Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
  • A61K8/73—Polysaccharides
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
  • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
  • A61K8/86—Polyethers
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
  • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q19/00—Preparations for care of the skin
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
  • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
  • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
  • C07D233/30—Oxygen or sulfur atoms
  • C07D233/32—One oxygen atom
  • C07D233/34—Ethylene-urea

Definitions

• the present invention relates to a cosmetic comprising a cyclic carboxamide derivative having a specific structure or a salt thereof and fine cellulose fibers.
• cellulose nanofibers which are finer cellulose fibers
• a viscous aqueous composition containing a combination of cellulose fibers having a specific fiber diameter and structure and a thickening accelerator has been proposed, and it is disclosed that a small amount increases the thickening effect (Patent Document 1).
• Patent Document 1 a viscous aqueous composition containing a combination of cellulose fibers having a specific fiber diameter and structure and a thickening accelerator has been proposed, and it is disclosed that a small amount increases the thickening effect.
• Patent Document 1 With regard to such cosmetics, users are demanding that they have a better feeling during use, and there is room for further improvement in the feeling during use.
• cyclic carboxamide derivatives tend to be sticky when used in cosmetics.
• the present inventors have surprisingly found that using a cosmetic containing a combination of fine cellulose fibers and a specific cyclic carboxamide derivative can achieve excellent usability.
• the present invention is based on these findings.
• a cyclic carboxamide derivative represented by formula (1) or a salt thereof (In the formula, R 1 is a hydrocarbon group having 1 to 6 carbon atoms which may be substituted with a hydroxyl group, or a hydrogen atom, X is —CH 2 — or —N(R 2 )—, wherein R 2 is a hydrocarbon group having 1 to 6 carbon atoms which may be substituted with a hydroxyl group, or a hydrogen atom, and n is an integer from 1 to 3),
• a cosmetic comprising (B) fine cellulose fibers and (C) water.
• R 1 is a hydroxyalkyl group having 1 to 3 carbon atoms
• the component (B) has a maximum fiber diameter of 1000 nm or less.
• the present invention it is possible to provide cosmetics with excellent usability.
• freshness and fit are obtained during application, and the skin is moisturized after application, and stickiness is suppressed.
• the present invention relates to a cosmetic comprising (A) a cyclic carboxamide derivative having a specific structure or a salt thereof, (B) fine cellulose fibers, and (C) water.
• the cosmetic according to the present invention is a cyclic carboxamide derivative represented by formula (1) or a salt thereof (hereinafter sometimes referred to as component (A). The same applies to other components). There is.).
• component (A) Cyclic carboxamide derivative or salt thereof
• R 1 is a hydrocarbon group having 1 to 6 carbon atoms which may be substituted with a hydroxyl group, or a hydrogen atom
• X is —CH 2 — or —N(R 2 )—
• R 2 is a hydrocarbon group having 1 to 6 carbon atoms which may be substituted with a hydroxyl group, or a hydrogen atom
• n is an integer of 1-3.
• the above hydrocarbon group is not particularly limited, and may be, for example, an alkyl group, a cycloalkyl group, an alkenyl group, an alkynyl group, a cycloalkylalkyl group, a haloalkyl group, an alkoxyalkyl group, or an alkoxycarbonylalkyl group, preferably is an alkyl group.
• R 1 is a hydroxyalkyl group having 1 to 3 carbon atoms
• X is —CH 2 — or —NH—
• n is 1.
• Specific examples of the cyclic carboxamide derivative represented by formula (1) include the following.
• Component (A) is most preferably 1-(2-hydroxyethyl)-2-imidazolidinone.
• the (A) component may be a salt of the cyclic carboxamide derivative represented by formula (1).
• the type of salt is not particularly limited as long as it is a pharmacologically acceptable salt, and may be an inorganic salt or an organic salt.
• inorganic salts include hydrochlorides, sulfates, phosphates, hydrobromides, sodium salts, potassium salts, magnesium salts, calcium salts, magnesium salts, ammonium salts and the like.
• organic salts include acetates, lactates, maleates, fumarates, tartrates, methanesulfonates, p-toluenesulfonates, triethanolamine salts, amino acid salts and the like.
• component (A) component can be blended one or two or more.
• the amount of component (A) is preferably 0.05 to 7% by mass, more preferably 0.1 to 6% by mass, and still more preferably 1 to 6% by mass, relative to the total amount of the cosmetic. is.
• component (B) Fine Cellulose Fibers
• component (B) means nanofibers (microfibrils) made of plant-derived cellulose.
• Component (B) is more preferably composed of microfibrils substantially dispersed one by one (also called cellulose single nanofibers: CSNF). Cellulose single nanofibers have a high thickening effect on water.
• component (B) Component preferably contains crystalline cellulose. More preferably, the cellulose constituting component (B) has a type I crystal structure.
• the component (B) is fibers obtained by subjecting a naturally-derived solid cellulose raw material having a type I crystal structure to surface oxidation and refining. In the process of biosynthesis of natural cellulose, nanofibers called microfibrils are first formed almost without exception, and these bundles are bundled to form a higher-order solid structure. In order to weaken the intersurface hydrogen bonds that drive the strong cohesive forces between microfibrils, some of the hydroxyl groups have been oxidized and converted to aldehyde and carboxyl groups.
• component (B) is modified by selectively oxidizing the hydroxyl group at the C6 position of the glucose unit in the cellulose molecule into an aldehyde group and a carboxyl group.
• the amount of carboxyl groups is preferably 0.6 to 2.2 mmol/g, more preferably 0.6 to 2.0 mmol/g from the viewpoint of shape retention performance and dispersion stability.
• the amount of aldehyde groups is preferably 0.03-0.3 mmol/g, more preferably 0.10-0.25 mmol/g.
• the amount of carboxyl groups and the amount of aldehyde groups contained in the fine cellulose fibers can be measured by potentiometric titration of water in which the fine cellulose fibers are dispersed.
• the amount of carboxyl groups and the amount of aldehyde groups in the fine cellulose fibers can be adjusted by controlling the amount of co-oxidizing agent added and the reaction time used in the step of oxidizing the cellulose fibers. Further, introduction of an aldehyde group or a carboxyl group into the fine cellulose fibers can be confirmed by total reflection infrared spectroscopy (ATR) analysis.
• ATR total reflection infrared spectroscopy
• the maximum fiber diameter of component (B) is preferably 1000 nm or less, more preferably 1000 nm or less and a number average fiber diameter of 2 to 100 nm, and from the viewpoint of dispersion stability, the maximum fiber diameter is 500 nm. It is more preferable that the number average fiber diameter is 3 to 80 nm.
• the number average fiber diameter and maximum fiber diameter of fine cellulose fibers can be measured, for example, as follows. Water is added to the cellulose fibers to adjust the solid content of cellulose to 1% by mass.
• Japanese Patent No. 5243371 The method disclosed in Japanese Patent No. 5243371 can be adopted as the above-described specific method for measuring fine cellulose fibers.
• component (B) for example, a product commercially available from Daiichi Kogyo Seiyaku Co., Ltd. under the trade name of "Rheocrysta” can be used.
• “Rheocrysta C-2SP” (trade name) is a product containing 2% by mass of fine cellulose fibers, 1% by mass of phenoxyethanol in 97% by mass of water.
• the blending amount of component (B) is preferably 0.005 to 1% by mass, more preferably 0.005 to 0.3% by mass, and still more preferably 0.015, relative to the total amount of the cosmetic. 0.15% by mass, and more preferably 0.015 to 0.08% by mass.
• the blending amount of component (A) with respect to the blending amount of component (B) ((A)/(B)) is preferably 1-300, more preferably 50-280, in mass ratio.
• the cosmetic according to the present invention comprises (C) water.
• water water used in cosmetics, quasi-drugs, etc. can be used, and for example, purified water, ion-exchanged water, tap water, etc. can be used.
• the blending amount of water is preferably 40 to 95% by mass, more preferably 50 to 90% by mass, based on the total amount of the cosmetic composition according to the present invention.
• Succinoglycans are a class of microbially derived polysaccharides derived from sugar units derived from galactose and glucose, plus succinic and pyruvic acids and optionally acetic acid, or salts of these acids. It contains units. More specifically, succinoglycans are water-soluble macromolecules containing approximately 7:1:1:1 glucose units: galactose units: succinate units: pyruvate units.
• the blending amount of component (D) is preferably 0.005 to 1% by mass, more preferably 0.01 to 0.5% by mass, and still more preferably 0.01%, based on the total amount of the cosmetic. ⁇ 0.1% by mass.
• the blending amount of component (A) relative to the blending amount of component (D) ((A)/(D)) is preferably 1 to 300, more preferably 50 to 200, in mass ratio.
• the cosmetic according to the present invention may further contain (E) polyethylene glycol (PEG).
• Component (E) preferably has a weight average molecular weight of 150 to 23,000, more preferably 150 to 3,000.
• Component (E) includes, for example, PEG-6, PEG-20, PEG-32, PEG-75, PEG-400 and the like.
• component (E) component can be blended one or two or more.
• the blending amount of component (E) is preferably 0.1 to 5% by mass, more preferably 0.3 to 3% by mass, and still more preferably 0.7 to 2%, based on the total amount of the cosmetic. % by mass.
• the cosmetics according to the present invention can contain optional ingredients that are usually used in cosmetics and pharmaceuticals.
• optional ingredients include moisturizers, lower alcohols, thickeners, surfactants, sequestering agents, neutralizers, pH adjusters, antioxidants, preservatives, drugs, and the like, and the effects of the present invention. 1 or 2 or more can be blended as long as the
• moisturizing agents examples include propylene glycol, dipropylene glycol (DPG), glycerin, 1,3-butylene glycol (BG), erythritol, xylitol, sorbitol, maltitol, chondroitin sulfate, hyaluronic acid, mucoitin sulfate, caronin acid, Atelocollagen, cholesteryl-12-hydroxystearate, sodium lactate, bile salts, dl-pyrrolidone carboxylate, short-chain soluble collagen, rose rose extract, yarrow extract, melilot extract and the like.
• DPG dipropylene glycol
• BG 1,3-butylene glycol
• BG 1,3-butylene glycol
• sorbitol maltitol
• maltitol maltitol
• chondroitin sulfate hyaluronic acid
• mucoitin sulfate caronin
• lower alcohols examples include ethanol, 1-propanol, 2-propanol, isobutyl alcohol, t-butyl alcohol and the like.
• Thickeners include, for example, gum arabic, carrageenan, karaya gum, tragacanth gum, carob gum, quince seed (quince), casein, dextrin, gelatin, sodium pectate, sodium araginate, PVA, PVM, PVP, sodium polyacrylate, Carboxyvinyl polymer (carbomer), (dimethylacrylamide/acryloyldimethyltaurate Na) crosspolymer, (acryloyldimethyltaurate ammonium/VP) copolymer, (acryloyldimethyltaurate ammonium methacrylate beheneth-25) crosspolymer, (acrylate Na/ Acryloyldimethyltaurate Na) copolymer, locust bean gum, guar gum, tamarind gum, xanthan gum, magnesium aluminum silicate, bentonite, hectorite, A1Mg silicate (Vegum), laponite, silicic anhydride and the like.
• Lipophilic nonionic surfactants include, for example, lipophilic nonionic surfactants such as sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostea sorbitan fatty acid esters such as sorbitan sesquioleate, diglycerol sorbitan penta-2-ethylhexylate, glycerin such as glyceryl monostearate, ⁇ , ⁇ '-oleic acid pyroglutamic acid glyceryl, glyceryl monostearate malate or Polyglycerin esters, propylene glycol fatty acid esters such as propylene glycol monostearate, hydrogenated castor oil derivatives, glycerin alkyl ethers and the like can be mentioned.
• lipophilic nonionic surfactants such as sorbitan monooleate, sorbitan monoisostearate, sorb
• hydrophilic nonionic surfactants include polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan monooleate and polyoxyethylene sorbitan monostearate; polyoxyethylene sorbit monolaurate, polyoxyethylene sorbit Polyoxyethylene sorbitol fatty acid esters such as monooleate and polyoxyethylene sorbitol monostearate; Polyoxyethylene fatty acid esters such as oxyethylene glycerin fatty acid ester, polyoxyethylene monooleate, polyoxyethylene distearate; polyoxyethylene lauryl ether, polyoxyethylene oleyl ether, polyoxyethylene stearyl ether, polyoxyethylene -polyoxyethylene alkyl ethers such as 2-octyldodecyl ether and polyoxyethylene cholestanol ether; polyoxyethylene alkyl ethers such as polyoxyethylene octylphenyl ether, polyoxyethylene nonylphenyl ether and polyoxyethylene din
• polyoxyethylene propylene glycol fatty acid esters polyoxyethylene alkylamines, polyoxyethylene fatty acid amides, sucrose fatty acid esters, polyoxyethylene nonylphenyl formaldehyde condensates, alkylethoxydimethylamine oxides, trioleyl phosphate, etc. be done.
• anionic surfactants include fatty acid soaps such as sodium laurate and sodium palmitate; higher alkyl sulfate salts such as sodium lauryl sulfate and potassium lauryl sulfate; Alkyl ether sulfate ester salts such as sodium lauryl sulfate; N-acylsarcosic acid such as sodium lauroyl sarcosinate, sodium N-myristoyl-N-methyltaurate, sodium N-stearoyl-N-methyltaurate, sodium cocoate methyl tauride, Higher fatty acid amide sulfonates such as sodium lauryl methyl tauride; Phosphate ester salts such as sodium polyoxyethylene oleyl ether phosphate and sodium polyoxyethylene stearyl ether phosphate; sulfosuccinates such as sodium ethanolamide polyoxyethylene sulfosuccinate and sodium lauryl polypropylene glycol sulfosuccinate;
• cationic surfactants include alkyltrimethylammonium salts such as stearyltrimethylammonium chloride and lauryltrimethylammonium chloride; dialkyldimethylammonium salts such as distearyldimethylammonium chloride; ,-methylenepiperidinium), alkylpyridinium salts such as cetylpyridinium chloride, alkylquaternary ammonium salts, alkyldimethylbenzylammonium salts, alkylisoquinolinium salts, dialkylmorphonium salts, polyoxyethylenealkylamines, Alkylamine salts, polyamine fatty acid derivatives, amyl alcohol fatty acid derivatives, benzalkonium chloride, benzethonium chloride, cationic polymers, ⁇ -NN-dimethyl-N-ethylammonioethyl chloride vinylpyrrolidone chloride copolymers, etc. be done.
• Amphoteric surfactants include, for example, 2-undecyl-N,N,N,-(hydroxyethylcarboxymethyl)-2-imidazoline sodium, 2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxy 2 imidazoline-based amphoteric surfactants such as sodium salts; betaine-based amphoteric surfactants such as 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryldimethylaminoacetate betaine, alkylbetaine, amidobetaine, sulfobetaine, etc. agents and the like.
• sequestering agents include 1-hydroxyethane-1,1-diphosphonic acid, tetrasodium 1-hydroxyethane-1,1-diphosphonic acid, disodium edetate (EDTA-2Na), and trisodium edetate.
• EDTA-2Na disodium edetate
• trisodium edetate tetrasodium edetate, sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, phosphoric acid, citric acid, succinic acid, edetic acid, trisodium ethylenediaminehydroxyethyl triacetate, and the like.
• neutralizing agents examples include 2-amino-2-methyl-1-propanol, 2-amino-2-methyl-1,3-propanediol, potassium hydroxide, sodium hydroxide, triethanolamine, sodium carbonate, and the like. is mentioned.
• pH adjusters include buffers such as lactic acid-sodium lactate, citric acid-sodium citrate, and succinic acid-sodium succinate.
• antioxidants include dibutylhydroxytoluene, butylhydroxyanisole, sodium pyrosulfite, and gallic acid esters.
• antiseptics include paraoxybenzoic acid esters such as methylparaben, ethylparaben, and butylparaben, benzoic acid, salicylic acid, sorbic acid, parachlorometacresol, hexachlorophene, benzalkonium chloride, chlorhexidine chloride, and trichlorocarbanilide. , a photosensitive element, phenoxyethanol, and the like.
• drugs include ascorbic acid (vitamin C), tranexamic acid, kojic acid, ellagic acid, arbutin, alkoxysalicylic acid, glycyrrhizic acid, tocopherol, retinol, and salts or derivatives thereof (e.g., sodium L-ascorbate, L -ascorbic acid ester magnesium salt, L-ascorbic acid glucoside, 2-O-ethyl-L-ascorbic acid, 3-O-ethyl-L-ascorbic acid, 4-methoxysalicylic acid sodium salt, 4-methoxysalicylic acid potassium salt, glycyrrhizin dipotassium acid, stearyl glycyrrhizinate, tocopherol acetate, retinol acetate, retinol palmitate, etc.), nicotinic acid and its derivatives (e.g.
• nicotinamide caffeine, tannins, verapamil and its derivatives, licorice extract, glabridin, fire thorns fruit hot water extract, various crude drugs, hydrolyzed silk, hydrolyzed conchiolin, tea extract, tormentilla root extract, Angelica keiskei leaf/stem extract, aloe vera leaf extract, cherry leaf extract, angelica root extract, shiikuwasha pericarp extract, iris root extract , Soarthorn/Hijirimen/Mitsui kelp/Usuva green laver/Wakame extract, Cattail extract, Toad leaf/stem extract, Camellia seed extract, Honey kelp/Wakame extract, Mishima radish root extract, Dutch mustard leaf/stem extract, Cassia bark extract, Rosemary Leaf oil, lavender oil, glutamic acid, trimethylglycine, chlorphenesin, menthoxypropanediol and the like.
• UV absorbers powder ingredients, fragrances, etc. can be added as appropriate.
• the dosage form of the cosmetic according to the present invention is not particularly limited and includes, for example, a solution system, a solubilization system, an emulsification system, a water-2-oil two-layer system, and a water-oil-powder three-layer system.
• Cosmetics according to the present invention include, for example, skin care cosmetics (e.g. lotions, milky lotions, creams, serums, packs, etc.), makeup cosmetics (e.g., foundations, makeup bases, etc.), skin cleansers (e.g., facial cleansers). cosmetics, makeup removers, etc.), sunscreen cosmetics, ointments, and the like.
• the cosmetic of the present invention can be produced according to a conventional method.
• the method of emulsification is not particularly limited.
• Examples 1 to 13 and Comparative Examples 1 and 2 Cosmetics of Examples 1 to 13 and Comparative Examples 1 and 2 were prepared with the formulations shown in Tables 1 and 2.
• crystalline cellulose (cellulose nanofiber) * 1 is fine fibrous cellulose fine cellulose (“Rheocrysta C-2SP” (trade name), manufactured by Daiichi Kogyo Seiyaku Co., Ltd.) having a maximum fiber diameter of 1000 nm or less.
• “Rheocrysta C-2SP” is a product containing 2% by mass of fine fibrous cellulose, 1% by mass of phenoxyethanol (preservative) in 97% by mass of water, and is described in the specification and tables. % by mass indicates only fine fibrous cellulose, and does not include water and preservatives contained in the product.

Landscapes

• Health & Medical Sciences (AREA)
• Life Sciences & Earth Sciences (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Veterinary Medicine (AREA)
• Chemical & Material Sciences (AREA)
• Organic Chemistry (AREA)
• Birds (AREA)
• Epidemiology (AREA)
• Dermatology (AREA)
• Cosmetics (AREA)

Priority Applications (2)

Applications Claiming Priority (2)

Publications (1)

Family

ID=86730194

Family Applications (1)

Country Status (3)

Citations (7)

• 2022
  • 2022-11-25 JP JP2023566230A patent/JPWO2023106123A1/ja active Pending
  • 2022-11-25 WO PCT/JP2022/043475 patent/WO2023106123A1/ja active Application Filing
  • 2022-11-25 CN CN202280074583.5A patent/CN118251204A/zh active Pending

Patent Citations (7)

Also Published As

Similar Documents

Legal Events