2h ),3'-bipiridin]-2-on és alkalmazására szolgáló eljárások |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3441648A (en) * | 1967-02-07 | 1969-04-29 | Smithkline Corp | Compositions and methods for lowering blood pressure with 1,4-dihydropyridines |
| US4031104A (en) * | 1972-04-18 | 1977-06-21 | Bayer Aktiengesellschaft | 1,4-Dihydropyridine carboxylic acid esters |
| JPS5978186A (ja) * | 1982-10-27 | 1984-05-04 | Yoshitomi Pharmaceut Ind Ltd | １，４−ジヒドロピリジン−３，５−ジカルボン酸エステル誘導体 |
| ES8507495A1 (es) * | 1984-03-27 | 1985-09-01 | Inst Investigacion Desarrollo | Un procedimiento para la preparacion de nuevas 1,4-dihidropirinas-4-(polioxialquilfenil)-sustituidas |
| IE57810B1 (en) * | 1984-03-27 | 1993-04-21 | Delagrange Lab | 1,4-dihydropyridine derivatives,their preparation and their use |
| JPH068294B2 (ja) * | 1985-02-26 | 1994-02-02 | 富山化学工業株式会社 | 新規な１，４−ジヒドロピリジン誘導体およびその塩 |
| EP0174131A3 (en) * | 1984-09-01 | 1989-06-07 | FISONS plc | Dihydropyridines, processes and intermediates for their production, and pharmaceutical formulations containing them |
| JPH01207267A (ja) * | 1987-03-05 | 1989-08-21 | Yamanouchi Pharmaceut Co Ltd | ピリジン誘導体及び該化合物を含有する肝疾患治療剤 |
-
1987
- 1987-08-03 EP EP87401799A patent/EP0302980B1/fr not_active Expired - Lifetime
- 1987-08-03 AT AT87401799T patent/ATE61588T1/de active
- 1987-08-03 DE DE8787401799T patent/DE3768658D1/de not_active Expired - Lifetime
-
1988
- 1988-07-27 LU LU87297A patent/LU87297A1/fr unknown
- 1988-07-29 YU YU147088A patent/YU46547B/sh unknown
- 1988-07-29 CA CA000573422A patent/CA1306261C/fr not_active Expired - Lifetime
- 1988-07-29 DE DE3825962A patent/DE3825962A1/de not_active Withdrawn
- 1988-08-01 DD DD88318537A patent/DD282008A5/de not_active IP Right Cessation
- 1988-08-01 JP JP63192591A patent/JPH0733383B2/ja not_active Expired - Lifetime
- 1988-08-01 NO NO883406A patent/NO170934C/no unknown
- 1988-08-01 FI FI883603A patent/FI91406C/fi not_active IP Right Cessation
- 1988-08-01 MA MA21587A patent/MA21344A1/fr unknown
- 1988-08-02 DK DK430288A patent/DK430288A/da not_active Application Discontinuation
- 1988-08-02 IE IE236488A patent/IE60358B1/en not_active IP Right Cessation
- 1988-08-02 CH CH2922/88A patent/CH675999A5/fr not_active IP Right Cessation
- 1988-08-02 GR GR880100507A patent/GR880100507A/el unknown
- 1988-08-02 US US07/227,373 patent/US4952592A/en not_active Expired - Fee Related
- 1988-08-02 ES ES8802413A patent/ES2007543A6/es not_active Expired
- 1988-08-02 GB GB8818356A patent/GB2208861B/en not_active Expired - Lifetime
- 1988-08-02 IL IL87321A patent/IL87321A/xx not_active IP Right Cessation
- 1988-08-02 IT IT8848259A patent/IT1235013B/it active
- 1988-08-02 HU HU884065A patent/HU204523B/hu not_active IP Right Cessation
- 1988-08-02 PT PT88173A patent/PT88173B/pt not_active IP Right Cessation
- 1988-08-02 SK SK5413-88A patent/SK541388A3/sk unknown
- 1988-08-02 NZ NZ225661A patent/NZ225661A/xx unknown
- 1988-08-02 IS IS3378A patent/IS1549B/is unknown
- 1988-08-02 BE BE8800893A patent/BE1001055A4/fr not_active IP Right Cessation
- 1988-08-02 CN CN88106537A patent/CN1038587C/zh not_active Expired - Fee Related
- 1988-08-02 KR KR1019880009867A patent/KR960001724B1/ko not_active Expired - Fee Related
- 1988-08-02 TN TNTNSN88081A patent/TNSN88081A1/fr unknown
- 1988-08-02 CZ CS885413A patent/CZ282077B6/cs not_active IP Right Cessation
- 1988-08-03 IN IN556/MAS/88A patent/IN167550B/en unknown
- 1988-08-03 PH PH37337A patent/PH25645A/en unknown
- 1988-08-03 ZA ZA885684A patent/ZA885684B/xx unknown
-
1990
- 1990-08-28 CA CA000615848A patent/CA1306262C/fr not_active Expired - Lifetime
-
1991
- 1991-05-22 GR GR91400660T patent/GR3001984T3/el unknown
-
1992
- 1992-03-31 RU SU925011204A patent/RU2036922C1/ru active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| YU46547B (sh) | 1,4-dihidropiridini i postupak za njihovo dobijanje | |
| RS49531B (sr) | Estrogen agonisti/antagonisti | |
| YU164791A (sh) | Nezasićene hidroksialkilhinolin kiseline | |
| YU35697A (en) | Substituted 6,6-hetero-bicyclic derivatives | |
| DE69032981D1 (de) | N-Heteroarylamidederivate als Inhibitoren von Acyl-Coenzym A: Cholesterol-Acyl-Transferase | |
| ATE26120T1 (de) | Substituierte acyl-derivate von 1,2,3,4tetrahydro-6,7-dimethoxy-3-isoquinolincarbons|ure. | |
| AR241528A1 (es) | Un procedimiento para la preparacion de n-(3- o 4-((alquilamino)alquil)-fenil)alcansulfonamidas y sus sales. | |
| ATE44954T1 (de) | Carbostyrilderivat und verfahren zu seiner herstellung. | |
| FI862757A0 (fi) | Pyridonkarbonsyraderivat och foerfarande foer framstaellning av dessa. | |
| FI855117A0 (fi) | Segmenttipolyestereitä ja niiden kaltaisia yhdisteitä käytettäviksi lianirrotusaineina pesuainekoostumuksissa | |
| WO1991013055A3 (en) | New aryl- and heteroarylethenylene derivatives and process for their preparation | |
| ES2045109T3 (es) | 1-fenil-3-naftaleniloxipropanaminas. | |
| YU47554B (sh) | RACEMSKI I OPTIČKI AKTIVNI DERIVATI PIRIDO (1,2-a) PIRAZINA I NJIHOVI INTERMEDIJERI | |
| BG92179A (bg) | Метод за получаване на 7-заместена-хепт-6-еноена и -хептаноена киселина и техни производни и междинни съединения | |
| ATE45354T1 (de) | Chinoloncarbonsaeurederivate. | |
| DE3665711D1 (de) | Novel guanidinomethylbenzoic acid derivatives | |
| ES2045485T3 (es) | Metodo de preparacion de derivados de fenil-6 piperazinilalquil-3 1h, 3h-pirimidinediona-2,4, y su aplicacion en terapeutica. | |
| YU45810B (sh) | Postupak za dobijanje hinolin karboksilnih kiselina | |
| EP0331078A3 (en) | Process for the preparation of optically active 4-oxo-1-benzopyran-2-carboxylic acid derivatives and intermediates thereof | |
| HRP20000027B1 (en) | Process for the preparation of alkoxyfuranoneamine derivatives, compounds obtained by this process, and the use of these compounds | |
| YU46483B (sh) | Postupak za dobijanje kondenzovanih derivata pirimidina | |
| ES517779A0 (es) | Procedimiento de preparacion de nuevos derivados de 2-fenilmorfolina. | |
| BG92000A (bg) | Метод за получаване на соли на 2',3'-дидеоксиинозин монохидрат,2',3'-дидеокси-2',3'-дидехидротимидин моно- хидрат и 2',3'-дидеокси-2'-флуоринозин хемихидрат | |
| ATE58135T1 (de) | 1,3-oxathianderivate. | |
| YU47096B (sh) | Antivirusna jedinjenja i postupak za njihovo dobijanje |