WO1999002193A3 - Perfluoralkylgruppenhaltige trijodaromaten, verfahren zu deren herstellung und deren verwendung als kontrastmittel - Google Patents

Perfluoralkylgruppenhaltige trijodaromaten, verfahren zu deren herstellung und deren verwendung als kontrastmittel Download PDF

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Publication number
WO1999002193A3
WO1999002193A3 PCT/EP1998/004169 EP9804169W WO9902193A3 WO 1999002193 A3 WO1999002193 A3 WO 1999002193A3 EP 9804169 W EP9804169 W EP 9804169W WO 9902193 A3 WO9902193 A3 WO 9902193A3
Authority
WO
WIPO (PCT)
Prior art keywords
aromates
triiodine
production
contrast agents
perfluoroalkyl groups
Prior art date
Application number
PCT/EP1998/004169
Other languages
English (en)
French (fr)
Other versions
WO1999002193A2 (de
Inventor
Johannes Platzek
Ulrich Niedballa
Michael Bauer
Wolfgang Schlecker
Hanns-Joachim Weinmann
Thomas Frenzel
Werner Krause
Original Assignee
Schering Ag
Johannes Platzek
Ulrich Niedballa
Michael Bauer
Wolfgang Schlecker
Weinmann Hanns Joachim
Thomas Frenzel
Werner Krause
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag, Johannes Platzek, Ulrich Niedballa, Michael Bauer, Wolfgang Schlecker, Weinmann Hanns Joachim, Thomas Frenzel, Werner Krause filed Critical Schering Ag
Priority to AU89734/98A priority Critical patent/AU8973498A/en
Publication of WO1999002193A2 publication Critical patent/WO1999002193A2/de
Publication of WO1999002193A3 publication Critical patent/WO1999002193A3/de

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/68—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/69—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/09—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton the carbon skeleton being further substituted by at least two halogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Die Erfindung betrifft neue, perfluoralkylgruppenhaltige Trijodaromaten, Verfahren zu deren Herstellung, deren Verwendung als Kontrastmittel für die Röntgendiagnostik sowie für die Magnetresonanzdiagnostik und -spektroskopie mittels Fluor-Messung. Gegenstand der Erfindung sind auch diagnostische Mittel enthaltend diese neuen Verbindungen.
PCT/EP1998/004169 1997-07-11 1998-07-08 Perfluoralkylgruppenhaltige trijodaromaten, verfahren zu deren herstellung und deren verwendung als kontrastmittel WO1999002193A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU89734/98A AU8973498A (en) 1997-07-11 1998-07-08 Triiodine aromates containing perfluoroalkyl groups, method for the production and use thereof as contrast agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19731300.0 1997-07-11
DE1997131300 DE19731300C1 (de) 1997-07-11 1997-07-11 Perfluoralkylgruppenhaltige Trijodaromaten, Verfahren zu deren Herstellung und deren Verwendung als Kontrastmittel

Publications (2)

Publication Number Publication Date
WO1999002193A2 WO1999002193A2 (de) 1999-01-21
WO1999002193A3 true WO1999002193A3 (de) 1999-05-14

Family

ID=7836420

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/004169 WO1999002193A2 (de) 1997-07-11 1998-07-08 Perfluoralkylgruppenhaltige trijodaromaten, verfahren zu deren herstellung und deren verwendung als kontrastmittel

Country Status (3)

Country Link
AU (1) AU8973498A (de)
DE (1) DE19731300C1 (de)
WO (1) WO1999002193A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19731591C2 (de) * 1997-07-17 1999-09-16 Schering Ag Pharmazeutische Mittel enthaltend perfluoralkylgruppenhaltige Trijodaromaten und ihre Verwendung in der Tumortherapie und interventionellen Radiologie
CZ2002343A3 (cs) * 1999-07-29 2002-08-14 Epix Medical, Inc. Cílená multimerní zobrazovací činidla s multilokální vazebnou schopností
TWI221406B (en) 2001-07-30 2004-10-01 Epix Medical Inc Systems and methods for targeted magnetic resonance imaging of the vascular system
WO2003013610A2 (en) * 2001-08-03 2003-02-20 Glaxo Group Limited Surfactant compounds and uses thereof
DE10209018C1 (de) * 2002-02-28 2003-11-20 Schering Ag Perfluoralkylgruppenhaltige micellenbildende Trijodaromaten, Verfahren zu deren Herstellung und deren Verwendung als Kontrastmittel sowie diese enthaltende diagnostische Mittel
CN113816868B (zh) * 2021-09-28 2023-07-21 浙江海洲制药有限公司 一种碘海醇的合成方法

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4285928A (en) * 1979-01-25 1981-08-25 Juro Wada Contrast composition for angiography
WO1994016742A1 (en) * 1993-01-28 1994-08-04 S.A. A.T.T.A. Applications Et Transferts De Technologies Avancees Iodine-containing fluorocarbon contrast agents
EP0609586A2 (de) * 1993-02-02 1994-08-10 Nycomed Imaging As Iodophenoxyalkanen- und Iodophenylether-Zusammensetzungen für Bildformung des Gastrointestinaltraktes
EP0609587A2 (de) * 1993-02-02 1994-08-10 Nycomed Imaging As Iodophenoxyalkanen- und Iodophenylether-Zusammensetzungen in schichtbildenden Materalien für Bildformung des Gastrointestinaltraktes
EP0614668A2 (de) * 1993-03-11 1994-09-14 Nycomed Imaging As Zusammensetzung von Iodobenzoesäurederivaten zur Abbildung des Gastrointestinaltraktes
EP0617969A2 (de) * 1993-03-31 1994-10-05 Nycomed Imaging As Iodophenyl-Ester und Sulfonaten Zusammensetzungen für die Visualisation des Gastrointestinaltraktes
US5401493A (en) * 1993-03-26 1995-03-28 Molecular Biosystems, Inc. Perfluoro-1H,-1H-neopentyl containing contrast agents and method to use same
WO1996014878A2 (en) * 1994-11-15 1996-05-23 Molecular Biosystems, Inc. Calixarene conjugates useful as mri and ct diagnostic imaging agents

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5250283A (en) * 1990-03-28 1993-10-05 Molecular Biosystems, Inc. Organic contrast agent analog and method of making same

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4285928A (en) * 1979-01-25 1981-08-25 Juro Wada Contrast composition for angiography
WO1994016742A1 (en) * 1993-01-28 1994-08-04 S.A. A.T.T.A. Applications Et Transferts De Technologies Avancees Iodine-containing fluorocarbon contrast agents
EP0609586A2 (de) * 1993-02-02 1994-08-10 Nycomed Imaging As Iodophenoxyalkanen- und Iodophenylether-Zusammensetzungen für Bildformung des Gastrointestinaltraktes
EP0609587A2 (de) * 1993-02-02 1994-08-10 Nycomed Imaging As Iodophenoxyalkanen- und Iodophenylether-Zusammensetzungen in schichtbildenden Materalien für Bildformung des Gastrointestinaltraktes
EP0614668A2 (de) * 1993-03-11 1994-09-14 Nycomed Imaging As Zusammensetzung von Iodobenzoesäurederivaten zur Abbildung des Gastrointestinaltraktes
US5401493A (en) * 1993-03-26 1995-03-28 Molecular Biosystems, Inc. Perfluoro-1H,-1H-neopentyl containing contrast agents and method to use same
EP0617969A2 (de) * 1993-03-31 1994-10-05 Nycomed Imaging As Iodophenyl-Ester und Sulfonaten Zusammensetzungen für die Visualisation des Gastrointestinaltraktes
WO1996014878A2 (en) * 1994-11-15 1996-05-23 Molecular Biosystems, Inc. Calixarene conjugates useful as mri and ct diagnostic imaging agents

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
LOWE K.C.: "Perfluorocarbons as oxygen-transport fluids", COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY - A PHYSIOLOGY, VOL. 87, NO. 4, PAGE(S) 825-838, 1987, XP002095316 *
LOWE K: "SYNTHETIC OXYGEN TRANSPORT FLUIDS BASED ON PERFLUOROCHEMICALS APPLICATIONS IN MEDICINE AND BIOLOGY", VOX SANGUINIS, vol. 60, no. 3, 1991, pages 129 - 140, XP002095317 *
MASON RP: "Non-invasive physiology: 19F NMR of perfluorocarbons.", ARTIF CELLS BLOOD SUBSTIT IMMOBIL BIOTECHNOL, 1994, VOL. 22, NO. 4, PAGE(S) 1141-53, XP002095318 *
MATTREY R F ET AL: "PERFLUOROCHEMICALS AS GASTROINTESTINAL CONTRAST AGENTS FOR MR IMAGING: PRELIMINARY STUDIES IN RATS AND HUMANS", AMERICAN JOURNAL OF ROENTGENOLOGY, vol. 148, 1 June 1987 (1987-06-01), pages 1259 - 1263, XP000565391 *
MATTREY R F: "PERFLUOROOCTYLBROMIDE: A NEW CONTRAST AGENT FOR CT, SONOGRAPHY, ANDMR IMAGING", AMERICAN JOURNAL OF ROENTGENOLOGY, vol. 152, 1 February 1989 (1989-02-01), pages 247 - 252, XP000565410 *
PENG C T: "CHAPTER 61: RADIOPAQUES", M.E. WOLFF (ED.): BURGER'S MEDICINAL CHEMISTRY, EDITION 4, PART III, 1979, J. WILEY & SONS, NEW YORK, US, pages 1139 - 1203, XP002005069 *
SAKAS D.E. ET AL: "Perfluorocarbons: Recent developments and implications for neurosurgery", JOURNAL OF NEUROSURGERY, VOL. 85, NO. 2, PAGE(S) 248-254, August 1996 (1996-08-01), XP002095315 *

Also Published As

Publication number Publication date
DE19731300C1 (de) 1999-01-21
AU8973498A (en) 1999-02-08
WO1999002193A2 (de) 1999-01-21

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