WO2021128997A1

WO2021128997A1 - Natural plant eye spray and preparation method therefor

Info

Publication number: WO2021128997A1
Application number: PCT/CN2020/116719
Authority: WO
Inventors: 林泽斌; 黄建香; 朱丹霞; 曾倚琪; 陈敏; 黄雅乐
Original assignee: 广东暨晴生物医药科技有限公司
Priority date: 2019-12-26
Filing date: 2020-09-22
Publication date: 2021-07-01
Also published as: CN110946928A

Abstract

A natural plant eye spray and a preparation method therefor. The eye spray comprises: 50-70 parts of folium artemisiae argyi water, 10-20 parts of green tea leaf water, 10-20 parts of chrysanthemum flower water, 5-10 parts of roselle flower water, and 0.2-1.0 part of a peony root-bark extract. The preparation method comprises: weighing and taking the folium artemisiae argyi water, the green tea leaf water, the chrysanthemum flower water, and the roselle flower water prepared by means of steam distillation according to the parts by mass, fully blending and uniformly mixing, performing filtering by means of an ultrafiltration membrane for sterilization and impurity removal, performing ultra-temperature instant sterilization, adding the peony root-bark extract according to the part by mass in a sterile environment, fully and uniformly stirring, and performing sterile filling and package to obtain the eye spray. The eye spray can moisten the skin around eyes while effectively relieving asthenopia, xerophthalmia and the like, and has the dual effects of brightening and moistening the eyes.

Description

Natural plant eye spray and preparation method thereof

Technical field

The invention relates to the technical field of eye care daily necessities, in particular to a natural plant eye spray and a preparation method thereof.

Background technique

With the development of the times and the advancement of technology, the types and quantities of electronic technology products are increasing, making people's lives and work more and more inseparable from electronic products such as mobile phones and computers. Long-term light radiation directly damages human eyes, causing fatigue, dryness, tearing, pain and even blurred vision.

At present, eye care products on the market generally have a trend of convenient development, such as eye patch, steam eye mask, eye drops, tear substitutes and so on. However, both the eye patch and the steam eye mask have time and space limitations; the eye drops directly contact the eyeball when in use, which is irritating and easily damages the structure of the eyeball; artificial tears are the main treatment method for dry eye, but the effect is short-lived. Moreover, no matter what kind of product, most of them are added with chemical additives such as chemical preservatives, long-term use is easy to produce toxic and side effects on the cells of the eye tissue, causing safety risks to users.

Summary of the invention

The purpose of the present invention is to provide a natural plant eye spray against the defects or deficiencies in the prior art. The natural plant eye spray of the present invention has no chemical preservatives added, is safe, reliable, and non-irritating, and can make up for the lack of safety, convenience of use, and insignificant effects of most existing eye protection products, and is effective in relieving It also moisturizes the skin around the eyes while treating problems such as visual fatigue and eye interference, which has the dual effects of brightening and moisturizing the eyes.

The object of the present invention is also to provide a method for preparing the natural plant eye spray.

The purpose of the present invention is achieved through the following technical solutions.

A natural plant eye spray, in parts by mass, including the following components:

50-70 parts of mugwort water, 10-20 parts of green tea water, 10-20 parts of chrysanthemum water, 5-10 parts of roselle flower water, 0.2-1.0 parts of peony root bark extract.

As a preferred embodiment of a natural plant eye spray, the mugwort leaf water, green tea leaf water, chrysanthemum water and roselle flower water are all prepared by the following method:

After weighing the freshly picked mugwort leaves, green tea leaves, chrysanthemum or roselle flowers, they are washed, cut into pieces, steam distilled, and condensed to collect 2-8 times the weight of the distillate.

As a natural plant eye spray as a preferred embodiment, the peony root bark extract is extracted from the dried root bark of the Ranunculaceae plant peony, the grade is food grade, and the solubility is water-soluble.

As a preferred embodiment of a natural plant eye spray, the natural plant eye spray is used in conjunction with a spray bottle.

The method for preparing the natural plant eye spray described in any one of the above includes the following steps:

(1) Weigh wormwood water, green tea leaf water, chrysanthemum water and roselle flower water according to the said mass parts, fully mix and mix to obtain eye spray lotion;

(2) Filter the eye spray lotion through an ultrafiltration membrane to remove bacteria and impurities to obtain a pure eye spray lotion;

(3) Subjecting the pure eye spray lotion to ultra-high temperature instantaneous sterilization to obtain a sterile eye spray lotion;

(4) According to the mass parts, weigh the peony root bark extract, add it to the aseptic eye spray lotion in an aseptic environment, stir well, fill and seal aseptically to obtain the natural Plant eye spray.

Preferably, in step (2), the ultrafiltration membrane is a food-grade folded simple microporous polyethersulfone membrane with a pore size of 0.22 μm.

Preferably, in step (2), the ultrafiltration membrane is used for positive pressure filtration, and the filtration pressure difference is less than 0.3 MPa.

Preferably, in the step (3), the ultra-high temperature instantaneous sterilization is to rapidly cool to below 40°C after being insulated and sterilized at 130-140°C for 4-6 seconds.

Preferably, in step (3), the aseptic filling includes ozone disinfection of the inner packaging material before filling, ultraviolet space disinfection of the filling room, and aseptic operation by the operator.

The natural plant eye spray of the present invention contains the steam-distilled extract of mugwort leaf, mugwort leaf water, which is rich in phenols and flavonoids, exhibits high scavenging power for various free radicals, and can effectively reduce or eliminate hydroxyl free radicals Oxidative damage to DNA; Mugwort leaf water distilled from Mugwort leaf has anti-inflammatory, anti-allergic and calming effects on the skin, accelerates skin blood circulation, speeds up cell renewal, diminishes pigmentation, reduces wrinkles, improves eye bags, diminishes dark circles and other eye problems , Used for wet compresses, can relieve muscle soreness caused by overuse.

The natural plant eye spray of the present invention contains the steam distilled extract of green tea green tea leaf water. The green tea leaf contains a large amount of natural active substances such as catechins, flavonoids, phenolic acids, etc., which has powerful antioxidant, anti-aging, and anti-inflammatory And so on. The green tea water distilled from green tea leaves can not only prevent the damage of chemical light/ultraviolet light to the eyes, but also can improve the dermal elastic fiber lesions caused by photoaging through anti-oxidation, improve the fine lines of the eyes, and brighten the eyes evenly. color.

The natural plant eye spray of the present invention contains chrysanthemum water, a steam distillation extract of chrysanthemum. It has long been recorded in "Shen Nong's Materia Medica" that Hangbai chrysanthemum tea can "maintain dizziness, swelling and pain, loss of eyesight, dead muscles of the skin, aversion to rheumatism, long-term service and energy, light body and long-term life." Chrysanthemum contains lutein and a variety of vitamins, which have a protective effect on vision. Its antioxidant properties can resist cell and organ damage caused by free radicals in the human body, effectively prevent cataracts and delay senile vision decline. It is often used clinically to treat liver Eye diseases caused by wind-heat; In addition, the total flavonoids of chrysanthemum can inhibit the apoptosis of lacrimal gland acinar and duct cells, increase the basal secretion of tear fluid, maintain the stability of the tear film, promote the repair of corneal damage, reduce inflammation, and improve ocular surface Dry state. In summary, chrysanthemum has a good effect on the treatment of dry eyes, fatigue and blurred vision, and is a good product for "eye improvement" and "eye improvement".

The natural plant eye spray of the present invention contains roselle flower water, a steam distillation extract of roselle flower. Roselle flower is a medicinal and edible plant, rich in organic acids, vitamin C, a variety of amino acids, flavonoids, anthocyanins, etc. It has the effects of eliminating fatigue, anti-oxidation, protection against electronic radiation, and can effectively relieve mobile phones , Eye fatigue caused by computer and video display terminal operations. The roselle flower water distilled from roselle flowers is used as a powerful moisturizer, which can increase the water retention of the skin's stratum corneum cells, so that the skin can be nourished and rejuvenated.

The natural plant eye spray of the present invention contains a water-soluble extract of tree peony root bark. As a plant astringent and antioxidant, tree peony root bark extract has inhibitory effects on metalloproteinases and elastase, and has activating effects on cathepsins, all indicating that it has skin activating and anti-aging functions, combined with excellent antioxidant properties, and can be used Anti-aging cosmetics; In addition, it has a good contraction effect on collagen fiber gel, which means that it has astringent effect on the dermis of the skin. It can be used in products for firming and removing eye bags. In addition, it has good antibacterial and antibacterial and antibacterial properties. Inflammation can replace chemical preservatives and provide quality and safety guarantee for products.

Compared with the prior art, the present invention has the following advantages and beneficial effects:

(1) The natural plant eye spray of the present invention has no chemical preservatives, is safe, reliable, and non-irritating, and makes up for the shortcomings of most existing eye care products in terms of safety, ease of use, and insignificant effects. While effectively alleviating visual fatigue, eye interference and other problems, it can also moisturize the skin around the eyes. It has the dual effect of brightening and moisturizing eyes. It is especially suitable for computer people, elderly people with dry eyes and itchy eyes, and long-term driving with eyes. Members, students and other groups.

(2) Each component in the natural plant eye spray of the present invention is in the form of steam distillate, and the components are in the form of small molecules, with strong permeability, can reach the base directly, and moisturize the eyes and the skin around the eyes more deeply , Reduce eye damage and lasting effect.

(3) The natural plant eye spray of the present invention is used in conjunction with a spray bottle, which is more convenient and portable to use, and is not limited by the time, space and frequency of use.

(4) In the preparation method of the present invention, microporous membrane filtration, ultra-high temperature instantaneous sterilization technology and a combined sterilization form of natural plant antibacterial agents are used for sterilization treatment, which greatly reduces the risk of contamination and ensures the use of products safety.

Detailed ways

The technical solutions of the present invention will be further described in detail below with reference to specific examples, but the protection scope and implementation manners of the present invention are not limited thereto. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the technical field of the present invention. The terminology used in the specification of the present invention herein is only for the purpose of describing specific embodiments, and is not intended to limit the present invention. In the specific embodiments, unless otherwise explained, the technical means used are in accordance with the conventional means used by those skilled in the technical field of the present invention.

In a specific embodiment, the peony root bark extract used is extracted from the dried root bark of the Ranunculaceae plant peony, the grade is food grade, and the solubility is water-soluble.

Example 1

50 parts of mugwort water, 20 parts of green tea water, 20 parts of chrysanthemum water, 9 parts of roselle flower water, 1 part of peony root bark extract.

Wherein, the mugwort leaf water, green tea leaf water, chrysanthemum water and roselle flower water are all prepared by the following methods:

Weigh the freshly picked mugwort leaves, green tea leaves, chrysanthemum or roselle flowers, wash and cut them, steam distill, condense and collect 2-8 times the weight of the distillate to obtain mugwort leaf water, green tea leaf water, and chrysanthemum water. And roselle flower water. And, in this embodiment, specifically, the collected weight of the distillate of mugwort leaf water is twice the weight of freshly picked mugwort leaves, the collected weight of the distilled liquid of green tea leaf water is 4 times the weight of freshly picked green tea leaves, and the weight of chrysanthemum water is 4 times the weight of freshly picked green tea leaves. The weight of distillate collected is 8 times the weight of freshly picked chrysanthemums, and the weight of distillate collected from roselle flower water is 6 times the weight of freshly picked roselle flowers.

The natural plant eye spray of this embodiment is used in conjunction with a spray bottle, which is more convenient and portable to use, and is not limited by the time, space and frequency of use.

To prepare the natural plant spray of this embodiment, the specific steps are as follows

(1) According to the said mass parts, weigh the moxa leaf water, green tea leaf water, chrysanthemum water and roselle flower water, fully mix and mix to obtain eye spray lotion.

(2) Pass the eye spray lotion through a food-grade folded simple microporous polyethersulfone filter membrane with a pore size of 0.22μm for positive pressure filtration to remove impurities and sterilize, and the filter pressure difference is 0.2MPa to obtain a pure eye spray lotion .

(3) After heat preservation and sterilization of the pure eye spray lotion at 130°C for 6 seconds, it is quickly cooled to below 40°C to complete the ultra-high temperature instantaneous sterilization to obtain a sterile eye spray lotion.

(4) Weigh the peony root bark extract according to the said mass parts, and add it to the above-mentioned sterile eye spray lotion in a sterile environment, and stir it evenly to obtain the eye spray use solution.

(5) Perform aseptic filling of the eye spray liquid in the aseptic production workshop, and the aseptic filling includes ozone disinfection of the inner packaging material before filling, ultraviolet space sterilization in the filling room, and aseptic operation by the operator. , To obtain the natural plant eye spray.

Example 2

70 parts of mugwort water, 14.3 parts of green tea water, 10 parts of chrysanthemum water, 5 parts of roselle flower water, and 0.7 parts of peony root bark extract.

Weigh the freshly picked mugwort leaves, green tea leaves, chrysanthemum or roselle flowers, wash and cut them, steam distill, condense and collect 2-8 times the weight of the distillate to obtain mugwort leaf water, green tea leaf water, and chrysanthemum water. And roselle flower water. And, in this embodiment, specifically, the collected weight of the distillate of mugwort leaf water is 8 times the weight of freshly picked mugwort leaves, the collected weight of the distilled liquid of green tea leaf water is twice the weight of freshly picked green tea leaves, and the weight of chrysanthemum water is 8 times the weight of freshly picked mugwort leaves. The weight of distillate collected is 6 times the weight of freshly picked chrysanthemums, and the weight of distillate collected from roselle flower water is twice the weight of freshly picked roselle flowers.

(1) According to the said mass parts, weigh the moxa leaf water, the green tea leaf water, the chrysanthemum water and the roselle flower water, fully mix and mix to obtain the eye spray lotion.

(3) After heat preservation and sterilization of the pure eye spray lotion at 137°C for 4 seconds, it is quickly cooled to below 40°C to complete the ultra-high temperature instantaneous sterilization to obtain a sterile eye spray lotion.

Example 3

65 parts of mugwort leaf water, 10 parts of green tea leaf water, 14.8 parts of chrysanthemum water, 10 parts of roselle flower water, 0.2 parts of Dandan root bark extract.

Weigh the freshly picked mugwort leaves, green tea leaves, chrysanthemum or roselle flowers, wash and cut them, steam distill, condense and collect 2-8 times the weight of the distillate to obtain mugwort leaf water, green tea leaf water, and chrysanthemum water. And roselle flower water. And, in this embodiment, specifically, the collected weight of the distillate of mugwort leaf water is 5 times the weight of the freshly picked mugwort leaves, and the collected weight of the distilled liquid of green tea leaf water is 8 times the weight of the freshly picked green tea leaves. The collected weight of the distillate is twice the weight of the freshly picked chrysanthemum, and the collected weight of the distillate of the roselle flower water is 8 times the weight of the freshly picked roselle.

(2) Pass the eye spray lotion through a food-grade folded simple microporous polyethersulfone filter membrane with a pore size of 0.22 μm for positive pressure filtration to remove impurities and bacteria, and the filtration pressure difference is 0.25 MPa to obtain a pure eye spray lotion .

(3) After heat preservation and sterilization of the pure eye spray lotion at 135°C for 5 seconds, it is quickly cooled to below 40°C to complete the ultra-high temperature instantaneous sterilization to obtain a sterile eye spray lotion.

Animal experiment

In order to demonstrate the zero irritation of the natural plant eye spray of the present invention to eyeballs, an animal eye irritation experiment is now performed. In the experiment, 4 female New Zealand rabbits of equal weight were selected, and self-control was used. The left eye of the animal was the test eye and the right eye was the blank control eye. The eye spray liquid used in Example 2 was used for the rabbit eyes at a dose of 0.1ml/eye. After exposure, the eye irritation response was observed at 1h, 24h, 48h, and 72h respectively. The experimental results are shown in Table 1.

Table 1 Animal eye irritation test results

From the results shown in Table 1, it can be seen that after the natural plant eye spray of Example 2 was applied to the eyes of New Zealand rabbits, no adverse symptoms occurred, suggesting that the natural plant eye spray of the present invention is not irritating to the eyes.

In order to further consider the safety of the natural eye spray of the present invention on the skin around the eyes, several skin irritation experiments are now conducted. In the experiment, 4 female New Zealand rabbits of equal weight were selected. 24 hours before the experiment, the hair on both sides of the rabbit's back spine was removed with a razor. The left and right sides were 3cm*3cm. As the test area and the control area, 0.5ml of the natural in Example 2 was taken. The plant eye spray was applied to the test area once a day for 14 consecutive days; and from the second day, the skin of the test area and the control area were observed and scored 1 hour before each application. The experimental results are shown in Table 2.

Table 2 Results of safety test on animal eye skin

From the results shown in Table 2, it can be seen that after the natural plant eye spray of Example 2 was continuously applied to the skin of New Zealand rabbits, there were no adverse symptoms or abnormal phenomena, suggesting that the natural plant eye spray of the present invention has no effect on the skin. Irritating.

Effect

The natural plant eye spray product in Example 2 was used to conduct a market trial survey on 30 office workers, 4-6 times per day, and the trial time was 1 week. When using, make sure that the spray sweeps the eyes back and forth 2-3 times, blink your eyes lightly for natural absorption.

According to statistics, 80% of people report that their eyes feel more comfortable after use, which can instantly relieve eye fatigue; 40% of testers report that the preparation can significantly improve the dryness and soreness of eyes caused by watching the computer screen for a long time and not paying attention to rest. ; Another 2% of the testers said they felt their eyes brighter after use.

In summary, the natural plant eye spray provided by the present invention has the effects of relieving visual fatigue, dry eyes, and blurred vision caused by excessive eye use, and has achieved good effects in improving eyesight and protecting eyesight.

The above embodiments are only preferred embodiments of the present invention, and only provide a further detailed description of the technical solution of the present invention to help understand the principle of the technical solution of the present invention. At the same time, for those of ordinary skill in the art, according to the technical solution of the present invention, there will be changes in the specific implementation and the scope of application. In summary, any work done without departing from the principle and spirit of the present invention Changes, combinations, deletions, replacements or modifications, etc. will all be included in the protection scope of the present invention.

Claims

A natural plant eye spray, characterized in that, in parts by mass, it comprises the following components:

50-70 parts of mugwort water, 10-20 parts of green tea water, 10-20 parts of chrysanthemum water, 5-10 parts of roselle flower water, 0.2-1.0 parts of peony root bark extract.
The natural plant eye spray according to claim 1, wherein the mugwort leaf water, green tea leaf water, chrysanthemum water and roselle flower water are all prepared by the following methods:

After weighing the freshly picked mugwort leaves, green tea leaves, chrysanthemum or roselle flowers, they are washed, cut into pieces, steam distilled, and condensed to collect 2-8 times the weight of the distillate.
The natural plant eye spray according to claim 1, wherein the peony root bark extract is extracted from the dried root bark of the Ranunculaceae plant peony, the grade is food grade, and the solubility is water-soluble.
The natural plant eye spray according to any one of claims 1 to 3, wherein the natural plant eye spray is used in combination with a spray bottle.
The method for preparing the natural plant eye spray according to any one of claims 1 to 4, characterized in that it comprises the following steps:

(1) According to the said mass parts, weigh the mugwort leaf water, the green tea leaf water, the chrysanthemum water and the roselle flower water, fully mix and mix to obtain the eye spray lotion;

(2) Filter the eye spray lotion through an ultrafiltration membrane to remove bacteria and impurities to obtain a pure eye spray lotion;

(3) Subjecting the pure eye spray lotion to ultra-high temperature instantaneous sterilization to obtain a sterile eye spray lotion;

(4) Weigh the peony root bark extract according to the said mass parts, add it to the aseptic eye spray lotion in an aseptic environment, stir thoroughly, fill and seal aseptically to obtain the natural Plant eye spray.
The preparation method according to claim 5, characterized in that, in step (2), the ultrafiltration membrane is a food-grade folded simple microporous polyethersulfone membrane with a pore size of 0.22 μm, and its fine pore size has the ability to filter out Bacteria effect.
The preparation method according to claim 5, wherein in step (2), the ultrafiltration membrane is used for positive pressure filtration, and the filtration pressure difference is less than 0.3 MPa.
The preparation method according to claim 5, characterized in that, in step (3), the ultra-high temperature instantaneous sterilization is rapid cooling to below 40°C after being kept at 130-140°C and sterilized for 4-6 seconds.
The preparation method according to claim 5, characterized in that, in step (3), the aseptic filling includes ozone disinfection of the inner packaging material before filling, ultraviolet space sterilization of the filling room, and aseptic operation of the operator .