JP4912032B2 - 乳化剤形の皮膚外用剤 - Google Patents
乳化剤形の皮膚外用剤 Download PDFInfo
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- JP4912032B2 JP4912032B2 JP2006136249A JP2006136249A JP4912032B2 JP 4912032 B2 JP4912032 B2 JP 4912032B2 JP 2006136249 A JP2006136249 A JP 2006136249A JP 2006136249 A JP2006136249 A JP 2006136249A JP 4912032 B2 JP4912032 B2 JP 4912032B2
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Description
、コンパクトに密集した形態を取っており、構造的に歪みも存する。この為、フィトステロール配糖体、スフィンゴ糖脂質、ウルソール酸、ウルソール酸エステル等の溶解度の低い成分が油相中に存在する場合、4年以上の長期の保存に於いて、この様な成分が析出し、結晶化する場合が存する。この様な現象は、保存期間4年を越えたところで、20℃近辺の保存条件で観察される場合が存する。特に、非極性成分を油相に多量に含有する場合に、この様な現象は著しいと言われている。即ち、前記の様な油中水乳化組成物に於いて、この様な溶解度の低い成分を安定に配合する技術の開発が望まれていたと言える。
(1)油相中にフィトステロール配糖体、スフィンゴ糖脂質、ウルソール酸、ウルソール酸エステル及びこれらの塩から選択される成分を含有する油中水乳化剤形の皮膚外用剤であって、油相中に1)有機変性粘土鉱物と、2)シクロメチコン及び/又は粘度1mPa・s以下のジメチコンを油相全量に対して50質量%以上で含有し、水相中に3)ポリアクリル酸、アルキル化されていても良いカルボキシビニルポリマー及びこれらの塩から選択される1種又は2種以上とを含有することを特徴とする、皮膚外用剤。
(2)更に、L−カルニチン及び/又はその塩を含有することを特徴とする、(1)に記載の皮膚外用剤。
(3)更に、ポリエーテル変性ジメチコンを含有することを特徴とする、(1)又は(2)に記載の皮膚外用剤。
(4)更に、グリセリン、ジグリセリン及びジプロピレングリコールから選択される1種乃至は2種以上を10〜30質量%含有することを特徴とする、(1)〜(3)何れかに記載の皮膚外用剤。
本発明の皮膚外用剤は有機変性粘土鉱物を必須成分として含有することを特徴とする。ここで有機変性とは、粘土鉱物の一部に有機化合物の一部を共有結合乃至はイオン結合を介して強固乃至は緩やかな結合を生ぜしめ、有機化合物の性質の一部乃至は全部を粘土鉱物に付与させることを意味し、この様な変性としては4級アミン基と粘土鉱物のアニオン部分を結合させる方法、カルボキシル基と粘土鉱物のカチオン部分を結合させる方法等が例示でき、4級アミン基と粘土鉱物のアニオン部分を結合させる方法が特に好ましく例示できる。
前記未変性粘土鉱物を分散媒に分散させる。該分散剤は水系の溶媒であることが好ましく、水であってもよい。分散未変性粘土鉱物を含む分散液に、さらに4級アミノ基を有する化合物を加え、よく撹拌する。4級アミノ基を有する化合物は、水に溶解されて加えられてもよい。加えられる4級アミノ基を有する化合物の量は、分散未変性粘土鉱物の量に対して0.1〜20質量%であることが好ましく、0.5〜15質量%であることがより好ましい。この様な構成を取ることにより、乳化系において、好ましい使用感を呈するためである。撹拌後、分散質を濾取し、脱水、乾固することにより本発明における変性粘土鉱物を得ることができる。あるいは、分散質を濾取することなく、減圧濃縮することにより分散剤を除去して乾固させることにより、本発明における変性粘土鉱物を得ることもできる。得られた変性粘土鉱物は、好ましくは所望のサイズ(粒径が1〜1000μmであることが好ましい)に粉砕され、本発明の皮膚外用剤に含有される。
本発明の皮膚外用剤は、ポリアクリル酸類、即ち、ポリアクリル酸、アルキル化されていても良いカルボキシビニルポリマー及びこれらの塩から選択される1種乃至は2種以上を必須成分として含有することを特徴とする。これらはアクリル酸ビニルエステルなどの架橋性モノマーの共存によって、部分的に架橋構造を有することも許容される。これらは何れも化粧料などの皮膚外用剤汎用原料であり、既に市販されているものを購入し使用することができる。この様な市販品としては、例えば、「ジュリマーAC−10NP」(ポリアクリル酸ナトリウム;日本純薬株式会社製)、「ジュリマーAC−10NP」(ポリアクリル酸;日本純薬株式会社製)、「ジュンロンーPW−110」(架橋型ポリアクリル酸;日本純薬株式会社製)、「レオジック250H」(架橋型ポリアクリル酸ナトリウム;日本純薬株式会社製)、「レオジック252L」(架橋型ポリアクリル酸ナトリウム;日本純薬株式会社製)、「アロンビスSS」(ポリアクリル酸ナトリウム;日本純薬株式会社製)、「アクアリックL」(ポリアクリル酸ナトリウム:日本触媒株式会社製)、「アクアリックH」(ポリアクリル酸ナトリウム:日本触媒株式会社製)、「アロンA20L」(ポリアクリル酸ナトリウム;東亞合成株式会社製)、「シンタレンK」(カルボキシビニルポリマー;和光純薬株式会社製)、「カーボポールUltrez10」(カルボキシビニルポリマー;BFグッドリッチ社製)、「カーボポール1382」(アルキル変性カルボキシビニルポリマー;BFグッドリッチ社製)、「ペムレンTR−1」(アルキル変性カルボキシビニルポリマー;BFグッドリッチ社製)、「ペムレンTR−2」(アルキル変性カルボキシビニルポリマー;BFグッドリッチ社製)等が好ましく例示できる。これらの塩としては、皮膚外用剤で使用されるものであれば、特段の限定無く使用でき、例えば、ナトリウム塩、カリウム塩等のアルカリ金属塩、カルシウム塩、マグネシウム塩等のアルカリ土類金属塩、アンモニウム塩、トリエチルアミン塩、トリエタノールアミン塩、モノエタノールアミン塩等の有機アミン塩、リジン塩、アルギン酸塩等の塩基性アミノ酸塩等が好適に例示できる。これらは唯一種を含有することもできるし、二種以上を組み合わせて含有させることもできる。かかる成分は、前記有機変性粘土鉱物とともに働いて、溶解性の低い成分の長期経時での結晶析出を抑制する作用を有する。この様な効果を奏するためには、かかる成分を総量で、皮膚外用剤全量に対して、0.01〜0.5質量%、より好ましくは0.05〜0.3質量%含有させることが好ましい。これは、含有量が多すぎると、前記有機変性粘土鉱物の効果を損なう場合が存し、少なすぎると長期経時安定化効果を奏さない場合が存するためである。
本発明の皮膚外用剤は、前記必須成分及び後記するシクロメチコン及び/又は粘度1mPa・s以下のジメチコンを含有することを特徴とする。本発明の皮膚外用剤としては、皮膚に外用で適用されるものであれば、特段の限定無く使用することができ、例えば、化粧料、皮膚外用医薬、皮膚外用雑貨などが好適に例示でき、化粧料に適用することが特に好ましい。これは本発明の皮膚外用剤が、比類無き使用感の様さを有しているため、使用感が重要な化粧料に特に好適であるためである。化粧料としては、油中水乳化剤形を応用できるものであれば、特段の限定はなく、例えば、エッセンス、乳液、クリーム等の基礎化粧料、アンダーメークアップ、ファンデーション、チークカラー、マスカラ、アイライナーなどのメークアップ化粧料、ヘアクリームなどの毛髪化粧料などが好適に例示できる。
リコール、グリセリン、エリスリトール、ソルビトール、キシリトール、マルチトール、プロピレングリコール、2,4−ヘキサンジオール等の多価アルコール類;ピロリドンカルボン酸ナトリウム、乳酸、乳酸ナトリウム等の保湿成分類;表面を処理されていても良い、マイカ、タルク、カオリン、合成雲母、炭酸カルシウム、炭酸マグネシウム、無水ケイ酸(シリカ)、酸化アルミニウム、硫酸バリウム等の粉体類、;表面を処理されていても良い、ベンガラ、黄酸化鉄、黒酸化鉄、酸化コバルト、群青、紺青、酸化チタン、酸化亜鉛の無機顔料類;表面を処理されていても良い、雲母チタン、魚燐箔、オキシ塩化ビスマス等のパール剤類;レーキ化されていても良い赤色202号、赤色228号、赤色226号、黄色4号、青色404号、黄色5号、赤色505号、赤色230号、赤色223号、橙色201号、赤色213号、黄色204号、黄色203号、青色1号、緑色201号、紫色201号、赤色204号等の有機色素類;ポリエチレン末、ポリメタクリル酸メチル、ナイロン粉末、オルガノポリシロキサンエラストマー等の有機粉体類;パラアミノ安息香酸系紫外線吸収剤;アントラニル酸系紫外線吸収剤;サリチル酸系紫外線吸収剤;桂皮酸系紫外線吸収剤;ベンゾフェノン系紫外線吸収剤;糖系紫外線吸収剤;2−(2’−ヒドロキシ−5’−t−オクチルフェニル)ベンゾトリアゾール、4−メトキシ−4’−t−ブチルジベンゾイルメタン等の紫外線吸収剤類;エタノール、イソプロパノール等の低級アルコール類;ビタミンA又はその誘導体、ビタミンB 6 塩酸塩、ビタミンB 6 トリパルミテート、ビタミンB 6 ジオクタノエート、ビタミンB 2 又はその誘導体、ビタミンB 12 、ビタミンB 15 又はその誘導体等のビタミンB類;α−トコフェロール、β−トコフェロール、γ−トコフェロール、ビタミンEアセテート等のビタミンE類、ビタミンD類、ビタミンH、パントテン酸、パンテチン、ピロロキノリンキノン等のビタミン類等;フェノキシエタノール等の抗菌剤などが好ましく例示できる。
化粧料1、比較例1及び比較例2を20℃に5年間保存し、3年間保存時、4年間保存時及び5年間保存時に、サンプルを顕微鏡で150倍に拡大して、20視野観察し、1視野あたりの結晶物の計数値の平均を求めた。結果を表2に示す。これより、本発明の皮膚外用剤は、有効成分の溶存安定性に極めて優れることがわかる。
Claims (4)
- 油相中にフィトステロール配糖体、スフィンゴ糖脂質、ウルソール酸、ウルソール酸エステル及びこれらの塩から選択される成分を含有する油中水乳化剤形の皮膚外用剤であって、
油相中に1)有機変性粘土鉱物と、2)シクロメチコン及び/又は粘度1mPa・s以下のジメチコンを油相全量に対して50質量%以上で含有し、水相中に3)ポリアクリル酸、アルキル化されていても良いカルボキシビニルポリマー及びこれらの塩から選択される1種又は2種以上とを含有することを特徴とする、皮膚外用剤。 - 更に、L−カルニチン及び/又はその塩を含有することを特徴とする、請求項1に記載の皮膚外用剤。
- 更に、ポリエーテル変性ジメチコンを含有することを特徴とする、請求項1又は2に記載の皮膚外用剤。
- 更に、グリセリン、ジグリセリン及びジプロピレングリコールから選択される1種乃至は2種以上を10〜30質量%含有することを特徴とする、請求項1〜3何れか1項に記載の皮膚外用剤。
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