WO2021136350A1 - Stent de récupération de thrombus et système de récupération de thrombus - Google Patents

Stent de récupération de thrombus et système de récupération de thrombus Download PDF

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Publication number
WO2021136350A1
WO2021136350A1 PCT/CN2020/141281 CN2020141281W WO2021136350A1 WO 2021136350 A1 WO2021136350 A1 WO 2021136350A1 CN 2020141281 W CN2020141281 W CN 2020141281W WO 2021136350 A1 WO2021136350 A1 WO 2021136350A1
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WO
WIPO (PCT)
Prior art keywords
stent
closed
bracket
thrombus
bolt
Prior art date
Application number
PCT/CN2020/141281
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English (en)
Chinese (zh)
Inventor
王永胜
尤岩
高国庆
舒素云
Original Assignee
杭州德诺脑神经医疗科技有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority claimed from CN201911423136.2A external-priority patent/CN113116461A/zh
Priority claimed from CN201911424621.1A external-priority patent/CN113116462A/zh
Application filed by 杭州德诺脑神经医疗科技有限公司 filed Critical 杭州德诺脑神经医疗科技有限公司
Publication of WO2021136350A1 publication Critical patent/WO2021136350A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/221—Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions

Definitions

  • the invention relates to the technical field of medical devices, in particular to a thrombus removal stent and a thrombus removal system.
  • Thrombus is a small piece of blood that forms on the surface of the exfoliated or repaired part of the inner surface of the blood vessel of the cardiovascular system. Thrombosis spreads throughout the cardiovascular system and spreads to tissues and organs throughout the body. It is not limited to myocardial infarction, deep vein thrombosis or cerebrovascular thrombosis. Thrombosis can occur in blood vessels in any part of the body. Intracranial thrombosis is a special clinical type of cerebrovascular disease. It is easy to cause cerebral embolism. It has the characteristics of high morbidity, disability, mortality and recurrence. It is fatal and disabling for middle-aged and elderly people. The main disease.
  • the recanalization of blood vessels is the key to the treatment of acute ischemic stroke.
  • the conventional methods for the treatment of ischemic stroke include two categories: drug thrombolysis or mechanical thrombectomy.
  • Drug thrombolysis is a catheter injecting a thrombolytic agent into the attachment of the lesion in the blood vessel referred to by the lesion, and a high concentration of thrombolytic agent is formed in the local area of the lesion, thereby accelerating the speed of thrombolysis and increasing the chance of vascular recanalization.
  • intravenous thrombolysis should be performed within 3 hours of onset, and the arterial thrombolysis time window is within 6 hours. Therefore, drug thrombolytic therapy is only suitable for smaller blood clots. When the volume of the thrombus is too large, a very large dose is needed to dissolve the large blood clot, and it is easy to cause various complications and the risk is high.
  • Mechanical thrombectomy includes the following methods: thrombectomy, laser thrombectomy, thrombectomy with catcher, thrombectomy with thrombectomy net.
  • the thrombectomy is more thorough in removing the thrombus, but it damages the blood vessel wall too much, which can easily cause various concurrent inflammations.
  • the operation of laser thrombus breaking is difficult. If the laser energy is too low, it will be ineffective. If the energy is too high, the blood vessels will be damaged, and it is also easy to cause various complications.
  • the operation of the catcher to remove the thrombus is simple, and it does little damage to the blood vessel wall, but it often fails to catch the blood clot.
  • the operation of the thrombus-trapping net to remove the thrombus is simple, but it cannot be used in intracranial blood vessels because of the large volume of the thrombus-trapping net.
  • the existing mechanical thrombectomy methods fail to meet the characteristics of high thrombus capture efficiency and small mechanical damage at the same time.
  • an embodiment of the present invention provides a plug-removing stent, which includes a stent body having a tubular and/or cage-like structure.
  • the stent body includes a first stent body and a distal end of the first stent body.
  • a second stent body, the first stent body and the second stent body are smoothly transitionally connected, and the second stent body includes a large pipe diameter section and a small pipe diameter section that are alternately connected.
  • an embodiment of the present invention provides a thrombus removal system, including a microcatheter, a push rod, and the thrombus removal stent as described above, the push rod is connected to the proximal end of the thrombus removal stent, and the push rod The rod and the thrombus removal stent are crimped and introduced into the microcatheter. The thrombus removal stent can be pushed and pulled by the push rod to move inside and outside the microcatheter.
  • the bolt removal stent and bolt removal system are based on the smooth transition connection between the first stent body and the second stent body, and the second stent body includes alternately connected Large pipe diameter section and small pipe diameter section.
  • the thrombus removal stent has flexibility, it also has a certain radial and axial support force, and effectively prevents the thrombus removal stent from collapsing when it completely passes through the blood vessel, thereby improving the efficiency of thrombus capture and the process of thrombus removal. It reduces the damage to the blood vessel caused by the embolization stent.
  • Fig. 1 is a schematic diagram of the structure of the bolt removal bracket provided by the first embodiment of the present invention.
  • Fig. 2 is a three-dimensional development view of the bolt removal bracket in Fig. 1 in a plane.
  • Fig. 3 is a schematic diagram of the structure of the bolt removal bracket provided by the second embodiment of the present invention.
  • Fig. 4 is a schematic diagram of the structure of the bolt removal bracket provided by the third embodiment of the present invention.
  • Fig. 5 is a schematic diagram of the structure of the bolt removal bracket provided by the fourth embodiment of the present invention.
  • Fig. 6 is a schematic structural diagram of a bolt removal bracket provided by a fifth embodiment of the present invention.
  • Fig. 7 is a schematic structural diagram of a bolt removal bracket provided by a sixth embodiment of the present invention.
  • Fig. 8 is a schematic structural diagram of a bolt removal system provided by an embodiment of the present invention.
  • the end of the instrument close to the operator is usually called the proximal end, and the end of the instrument far away from the operator is called the distal end.
  • the distal end refers to the end of the instrument that can be freely inserted into the animal or human body.
  • the near end refers to the end used for user or machine operation or the end used to connect to other devices.
  • FIG. 1 is a schematic structural diagram of a bolt removing bracket 100 provided by a first embodiment of the present invention
  • FIG. 2 is a planar three-dimensional expanded view of the bolt removing bracket 100.
  • the plug-removing stent 100 includes a stent body 101 having a tubular and/or cage-like structure.
  • the stent body 101 includes a first stent body 10 and a second stent body 30 provided at the distal end of the first stent body 10.
  • the first bracket body 10 and the second bracket body 30 are integrally formed and smoothly transitioned.
  • the second bracket body 30 includes a large pipe diameter section 31 and a small pipe diameter section 33 that are alternately connected.
  • the thrombus removal stent 100 has flexibility, it also has a certain radial and axial support force, and effectively prevents the thrombus removal stent 100 from collapsing when it passes through the blood vessel completely, thereby improving the efficiency of thrombus capture, and During the embolization process, the damage to the blood vessel of the embolization stent is reduced.
  • first bracket body 10 and the second bracket body 30 are integrally formed so as to improve the stability and reliability of the connection between the first bracket body 10 and the second bracket body 30.
  • first bracket body 10 and the second bracket body 30 may also be fixedly connected together by technical means commonly used in the art, such as pressing, hot melting, bonding, welding, or pressure riveting.
  • both the proximal end and the distal end of the second stent body 30 are configured as large diameter sections 31.
  • the small pipe diameter section 33 is arranged between two adjacent large pipe diameter sections 31.
  • the second bracket body 30 includes a plurality of first closed loop units 311, a plurality of second closed loop units 312 and a plurality of third closed loop units 331.
  • the plurality of first closed loop units 311 and the plurality of second closed loop units 312 are connected to each other to form a large pipe diameter section 31.
  • the plurality of third closed-loop units 331 are connected to each other to form a small pipe diameter section 33.
  • the second stent body 30 includes two large diameter sections 31 and one small diameter section 33.
  • the two large diameter sections 31 are located at the proximal and distal ends of the second stent body 30.
  • the small pipe diameter section 33 is arranged in the middle of the second bracket body 30 and is located between two adjacent large pipe diameter sections 31.
  • the area of the first closed-loop unit 311 is smaller than the area of the second closed-loop unit 312 and larger than the area 331 of the third closed-loop unit, so that the thrombus removal stent 100 can provide a certain pulling force during the thrombus removal process, and effectively prevent thrombosis. Move, and then facilitate the removal of the thrombus.
  • the area of the second closed-loop unit 312 is relatively large, it is suitable for blood vessels of different sizes, that is, the second closed-loop unit 312 can be fully expanded for large blood vessels, and the second closed-loop unit 312 can be overlapped for small blood vessels. Thereby, the thrombus can be captured more firmly. Since the area of the area 331 of the first closed loop unit 311 and the third closed loop unit is relatively small, the contact area with the blood vessel wall is reduced, and the damage to the blood vessel wall is reduced.
  • the first closed-loop unit 311 surrounds the second closed-loop unit 312, and two adjacent second closed-loop units 312 are arranged at intervals along the circumferential direction of the second bracket body 30.
  • the second closed loop unit 312 is evenly distributed along the axial and circumferential directions of the second stent body 30 so that the thrombus can enter the thrombus removal stent 100.
  • a plurality of second closed-loop units 312 are located on the same layer in the radial direction of each large pipe diameter section 31.
  • the plurality of second closed-loop units 312 are located on different layers in the radial direction of each large pipe diameter section 31, and the plurality of second closed-loop units 312 of two adjacent layers are along the line of the second stent body 30. Circumferentially staggered settings in order to firmly capture the thrombus, thereby increasing the effective capture rate of the thrombus.
  • the shapes of the first closed-loop unit 311 and the third closed-loop unit 331 include, but are not limited to, one or more of a circle, an ellipse, a triangle, a diamond, a trapezoid, and a hexagon.
  • the second closed-loop unit 312 is approximately in the shape of an hourglass, so that when the second stent unit 30 is squeezed in the blood vessel, it can make a large deformation, so that the second stent unit 30 has better flexibility, thereby improving thrombus. Capture efficiency, and reduce the damage to the blood vessel of the embolization stent during the embolectomy process.
  • the second closed-loop unit 312 since the second closed-loop unit 312 is in the shape of an hourglass, the second closed-loop unit 312 can adapt to thrombus of different sizes, which improves the effective capture rate of thrombus.
  • both the first closed-loop unit 311 and the third closed-loop unit 331 are composed of a closed grid.
  • the second closed loop unit 312 is enclosed by two semi-closed grids.
  • a plurality of grids are arranged in a row in sequence, and the grids of two adjacent rows are arranged in a staggered manner.
  • Two adjacent grids are connected together by connecting ribs 103.
  • the grid of one row faces the gap between the two adjacent grids in the other row, so that the bolt removal stent 100 is more easily compressed and more adaptable Small blood vessels, and easy to introduce into the micro catheter 300 (refer to Figure 8).
  • the second closed loop unit 312 includes a first grid 3121, a second grid 3122, and a channel 3123 connecting the first grid 3121 and the second grid 3122.
  • the first grid 3121 and the first closed-loop unit 311 are sequentially arranged in a row
  • the second grid 3122 is also sequentially arranged in a row with the first closed-loop unit 311
  • the channel 3123 is also sequentially arranged in a row with the first closed-loop unit 311.
  • the multiple second closed-loop units 312 on the same layer are symmetrically distributed from the central axis of the second bracket body 30.
  • the extending direction of the channel 3123 is parallel to the central axis of the second bracket body 30. In the radial direction of the large pipe diameter section 31 of the same layer, the channel 3123 and the connecting rib 103 are directly opposite.
  • the first stent body 10 is configured in a funnel structure
  • the second stent body 30 is configured in a straight tube structure, so that the thrombus removal stent 100 avoids falling off of the thrombus when retracting toward the proximal end of the thrombus removal stent 100.
  • the first bracket body 10 includes a plurality of fourth closed-loop units 11. A plurality of fourth closed-loop units 11 are connected to each other to form the funnel structure.
  • the tube diameter of the first stent body 10 gradually increases from its proximal end to the distal direction, so as to prevent the proximal end of the first stent body 10 from being removed due to bolt removal during the process of retreating the bolt removal stent 100 toward its proximal direction.
  • the influence of the withdrawal force of the stent 100 causes the overall diameter of the stent 100 to be reduced or kinked, thereby improving the efficiency of capturing thrombus and reducing the damage to the blood vessel caused by the thrombus removal stent 100. In this way, a smooth transitional connection between the first stent body 10 and the second stent body 30 is ensured, thereby reducing the damage to the blood vessel caused by the thrombus removal stent during the thrombus removal process.
  • the area of the fourth closed-loop unit 11 is equal to the area of the first closed-loop unit 311, thereby reducing the contact area between the first stent body 10 and the second stent body 30 and the blood vessel wall, thereby reducing the impact on the blood vessel wall. damage.
  • FIG. 3 is a schematic structural diagram of a bolt-removing bracket 100 a provided by the second embodiment of the present invention.
  • the structure of the bolt removal bracket 100a is similar to the structure of the bolt removal bracket 100 of the first embodiment.
  • the proximal end of the first stent body 10a is configured as an oblique cone-shaped structure.
  • the proximal end of the first stent body 10a forms a sloped entrance 15a.
  • the shape of the inlet 15a is cone-shaped, like a drop shape. In this embodiment, the shape of the inlet 15a is a fusiform.
  • the bracket body 101 further includes a plurality of connecting ribs 103 connecting the first closed loop unit 311, the second closed loop unit 312, the third closed loop unit 331 and the fourth closed loop unit 11.
  • the plurality of connecting ribs 103 are parallel to the central axis of the bracket body 101.
  • the proximal end of the first stent body 10 is also provided with a connecting head 13.
  • the connector 13 extends in the direction of the central axis of the bracket body 101.
  • the traction force will be concentrated on the extension line where the connecting head 13 is located, ensuring that the diameter of the distal end of the stent body 101 remains unchanged, thereby improving the efficiency of thrombus capture.
  • the connecting head 13 is provided with a developing positioning element 102 so as to indicate the position of the plug-removing bracket 100 through the position of the developing positioning element 102 under the detection of the instrument.
  • the developing positioning member 102 is made of a radiopaque material.
  • the radiopaque material is preferably a precious metal material such as gold, platinum, or tantalum.
  • the developing positioning element 102 can take various forms such as ring shape, wire shape, ribbon shape, or dot shape, and is fixed to the bolt removal bracket 100 by pressing, hot melting, bonding, welding or pressure riveting and other common technical means in the art. on.
  • the developing positioning element 102 may be ring-shaped, and the developing positioning element 102 is sleeved outside the connecting head 13.
  • two visualization positioning elements 102 are respectively provided at the distal and proximal positions of the thrombus removal stent 100 to accurately locate the position of the thrombus, so that the thrombus can be detected during the thrombus removal process using the thrombus removal stent 100
  • the middle part of the thrombus removal stent 100 may also be provided with multiple visualization positioning elements to more accurately locate the position of the thrombus.
  • both the first stent body 10 and the second stent body 30 are made of a metal material with a memory effect or a polymer material with elasticity, so that the stent body 101 self-expands to form a tube and/or a cage. structure.
  • the metal material is, for example, but not limited to nickel-titanium alloy or cobalt-based alloy.
  • the first stent body 10 and the second stent body 30 can be formed by laser cutting a plate-shaped nickel-titanium alloy to form a tubular or cage-like structure with a hollow structure, and then be crimped, heat-treated and shaped.
  • first stent body 10 and the second stent body 30 can also form a tubular or cage-like structure with the hollow structure by weaving a wire-like Nitinol alloy.
  • first bracket body 10 and the second bracket body 30 may also be processed by using elastic plastic materials.
  • FIG. 4 is a schematic structural diagram of a bolt removal bracket 100b provided by the third embodiment of the present invention.
  • the structure of the bolt removal bracket 100b is similar to the structure of the bolt removal bracket 100 of the first embodiment.
  • the second bracket body 30b includes three large diameter sections 31b and two small diameter sections 33b.
  • the three large pipe diameter sections 31b and the two small pipe diameter sections 33b are integrally formed and smoothly transitioned.
  • the large pipe diameter section 31b, the small pipe diameter section 33b, the large pipe diameter section 31b, the small pipe diameter section 33b, and the large pipe diameter section 31b are sequentially connected to form the second stent body 30b.
  • two small pipe diameter sections 33b are arranged at intervals, and each small pipe diameter section 33b is arranged between two adjacent large pipe diameter sections 31b.
  • Both the proximal and distal ends of the second stent body 30b are configured as large diameter sections 31b.
  • the number of large diameter sections and small diameter sections can be designed according to actual environmental conditions such as thrombus size or blood vessel thickness, which is not limited in the present invention.
  • FIG. 5 is a schematic structural diagram of a bolt removal bracket 100c provided by the fourth embodiment of the present invention.
  • the structure of the bolt removal bracket 100c is similar to the structure of the bolt removal bracket 100b of the third embodiment. The difference is that the bolt removal bracket 100c further includes a plurality of capturing units 20c and a plurality of auxiliary capturing units 50c.
  • multiple capture units 20c are arranged at the junction of the large pipe diameter section 31c and the small pipe diameter section 33c, that is, the small pipe diameter section 33c is provided with multiple capture units at the proximal and distal ends. 20c to further improve the capture efficiency of the thrombus removal stent 100c.
  • the multiple catching units 20c are evenly distributed in the circumferential direction of the bolt removal bracket 100c.
  • a plurality of catching units 20c are enclosed in a circle from the circumference of the bolt-removing bracket 100c.
  • a circle can include 2-6 capture units.
  • the bolt-removing bracket 100c can be provided with 2-4 rounds of capture units in the axial direction.
  • each capture unit 20c is configured as a closed loop structure.
  • Each catching unit 20c includes a connecting part 21c and a catching part 22c opposed to each other.
  • the connecting portion 21c is substantially in an inverted V shape, and the capturing portion 22c is substantially in a V shape.
  • the connecting portion 21c is connected to the bracket body 101, and the capturing portion 22c can extend outward or inward relative to the bracket body 101c, so that a receiving space 201c is formed between the capturing portion 22c and the bracket body 101c.
  • the capturing portion 22c can move in a direction perpendicular to the axis of the bolt removal bracket 100c. In this way, it is avoided that when the thrombus removal stent 100c moves in the blood vessel, the capturing portion 22c does not directly contact the blood vessel wall, thereby avoiding damage to the blood vessel wall tissue.
  • the distal end of the capturing portion 22c is provided with an arc-shaped chamfer to further prevent the capturing portion 22c of the capturing unit 20 from damaging the blood vessel wall.
  • the capturing portion 22c of each capturing unit 20c is located outside the closed loop unit 32c of the bracket body 101c, that is, there is a gap between the capturing portion 22c and the bracket body 101c for capturing
  • the capturing part 22c of the unit 20c is inserted into the thrombus, or the thrombus is clamped in the accommodating space 201c, thereby improving the anchoring of the thrombus by the thrombus removal stent 100c.
  • each auxiliary catching unit 50c is fixed at the junction of the connecting part 21c and the catching part 22c of the catching unit 20c.
  • each auxiliary capture unit 50c is arranged between two adjacent capture units 20c.
  • the plurality of auxiliary catching units 50c are all configured in a barbed structure.
  • Each auxiliary catching unit 50c includes opposite connecting ends 51c and free ends 52c.
  • the proximal end of each auxiliary capturing unit 50c is a connecting end 51c
  • the distal end of each auxiliary capturing unit 50c is a free end 52c.
  • Each auxiliary catching unit 50c can also be directly connected to the connecting rib 103c of the bolt-removing bracket 100c.
  • Each auxiliary catching unit 50c and the connecting rib 103c are integrally formed.
  • the free end 52c of the auxiliary catching unit 50c can extend outward or inward relative to the bracket body 101c, and move in a direction perpendicular to the axis of the bolt removal bracket 100c.
  • the auxiliary catching unit 50c can be arranged in 2-6 circles along the axial direction of the stent body 101c, and each circle has 2-6 auxiliary catching units 50c, so as to further improve the thrombus catching efficiency of the thrombus removal stent 100c.
  • the auxiliary capture unit 50c has self-expandability.
  • the material contained in the auxiliary capture unit 50c can be the material contained in the bolt-removing bracket 100c, which will not be repeated here.
  • a receiving space 501c is formed between the free end of each auxiliary capture unit 50c and the bracket body 101c. In this way, when the thrombus removal stent 4c is in the released state, there is a gap between the free end of each auxiliary capture unit 50c and the stent body 101c, so that the auxiliary capture unit 50c can be inserted into the thrombus, or the thrombus can be held in the containing space. 501c, thereby further improving the anchoring of thrombus by the thrombus removal stent 100c.
  • each auxiliary capture unit 50c is provided with an arc-shaped chamfer to avoid damage to the blood vessel wall by the auxiliary capture unit 50c.
  • multiple auxiliary capturing units 50c are located at the junction of the large diameter section 31c and the small diameter section 33c, so as to reduce the risk of the auxiliary capturing unit 50c damaging the blood vessel wall.
  • the number of capture units 20c and auxiliary capture units 50c can be set according to the diameter of the plug-removing bracket 100c, and the arrangement positions, lengths, and inclination angles of the multiple auxiliary capture units 50c can be the same as each other. They may also be different from each other, and the present invention is not limited.
  • FIG. 6 is a schematic structural diagram of a bolt removal bracket 100 d according to a fifth embodiment of the present invention.
  • the structure of the bolt removing bracket 100d is similar to the structure of the bolt removing bracket 100c of the fourth embodiment.
  • the proximal end of the first stent body 10e is configured as an oblique cone-shaped structure.
  • the description of the second embodiment for the specific structure of the oblique cone cylindrical structure.
  • FIG. 7 is a schematic structural diagram of a bolt removal bracket 100 d according to a sixth embodiment of the present invention.
  • the structure of the bolt removal bracket 100e is similar to the structure of the bolt removal bracket 100c of the fourth embodiment. The difference is that the bolt removal bracket 100e further includes a plurality of connecting members 53e, and the plurality of auxiliary capturing units 50e are connected to the bracket body 101e through the corresponding connecting members 53e.
  • each connecting member 53e is configured as a curved structure, and each connecting member 53e is bent inwardly relative to the bracket body 101e to increase the receiving space 501e formed between the auxiliary catching unit 50e and the bracket body 101e. So as to provide more accommodation space for the thrombus. Specifically, a distance is formed between the inner side of each connecting piece 53e and the axis of the stent body 101e, and the outer side of each connecting piece 53e is connected to the periphery of the stent body 101e, so as to prevent the connecting piece 53e from intercepting the thrombus and preventing entry. Take the bolt inside the bracket 100e. The plurality of connecting members 53e are evenly distributed from the circumferential direction of the bracket body 101e.
  • Each connecting member 53e can be integrally formed with the bracket body 101e. In other embodiments, each connecting member 53e can also be fixed to the bracket body 101e by a mounting structure.
  • the mounting structure is, for example, but not limited to an adhesive, a crimping structure or a riveting structure.
  • each auxiliary capture unit 50e is connected to the bracket body 101e through a corresponding connecting member 53e.
  • Each auxiliary catching unit 50e is arranged at the connection between the connecting piece 53e and the catching unit 20e. Specifically, the connecting end 51e of the auxiliary capturing unit 50e is connected to the proximal end of the connecting piece 53e.
  • the plurality of connecting members 53e and the plurality of catching units 20e are alternately arranged and connected to each other to ensure the flexibility of the bolt removal stent 100e and a certain supporting force in the radial and axial directions of the bolt removal stent 100e.
  • the design of the connecting piece 53e can also increase the space between the capturing portion 22e and the stent body 101e, and provide more accommodating space for thrombus.
  • the proximal end of each connecting piece 53e is connected to the distal end of the connecting portion 21e of one of the catching units 20e (that is, the proximal end of the catching portion 22e), and the distal end of each connecting piece 53e is connected to the other catching unit.
  • each connecting member 53e can be integrally formed with the bracket body 101e. In some other embodiments, each connecting member 53e may also be fixed on the bracket body 101e by a mounting structure.
  • the mounting structure is, for example, but not limited to an adhesive, a crimping structure or a riveting structure.
  • the free end 52e of the auxiliary capturing unit 50e is configured as a curved structure, and the bending direction of the auxiliary capturing unit 50e is opposite to the bending direction of the connecting member 53e.
  • each auxiliary catching unit 50e is bent outward relative to the bolt-taking bracket 100e to further increase the accommodating space 201e formed between the auxiliary catching unit 20e and the bracket body 101e and to increase the auxiliary catching unit 50e and the bracket body 101e
  • the accommodating space 501e formed therebetween provides more accommodating space for further thrombosis.
  • the design of the curved structure of the auxiliary capture unit 50e can hold the thrombus more firmly, and improve the safety of the thrombus removal stent 100e, prevent the free end 52e from piercing the direction of the blood vessel wall, and increase the adhesion to the blood vessel wall. Avoid damaging the blood vessel wall tissue.
  • FIG. 8 is a schematic structural diagram of a bolt removal system 1000 according to an embodiment of the present invention.
  • the thrombus removal system 1000 includes the above-mentioned thrombus removal stent 100d, a push rod 200 and a micro catheter 300.
  • the push rod 200 is connected to the proximal end of the thrombus removal stent 100d, and the push rod 200 and the thrombus removal stent 100d are crimped and introduced into the microcatheter 300.
  • the plug-removing stent 100d can move inside and outside the microcatheter 300 by pushing and pulling the push rod 200.
  • the thrombus removal stent 100d When the push rod 200 moves toward its proximal end, the thrombus removal stent 100d is recovered into the micro catheter 300; when the push rod 200 moves away from its proximal end, the thrombus removal stent 100d is pushed out of the micro catheter 300 .
  • connection between the proximal end of the bolt-removing bracket 100d and the distal end of the push rod 200 includes welding, sleeve connection, or glue-fixed connection.
  • welding includes, but is not limited to silver welding or gold welding.
  • Adhesives include, but are not limited to UV glue or epoxy glue.
  • the micro catheter 300 is sleeved outside the pushing rod 200.
  • the bolt removal system 1000 further includes a loading tube 400. The loading tube 400 is used to fix the micro catheter 300.
  • the microcatheter 300 When in use, first connect the proximal end of the thrombus removal stent 100d and the distal end of the push rod 200, and then compress the installed thrombus removal stent 100d and the push rod 200 into the microcatheter 300 in advance.
  • the microcatheter 300 is delivered to the diseased part of the blood vessel, passes through the thrombus, and fixes the microcatheter 300.
  • the plug removal stent 100d is made of a shape memory material, the plug removal stent 100d has elasticity, so that the plug removal stent 100d can switch between a compressed state and a released state. By releasing the thrombus removal stent 100d, the thrombus removal stent 100d can be completely embedded inside the thrombus. After waiting for a certain period of time, the push rod 200 is pulled back, and the thrombus removal stent 100d is retracted to capture the thrombus, until the thrombus removal stent 100d together with the microcatheter 300 is retracted out of the body to complete the entire embolization process.
  • the thrombus removal device 1000 as a whole is crimped and introduced into the microcatheter 300, that is, the thrombus removal stent 100d is delivered to the diseased part of the blood vessel through the microcatheter 300.
  • bolt removal brackets 100, 100a, 100b, 100c, 100e in the first embodiment to the fourth embodiment and the sixth embodiment can all be applied to the bolt removal system, which will not be repeated here.
  • the bolt removal stent and bolt removal system provided by the embodiments of the present invention are based on the smooth transitional connection between the first stent body and the second stent body, and the second stent body includes alternately connected large pipe diameter sections and small pipe diameter sections.
  • the thrombus removal stent has flexibility, it also has a certain radial and axial support force, and effectively prevents the thrombus removal stent from collapsing when it completely passes through the blood vessel, thereby improving the efficiency of thrombus capture and the process of thrombus removal. It reduces the damage to the blood vessel caused by the embolization stent.

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Abstract

La présente invention concerne un stent de récupération de thrombus (100, 100a, 100b, 100c, 100d, 100e) qui comprend un corps principal (101, 101a, 101b, 101c, 101d, 101e) tubulaire et/ou en forme de cage de stent. Le corps principal (101, 101a, 101b, 101c, 101d, 101e) de stent comprend un premier corps principal (10, 10a, 10b, 10c, 10d, 10e) de stent et un second corps principal (30, 30a, 30b, 30c, 30d, 30e) de stent disposé au niveau d'une extrémité distale du premier corps principal (10, 10a, 10b, 10c, 10d, 10e) de stent. Le premier corps principal (10, 10a, 10b, 10d, 10e) de stent et le second corps principal (30, 30a, 30b, 30d, 30e) de stent sont en liaison de transition douce. Le second corps principal (30, 30a, 30b, 30c, 30d, 30e) de stent comprend des sections de grand diamètre (31, 31a, 31b, 31c, 31d, 31e) et des sections de petit diamètre (33, 33a, 33b, 33c, 33d, 33e) disposées de manière alternée et reliées ensemble.
PCT/CN2020/141281 2019-12-30 2020-12-30 Stent de récupération de thrombus et système de récupération de thrombus WO2021136350A1 (fr)

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