BE902528A - 1,24-dihydroxy-delta 22-vitamines d3 et procede pour les preparer. - Google Patents

1,24-dihydroxy-delta 22-vitamines d3 et procede pour les preparer.

Info

Publication number
BE902528A
BE902528A BE0/215091A BE215091A BE902528A BE 902528 A BE902528 A BE 902528A BE 0/215091 A BE0/215091 A BE 0/215091A BE 215091 A BE215091 A BE 215091A BE 902528 A BE902528 A BE 902528A
Authority
BE
Belgium
Prior art keywords
bone
hydrogen atom
application
vitamin
dihydroxy
Prior art date
Application number
BE0/215091A
Other languages
English (en)
Inventor
Luca H F De
N Ikekawa
Y Tanaka
Original Assignee
Wisconsin Alumni Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found
Publication of BE902528A publication Critical patent/BE902528A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Composé de formule I où l'un d'entre R1 et R2 représente un atome d'hydrogène et l'autre représente un radical hydroxyle, et R3 et R4 représentent chacun indépendamment un atome d'hydrogène ou un radical acyle de 1 à 4 atomes de carbone. Les composés manifestent une activité vitaminoide D par leur aptitude à stimuler le transport du calcium intestinal, à augmenter le taux de phosphore inorganique sérique et la minéralisation osseuse, ce qui indique leur application pour le traitement de différentes affections métaboliques des os. Le fait que les composés de l'invention ne provoquent pas la mobilisation osseuse suggère qu'ils trouveraient une application dans des combinaisons avec la vitamine D pour assurer une minéralisation osseuse ménagée.
BE0/215091A 1984-05-31 1985-05-29 1,24-dihydroxy-delta 22-vitamines d3 et procede pour les preparer. BE902528A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/615,974 US4588528A (en) 1984-05-31 1984-05-31 1,24-dihydroxy-Δ22 -vitamin D3 and process for preparing same

Publications (1)

Publication Number Publication Date
BE902528A true BE902528A (fr) 1985-09-16

Family

ID=24467528

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/215091A BE902528A (fr) 1984-05-31 1985-05-29 1,24-dihydroxy-delta 22-vitamines d3 et procede pour les preparer.

Country Status (9)

Country Link
US (1) US4588528A (fr)
JP (2) JPS61502257A (fr)
AU (1) AU4063985A (fr)
BE (1) BE902528A (fr)
DE (2) DE3590232T (fr)
FR (1) FR2565227B1 (fr)
GB (1) GB2159520B (fr)
IE (1) IE58286B1 (fr)
WO (1) WO1985005622A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5786348A (en) * 1991-01-08 1998-07-28 Bone Care International, Inc. Methods for preparation and use of 1α,24(S)-dihydroxy vitamin D2

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5120722A (en) * 1984-02-08 1992-06-09 Hoffmann-La Roche Inc. Trihydroxy-cholecacliferol and trihydroxy-ergocalciferol for treating leukemia
US4973584A (en) * 1989-03-09 1990-11-27 Deluca Hector F Novel 1α-hydroxyvitamin D2 epimer and derivatives
CZ280203B6 (cs) * 1990-02-06 1995-11-15 Schering Aktiengesellschaft Deriváty vitaminu D s homology bočního řetězce a způsob jejich výroby
US5030772A (en) * 1990-02-14 1991-07-09 Deluca Hector F Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives
US5260290A (en) * 1990-02-14 1993-11-09 Wisconsin Alumni Research Foundation Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
US20040009958A1 (en) * 1991-01-08 2004-01-15 Bone Care International, Inc. Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2
ATE179604T1 (de) * 1991-01-08 1999-05-15 Bone Care Int Inc Verfahren zur herstellung und verwendung von 1alpha,24-dihydroxy vitamin-d2
AU666529B2 (en) * 1992-04-24 1996-02-15 Wisconsin Alumni Research Foundation Method of treating osteoporosis with 1 alpha, 24 (R)-dihydroxy-22 (E)-dehydro-vitamin D3
KR960013798B1 (ko) * 1992-04-24 1996-10-10 재단법인 한국전자통신연구소 평면 도파로형 공간 스위치
US5247104A (en) * 1992-11-04 1993-09-21 Wisconsin Alumni Research Foundation Preparation of 1α, 24-dihydroxyvitamin D analogs
US5422127A (en) * 1992-12-21 1995-06-06 Bristol-Myers Squibb Company Nutritional compositions containing vitamin D esters
US5716946A (en) * 1996-02-13 1998-02-10 Wisconsin Alumni Research Foundation Multiple sclerosis treatment
US6136799A (en) * 1998-04-08 2000-10-24 Abbott Laboratories Cosolvent formulations
US6479474B2 (en) * 1999-07-08 2002-11-12 Wisconsin Alumni Research Foundation Dietary calcium as a supplement to vitamin D compound treatment of multiple sclerosis
MX339746B (es) 2009-01-27 2016-06-08 Berg Llc Vitamina d3 y análogos de la misma para aliviar efectos secundarios asociados con la quimioterapia.
JP5978130B2 (ja) 2009-08-14 2016-08-24 バーグ エルエルシー 脱毛症を治療するためのビタミンｄ３およびその類似体
WO2014194133A1 (fr) 2013-05-29 2014-12-04 Berg Llc Prévention ou atténuation de l'alopécie induite par la chimiothérapie au moyen de vitamine d
JP6812405B2 (ja) * 2015-07-12 2021-01-13 ツェーエフエスオー・ゲーエムベーハー コレカルシフェロール硫酸塩及びビタミンｄ欠乏症の処置のためのこれらの使用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3786062A (en) * 1973-02-16 1974-01-15 Wisconsin Alumni Res Found 22-dehydro-25-hydroxycholecalciferol and process for preparing same
US4202829A (en) * 1978-01-05 1980-05-13 Wisconsin Alumni Research Foundation Process for preparing 1α-hydroxylated compounds
US4267117A (en) * 1978-06-19 1981-05-12 The Upjohn Company Compounds and process
US4206131A (en) * 1978-06-19 1980-06-03 The Upjohn Company Compounds and process
US4225596A (en) * 1978-10-13 1980-09-30 Wisconsin Alumni Research Foundation Method for treating calcium imbalance and improving calcium absorption in mammals
US4265822A (en) * 1979-09-10 1981-05-05 Wisconsin Alumni Research Foundation Process for preparing 1-hydroxylated vitamin D compounds from 5,6-trans-vitamin D compounds
US4313942A (en) * 1979-10-09 1982-02-02 Wisconsin Alumni Research Foundation Activated vitamin D rodenticides
US4448721A (en) * 1982-09-20 1984-05-15 Wisconsin Alumni Research Foundation Hydroxyvitamin D2 compounds and process for preparing same

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5786348A (en) * 1991-01-08 1998-07-28 Bone Care International, Inc. Methods for preparation and use of 1α,24(S)-dihydroxy vitamin D2

Also Published As

Publication number Publication date
JPH0576940B2 (fr) 1993-10-25
AU4063985A (en) 1985-12-31
FR2565227B1 (fr) 1987-01-16
DE3590232C2 (de) 1992-09-17
GB8513721D0 (en) 1985-07-03
US4588528A (en) 1986-05-13
IE58286B1 (en) 1993-08-25
JPH0662664B2 (ja) 1994-08-17
GB2159520A (en) 1985-12-04
WO1985005622A1 (fr) 1985-12-19
FR2565227A1 (fr) 1985-12-06
IE851284L (en) 1985-11-30
GB2159520B (en) 1987-12-16
DE3590232T (de) 1986-06-26
JPS61502257A (ja) 1986-10-09
JPH0692989A (ja) 1994-04-05

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: WISCONSIN ALUMNI RESEARCH FOUNDATION

Effective date: 20010531