CN110613643A - Repair wrinkle-removing cream and preparation method thereof - Google Patents
Repair wrinkle-removing cream and preparation method thereof Download PDFInfo
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Abstract
The invention provides a repair wrinkle-removing cream which is characterized by being prepared from the following raw materials in percentage by mass: cannabidiol CBD2-20%, ginkgo leaf extract 1-5%, ganoderma lucidum extract 1-5%, immature bitter orange extract 0.1-0.5%, mineral concentrate 2-20%, hydrogenated castor oil polyoxyethylene ether-402-8%, castor oil polyoxyethylene ether-601-10%, medium-chain triglyceride 2-15%, glycerol 1-5%, stearic acid 1-5%, monoglyceride 1-5%, hyaluronic acid 0.1-0.5%, sorbic acid 0.02-0.1%, and the balance of water, wherein the total amount of the components is 100%. The cream solves the problems of poor transdermal effect, difficult skin absorption, serious loss of effective components and the like of the existing cream, improves the skin permeability and solubility of CBD, promotes the differentiation and proliferation of epidermal cells, makes the cuticle become firm, and enhances the curative effect of CBD by combining the synergistic effect of ginkgo leaf extract, ganoderma lucidum extract and immature bitter orange extract, so that the skin has obvious effects of elasticity, whiteness, glossiness, aging resistance, wrinkle resistance and oxidation resistance.
Description
Technical Field
The invention relates to a repair wrinkle-removing cream and a preparation method thereof, belonging to the technical field of cosmetics.
Background
With the rapid development of society, people pay more and more attention to skin care, the demand of cosmetics on the market is larger and larger, and the elements of beautiful skin are moisture retention, wrinkle resistance, whitening, oil control, nutrition supplement and the like. Due to daily ultraviolet rays and the damage of pollutants in the air, the skin color of modern urban people with high living pressure and fast pace is dark, dark yellow, lack of luster, easy allergy, pigmentation and the like, and the quality of life of women is directly influenced. How to care the skin becomes one of the most concerned issues for consumers. Wrinkles refer to small fine lines and wrinkles formed by the skin being affected by the external environment to form free radicals, which destroy collagen and active substances in normal cell membrane tissues and oxidize cells. The order of appearance of wrinkles is typically forehead, upper and lower eyelids, anterior ear, cheek, neck, chin, perioral. At present, most of wrinkle-removing repair creams in the market are composed of chemical components, and after the wrinkle-removing repair cream is smeared, the wrinkle-removing repair cream is not ideal in effect, has certain toxic and side effects and is greatly harmful to skin. With the improvement of living standard and the demand for self health, people pay more and more attention to the use effect of cosmetics while pursuing high-quality life, and try to keep skin beautiful.
The CBD is an effective component extracted from industrial hemp with THC content lower than 0.5 percent, is an extract of dry matter of flowers and leaves of the industrial hemp, is applied to the field of cosmetics, mainly can repair nerve fibers of a human body, has pharmacological activities of anti-inflammation, anti-allergy, anti-aging, antibiosis, antioxidation, ultraviolet resistance and the like, can relieve skin after being taken into the human body through the skin, and maintains the optimal state of the skin, thereby improving the skin quality from inside to outside, has wide development and application prospects, and has the wrinkle removing effect on the skin reported by the prior patent No. CN 108685729A. Therefore, there is a need for improvements in the prior art.
Disclosure of Invention
The first purpose of the invention is to provide a repair wrinkle-removing cream.
The second purpose of the invention is to provide a preparation method of the repair wrinkle-removing cream.
The first purpose of the invention is realized by the following technical scheme: the repair wrinkle-removing cream is characterized by being prepared from the following raw materials in percentage by mass:
the sum of the above components is 100%.
The cannabidiol CBD is a commercial product, is an effective component extracted from industrial cannabis with THC content lower than 0.3%, belongs to a non-addictive active substance, has the effects of easing pain, resisting tumor, resisting nausea and vomiting, treating mental and cerebral diseases, resisting inflammation, resisting bacteria and the like, can mainly repair nerve fibers of a human body in the field of cosmetics, and has pharmacological activities of resisting inflammation, allergy, aging, bacteria, oxidation, ultraviolet rays and the like.
The folium Ginkgo extract is extracted from dry leaves of Ginkgo biloba of Ginkgoaceae, and has effects of promoting blood circulation for removing blood stasis, dredging collaterals, relieving pain, astringing lung, relieving asthma, eliminating turbid pathogen, and reducing blood lipid.
The Ganoderma extract is extracted from fruiting body of Ganoderma of Polyporaceae, and has effects of invigorating qi, tranquilizing mind, relieving cough and asthma, and prolonging life.
The fructus Aurantii Immaturus extract is essential oil extracted from dried young fruit of Citrus aurantium L or Citrus sinensis Roxb of Rutaceae.
The mineral substance concentrated solution is a commercial product and is a green and healthy raw material type component.
The hydrogenated castor oil polyoxyethylene ether-40 and the castor oil polyoxyethylene ether-60 are cosmetic grade emulsifiers and are used as surfactants or emulsifiers for cream.
The medium chain triglycerides are oil phases.
The glycerol is a commercially available cosmetic grade product and is used as a cream humectant.
The stearic acid and the monoglyceride are commercially available cosmetic products and are used as main oil phases of cream.
The hyaluronic acid is a commercially available cosmetic grade product and is used as a main moisturizing raw material of cream.
The sorbic acid is a medical grade preservative and a preservative which are purchased in the market.
The second purpose of the invention is realized by the following technical scheme: the preparation method of the repair wrinkle-removing cream is characterized by comprising the following steps:
1) preparing the following raw materials in percentage by mass:
the sum of the components is 100 percent;
(2) placing cannabidiol CBD into medium-chain triglyceride, heating and stirring until the temperature of the medium-chain triglyceride reaches 30-67 ℃, completely dissolving the cannabidiol CBD, and standing to room temperature to obtain an oil solution;
(3) adding castor oil polyoxyethylene ether-60, hydrogenated castor oil polyoxyethylene ether-40, glycerol, hyaluronic acid and an immature bitter orange extract into the oil soluble substance obtained in the step (2), uniformly mixing, adding mineral concentrated solution diluted by water into the mixture to form mineral concentrated solution with volume concentration of 15% -30%, and stirring the mineral concentrated solution at the speed of 10-50r/s until solid is completely dissolved to obtain a base material;
(4) adding stearic acid, monoglyceride, folium Ginkgo extract, and Ganoderma extract into water, heating and stirring at 40-60 deg.C and 20-80r/s until the solid is completely dissolved to obtain dissolved substance;
(5) and (4) dropwise adding the base material obtained in the step (3) into the dissolved substance obtained in the step (4), and adding sorbic acid to adjust the pH value to 5-6 to obtain the repairing and wrinkle-removing cream containing cannabidiol CBD.
The ginkgo leaf extract is prepared by the following operations: adding 95% ethanol into dry folium Ginkgo, stirring for 1-4 hr to swell, adding the same ethanol, soaking for 8-12 hr, percolating, collecting filtrate, and concentrating the filtrate under reduced pressure to obtain extract.
The ganoderma lucidum extract is prepared by the following steps: naturally drying Ganoderma, baking at 50-80 deg.C for 1-5 hr, pulverizing the baked Ganoderma, adding 95% ethanol at a material liquid mass ratio of 1:4-1:10, distilling under reduced pressure, and concentrating the collected ethanol extractive solution under reduced pressure for 2-3 hr to obtain Ganoderma extract.
The immature bitter orange extract is prepared by the following steps: sun drying fructus Aurantii Immaturus, pulverizing, adding 10-30 times of water, soaking for 4-8 hr, distilling for 8 hr, and collecting essential oil to obtain fructus Aurantii Immaturus extract.
The invention has the following advantages and effects: the repair wrinkle-removing cream containing cannabidiol CBD obtained by adopting the technical scheme solves the problems of poor transdermal effect, difficult skin absorption, serious loss of effective components and the like of the existing cream, particularly, through a nano-emulsion technology, an oil phase, a water phase, a surfactant and a cosurfactant form a transparent or semitransparent dispersion, the problem that the existing cannabidiol CBD is difficult to dissolve is solved, the skin permeability and the solubility of the cannabidiol CBD are improved, the added mineral concentrated solution is very close to body fluid of a human body, contains balanced minerals and is easy to be absorbed by the skin, the differentiation and the proliferation of epidermal cells are promoted, the stratum corneum is firmed, the cell metabolism is promoted, the natural healing force of the skin is improved, and meanwhile, the synergistic effect of the cannabidiol CBD is enhanced and the effect of medicaments is stabilized by combining the synergistic effect of ginkgo leaf extract, ganoderma lucidum extract and immature bitter orange extract, it also has effects in improving skin elasticity, whitening skin, and restoring skin luster, and has antiaging, wrinkle removing, and antioxidant effects.
Detailed Description
The present invention will be further described with reference to the following examples.
Example 1
A preparation method of a repair wrinkle-removing cream comprises the following steps:
1) preparing the following raw materials in percentage by mass:
(2) firstly, placing cannabidiol CBD into medium-chain triglyceride, heating and stirring until the temperature of the medium-chain triglyceride reaches 30 ℃, completely dissolving the cannabidiol CBD, and then placing the mixture to room temperature to obtain an oil soluble substance;
(3) adding castor oil polyoxyethylene ether-60, hydrogenated castor oil polyoxyethylene ether-40, glycerol, hyaluronic acid and an immature bitter orange extract into the oil soluble substance obtained in the step (2), uniformly mixing, adding mineral concentrated solution diluted by water to form 15% volume concentration, and stirring at the speed of 50r/s until solid substances are completely dissolved to obtain a base material;
(4) heating stearic acid, monoglyceride, folium Ginkgo extract, and Ganoderma extract at 40 deg.C until stearic acid and monoglyceride are dissolved, adding glycerol, hyaluronic acid and the rest water, and stirring at 20r/s until folium Ginkgo extract and Ganoderma extract are completely dissolved to obtain solution;
(5) and (4) dropwise adding the base material obtained in the step (3) into the dissolved substance obtained in the step (4), and adding sorbic acid to adjust the pH value to 6 to obtain the repairing and wrinkle-removing cream containing cannabidiol CBD.
The ginkgo leaf extract is prepared by the following operations: adding 95 v/v% ethanol into dried folium Ginkgo, stirring for 1 hr for swelling, adding 95% ethanol, soaking for 10 hr, percolating, collecting filtrate, and concentrating the filtrate under reduced pressure to obtain extract.
The ganoderma lucidum extract is prepared by the following steps: naturally drying Ganoderma, baking at 50 deg.C for 1 hr, pulverizing the baked Ganoderma, adding 95 v/v% ethanol, distilling under reduced pressure at a ratio of material to liquid of 1:4, collecting ethanol extractive solution, and concentrating the ethanol extractive solution for 2 hr to obtain Ganoderma extract.
The immature bitter orange extract is prepared by the following steps: sun drying fructus Aurantii Immaturus, pulverizing, adding 10 times of water, soaking for 8 hr, distilling with steam distillation device for 8 hr, and collecting essential oil to obtain fructus Aurantii Immaturus extract.
Example 2
A preparation method of a repair wrinkle-removing cream comprises the following steps:
1) preparing the following raw materials in percentage by mass:
(2) placing cannabidiol CBD into medium-chain triglyceride, heating and stirring at 40 deg.C until the temperature of medium-chain triglyceride reaches 40 deg.C, completely dissolving cannabidiol CBD, and standing to room temperature to obtain oil solution;
(3) adding castor oil polyoxyethylene ether-60, hydrogenated castor oil polyoxyethylene ether-40, glycerol, hyaluronic acid and an immature bitter orange extract into the oil soluble substance obtained in the step (2), uniformly mixing, adding a mineral concentrated solution diluted by water to form a mineral concentrated solution with the volume concentration of 17%, and stirring at the speed of 20r/s until the solid is completely dissolved to obtain a base material;
(4) heating stearic acid, monoglyceride, folium Ginkgo extract and Ganoderma extract at 40-60 deg.C until stearic acid and monoglyceride are dissolved, adding glycerol, hyaluronic acid and the rest water, and stirring at 40r/s until folium Ginkgo extract and Ganoderma extract are completely dissolved to obtain solution;
(5) and (4) dropwise adding the base material obtained in the step (3) into the dissolved substance obtained in the step (4), and adding sorbic acid to adjust the pH value to 6 to obtain the repairing and wrinkle-removing cream containing cannabidiol CBD.
The ginkgo leaf extract is prepared by the following operations: adding 95 v/v% ethanol into dried folium Ginkgo, stirring for 2.5 hr for swelling, adding 95% ethanol, soaking for 10-12 hr, percolating, collecting filtrate, and concentrating the filtrate under reduced pressure to obtain flos Lonicerae extract.
The ganoderma lucidum extract is prepared by the following steps: naturally drying Ganoderma, baking at 65 deg.C for 2 hr, pulverizing the baked Ganoderma, adding 95 v/v% ethanol, distilling under reduced pressure at a ratio of material to liquid of 1:5, collecting ethanol extractive solution, and concentrating the ethanol extractive solution for 2 hr by reduced pressure distillation device to obtain Ganoderma extract.
The immature bitter orange extract is prepared by the following steps: sun drying fructus Aurantii Immaturus, pulverizing, adding 30 times of water, soaking for 4 hr, distilling with steam distillation device for 8 hr, and collecting essential oil to obtain fructus Aurantii Immaturus extract.
Example 3
A preparation method of a repair wrinkle-removing cream comprises the following steps:
(1) preparing the following raw materials in percentage by mass:
the sum of the components is 100 percent;
(2) placing cannabidiol CBD into medium-chain triglyceride, heating and stirring at 45 ℃ until the temperature of the medium-chain triglyceride reaches 45 ℃ to completely dissolve the cannabidiol CBD, and then placing to room temperature to obtain an oil soluble substance;
(3) adding castor oil polyoxyethylene ether-60, hydrogenated castor oil polyoxyethylene ether-40, glycerol, hyaluronic acid and an immature bitter orange extract into the oil soluble substance obtained in the step (2), uniformly mixing, adding a mineral concentrated solution diluted by water to form a volume concentration of 19%, and stirring at the speed of 30r/s until the solid is completely dissolved to obtain a base material;
(4) heating stearic acid, monoglyceride, folium Ginkgo extract, and Ganoderma extract at 50 deg.C until stearic acid and monoglyceride are dissolved, adding glycerol, hyaluronic acid and the rest water, and stirring at 20-80r/s until folium Ginkgo extract and Ganoderma extract are completely dissolved to obtain solution;
(5) and (4) dropwise adding the base material obtained in the step (3) into the dissolved substance obtained in the step (4), and adding sorbic acid to adjust the pH value to 6 to obtain the repairing and wrinkle-removing cream containing cannabidiol CBD.
The ginkgo leaf extract is prepared by the following operations: adding 95 v/v% ethanol into dried folium Ginkgo, stirring for 2-4 hr for swelling, adding 95% ethanol, soaking for 10 hr, percolating, collecting filtrate, and concentrating the filtrate under reduced pressure to obtain extract.
The ganoderma lucidum extract is prepared by the following steps: naturally drying Ganoderma, baking at 70 deg.C for 2 hr, pulverizing the baked Ganoderma, adding 95 v/v% ethanol, distilling under reduced pressure at a material-liquid ratio of 1:4-8, collecting ethanol extractive solution, and concentrating the ethanol extractive solution for 2 hr to obtain Ganoderma extract.
The immature bitter orange extract is prepared by the following steps: sun drying fructus Aurantii Immaturus, pulverizing, adding 20 times of water, soaking for 6 hr, distilling with steam distillation device for 8 hr, and collecting essential oil to obtain fructus Aurantii Immaturus extract.
Example 4
A preparation method of a repair wrinkle-removing cream comprises the following steps:
(1) preparing the following raw materials in percentage by mass:
the sum of the components is 100 percent;
(2) placing cannabidiol CBD into medium-chain triglyceride, heating and stirring at 60 ℃ until the temperature of the medium-chain triglyceride reaches 60 ℃, completely dissolving the cannabidiol CBD, and then placing to room temperature to obtain an oil soluble substance;
(3) adding castor oil polyoxyethylene ether-60, hydrogenated castor oil polyoxyethylene ether-40, glycerol, hyaluronic acid and an immature bitter orange extract into the oil soluble substance obtained in the step (2), uniformly mixing, adding a mineral concentrated solution diluted by water to form a volume concentration of 25%, and stirring at a speed of 10-40r/s until the solid is completely dissolved to obtain a base material;
(4) heating stearic acid, monoglyceride, folium Ginkgo extract, and Ganoderma extract at 55 deg.C until stearic acid and monoglyceride are dissolved, adding glycerol, hyaluronic acid and the rest water, and stirring at 60r/s until folium Ginkgo extract and Ganoderma extract are completely dissolved to obtain solution;
(5) and (4) dropwise adding the base material obtained in the step (3) into the dissolved substance obtained in the step (4), and adding sorbic acid to adjust the pH value to 6 to obtain the repairing and wrinkle-removing cream containing cannabidiol CBD.
The ginkgo leaf extract is prepared by the following operations: adding 95 v/v% ethanol into dried folium Ginkgo, stirring for 2-4 hr for swelling, adding 95% ethanol, soaking for 10 hr, percolating, collecting filtrate, and concentrating the filtrate under reduced pressure to obtain extract.
The ganoderma lucidum extract is prepared by the following steps: naturally drying Ganoderma, baking at 75 deg.C for 2.5h, pulverizing the baked Ganoderma, adding 95 v/v% ethanol, distilling under reduced pressure at a material-liquid ratio of 1:4-8, collecting ethanol extractive solution, and concentrating the ethanol extractive solution for 2h to obtain Ganoderma extract.
The immature bitter orange extract is prepared by the following steps: sun drying fructus Aurantii Immaturus, pulverizing, adding 15 times of water, soaking for 7 hr, distilling with steam distillation device for 8 hr, and collecting essential oil to obtain fructus Aurantii Immaturus extract.
Example 5
A preparation method of a repair wrinkle-removing cream comprises the following steps:
(1) preparing the following raw materials in percentage by mass:
the sum of the components is 100 percent;
(2) firstly, placing cannabidiol CBD into medium-chain triglyceride, heating and stirring at 67 ℃ until the temperature of the medium-chain triglyceride reaches 67 ℃, completely dissolving the cannabidiol CBD, and then placing to room temperature to obtain an oil soluble substance;
(3) adding castor oil polyoxyethylene ether-60, hydrogenated castor oil polyoxyethylene ether-40, glycerol, hyaluronic acid and an immature bitter orange extract into the oil soluble substance obtained in the step (2), uniformly mixing, adding a mineral concentrated solution diluted by water to be 30% in volume concentration, and stirring at the speed of 40r/s until the solid is completely dissolved to obtain a base material;
(4) heating stearic acid, monoglyceride, folium Ginkgo extract, and Ganoderma extract at 60 deg.C until stearic acid and monoglyceride are dissolved, adding glycerol, hyaluronic acid and the rest water, and stirring at 80r/s until folium Ginkgo extract and Ganoderma extract are completely dissolved to obtain solution;
(5) and (4) dropwise adding the base material obtained in the step (3) into the dissolved substance obtained in the step (4), and adding sorbic acid to adjust the pH value to 6 to obtain the repairing and wrinkle-removing cream containing cannabidiol CBD.
The ginkgo leaf extract is prepared by the following operations: adding 95 v/v% ethanol into dried folium Ginkgo, stirring for 4 hr to swell, adding 95% ethanol, soaking for 10 hr, percolating, collecting filtrate, and concentrating the filtrate under reduced pressure to obtain extract.
The ganoderma lucidum extract is prepared by the following steps: naturally drying Ganoderma, baking at 80 deg.C for 3 hr, pulverizing the baked Ganoderma, adding 95 v/v% ethanol, distilling under reduced pressure at a ratio of material to liquid of 1:8, collecting ethanol extractive solution, and concentrating the ethanol extractive solution for 3 hr by reduced pressure distillation device to obtain Ganoderma extract.
The immature bitter orange extract is prepared by the following steps: sun drying fructus Aurantii Immaturus, pulverizing, adding 10 times of water, soaking for 8 hr, distilling with steam distillation device for 8 hr, and collecting essential oil to obtain fructus Aurantii Immaturus extract.
Examples of the experiments
The invention is tested by the following test examples to test the safety of the product
Experimental example I detection of microorganisms
The detection method comprises the following steps: refer to technical Specification for safety of cosmetics
1. The detection items are as follows:
limit detection of total number of bacteria (cfu/mL), detection of fecal colibacillus, pseudomonas aeruginosa, staphylococcus aureus and pseudomonas aeruginosa
2. The result of the detection
| Detecting items | Detection standard | The result of the detection |
| Total number of bacteria/mL | ≦1000 | <5 |
| Fecal colibacillus per mL | Cannot be detected | Not detected out |
| Pseudomonas aeruginosa | Cannot be detected | Not detected out |
| Staphylococcus aureus | Cannot be detected | Not detected out |
| Pseudomonas aeruginosa | Cannot be detected | Not detected out |
Results
The microbial detection result of the invention is the limit result of the total number of bacteria (cfu/mL): <5, fecal escherichia coli, pseudomonas aeruginosa, staphylococcus aureus and pseudomonas aeruginosa were not detected, and the judgment was: the microbiological test for repairing the wrinkle removing cream of examples 1-5 reaches the standard
Third example, one-time damaged skin irritation test
Experimental reagents and materials: the repair wrinkle removal cream of examples 1 to 5, physiological saline, depilatory, 75% alcohol, scissors, dropper, gauze, plastic film, adhesive tape, sterile blade;
experimental animals: five rabbits were used for each example, with intact skin;
specific experimental method
(1) The hair on both sides of the spine of the rabbit is removed by depilatory 24 hours before the experiment, and the skin is not damaged. The dehairing range was about 3cmx3cm for each of the left and right.
(2) Before applying the test substance, the skin is cleaned with 75% alcohol on the unhaired skin with 2.5cm x2.5cm, the exposed skin is disinfected, after the alcohol is volatilized, a sterilized blade or an injection needle is used for scratching a 'well' -shaped damaged wound (the damaged skin only reaches the epidermis and does not damage the dermis) in the skin area, the damaged area is 6 x 6cm, the distance is 2cm, and 0.5ml of the test substance is applied to the damaged skin area. Bandaging and fixing, and using the skin on the other side as a blank control. After 24h, the residual test substance is removed by warm water or non-irritant solvent, and the condition of erythema and edema at the coating part and the recovery time and condition of skin change and the like are observed in 1h, 24h and 48h after the test substance is removed.
(3) The skin preparation before operation, the application of the test substance after operation and the observation of local skin reaction, and the scoring method are the same as above. Care was taken to identify differences between infection and primary stimulus response, and if infection was suspected, repeat testing should be performed.
The evaluation rules are: at each observation time point, animals were scored for erythema and edema formation according to the following table, and the scores of 3 animals were added at each time point (1h, 24h, 48h) and divided by the number of animals to obtain the skin irritation response integral mean (irritation index) at each time point.
Skin irritation response scoring criteria
The highest skin irritation index was taken and the test article was rated for its level of skin irritation intensity on animals according to the following table.
Skin irritation intensity grading
The experimental results are as follows:
skin breakdown test scoring results of example 1
Skin breakdown test scoring results of example 2
Skin breakdown test scoring results of example 3
Skin breakdown test scoring results of example 4
Skin Damage test scoring results of example 5
Experiments showed that each example and rabbit A, B, C produced a total integral of damage over the 1h, 24h, 48h time period: the stimulation index was 1. The eye observation group and the control group showed slight red swelling on the damaged skin after 24 hours, which is a normal reaction after the skin was damaged. After 72 hours, the skin is observed, the conditions such as erythema, edema and the like do not occur, bacterial infection does not exist, the wound is quickly recovered, and the skin irritation index is 0, which indicates that the repair wrinkle-removing cream prepared by the invention is safe in clinical medication and belongs to a non-irritant product.
Experimental example four
The CBD repair wrinkle-removing cream containing cannabidiol has the following effects on improving and repairing skin wrinkles, dryness, dark skin color, dark yellow, lack of luster, easy allergy, pigmentation and other skin problems after being smeared:
120 women with the ages of 25-60 years are selected, and the skin states of the women at different ages are respectively the problems of wrinkle, dryness, dark skin color, dull yellow, lack of luster, easy allergy, pigmentation and the like of the skin, so that the women respectively perform the trial experience.
Grouping design
120 women are randomly divided into 6 groups, namely an experimental group I, an experimental group II, an experimental group III, an experimental group IV, an experimental group V and a control group, wherein 20 women have no significant difference (P >0.05) in sex and age disease degree after statistical treatment.
1. The treatment method comprises the following steps that experimental groups 1-5 are coated with the CBD repair wrinkle-removing cream containing cannabidiol obtained in examples 1-5, and the cream is applied for 2 times a day for 30 days; the control group was applied with a commercially available skin-repair wrinkle-removal cream for 30 days, 2 times a day.
2. And (3) evaluating the curative effect:
the problems of dry skin, easy allergy and pigmentation after being smeared are solved, the problems of ruddy, glossy and fair skin complexion and smooth facial fine wrinkles are solved, the problems of dry skin, easy allergy and pigmentation after being smeared are solved, the ruddy and glossy skin complexion is effective, no feeling is caused after being smeared, and the problems of dry skin, allergy, dark skin complexion, dark yellow skin and lack of gloss are ineffective.
The total effective rate is as follows: (number of effective cases + number of effective cases)/number of experiments
Test results
And (4) conclusion: the effective rate of the treatment group is obviously superior to that of the control group, which shows that the repair wrinkle-removing cream has obvious effect on improving and repairing the problems of female skin wrinkles, dryness, dark and yellow skin color, lack of luster, easy allergy, pigmentation and the like after being smeared.
Claims (5)
1. The repair wrinkle-removing cream is characterized by being prepared from the following raw materials in percentage by mass:
2 to 20 percent of cannabidiol CBD,
1-5% of ginkgo leaf extract
1-5% of ganoderma lucidum extract
Fructus Aurantii Immaturus extract 0.1-0.5%
2 to 20 percent of mineral concentrated solution
Hydrogenated castor oil polyoxyethylene ether-402-8%
601-10% of castor oil polyoxyethylene ether,
medium chain triglycerides 2-15%
1-5% of glycerin
Stearic acid 1-5%
1 to 5 percent of monoglyceride
0.1 to 0.5 percent of hyaluronic acid,
sorbic acid 0.02-0.1%
Balance of water
The sum of the above components is 100%.
2. The preparation method of the repair wrinkle-removing cream is characterized by comprising the following steps:
(1) preparing the following raw materials in percentage by mass:
2 to 20 percent of cannabidiol CBD,
1-5% of ginkgo leaf extract
1-5% of ganoderma lucidum extract
Fructus Aurantii Immaturus extract 0.1-0.5%
2 to 20 percent of mineral concentrated solution
Hydrogenated castor oil polyoxyethylene ether-402-8%
601-10% of castor oil polyoxyethylene ether,
medium chain triglycerides 2-15%
1-5% of glycerin
Stearic acid 1-5%
1 to 5 percent of monoglyceride
0.1 to 0.5 percent of hyaluronic acid,
sorbic acid 0.02-0.1%
Balance of water
The sum of the components is 100 percent;
(2) placing cannabidiol CBD into medium-chain triglyceride, heating and stirring until the temperature of the medium-chain triglyceride reaches 30-67 ℃, completely dissolving the cannabidiol CBD, and standing to room temperature to obtain an oil solution;
(3) adding castor oil polyoxyethylene ether-60, hydrogenated castor oil polyoxyethylene ether-40, glycerol, hyaluronic acid and an immature bitter orange extract into the oil soluble substance obtained in the step (2), uniformly mixing, adding mineral concentrated solution diluted by water into the mixture to form mineral concentrated solution with volume concentration of 15% -30%, and stirring the mineral concentrated solution at the speed of 10-50r/s until solid is completely dissolved to obtain a base material;
(4) adding stearic acid, monoglyceride, folium Ginkgo extract, and Ganoderma extract into water, heating and stirring at 40-60 deg.C and 20-80r/s until the solid is completely dissolved to obtain dissolved substance;
(5) and (4) dropwise adding the base material obtained in the step (3) into the dissolved substance obtained in the step (4), and adding sorbic acid to adjust the pH value to 5-6 to obtain the repairing and wrinkle-removing cream containing cannabidiol CBD.
3. The cream for repairing and removing wrinkles as claimed in claim 1, wherein said ginkgo biloba leaf extract is prepared by the following steps: adding 95% ethanol into dry folium Ginkgo, stirring for 1-4 hr to swell, adding the same ethanol, soaking for 8-12 hr, percolating, collecting filtrate, and concentrating the filtrate under reduced pressure to obtain extract.
4. The cream for repairing and removing wrinkles as claimed in claim 1, wherein said extract of Ganoderma lucidum is prepared by the following steps: naturally drying Ganoderma, baking at 50-80 deg.C for 1-5 hr, pulverizing the baked Ganoderma, adding 95% ethanol at a material liquid mass ratio of 1:4-1:10, distilling under reduced pressure, and concentrating the collected ethanol extractive solution under reduced pressure for 2-3 hr to obtain Ganoderma extract.
5. The cream for repairing and removing wrinkles as claimed in claim 1, wherein said extract of immature bitter orange is prepared by the following steps: sun drying fructus Aurantii Immaturus, pulverizing, adding 10-30 times of water, soaking for 4-8 hr, distilling for 8 hr, and collecting essential oil to obtain fructus Aurantii Immaturus extract.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114159496A (en) * | 2020-09-10 | 2022-03-11 | 云南康恩贝植物研究院有限公司 | Hemp leaf extract and preparation method and application thereof |
| WO2024027113A1 (en) * | 2022-08-02 | 2024-02-08 | 安徽中医药大学 | Ganoderma lucidum extract nanoemulsion, preparation method therefor, and use thereof |
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2019
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114159496A (en) * | 2020-09-10 | 2022-03-11 | 云南康恩贝植物研究院有限公司 | Hemp leaf extract and preparation method and application thereof |
| WO2024027113A1 (en) * | 2022-08-02 | 2024-02-08 | 安徽中医药大学 | Ganoderma lucidum extract nanoemulsion, preparation method therefor, and use thereof |
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Application publication date: 20191227 |