EA200800439A1 - Выбранные cgrp-антагонисты, способ их получения, а также их применение в качестве лекарственных средств - Google Patents

Выбранные cgrp-антагонисты, способ их получения, а также их применение в качестве лекарственных средств

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Publication number
EA200800439A1
EA200800439A1 EA200800439A EA200800439A EA200800439A1 EA 200800439 A1 EA200800439 A1 EA 200800439A1 EA 200800439 A EA200800439 A EA 200800439A EA 200800439 A EA200800439 A EA 200800439A EA 200800439 A1 EA200800439 A1 EA 200800439A1
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EA
Eurasian Patent Office
Prior art keywords
antagonists
production
salts
hydrates
general formula
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Application number
EA200800439A
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English (en)
Inventor
Штефан Георг Мюллер
Клаус Рудольф
Филипп Лустенбергер
Герхард Шэнцле
Марко Сантагостино
Дирк Штенкамп
Кирстен Арндт
Хенри Додс
Original Assignee
Бёрингер Ингельхайм Интернациональ Гмбх
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Publication of EA200800439A1 publication Critical patent/EA200800439A1/ru

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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Otolaryngology (AREA)
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Abstract

В заявке описаны CGRP-антагонисты общей формулы (I)в которой R, R, Rи Rимеют указанные в п.1 формулы изобретения значения, их таутомеры, их изомеры, их диастереомеры, их энантиомеры, их гидраты, их смеси и их соли, а также гидраты солей, прежде всего их физиологически совместимые соли с неорганическими или органическими кислотами, включая те соединения общей формулы I, в которых один или несколько атомов водорода замещены на дейтерий, содержащие эти соединения лекарственные средства, их применение и способ их получения.
EA200800439A 2005-08-17 2006-08-15 Выбранные cgrp-антагонисты, способ их получения, а также их применение в качестве лекарственных средств EA200800439A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102005038831A DE102005038831A1 (de) 2005-08-17 2005-08-17 Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
DE102005050953A DE102005050953A1 (de) 2005-08-17 2005-10-25 Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
PCT/EP2006/065314 WO2007020261A2 (de) 2005-08-17 2006-08-15 Ausgewählte cgrp-antagonisten, verfahren zu deren herstellung sowie deren verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
EA200800439A1 true EA200800439A1 (ru) 2008-08-29

Family

ID=37496772

Family Applications (1)

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EA200800439A EA200800439A1 (ru) 2005-08-17 2006-08-15 Выбранные cgrp-антагонисты, способ их получения, а также их применение в качестве лекарственных средств

Country Status (18)

Country Link
US (3) US7579341B2 (ru)
EP (1) EP1917256A2 (ru)
JP (2) JP4852607B2 (ru)
KR (1) KR20080039990A (ru)
AR (1) AR056460A1 (ru)
AU (1) AU2006281416A1 (ru)
BR (1) BRPI0614831A2 (ru)
CA (1) CA2618834A1 (ru)
DE (2) DE102005038831A1 (ru)
EA (1) EA200800439A1 (ru)
EC (1) ECSP088194A (ru)
IL (1) IL189497A0 (ru)
MX (1) MX2008001977A (ru)
NO (1) NO20076680L (ru)
PE (2) PE20070355A1 (ru)
TW (1) TW200740795A (ru)
UY (1) UY29749A1 (ru)
WO (1) WO2007020261A2 (ru)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7595312B2 (en) * 2002-10-25 2009-09-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions
DE10250082A1 (de) * 2002-10-25 2004-05-13 Boehringer Ingelheim Pharma Gmbh & Co. Kg Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
DE102004015723A1 (de) * 2004-03-29 2005-10-20 Boehringer Ingelheim Pharma Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
US7491717B2 (en) * 2005-03-23 2009-02-17 Boehringer Ingelheim International Gmbh Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions
DE102005038831A1 (de) * 2005-08-17 2007-02-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
EP1770086A1 (de) * 2005-09-29 2007-04-04 Boehringer Ingelheim Pharma GmbH & Co. KG Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
PE20080370A1 (es) * 2006-06-08 2008-06-13 Boehringer Ingelheim Int Derivados de quinazolinona como antagonistas de cgrp
DE102007038250A1 (de) * 2007-08-13 2009-02-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Herstellverfahren
BRPI0817585A2 (pt) * 2007-09-28 2015-03-31 Boehringer Ingellheim Internat Gmbh Compostos
GB201707938D0 (en) 2017-05-17 2017-06-28 Univ Sheffield Compounds
USD922701S1 (en) 2019-12-23 2021-06-15 Samsung Electronics Co., Ltd. Shoe care machine

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US20030069231A1 (en) 1999-10-12 2003-04-10 Klaus Rudolf Modified aminoacids, pharmaceuticals containing these compounds and method for their production
DE10250080A1 (de) 2002-10-25 2004-05-13 Boehringer Ingelheim Pharma Gmbh & Co. Kg Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
DE10250082A1 (de) * 2002-10-25 2004-05-13 Boehringer Ingelheim Pharma Gmbh & Co. Kg Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
US7595312B2 (en) 2002-10-25 2009-09-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions
DE10300973A1 (de) 2003-01-14 2004-07-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Carbonsäuren und deren Ester, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE102004015723A1 (de) 2004-03-29 2005-10-20 Boehringer Ingelheim Pharma Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
DE102004018795A1 (de) 2004-04-15 2005-10-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
US20050282857A1 (en) 2004-04-15 2005-12-22 Boehringer Ingelheim International Gmbh Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions
DE102004018796A1 (de) * 2004-04-15 2005-11-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
DE102004019492A1 (de) * 2004-04-22 2005-11-10 Boehringer Ingelheim Pharma Gmbh & Co. Kg Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
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EP1770091A1 (de) * 2005-09-29 2007-04-04 Boehringer Ingelheim Pharma GmbH & Co. KG CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
US7491717B2 (en) 2005-03-23 2009-02-17 Boehringer Ingelheim International Gmbh Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions
US7439237B2 (en) 2005-04-15 2008-10-21 Boehringer Ingelheim International Gmbh Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions
DE102005038831A1 (de) * 2005-08-17 2007-02-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
EP1770086A1 (de) 2005-09-29 2007-04-04 Boehringer Ingelheim Pharma GmbH & Co. KG Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel

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Publication number Publication date
MX2008001977A (es) 2008-03-25
NO20076680L (no) 2008-04-30
PE20100570A1 (es) 2010-08-16
BRPI0614831A2 (pt) 2009-05-19
JP4852607B2 (ja) 2012-01-11
WO2007020261A3 (de) 2008-08-21
JP2009505985A (ja) 2009-02-12
EP1917256A2 (de) 2008-05-07
DE102005038831A1 (de) 2007-02-22
US20070049581A1 (en) 2007-03-01
AR056460A1 (es) 2007-10-10
CA2618834A1 (en) 2007-02-22
PE20070355A1 (es) 2007-04-30
TW200740795A (en) 2007-11-01
WO2007020261A2 (de) 2007-02-22
AU2006281416A1 (en) 2007-02-22
US20110034444A1 (en) 2011-02-10
US20100004228A1 (en) 2010-01-07
ECSP088194A (es) 2008-03-26
JP2011256200A (ja) 2011-12-22
DE102005050953A1 (de) 2007-04-26
US7579341B2 (en) 2009-08-25
UY29749A1 (es) 2007-03-30
US7858622B2 (en) 2010-12-28
IL189497A0 (en) 2008-08-07
KR20080039990A (ko) 2008-05-07

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