HUP9901909A3 - Spiro piperidine-4,1'-pyrrolo[3,4-c]pyrrole derivatives as agonist and/or antagonist of the orphanin fq(ofq)receptor, preparation and use thereof - Google Patents
Spiro piperidine-4,1'-pyrrolo[3,4-c]pyrrole derivatives as agonist and/or antagonist of the orphanin fq(ofq)receptor, preparation and use thereofInfo
- Publication number
- HUP9901909A3 HUP9901909A3 HU9901909A HUP9901909A HUP9901909A3 HU P9901909 A3 HUP9901909 A3 HU P9901909A3 HU 9901909 A HU9901909 A HU 9901909A HU P9901909 A HUP9901909 A HU P9901909A HU P9901909 A3 HUP9901909 A3 HU P9901909A3
- Authority
- HU
- Hungary
- Prior art keywords
- ofq
- orphanin
- pyrrolo
- agonist
- antagonist
- Prior art date
Links
- 239000000556 agonist Substances 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- PULGYDLMFSFVBL-SMFNREODSA-N nociceptin Chemical compound C([C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(O)=O)[C@@H](C)O)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 PULGYDLMFSFVBL-SMFNREODSA-N 0.000 title 1
- 125000003003 spiro group Chemical group 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98110803 | 1998-06-12 | ||
EP98124119 | 1998-12-18 |
Publications (3)
Publication Number | Publication Date |
---|---|
HU9901909D0 HU9901909D0 (en) | 1999-08-30 |
HUP9901909A2 HUP9901909A2 (hu) | 2000-04-28 |
HUP9901909A3 true HUP9901909A3 (en) | 2001-11-28 |
Family
ID=26149342
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9901909A HUP9901909A3 (en) | 1998-06-12 | 1999-06-09 | Spiro piperidine-4,1'-pyrrolo[3,4-c]pyrrole derivatives as agonist and/or antagonist of the orphanin fq(ofq)receptor, preparation and use thereof |
Country Status (27)
Country | Link |
---|---|
US (1) | US6075034A (hu) |
EP (1) | EP0963987B1 (hu) |
JP (1) | JP3308507B2 (hu) |
KR (1) | KR100346607B1 (hu) |
AR (1) | AR018650A1 (hu) |
AT (1) | ATE222908T1 (hu) |
AU (1) | AU749995B2 (hu) |
BR (1) | BR9902245A (hu) |
CA (1) | CA2274204C (hu) |
CO (1) | CO5060459A1 (hu) |
DE (1) | DE69902606T2 (hu) |
DK (1) | DK0963987T3 (hu) |
ES (1) | ES2181336T3 (hu) |
HR (1) | HRP990189A2 (hu) |
HU (1) | HUP9901909A3 (hu) |
ID (1) | ID23283A (hu) |
IL (1) | IL130376A0 (hu) |
MA (1) | MA26643A1 (hu) |
NO (1) | NO312069B1 (hu) |
NZ (1) | NZ336186A (hu) |
PE (1) | PE20000549A1 (hu) |
PL (1) | PL333694A1 (hu) |
PT (1) | PT963987E (hu) |
SG (1) | SG76623A1 (hu) |
TR (1) | TR199901304A2 (hu) |
TW (1) | TW523516B (hu) |
YU (1) | YU26599A (hu) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6969712B2 (en) | 2000-11-15 | 2005-11-29 | Banyu Pharmaceutical Co., Ltd. | Benzimidazole derivatives |
JP2005502619A (ja) * | 2001-07-02 | 2005-01-27 | オメロス コーポレイション | オピオイドレセプター様レセプター1アゴニストと交替でオピオイドレセプターアゴニストを投与することを含む、痛覚脱失を生成するための方法 |
US20030040479A1 (en) * | 2001-07-02 | 2003-02-27 | Omeros Corporation | Rotational intrathecal analgesia method and device |
JP2005289816A (ja) | 2002-05-14 | 2005-10-20 | Banyu Pharmaceut Co Ltd | ベンズイミダゾール誘導体 |
ZA200510329B (en) * | 2003-05-23 | 2007-04-25 | Zealand Pharma As | Triaza-spiro compounds as nociceptin analogues and uses thereof |
US20050228023A1 (en) * | 2003-12-19 | 2005-10-13 | Sri International | Agonist and antagonist ligands of the nociceptin receptor |
JP4446978B2 (ja) * | 2006-04-28 | 2010-04-07 | トヨタ自動車株式会社 | 車両用駆動力制御装置 |
JP5313865B2 (ja) * | 2007-03-01 | 2013-10-09 | 田辺三菱製薬株式会社 | ベンゾイミダゾール化合物およびその医薬用途 |
KR101561666B1 (ko) | 2014-08-12 | 2015-10-20 | 최인석 | 골프 퍼팅 교정장치 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5534520A (en) * | 1990-04-10 | 1996-07-09 | Fisher; Abraham | Spiro compounds containing five-membered rings |
CA2226058C (en) * | 1997-01-30 | 2008-01-29 | F. Hoffmann-La Roche Ag | 8-substituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives |
-
1999
- 1999-06-07 DK DK99110944T patent/DK0963987T3/da active
- 1999-06-07 AT AT99110944T patent/ATE222908T1/de active
- 1999-06-07 ES ES99110944T patent/ES2181336T3/es not_active Expired - Lifetime
- 1999-06-07 DE DE69902606T patent/DE69902606T2/de not_active Expired - Lifetime
- 1999-06-07 PT PT99110944T patent/PT963987E/pt unknown
- 1999-06-07 EP EP99110944A patent/EP0963987B1/en not_active Expired - Lifetime
- 1999-06-08 PE PE1999000485A patent/PE20000549A1/es not_active Application Discontinuation
- 1999-06-09 CO CO99036175A patent/CO5060459A1/es unknown
- 1999-06-09 HU HU9901909A patent/HUP9901909A3/hu unknown
- 1999-06-09 NZ NZ336186A patent/NZ336186A/xx unknown
- 1999-06-09 SG SG1999002779A patent/SG76623A1/en unknown
- 1999-06-09 CA CA002274204A patent/CA2274204C/en not_active Expired - Fee Related
- 1999-06-09 IL IL13037699A patent/IL130376A0/xx unknown
- 1999-06-10 YU YU26599A patent/YU26599A/sh unknown
- 1999-06-10 TR TR1999/01304A patent/TR199901304A2/xx unknown
- 1999-06-10 JP JP16397599A patent/JP3308507B2/ja not_active Expired - Fee Related
- 1999-06-10 MA MA25615A patent/MA26643A1/fr unknown
- 1999-06-10 AR ARP990102765A patent/AR018650A1/es active IP Right Grant
- 1999-06-10 KR KR1019990021570A patent/KR100346607B1/ko not_active IP Right Cessation
- 1999-06-11 PL PL99333694A patent/PL333694A1/xx unknown
- 1999-06-11 AU AU35003/99A patent/AU749995B2/en not_active Ceased
- 1999-06-11 BR BR9902245A patent/BR9902245A/pt not_active Application Discontinuation
- 1999-06-11 HR HR98124119.3A patent/HRP990189A2/hr not_active Application Discontinuation
- 1999-06-11 US US09/330,857 patent/US6075034A/en not_active Expired - Fee Related
- 1999-06-11 NO NO19992872A patent/NO312069B1/no unknown
- 1999-06-14 ID IDP990577A patent/ID23283A/id unknown
- 1999-06-21 TW TW088110336A patent/TW523516B/zh active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU4343396A (en) | Tetracyclic spiro compounds, process for their preparation and their use as 5ht1d receptor antagonists | |
HUP0600239A2 (en) | 5-amino-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives, process for their preparation, their use as adenosine a2a receptor antagonists and pharmaceutical compositions containing them | |
AU2875999A (en) | Antagonists of a2b human adenosine receptors | |
HUP0202202A3 (en) | Benzoxepino [2,3-b]pyridine derivatives and analogues as chemokine receptor antagonists and the use thereof | |
HUP9802940A3 (en) | Quinoline-2(1h)-one derivatives as serotonin antagonists, preparation and use thereof | |
HUP0402270A3 (en) | [1,2,4]triazolo[1,5-c]pyrimidin-5-yl-amines as adenosine a2a receptor antagonists and pharmaceutical compositions containing them | |
AU6751301A (en) | 1,3,8-triaza-spiro'4,5]decan-4-one derivatives as neurokinin receptor antagonists | |
HUP0000582A3 (en) | Insecticidal, acaricidal and nematocidal 8-azabicyclo[3.2.1]octane-, 8-azabicyclo[3.2.1]oct-6-ene-, 9-azabicyclo[3.3.1]nonane-, 9-aza-3-oxabicyclo[3.3.1]nonane- and 9-aza-3-thiabicyclo[3.3.1]nonane derivatives, preparation and use thereof | |
HUP0402018A3 (en) | 5-amino-7h-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives, their use and pharmaceutical compositions containing them | |
HUP0002902A3 (en) | 3-substituted 3,4 dyhydro-thieno[2,3-d]pyrimidine derivatives and their use for the preparation of pharmaceutical compositions | |
HUP9904107A3 (en) | 3-substituted pyrido[4',3':4,5]thieno[2,3-d]pyrimidine derivatives,their preparation and their use | |
AU5844896A (en) | Tricyclic diazepines useful as gnrh receptor antagonists | |
HUP0402324A3 (en) | [1,2,4]triazolo[1,5-a]pyridine and [1,2,4]triazolo[1,5-c]pyrimidine derivatives as adenosine a2a receptor antagonists and pharmaceutical compositions containing them | |
HK1030939A1 (en) | Aroyl-piperazine derivatives, their preparation and their use as tachykinin antagonists | |
CZ2019997A3 (cs) | Deriváty pyridazino [4,5-B] chinolin-5-oxidu, způsob jejich přípravy a jejich použití jako antagonistů glycinu | |
IL132571A0 (en) | Ergoline derivatives and ther use as somatostatin receptor antagonists | |
HUP9901909A3 (en) | Spiro piperidine-4,1'-pyrrolo[3,4-c]pyrrole derivatives as agonist and/or antagonist of the orphanin fq(ofq)receptor, preparation and use thereof | |
HUP0203371A3 (en) | Adenosine receptor antagonists and methods of making and using the same | |
ZA937505B (en) | Imidazopyridine derivatives as 5-HT4 receptor antagonists | |
SG79259A1 (en) | Diaza-spiro[3,5]nonane deravatives | |
HUP0101311A3 (en) | 3-substituted 3,4,5,7-tetrahydro-pyrrolo[3',4':4,5]thieno [2,3-d]pyrimidine derivatives, their preparation and use as 5ht antagonists | |
HUP9901910A3 (en) | Di- or triaza-spiro[4,5]decane derivatives as agonist and/or antagonist of the orphanin fq(ofq) receptor, preparation and use thereof | |
HUP0003394A3 (en) | Pyrido[2,3-b][1,5]benzodiazepine derivatives, their use, process for their preparation and pharmaceutical compositions containing them | |
HUP0002736A3 (en) | 3-substituted pyrido [3',4':4,5]thieno[2,3-d]pyrimidine derivatives, and their use for the preparation of pharmaceutical compositions | |
HUP0201709A3 (en) | Ureidopiperidine derivatives as selective human nk3 receptor antagonists, pharmaceutical compositions containing them and use of them for producing pharmaceutical compositions |