EA200601459A1 - НОВЫЕ АМИДЫ КАРБОНОВЫХ КИСЛОТ В КАЧЕСТВЕ ИНГИБИТОРОВ ФАКТОРА Xa - Google Patents

НОВЫЕ АМИДЫ КАРБОНОВЫХ КИСЛОТ В КАЧЕСТВЕ ИНГИБИТОРОВ ФАКТОРА Xa

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Publication number
EA200601459A1
EA200601459A1 EA200601459A EA200601459A EA200601459A1 EA 200601459 A1 EA200601459 A1 EA 200601459A1 EA 200601459 A EA200601459 A EA 200601459A EA 200601459 A EA200601459 A EA 200601459A EA 200601459 A1 EA200601459 A1 EA 200601459A1
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EA
Eurasian Patent Office
Prior art keywords
inhibitors
factor
ambides
new
carbonic acids
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EA200601459A
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English (en)
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EA011245B1 (ru
Inventor
Кай Герлах
Роланд Пфау
Хеннинг Припке
Вольфганг Винен
Аннетте Мария Шулер-Метц
Георг Даманн
Герберт Нар
Зандра Рут Хандшух
Норберт Хауэль
Ирис Кауффманн-Хефнер
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Бёрингер Ингельхайм Интернациональ Гмбх
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Priority claimed from DE102004009835A external-priority patent/DE102004009835A1/de
Priority claimed from DE200410060984 external-priority patent/DE102004060984A1/de
Application filed by Бёрингер Ингельхайм Интернациональ Гмбх filed Critical Бёрингер Ингельхайм Интернациональ Гмбх
Publication of EA200601459A1 publication Critical patent/EA200601459A1/ru
Publication of EA011245B1 publication Critical patent/EA011245B1/ru

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
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Abstract

В заявке описаны новые замещенные амиды карбоновых кислот общей формулы (I)в которой А, В и R-Rимеют указанные в п. 1 формулы изобретения значения, их таутомеры, их энантиомеры, их диастереомеры, их смеси и их соли, прежде всего их физиологически совместимые соли с неорганическими или органическими кислотами или основаниями, обладающие ценными свойствами. Такие соединения обладают антитромботическим действием и являются ингибиторами фактора Ха.
EA200601459A 2004-02-28 2005-02-22 Амиды карбоновых кислот в качестве ингибиторов фактора ха EA011245B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102004009835A DE102004009835A1 (de) 2004-02-28 2004-02-28 Neue Carbonsäureamide, deren Herstellung und deren Verwendung als Arzneimittel
DE200410060984 DE102004060984A1 (de) 2004-12-18 2004-12-18 Neue Carbonsäureamide, deren Herstellung und deren Verwendung als Arzneimittel
PCT/EP2005/001796 WO2005082895A1 (de) 2004-02-28 2005-02-22 Neue carbonsäureamide als faktor xa-inhibitoren

Publications (2)

Publication Number Publication Date
EA200601459A1 true EA200601459A1 (ru) 2007-04-27
EA011245B1 EA011245B1 (ru) 2009-02-27

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EA200601459A EA011245B1 (ru) 2004-02-28 2005-02-22 Амиды карбоновых кислот в качестве ингибиторов фактора ха

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US (4) US7371743B2 (ru)
EP (1) EP1771441B8 (ru)
JP (1) JP4657282B2 (ru)
KR (1) KR101193823B1 (ru)
AR (1) AR047898A1 (ru)
AT (1) ATE520684T1 (ru)
AU (1) AU2005217074B2 (ru)
BR (1) BRPI0506988A (ru)
CA (1) CA2551788C (ru)
CY (1) CY1112005T1 (ru)
DK (1) DK1771441T3 (ru)
EA (1) EA011245B1 (ru)
EC (1) ECSP066802A (ru)
HK (1) HK1110592A1 (ru)
IL (1) IL177692A (ru)
NO (1) NO20064003L (ru)
NZ (1) NZ550055A (ru)
PE (1) PE20060011A1 (ru)
PL (1) PL1771441T3 (ru)
PT (1) PT1771441E (ru)
SI (1) SI1771441T1 (ru)
TW (1) TWI364421B (ru)
UY (1) UY28773A1 (ru)
WO (1) WO2005082895A1 (ru)

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ATE520684T1 (de) 2011-09-15
UY28773A1 (es) 2005-09-30
DK1771441T3 (da) 2011-11-28
EP1771441B1 (de) 2011-08-17
JP2007523935A (ja) 2007-08-23
EP1771441A1 (de) 2007-04-11
US20050203078A1 (en) 2005-09-15
BRPI0506988A (pt) 2007-07-10
US7947700B2 (en) 2011-05-24
KR20070012384A (ko) 2007-01-25
HK1110592A1 (en) 2008-07-18
IL177692A (en) 2012-02-29
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US7371743B2 (en) 2008-05-13
TWI364421B (en) 2012-05-21
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AR047898A1 (es) 2006-03-01
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TW200602033A (en) 2006-01-16
US20080146539A1 (en) 2008-06-19
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PE20060011A1 (es) 2006-02-28
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US8791103B2 (en) 2014-07-29
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