AR048589A1 - Derivados de pirrolidina -3,4-dicarboxamida - Google Patents

Derivados de pirrolidina -3,4-dicarboxamida

Info

Publication number
AR048589A1
AR048589A1 ARP050101146A ARP050101146A AR048589A1 AR 048589 A1 AR048589 A1 AR 048589A1 AR P050101146 A ARP050101146 A AR P050101146A AR P050101146 A ARP050101146 A AR P050101146A AR 048589 A1 AR048589 A1 AR 048589A1
Authority
AR
Argentina
Prior art keywords
dicarboxamida
derivatives
pirrolidine
pirrolidine derivatives
pyrrolidine
Prior art date
Application number
ARP050101146A
Other languages
English (en)
Inventor
Lilli Anselm
Katrin Groebke Zbinden
Wolfgang Haap
Jacques Himber
Stefan Thomi
Crhistoph Martin Stahl
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR048589A1 publication Critical patent/AR048589A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Se refiere a derivados de pirrolidina-3,4-dicarboxamida de la formula 1 en la que R1 a R9 y X tienen los significados definidos en la descripcion y en las reivindicaciones, así como las sales fisiologicamente aceptables de los mismos. Estos compuestos inhiben el factor de coagulacion Xa y pueden utilizarse como medicamentos.
ARP050101146A 2004-03-26 2005-03-23 Derivados de pirrolidina -3,4-dicarboxamida AR048589A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04101265 2004-03-26

Publications (1)

Publication Number Publication Date
AR048589A1 true AR048589A1 (es) 2006-05-10

Family

ID=34962445

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050101146A AR048589A1 (es) 2004-03-26 2005-03-23 Derivados de pirrolidina -3,4-dicarboxamida

Country Status (27)

Country Link
US (1) US7550487B2 (es)
EP (1) EP1732918B1 (es)
JP (1) JP4533428B2 (es)
KR (1) KR100847191B1 (es)
CN (1) CN1938294B (es)
AR (1) AR048589A1 (es)
AT (1) ATE414075T1 (es)
AU (2) AU2005225523B2 (es)
BR (1) BRPI0509256B1 (es)
CA (1) CA2560669C (es)
DE (1) DE602005010986D1 (es)
DK (1) DK1732918T3 (es)
ES (1) ES2314632T3 (es)
HK (1) HK1101856A1 (es)
HR (1) HRP20090050T3 (es)
IL (1) IL177662A (es)
MX (1) MXPA06010827A (es)
MY (1) MY144101A (es)
NO (1) NO338531B1 (es)
NZ (1) NZ549395A (es)
PL (1) PL1732918T3 (es)
PT (1) PT1732918E (es)
RU (1) RU2379288C2 (es)
SI (1) SI1732918T1 (es)
TW (1) TWI295290B (es)
WO (1) WO2005092881A1 (es)
ZA (1) ZA200607606B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100884146B1 (ko) * 2004-11-03 2009-02-17 에프. 호프만-라 로슈 아게 다이카복스아마이드 유도체 및 인자 Ｘａ 억제제로서의이의 용도
WO2006135054A1 (ja) 2005-06-16 2006-12-21 Dsm Ip Assets B.V. 光学的立体造形用放射線硬化性液状樹脂組成物及びそれを硬化させて得られる光造形物
WO2007053610A2 (en) * 2005-11-01 2007-05-10 The Regents Of The University Of California Methods of treating atrial fibrillation wtih pirfenidone
MX2009006818A (es) * 2006-12-22 2009-07-02 Hoffmann La Roche Procesos para la preparacion de (3r,4r)-n-(4-clorofenil)-1-(2,2-di fluoroetil)-n'-[2-fluoro-4-(2-oxo-1(2h)piridinil)fenil]-3,4-pirro dinadicarboxamida.
JP2010526789A (ja) * 2007-05-10 2010-08-05 エフ．ホフマン−ラ ロシュ アーゲー Ｆｘａインヒビターの新規固形形態
US8354444B2 (en) * 2008-09-18 2013-01-15 Hoffmann-La Roche Inc. Substituted pyrrolidine-2-carboxamides
US20110152233A1 (en) * 2009-12-18 2011-06-23 Henner Knust Pyrrolidine compounds
WO2012109996A1 (zh) 2011-02-18 2012-08-23 上海璎黎科技有限公司 一种芳基糖苷类化合物及其制备方法和应用
EP4171547A1 (en) 2020-05-27 2023-05-03 Axial Therapeutics, Inc. Tlr2 modulator compounds, pharmaceutical compositions and uses thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1087937A1 (en) * 1998-06-17 2001-04-04 Du Pont Pharmaceuticals Company Cyclic hydroxamic acids as metalloproteinase inhibitors
CA2382751A1 (en) * 1999-05-24 2000-11-30 Cor Therapeutics, Inc. Inhibitors of factor xa
EP1317429B1 (en) * 2000-09-11 2006-08-30 Genentech Inc. Amidine inhibitors of serine proteases
US7030141B2 (en) * 2001-11-29 2006-04-18 Christopher Franklin Bigge Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade
US7205318B2 (en) * 2003-03-18 2007-04-17 Bristol-Myers Squibb Company Lactam-containing cyclic diamines and derivatives as a factor Xa inhibitors
KR100884146B1 (ko) 2004-11-03 2009-02-17 에프. 호프만-라 로슈 아게 다이카복스아마이드 유도체 및 인자 Ｘａ 억제제로서의이의 용도
US7361672B2 (en) 2004-12-23 2008-04-22 Hoffmann-La Roche Inc. Heteroarylacetamide inhibitors of factor Xa
US7820699B2 (en) 2005-04-27 2010-10-26 Hoffmann-La Roche Inc. Cyclic amines
BRPI0613045A2 (pt) 2005-07-15 2010-12-14 Hoffmann La Roche aminas cÍclicas fundidas a heteroarila
US7678917B2 (en) 2005-09-01 2010-03-16 Hoffman-La Roche Inc. Factor Xa inhibitors
AU2006311101A1 (en) 2005-11-11 2007-05-18 F. Hoffmann-La Roche Ag Carbocyclic fused cyclic amines as inhibitors of the coagulation factor Xa
AU2006314637A1 (en) 2005-11-16 2007-05-24 F. Hoffmann-La Roche Ag Novel pyrrolidine derivatives as inhibitors of coagulation factor Xa
EP1847537A1 (en) 2006-04-21 2007-10-24 F. Hoffmann-La Roche Ag Dicarboxamide derivatives

Also Published As

Publication number Publication date
PT1732918E (pt) 2009-01-08
JP4533428B2 (ja) 2010-09-01
IL177662A (en) 2011-11-30
AU2005225523B2 (en) 2011-10-13
CA2560669A1 (en) 2005-10-06
US7550487B2 (en) 2009-06-23
PL1732918T3 (pl) 2009-04-30
MXPA06010827A (es) 2006-12-15
AU2005225523A1 (en) 2005-10-06
BRPI0509256B1 (pt) 2019-02-12
KR20060124781A (ko) 2006-12-05
RU2006137661A (ru) 2008-05-10
EP1732918A1 (en) 2006-12-20
CN1938294B (zh) 2012-09-26
US20050215599A1 (en) 2005-09-29
MY144101A (en) 2011-08-15
CA2560669C (en) 2012-09-18
ES2314632T3 (es) 2009-03-16
DE602005010986D1 (de) 2008-12-24
CN1938294A (zh) 2007-03-28
SI1732918T1 (sl) 2009-02-28
NO20064821L (no) 2006-10-24
ZA200607606B (en) 2008-05-28
NZ549395A (en) 2010-07-30
DK1732918T3 (da) 2009-01-12
JP2007530479A (ja) 2007-11-01
EP1732918B1 (en) 2008-11-12
AU2012200212A1 (en) 2012-02-02
NO338531B1 (no) 2016-08-29
BRPI0509256A (pt) 2007-09-11
TWI295290B (en) 2008-04-01
TW200534849A (en) 2005-11-01
ATE414075T1 (de) 2008-11-15
HK1101856A1 (en) 2007-10-26
WO2005092881A1 (en) 2005-10-06
IL177662A0 (en) 2006-12-31
AU2012200212A8 (en) 2012-02-16
HRP20090050T3 (en) 2009-03-31
RU2379288C2 (ru) 2010-01-20
KR100847191B1 (ko) 2008-07-17

Similar Documents

Publication Publication Date Title
AR048589A1 (es) Derivados de pirrolidina -3,4-dicarboxamida
ECSP088549A (es) Nuevos derivados de pirrol fusionado
CR9587A (es) Derivados de piridazina
UY30500A1 (es) Compuestos de azabencimidazolilo
UY28955A1 (es) Nuevos derivados fluoroglicosídicos de pirazoles, medicamentos que contienen estos compuestos, y el empleo de los mismos
CY1110835T1 (el) Διφαινυλ παραγωγα και η χρηση τους στη θεραπεια της ηπατιτιδας c
CR9703A (es) Derivados de pirazolona
SE0401971D0 (sv) Piperidne derivatives
PA8589201A1 (es) Derivados de acido mandelico
AR072261A1 (es) Derivados piperazin-pirazolicos, composiciones farmaceuticas que los contienen y usos de los mismos como agentes anticancerigenos.
CR8278A (es) Combinaciones sinergicas de productos activos, fungicidas
MY138941A (en) Aryl-pyridine derivatives
ECSP055853A (es) Nuevos derivados de fluoroglicosidos heterociclicos, productos farmaceuticos que contienen dichos compuestos, y el uso de los mismos
ECSP099413A (es) COMPUESTOS A BASE DE 4 - fenil - 6 - (2,2,2 - trifluoro - 1 - feniletoxi)pirimidina Y MÉTODOS PARA SU EMPLEO
UY30476A1 (es) Noveles compuestos derivados n-sustituidos de la 3-oxoisoindolin-1-carboxamida, sus sales aceptables, composiciones farmaccuticas y aplicaciones.
UY30316A1 (es) Derivados sustituidos de benzamidas, nicotinamidas, propanamidas, acetamidas y carboxamidas n-(2-(piperidin-1-ilmetil)ciclohexil)sustituidas, procesos de preparacion, composiciones conteniéndolos y aplicaciones
NO20070089L (no) DPP-IV inhibitorer
CR20110219A (es) Ácidos naftilacéticos
ATE449776T1 (de) Pyrroloä2,3-cüpyridinderivate
AR063027A1 (es) Derivados de sulfonamida
EA200801366A1 (ru) Производные 3,6-дигидро-2-оксо-6н-1,3,4-тиадиазина
UY30363A1 (es) Derivados sustituidos de la n-(3-oxo-2,3-dihidro-1h-isoindol-4-il)-1-naftamida, procesos de preparacion, composiciones farmacéuticas y aplicaciones
UY29134A1 (es) Sulfonamidas sustituidas por derivados de bencimidazol, composiciones que la contienen, procedimiento de preparacion y aplicaciones
DOP2010000317A (es) Nueva clase de espiro piperidinas para el tratamiento de enfermedades neurodegenerativas
UY27975A1 (es) Derivados de indolilo

Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed, e.g., due to non-payment of fee