YU104690A - Supstituisani imidazo-kondenzovani 6-člani heterocikli kao antagonisti angiotenzina 2 - Google Patents
Supstituisani imidazo-kondenzovani 6-člani heterocikli kao antagonisti angiotenzina 2Info
- Publication number
- YU104690A YU104690A YU104690A YU104690A YU104690A YU 104690 A YU104690 A YU 104690A YU 104690 A YU104690 A YU 104690A YU 104690 A YU104690 A YU 104690A YU 104690 A YU104690 A YU 104690A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- angiotensin
- antagonists
- condensed
- substituted
- imidaso
- Prior art date
Links
- 101800000733 Angiotensin-2 Proteins 0.000 title abstract 2
- 102400000345 Angiotensin-2 Human genes 0.000 title abstract 2
- CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title abstract 2
- 206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
- C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SUPSTITUISANI IMIDAZO-KONDENZOVANI 6-ČLANI HETEROCIKLI KAO ANTAGONISTI ANGIOTENZINA 2 , pronalazak se odnosi na postupak za izradu imidazo-kondenzovanih 6-članih heterocikla strukturne formule: u kojoj su A,B,C i D nezavisno atomi ugljenika ili atomi azota koji su antagonisti angiotenzina II podesni za lečenje hipertenzije i kongestivne srčane mane.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SI9011046A SI9011046A (sl) | 1989-05-30 | 1990-05-29 | Substituiraniimidazo-kondenzirani 6-členski heterocikli kot antagonisti angiotenzinaii |
HRP-1046/90A HRP930776A2 (en) | 1989-05-30 | 1993-04-02 | Substituted imidazo-fused 6-membered heterocycles as angiotensin ii antagonists |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35897189A | 1989-05-30 | 1989-05-30 | |
US07/516,286 US5332744A (en) | 1989-05-30 | 1990-05-04 | Substituted imidazo-fused 6-membered heterocycles as angiotensin II antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
YU104690A true YU104690A (sh) | 1992-12-21 |
Family
ID=23411780
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU104690A YU104690A (sh) | 1989-05-30 | 1990-05-29 | Supstituisani imidazo-kondenzovani 6-člani heterocikli kao antagonisti angiotenzina 2 |
Country Status (4)
Country | Link |
---|---|
US (1) | US5332744A (sh) |
KR (1) | KR900018072A (sh) |
YU (1) | YU104690A (sh) |
ZA (1) | ZA904094B (sh) |
Families Citing this family (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4305602A1 (de) * | 1992-06-17 | 1993-12-23 | Merck Patent Gmbh | Imidazopyridine |
EP0577025A3 (de) * | 1992-07-01 | 1998-02-04 | Hoechst Aktiengesellschaft | Angiotensin-II-Rezeptorantagonisten zur Behandlung und Prophylaxe von koronaren Herzerkrankungen |
US5627191A (en) * | 1992-07-10 | 1997-05-06 | The Boots Company Plc | Therapeutic agents |
AU675660B2 (en) * | 1992-07-17 | 1997-02-13 | Merck & Co., Inc. | Substituted biphenylmethylimidazopyridines |
WO1994013666A1 (en) * | 1992-12-07 | 1994-06-23 | Eisai Co., Ltd. | Process for producing imidazopyridine derivative and intermediate |
DE4318813A1 (de) * | 1993-06-07 | 1994-12-08 | Merck Patent Gmbh | Imidazopyridine |
KR0151819B1 (ko) * | 1994-06-11 | 1998-10-15 | 강박광 | 신규의 피리딜 n-옥사이드로 치환된 피디딜이미다졸 유도체 및 그의 제조방법 |
US5994361A (en) * | 1994-06-22 | 1999-11-30 | Biochem Pharma | Substituted purinyl derivatives with immunomodulating activity |
DE4432860A1 (de) * | 1994-09-15 | 1996-03-21 | Merck Patent Gmbh | Imidazopyridine |
WO1997000256A1 (en) * | 1995-06-15 | 1997-01-03 | Merck & Co., Inc. | Polymorphic forms of an angiotensin ii antagonist |
US5693812A (en) * | 1996-06-03 | 1997-12-02 | Merck & Co. Inc. | Polymorphic forms of an angiotensin II antagonist |
US6638937B2 (en) | 1998-07-06 | 2003-10-28 | Bristol-Myers Squibb Co. | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists |
TW526202B (en) | 1998-11-27 | 2003-04-01 | Shionogi & Amp Co | Broad spectrum cephem having benzo[4,5-b]pyridium methyl group of antibiotic activity |
JP3022528B1 (ja) | 1998-11-30 | 2000-03-21 | 三洋電機株式会社 | 固体高分子型燃料電池 |
MEP59808A (en) * | 2001-02-24 | 2011-05-10 | Boehringer Ingelheim Pharma | Xanthine derivative, production and use thereof as a medicament |
JP4397691B2 (ja) * | 2001-10-30 | 2010-01-13 | コンフォーマ・セラピューティクス・コーポレイション | Hsp90阻害活性を有するプリン類似体 |
US20070129334A1 (en) * | 2001-10-30 | 2007-06-07 | Conforma Therapeutics Corporation | Orally Active Purine-Based Inhibitors of Heat Shock Protein 90 |
ATE321039T1 (de) * | 2002-04-29 | 2006-04-15 | Teva Pharma | Verfahren zur herstellung von losartan und losartan-kaliumsalz |
US7495004B2 (en) * | 2002-06-17 | 2009-02-24 | Glaxo Group Limited | Purine derivatives as liver X receptor agonists |
GB0215293D0 (en) | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
US7482337B2 (en) * | 2002-11-08 | 2009-01-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions |
US7442709B2 (en) * | 2003-08-21 | 2008-10-28 | Osi Pharmaceuticals, Inc. | N3-substituted imidazopyridine c-Kit inhibitors |
CN101906106A (zh) | 2003-09-18 | 2010-12-08 | 康福玛医药公司 | 作为hsp90-抑制剂的新的杂环化合物 |
SG149067A1 (en) * | 2003-12-22 | 2009-01-29 | Leuven K U Res & Dev | IMIDAZO[4,5-c]PYRIDINE COMPOUNDS AND METHODS OF ANTIVIRAL TREATMENT |
US7501426B2 (en) * | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
DE102004030502A1 (de) * | 2004-06-24 | 2006-01-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Imidazole und Triazole, deren Herstellung und Verwendung als Arzneimittel |
DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
US20060252791A1 (en) * | 2004-12-21 | 2006-11-09 | Gilead Sciences, Inc. | Imidazo[4,5-c]pyridine compound and method of antiviral treatment |
US7723340B2 (en) * | 2005-01-13 | 2010-05-25 | Signal Pharmaceuticals, Llc | Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith |
US7759342B2 (en) | 2005-01-13 | 2010-07-20 | Signal Pharmaceuticals, Llc | Methods of treatment and prevention using haloaryl substituted aminopurines |
US7521446B2 (en) * | 2005-01-13 | 2009-04-21 | Signal Pharmaceuticals, Llc | Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith |
CA2602257A1 (en) * | 2005-03-30 | 2006-10-05 | Conforma Therapeutics Corporation | Alkynyl pyrrolopyrimidines and related analogs as hsp90-inhibitors |
DE102005035891A1 (de) | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
WO2007035963A2 (en) * | 2005-09-23 | 2007-03-29 | Conforma Therapeutics Corporation | Anti-tumor methods using multi drug resistance independent synthetic hsp90 inhibitors |
PE20110235A1 (es) * | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
CA2810839A1 (en) | 2006-05-04 | 2007-11-15 | Boehringer Ingelheim International Gmbh | A polymorphic form of 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(r)-amino-piperidin-1-yl)-xanthine |
EP1852108A1 (en) * | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
DE602007004220D1 (de) * | 2006-07-07 | 2010-02-25 | Leuven K U Res & Dev | Neue pyridazinverbindung und ihre verwendung |
JP2010500326A (ja) * | 2006-08-08 | 2010-01-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 糖尿病の治療のためのdpp−iv阻害剤としてのピロロ[3,2−d]ピリミジン |
KR101126383B1 (ko) | 2007-02-07 | 2012-04-12 | 교와 핫꼬 기린 가부시키가이샤 | 3환계 화합물 |
UA99466C2 (en) | 2007-07-06 | 2012-08-27 | Гилиад Сайенсиз, Инк. | Crystalline pyridazine compound |
CN101784278A (zh) * | 2007-08-17 | 2010-07-21 | 贝林格尔.英格海姆国际有限公司 | 用于治疗fab-相关的疾病的嘌呤衍生物 |
JP5638955B2 (ja) * | 2007-10-26 | 2014-12-10 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Pi3キナーゼ阻害剤として有用なプリン誘導体 |
PE20140960A1 (es) | 2008-04-03 | 2014-08-15 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
MX2010012583A (es) | 2008-05-30 | 2011-02-24 | Genentech Inc | Compuestos inhibidores de purina pi3k y métodos de uso. |
PE20100156A1 (es) * | 2008-06-03 | 2010-02-23 | Boehringer Ingelheim Int | Tratamiento de nafld |
UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
WO2010016549A1 (ja) | 2008-08-06 | 2010-02-11 | 協和発酵キリン株式会社 | 3環系化合物 |
KR20200118243A (ko) | 2008-08-06 | 2020-10-14 | 베링거 인겔하임 인터내셔날 게엠베하 | 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료 |
MX370599B (es) * | 2008-08-15 | 2019-12-18 | Boehringer Ingelheim Int | Derivados de purina para su uso en el tratamiento de enfermedades relacionadas con fab. |
US8513264B2 (en) | 2008-09-10 | 2013-08-20 | Boehringer Ingelheim International Gmbh | Combination therapy for the treatment of diabetes and related conditions |
US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
AU2009331471B2 (en) | 2008-12-23 | 2015-09-03 | Boehringer Ingelheim International Gmbh | Salt forms of organic compound |
TW201036975A (en) | 2009-01-07 | 2010-10-16 | Boehringer Ingelheim Int | Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy |
CA2761445A1 (en) | 2009-05-27 | 2010-12-02 | Genentech, Inc. | Bicyclic pyrimidine pi3k inhibitor compounds selective for p110 delta, and methods of use |
US8372862B2 (en) * | 2009-06-02 | 2013-02-12 | Korea Research Institute Of Chemical Technology | Pharmaceutical composition for preventing or treating osteoporosis or obesity comprising phenyltetrazole derivative |
KR20240090632A (ko) | 2009-11-27 | 2024-06-21 | 베링거 인겔하임 인터내셔날 게엠베하 | 리나글립틴과 같은 dpp-iv 억제제를 사용한 유전자형 검사된 당뇨병 환자의 치료 |
CN102946875A (zh) | 2010-05-05 | 2013-02-27 | 贝林格尔.英格海姆国际有限公司 | 组合疗法 |
CA2803504C (en) | 2010-06-24 | 2022-08-30 | Boehringer Ingelheim International Gmbh | A combination for diabetes therapy comprising linagliptin and a long-acting insulin |
WO2012007493A1 (en) | 2010-07-14 | 2012-01-19 | F. Hoffmann-La Roche Ag | Purine compounds selective for ρi3κ p110 delta, and methods of use |
US9034883B2 (en) | 2010-11-15 | 2015-05-19 | Boehringer Ingelheim International Gmbh | Vasoprotective and cardioprotective antidiabetic therapy |
AR084312A1 (es) | 2010-12-16 | 2013-05-08 | Genentech Inc | Compuestos triciclicos inhibidores de la pi3k y composiciones farmaceuticas |
BR112014001018A2 (pt) | 2011-07-15 | 2017-01-10 | Shionogi & Co | derivado de azabenzimidazol tendo atividade de ativação de ampk |
DK2731947T3 (en) | 2011-07-15 | 2019-04-23 | Boehringer Ingelheim Int | SUBSTITUTED DIMERIC QUINAZOLINE DERIVATIVE, PREPARATION AND USE thereof IN PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF TYPE I AND TYPE II DIABETES |
EP2740730B1 (en) | 2011-08-03 | 2016-11-16 | Kyowa Hakko Kirin Co., Ltd. | Dibenzooxepin derivative |
WO2013095761A1 (en) * | 2011-12-20 | 2013-06-27 | Glaxosmithkline Llc | Imidazopyridine derivatives as pi3 kinase inhibitors |
US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
EP2849755A1 (en) | 2012-05-14 | 2015-03-25 | Boehringer Ingelheim International GmbH | A xanthine derivative as dpp -4 inhibitor for use in the treatment of podocytes related disorders and/or nephrotic syndrome |
WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
GB201321741D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
JP6615109B2 (ja) | 2014-02-28 | 2019-12-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Dpp−4阻害薬の医学的使用 |
WO2017211979A1 (en) | 2016-06-10 | 2017-12-14 | Boehringer Ingelheim International Gmbh | Combinations of linagliptin and metformin |
EP3478672B1 (en) | 2016-06-29 | 2024-04-10 | Université de Montréal | Biarylmethyl heterocycles |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3347290A1 (de) * | 1983-12-28 | 1985-07-11 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue 2-phenyl-imidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel |
CA1334092C (en) * | 1986-07-11 | 1995-01-24 | David John Carini | Angiotensin ii receptor blocking imidazoles |
US4804658A (en) * | 1986-09-15 | 1989-02-14 | G. D. Searle & Co. | Imidazopyridine derivatives and pharmaceutical compositions |
US4880804A (en) * | 1988-01-07 | 1989-11-14 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking benzimidazoles |
EP0415886A3 (en) * | 1989-08-30 | 1991-10-23 | Ciba-Geigy Ag | Aza compounds |
IE70593B1 (en) * | 1989-09-29 | 1996-12-11 | Eisai Co Ltd | Biphenylmethane derivative the use of it and pharmacological compositions containing same |
IL96019A0 (en) * | 1989-10-31 | 1991-07-18 | Fujisawa Pharmaceutical Co | Imidazole derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same |
EP0434038A1 (en) * | 1989-12-22 | 1991-06-26 | Takeda Chemical Industries, Ltd. | Fused imidazole derivatives, their production and use |
US5196444A (en) * | 1990-04-27 | 1993-03-23 | Takeda Chemical Industries, Ltd. | 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof |
EP0461040A1 (fr) * | 1990-06-08 | 1991-12-11 | Roussel Uclaf | Dérivés de l'imidazole, leur procédé de préparation, les intermédiaires obtenus, leur application à titre de médicaments et les compositions pharmaceutiques les renfermant |
US5053329A (en) * | 1990-07-05 | 1991-10-01 | Merck & Co., Inc. | Process for preparation of novel angiotensin II antagonists |
US5057522A (en) * | 1990-07-19 | 1991-10-15 | Merck & Co., Inc. | Anti-hypersensitive N2-tetrazole-β-glucuronide analog |
EP0470543A1 (de) * | 1990-08-10 | 1992-02-12 | Dr. Karl Thomae GmbH | Heterocyclische Imidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zur ihrer Herstellung |
US5066586A (en) * | 1990-08-20 | 1991-11-19 | Merck & Co., Inc. | Process for preparation of novel angiotensin II antagonists |
US5049565A (en) * | 1990-12-07 | 1991-09-17 | Merck & Co., Inc. | Microbial transformation process for preparing anti-hypertensive products |
US5087702A (en) * | 1991-01-30 | 1992-02-11 | Merck & Co., Inc. | Microbial transformation process for producing an antihypertensive product |
-
1990
- 1990-05-04 US US07/516,286 patent/US5332744A/en not_active Expired - Lifetime
- 1990-05-29 ZA ZA904094A patent/ZA904094B/xx unknown
- 1990-05-29 YU YU104690A patent/YU104690A/sh unknown
- 1990-05-30 KR KR1019900008105A patent/KR900018072A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ZA904094B (en) | 1991-03-27 |
US5332744A (en) | 1994-07-26 |
KR900018072A (ko) | 1990-12-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
YU104690A (sh) | Supstituisani imidazo-kondenzovani 6-člani heterocikli kao antagonisti angiotenzina 2 | |
ES2124479T3 (es) | Composiciones biocidas. | |
ES2175066T3 (es) | Antagonistas triciclicos de la vasopresina. | |
BG102616A (en) | Substituted aza- and diazacycloheptane and cyclooctane derivatives and their application | |
EA199700117A1 (ru) | Трициклические бензазепиновые антагонисты вазопрессина, способ их получения, фармацевтическая композиция и способ лечения млекопитающих с использованием трициклических бензазепинов | |
DK0531410T3 (da) | (+)-alfa-(2,3-Demethoxyphenyl)-1-(2-(4-fluorphenyl)ethyl)-4-piperidinmethanol | |
FI20040479A (fi) | 3-aminopiperidiinijohdannaisia ja menetelmiä niiden valmistamiseksi | |
DE69616480D1 (de) | Piperidinderivate als neurokininantagonisten | |
EA200100058A1 (ru) | 4-бензилпиперидиналкилсульфоксидные гетероциклические соединения и их применение в качестве подтип-избирательных антагонистов nmda-рецепторов | |
EA199900620A1 (ru) | Фталазиноны | |
EA199700111A1 (ru) | Трициклические бензазепиновые антагонисты вазопрессина | |
TR200000025T2 (tr) | Azetidinilpropilpiperidin türevleri, ara bağlarıyla tacikinin antagonistleri olarak kullanımları. | |
NO930035L (no) | Eksitatoriske aminosyreantagonister | |
EA199900385A1 (ru) | Соединения 1-арил-2-ациламиноэтана и их применение в качестве антагонистов нейрокинина, в частности нейрокинина 1 | |
TR199900363T2 (xx) | NK1 ve NK2 antagonistleri olarak asilaminoalkenilen-amid t�revleri. | |
ES2135722T3 (es) | 1,5-benzodiacepinas 5-heterociclicas moduladoras de la cck o de la gastrina. | |
ES2183923T3 (es) | Derivados de cromona. | |
ATE185969T1 (de) | Potenzierung von nmda-antagonisten | |
EA199700243A1 (ru) | Производное аминотетралина для лечения сердечно-сосудистых заболеваний | |
ATE45739T1 (de) | Indolophenanthridine, ihre herstellung und verwendung. | |
MX9603199A (es) | Antagonistas de receptores a endotelina. | |
DE3873278D1 (de) | Aryl-substituierte thiophen-3-ole, ihre derivate und analoge als lipoxygenase-inhibitoren. | |
ES2089511T3 (es) | Dihidroquinolina antagonistas de nmda. | |
FI971831A0 (fi) | Heterosyklillä substituoituja propeenihappojohdannaisia NMDA-antagonisteina | |
MX9701764A (es) | Derivados de imidoacidos. |