YU26599A - Spiro/piperidin-4,1'-pirolo/3,4-c/pirol/ - Google Patents
Spiro/piperidin-4,1'-pirolo/3,4-c/pirol/Info
- Publication number
- YU26599A YU26599A YU26599A YU26599A YU26599A YU 26599 A YU26599 A YU 26599A YU 26599 A YU26599 A YU 26599A YU 26599 A YU26599 A YU 26599A YU 26599 A YU26599 A YU 26599A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- compounds
- loss
- memory
- disturbance
- pyrrolo
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Addiction (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Predmetni pronalazak odnosi se na jedinjenja, opšte formule u kojima su substituenti opisani u prijavi, i na njihove soli nastale dodavanjem faramceutski prihvatljivih kiselina. Jedinjenja na koja se odnosi pronalazak korisna su u terapiji bolesti vezanih za orfanin FQ (OFQ) receptor, koje uključuju psihijatrijske, neurološke i fiziološke poremećaje, kao što su anksioznost, stres, depresije, traume, gubitak memorije uzrokovan Alchajmerovom bolešću ili druge demencije, poremećaji pamćenja i učenja, epilepsije i konvulzije, akutna i/ili hronična stanja bola, i simptomi apstinencije od narkotika, kontrola vodenog balansa, izlučivanje Na+, poremećaji arterijskog krvnog pritiska i metabolički poremećaji, kao što je gojaznost. [The subject matter of the invention refers to the compounds, by a general formula (I), where substituents described in the invention, and their salts manufactured by adding pharmaceutically acceptable salts. The compounds to which the invention relates are useful in the therapy of illnesses connected to orfarine (OFQ) receptor, including psychiatric, neurologic and physiologic disturbances such as anxiety, stress, depression, trauma, loss of memory caused by Alzheimer's Disease and other dementia, loss of memory and learning, epilepsies and colvulsions, acute and/or chronic conditions of pain and symptoms of abstinence from narcotics, control of water ballance, excretes of Na, disturbance of arteria blood pressure and metabolic disturbance, such as fat.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98110803 | 1998-06-12 | ||
EP98124119 | 1998-12-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
YU26599A true YU26599A (sh) | 2002-09-19 |
Family
ID=26149342
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU26599A YU26599A (sh) | 1998-06-12 | 1999-06-10 | Spiro/piperidin-4,1'-pirolo/3,4-c/pirol/ |
Country Status (27)
Country | Link |
---|---|
US (1) | US6075034A (sh) |
EP (1) | EP0963987B1 (sh) |
JP (1) | JP3308507B2 (sh) |
KR (1) | KR100346607B1 (sh) |
AR (1) | AR018650A1 (sh) |
AT (1) | ATE222908T1 (sh) |
AU (1) | AU749995B2 (sh) |
BR (1) | BR9902245A (sh) |
CA (1) | CA2274204C (sh) |
CO (1) | CO5060459A1 (sh) |
DE (1) | DE69902606T2 (sh) |
DK (1) | DK0963987T3 (sh) |
ES (1) | ES2181336T3 (sh) |
HR (1) | HRP990189A2 (sh) |
HU (1) | HUP9901909A3 (sh) |
ID (1) | ID23283A (sh) |
IL (1) | IL130376A0 (sh) |
MA (1) | MA26643A1 (sh) |
NO (1) | NO312069B1 (sh) |
NZ (1) | NZ336186A (sh) |
PE (1) | PE20000549A1 (sh) |
PL (1) | PL333694A1 (sh) |
PT (1) | PT963987E (sh) |
SG (1) | SG76623A1 (sh) |
TR (1) | TR199901304A2 (sh) |
TW (1) | TW523516B (sh) |
YU (1) | YU26599A (sh) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6969712B2 (en) | 2000-11-15 | 2005-11-29 | Banyu Pharmaceutical Co., Ltd. | Benzimidazole derivatives |
US20030040479A1 (en) * | 2001-07-02 | 2003-02-27 | Omeros Corporation | Rotational intrathecal analgesia method and device |
EP1406629A1 (en) * | 2001-07-02 | 2004-04-14 | Omeros Corporation | Method for inducing analgesia comprising administration alternatively of an opioid receptor agonist and an opioid receptor like receptor 1 agonist for and an implantable infusion pump |
JP2005289816A (ja) | 2002-05-14 | 2005-10-20 | Banyu Pharmaceut Co Ltd | ベンズイミダゾール誘導体 |
CA2532059A1 (en) * | 2003-05-23 | 2004-12-02 | Zealand Pharma A/S | Triaza-spiro compounds as nociceptin analogues and uses thereof |
US20050228023A1 (en) * | 2003-12-19 | 2005-10-13 | Sri International | Agonist and antagonist ligands of the nociceptin receptor |
JP4446978B2 (ja) * | 2006-04-28 | 2010-04-07 | トヨタ自動車株式会社 | 車両用駆動力制御装置 |
ES2541133T3 (es) * | 2007-03-01 | 2015-07-16 | Mitsubishi Tanabe Pharma Corporation | Compuesto de bencimidazol y uso farmacéutico del mismo |
KR101561666B1 (ko) | 2014-08-12 | 2015-10-20 | 최인석 | 골프 퍼팅 교정장치 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5534520A (en) * | 1990-04-10 | 1996-07-09 | Fisher; Abraham | Spiro compounds containing five-membered rings |
CA2226058C (en) * | 1997-01-30 | 2008-01-29 | F. Hoffmann-La Roche Ag | 8-substituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives |
-
1999
- 1999-06-07 DK DK99110944T patent/DK0963987T3/da active
- 1999-06-07 AT AT99110944T patent/ATE222908T1/de active
- 1999-06-07 DE DE69902606T patent/DE69902606T2/de not_active Expired - Lifetime
- 1999-06-07 PT PT99110944T patent/PT963987E/pt unknown
- 1999-06-07 EP EP99110944A patent/EP0963987B1/en not_active Expired - Lifetime
- 1999-06-07 ES ES99110944T patent/ES2181336T3/es not_active Expired - Lifetime
- 1999-06-08 PE PE1999000485A patent/PE20000549A1/es not_active Application Discontinuation
- 1999-06-09 CA CA002274204A patent/CA2274204C/en not_active Expired - Fee Related
- 1999-06-09 CO CO99036175A patent/CO5060459A1/es unknown
- 1999-06-09 IL IL13037699A patent/IL130376A0/xx unknown
- 1999-06-09 HU HU9901909A patent/HUP9901909A3/hu unknown
- 1999-06-09 NZ NZ336186A patent/NZ336186A/xx unknown
- 1999-06-09 SG SG1999002779A patent/SG76623A1/en unknown
- 1999-06-10 AR ARP990102765A patent/AR018650A1/es active IP Right Grant
- 1999-06-10 KR KR1019990021570A patent/KR100346607B1/ko not_active IP Right Cessation
- 1999-06-10 TR TR1999/01304A patent/TR199901304A2/xx unknown
- 1999-06-10 MA MA25615A patent/MA26643A1/fr unknown
- 1999-06-10 YU YU26599A patent/YU26599A/sh unknown
- 1999-06-10 JP JP16397599A patent/JP3308507B2/ja not_active Expired - Fee Related
- 1999-06-11 AU AU35003/99A patent/AU749995B2/en not_active Ceased
- 1999-06-11 PL PL99333694A patent/PL333694A1/xx unknown
- 1999-06-11 BR BR9902245A patent/BR9902245A/pt not_active Application Discontinuation
- 1999-06-11 US US09/330,857 patent/US6075034A/en not_active Expired - Fee Related
- 1999-06-11 NO NO19992872A patent/NO312069B1/no unknown
- 1999-06-11 HR HR98124119.3A patent/HRP990189A2/hr not_active Application Discontinuation
- 1999-06-14 ID IDP990577A patent/ID23283A/id unknown
- 1999-06-21 TW TW088110336A patent/TW523516B/zh active
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