ES8507495A1 - Un procedimiento para la preparacion de nuevas 1,4-dihidropirinas-4-(polioxialquilfenil)-sustituidas - Google Patents

Un procedimiento para la preparacion de nuevas 1,4-dihidropirinas-4-(polioxialquilfenil)-sustituidas

Info

Publication number
ES8507495A1
ES8507495A1 ES531033A ES531033A ES8507495A1 ES 8507495 A1 ES8507495 A1 ES 8507495A1 ES 531033 A ES531033 A ES 531033A ES 531033 A ES531033 A ES 531033A ES 8507495 A1 ES8507495 A1 ES 8507495A1
Authority
ES
Spain
Prior art keywords
cardiovascular
trouble
medicine
novel
manufacture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES531033A
Other languages
English (en)
Other versions
ES531033A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Instituto de Investigacion y Desarrollo Quimico Biologico SA
Original Assignee
Instituto de Investigacion y Desarrollo Quimico Biologico SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Instituto de Investigacion y Desarrollo Quimico Biologico SA filed Critical Instituto de Investigacion y Desarrollo Quimico Biologico SA
Priority to ES531033A priority Critical patent/ES8507495A1/es
Priority to IE627/85A priority patent/IE57810B1/en
Priority to IN191/MAS/85A priority patent/IN163314B/en
Priority to NZ211456A priority patent/NZ211456A/xx
Priority to IL74634A priority patent/IL74634A/xx
Priority to ZA852025A priority patent/ZA852025B/xx
Priority to LU85816A priority patent/LU85816A1/fr
Priority to AU40146/85A priority patent/AU571316B2/en
Priority to GB08507358A priority patent/GB2156809B/en
Priority to GR850736A priority patent/GR850736B/el
Priority to IS2992A priority patent/IS1366B6/is
Priority to YU471/85A priority patent/YU44059B/xx
Priority to EP85103541A priority patent/EP0158211B1/fr
Priority to DE8585103541T priority patent/DE3586546T2/de
Priority to PH32032A priority patent/PH21945A/en
Priority to ZW53/85A priority patent/ZW5385A1/xx
Priority to MA20610A priority patent/MA20386A1/fr
Priority to AT85103541T priority patent/ATE79868T1/de
Priority to RO118129A priority patent/RO90954B/ro
Priority to BE0/214704A priority patent/BE902016A/fr
Priority to DE19853510762 priority patent/DE3510762A1/de
Priority to CH1325/85A priority patent/CH663020A5/fr
Priority to SU853873551A priority patent/SU1329619A3/ru
Priority to MX8511500U priority patent/MX7378E/es
Priority to PL1985252576A priority patent/PL147055B1/pl
Priority to NO851206A priority patent/NO167509C/no
Priority to FI851218A priority patent/FI82937C/fi
Priority to HU851141A priority patent/HU193746B/hu
Priority to FR8504483A priority patent/FR2562069A1/fr
Priority to BG069433A priority patent/BG41127A3/xx
Priority to ZM13/85A priority patent/ZM1385A1/xx
Priority to DD85274449A priority patent/DD234669A5/de
Priority to PT80166A priority patent/PT80166B/pt
Priority to IT8547865A priority patent/IT1209946B/it
Priority to DK135285A priority patent/DK167676B1/da
Priority to OA58547A priority patent/OA07972A/xx
Priority to CA000477661A priority patent/CA1253158A/fr
Priority to CS852213A priority patent/CS259877B2/cs
Priority to JP60064964A priority patent/JPS60248671A/ja
Publication of ES531033A0 publication Critical patent/ES531033A0/es
Publication of ES8507495A1 publication Critical patent/ES8507495A1/es
Priority to US06/875,324 priority patent/US4722931A/en
Expired legal-status Critical Current

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  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE NUEVAS 1,4-DIHIDROPIRIDINAS-4-(POLIOXIALQUILFENIL)-SUSTITUIDAS, CON PROPIEDADES ANTAGONISTAS DEL CALCIO Y ANTIHIPERTENSIVAS.CONSISTE EN HACER REACCIONAR UN BENZALDEHIDO POLIOXIALQUIL-SUSTITUIDO CON ACETOACETATO DE ETILO, PARA OBTENER EL CORRESPONDIENTE POLIOXIALQUILFENIL-ACRILATO DE ETILO. A CONTINUACION SE HACE REACCIONAR ESTE ULTIMO COMPUESTO CON AMINOCROTONATO DE METILO PARA OBTENER LA CORRESPONDIENTE 1,4-DIHIDROPIRIDINA-4-(-POLIOXIALQUILFENIL)-SUSTITUIDA.DE APLICACION EN LA PREPARACION DE FARMACOS POR SUS PROPIEDADES HIPOTENSORAS Y ANSIOLITICAS, ASI COMO POR SUS PROPIEDADES ANTAGONISTAS DEL CALCIO.
ES531033A 1984-03-27 1984-03-27 Un procedimiento para la preparacion de nuevas 1,4-dihidropirinas-4-(polioxialquilfenil)-sustituidas Expired ES8507495A1 (es)

Priority Applications (40)

Application Number Priority Date Filing Date Title
ES531033A ES8507495A1 (es) 1984-03-27 1984-03-27 Un procedimiento para la preparacion de nuevas 1,4-dihidropirinas-4-(polioxialquilfenil)-sustituidas
IE627/85A IE57810B1 (en) 1984-03-27 1985-03-11 1,4-dihydropyridine derivatives,their preparation and their use
IN191/MAS/85A IN163314B (es) 1984-03-27 1985-03-14
NZ211456A NZ211456A (en) 1984-03-27 1985-03-15 1,4-dihydropyridine derivatives and pharmaceutical compositions
IL74634A IL74634A (en) 1984-03-27 1985-03-18 1,4-dihydropyridine derivatives,their preparation and pharmaceutical compositions containing them
ZA852025A ZA852025B (en) 1984-03-27 1985-03-19 New 1,4-dihydropyridine derivatives,their method of synthesis and their application as medicines
LU85816A LU85816A1 (fr) 1984-03-27 1985-03-20 Nouveaux derives de 1,4-dihydropyridine,leur procede de preparation et leur application comme medicaments
AU40146/85A AU571316B2 (en) 1984-03-27 1985-03-20 3-phenyl-1,4-dihydropyridine derivatives
GB08507358A GB2156809B (en) 1984-03-27 1985-03-21 1,4-dihydropyridine derivatives, their preparations and their use
GR850736A GR850736B (es) 1984-03-27 1985-03-22
IS2992A IS1366B6 (is) 1984-03-27 1985-03-22 Ný efni sem leidd eru úr (úrefni) 1,4 dihydropyridine, aðferð við gerð þeirra og notkun þeirra sem lyf
YU471/85A YU44059B (en) 1984-03-27 1985-03-22 Process for obtaining new derivatives of 1,4-dihydropiridine
EP85103541A EP0158211B1 (fr) 1984-03-27 1985-03-25 Nouveaux dérivés de 1,4 dihydropyridine, leur procédé de préparation, et leur application comme médicaments
DE8585103541T DE3586546T2 (de) 1984-03-27 1985-03-25 1,4-dihydropyridin-derivate, verfahren zur herstellung und anwendung als heilmittel.
PH32032A PH21945A (en) 1984-03-27 1985-03-25 New 1,4 dihydropyridine derivative and their application as medicines
ZW53/85A ZW5385A1 (en) 1984-03-27 1985-03-25 New 1,4 dihydrophyridine derivatives,their method of synthesis and their application as medicines
MA20610A MA20386A1 (fr) 1984-03-27 1985-03-25 Nouveaux derives de 1,4 dihydropridine,leur procede de preparation et leur application
AT85103541T ATE79868T1 (de) 1984-03-27 1985-03-25 1,4-dihydropyridin-derivate, verfahren zur herstellung und anwendung als heilmittel.
RO118129A RO90954B (ro) 1984-03-27 1985-03-25 Procedeu pentru prepararea unor derivati de 1,4-dihidropiridina
BE0/214704A BE902016A (fr) 1984-03-27 1985-03-25 Nouveaux derives de 1,4-dihydropyridine, leur procede de preparation et leur application comme medicaments.
DE19853510762 DE3510762A1 (de) 1984-03-27 1985-03-25 1,4-dihydropyridinderivate
CH1325/85A CH663020A5 (fr) 1984-03-27 1985-03-26 Derives de 1,4-dihydropyridine, leur procede de preparation et compositions pharmaceutiques les contenant.
PT80166A PT80166B (pt) 1984-03-27 1985-03-26 Processo para a preparacao de novos derivados de 1,4-dihidropiridina
MX8511500U MX7378E (es) 1984-03-27 1985-03-26 Procedimiento para preparar derivados de 1,4-dihidropiridina
PL1985252576A PL147055B1 (en) 1984-03-27 1985-03-26 Method of obtaining novel derivatives of 1,4-dihydropyridine
NO851206A NO167509C (no) 1984-03-27 1985-03-26 Analogifremgangsmaate for fremstilling av terapeutisk virksomme 1,4-dihydropyridiner.
FI851218A FI82937C (fi) 1984-03-27 1985-03-26 Foerfarande foer framstaellning av terapeutiskt anvaendbara 1,4-dihydro-4-(2',3'-metylendioxifenyl) pyridinderivat.
HU851141A HU193746B (en) 1984-03-27 1985-03-26 Process for preparing 1,4-dihydropyridine derivatives
FR8504483A FR2562069A1 (fr) 1984-03-27 1985-03-26 Nouveaux derives de 1,4-dihydropyridine, leur procede de preparation, et leur application comme medicaments
BG069433A BG41127A3 (en) 1984-03-27 1985-03-26 Method for preparing 1, 4- dihydropyridine derivatives
ZM13/85A ZM1385A1 (en) 1984-03-27 1985-03-26 New 1,4 dihydropyridine derivatives,their method of synthesis and their application as medicines
DD85274449A DD234669A5 (de) 1984-03-27 1985-03-26 Verfahren zur herstellung von 1,4-dihydropyridinen
SU853873551A SU1329619A3 (ru) 1984-03-27 1985-03-26 Способ получени производных 1,4-дигидропиридина
IT8547865A IT1209946B (it) 1984-03-27 1985-03-26 Nuovi derivati della i,4-diidropiri dina,procedimento per la loro preparazione,e loro impiego come farmaci
DK135285A DK167676B1 (da) 1984-03-27 1985-03-26 1,4-dihydropyridinderivater, fremgangsmaade til fremstilling deraf samt laegemiddel indeholdende saadanne forbindelser
OA58547A OA07972A (fr) 1984-03-27 1985-03-26 Nouveaux dérivés de 1,4-dihydropyridine, leur procédé de préparation et leur application comme médicaments.
CA000477661A CA1253158A (fr) 1984-03-27 1985-03-27 Derives de 1,4 dihydropyridine, leur procede de preparation, et leur application comme medicaments
CS852213A CS259877B2 (en) 1984-03-27 1985-03-27 Method of new 1,4-dihydropyridine derivatives production
JP60064964A JPS60248671A (ja) 1984-03-27 1985-03-27 新規１，４−ジヒドロピリジン誘導体、それらの製造方法およびこれらを有効成分とする心臓血管障害の治療薬
US06/875,324 US4722931A (en) 1984-03-27 1986-06-17 Calcium antagonist

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES531033A ES8507495A1 (es) 1984-03-27 1984-03-27 Un procedimiento para la preparacion de nuevas 1,4-dihidropirinas-4-(polioxialquilfenil)-sustituidas

Publications (2)

Publication Number Publication Date
ES531033A0 ES531033A0 (es) 1985-09-01
ES8507495A1 true ES8507495A1 (es) 1985-09-01

Family

ID=8487103

Family Applications (1)

Application Number Title Priority Date Filing Date
ES531033A Expired ES8507495A1 (es) 1984-03-27 1984-03-27 Un procedimiento para la preparacion de nuevas 1,4-dihidropirinas-4-(polioxialquilfenil)-sustituidas

Country Status (7)

Country Link
JP (1) JPS60248671A (es)
DD (1) DD234669A5 (es)
ES (1) ES8507495A1 (es)
IN (1) IN163314B (es)
MA (1) MA20386A1 (es)
ZA (1) ZA852025B (es)
ZM (1) ZM1385A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3768658D1 (de) * 1987-08-03 1991-04-18 Delagrange Lab 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6056956A (ja) * 1983-09-08 1985-04-02 Shoichiro Ozaki １，４−ジヒドロピリジン誘導体及びその製法

Also Published As

Publication number Publication date
JPH0544453B2 (es) 1993-07-06
ZA852025B (en) 1985-11-27
ES531033A0 (es) 1985-09-01
MA20386A1 (fr) 1985-10-01
ZM1385A1 (en) 1985-11-22
DD234669A5 (de) 1986-04-09
JPS60248671A (ja) 1985-12-09
IN163314B (es) 1988-09-03

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970612