CN108853187A - A kind of Chinese medicine composition, ophthalmically acceptable compound medicinal formulation and the easypro eye water for being sprayed on eyelid - Google Patents
A kind of Chinese medicine composition, ophthalmically acceptable compound medicinal formulation and the easypro eye water for being sprayed on eyelid Download PDFInfo
- Publication number
- CN108853187A CN108853187A CN201710321572.3A CN201710321572A CN108853187A CN 108853187 A CN108853187 A CN 108853187A CN 201710321572 A CN201710321572 A CN 201710321572A CN 108853187 A CN108853187 A CN 108853187A
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- CN
- China
- Prior art keywords
- extract
- borneol
- cassia seed
- chinese medicine
- medicine composition
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
Abstract
The application belongs to eye externally-applied health-care products field, and in particular to a kind of Chinese medicine composition, ophthalmically acceptable compound medicinal formulation and the easypro eye water for being sprayed on eyelid.Have effects that eye-catching Chinese medicine composition of refreshing oneself the present invention provides a kind of, including：Mint extract, Honegsukle flower P.E, cassia seed extract and borneol, each component compatibility is reasonable, and synergistic, can effectively releive optic nerve, alleviates eye strain；It using the plant extracts of integration of drinking and medicinal herbs as raw material, has no toxic side effect, irritation is small, safely and effectively.The present invention also provides a kind of easypro eye water for being sprayed on eyelid, and preparation is simple, easy to use.
Description
Technical field
The invention belongs to eye externally-applied health-care products fields, and in particular to a kind of Chinese medicine composition, ophthalmically acceptable compound medicinal formulation
With the easypro eye water for being sprayed on eyelid.
Background technique
In recent years with the variation of social environment, the quickening of work rhythm, the popularization and application of video terminal, people's spirit need to
The case where that asks increases, excess load eye is more and more frequent, causes more and more visual fatigue class patients can be more and more.Depending on tired
Labor is a kind of ophthalmology common disease, and the symptom of patient is varied, and common are close eye cannot be lasting, around eye and eye socket
Pain, blurred vision, eyes are dry and astringent, shed tears, and serious person's headache, dizziness directly affect the work and life of people.According to report
Road, long-term visual fatigue will lead to migraine, facial paralysis, glaucoma and retinal detachment, or even cause sudden death, therefore visual fatigue
The phenomenon that be worth giving extensive concern.Therefore, people it is highly desirable develop it is a kind of can be effectively relieved visual fatigue, refresh oneself it is eye-catching
Pharmaceutical composition.
Summary of the invention
In view of this, having effects that eye-catching pharmaceutical composition of refreshing oneself the purpose of the present invention is to provide a kind of, for delaying
Solve visual fatigue.
The specific technical solution of the present invention is as follows：
The present invention provides a kind of Chinese medicine compositions, including：Mint extract, Honegsukle flower P.E, cassia seed extract
And borneol.
Preferably, the mint extract is peppermint oil dementholized.
Preferably, the Honegsukle flower P.E is the ethanol extract of honeysuckle；
The cassia seed extract is the ethanol extract of cassia seed.
Preferably, by weight, the mint extract is 2~8 parts；
The cassia seed extract is 0.2~2 part；
The Honegsukle flower P.E is 2~6 parts；
The borneol is 1~4 part.
It is furthermore preferred that by weight, the mint extract is 6 parts；
The cassia seed extract is 0.4 part；
The Honegsukle flower P.E is 4 parts；
The borneol is 3 parts.
The present invention also provides a kind of ophthalmically acceptable compound medicinal formulations, which is characterized in that includes above-mentioned Chinese medicine composition and medicine
Acceptable auxiliary material on.
Preferably, the dosage form of the ophthalmically acceptable compound medicinal formulation is Alevaire, aqua, ejection preparation, syrup, solid
Grain, pill or tablet.
The present invention also provides a kind of easypro eye water for being sprayed on eyelid, by weight, including：
Preferably, the preparation method of the easypro eye water includes：
(1) borneol is taken, the ethyl alcohol dissolution is added, ultrasound mixes, and obtains borneol ethanol solution；
(2) it takes the peppermint oil dementholized and the Tween-80 to mix, is added in the borneol ethanol solution of step (1), side edged
It stirs at same direction, obtains borneol peppermint oil ethanol solution；
(3) extracting honeysuckle granule and cassia seed granule, add ethyl alcohol to infiltrate, and sonic oscillation 5 minutes, filter, receive
Collect filtrate to get the ethanol extract of honeysuckle cassia seed；
(4) borneol peppermint oil ethanol solution obtained in step (2) honeysuckle obtained in step (3) is slowly added to determine
In the ethanol extract of pine torch, side edged is stirred at same direction to get easypro eye water magma；
(5) easypro eye water magma and water that step (4) obtains are mixed in proportion, obtains the easypro eye water.
It is furthermore preferred that ratio described in step (5) is volume ratio 1:(18~20).
In conclusion have effects that eye-catching Chinese medicine composition of refreshing oneself the present invention provides a kind of, including：Peppermint is extracted
Object, Honegsukle flower P.E, cassia seed extract and borneol, each component compatibility is reasonable, and synergistic, can effectively releive optic nerve,
Alleviate eye strain；Each component is the plant extract source of integration of drinking and medicinal herbs, is had no toxic side effect, and irritation is small, safely and effectively.
The present invention also provides a kind of easypro eye water for being sprayed on eyelid, and preparation is simple, easy to use；It wherein also added a small amount of ethyl alcohol,
Ethyl alcohol and borneol synergistic effect, too strong stimulation will not be not only caused to delicate eye part skin, also enhances ophthalmically acceptable compound medicine
The effect of object preparation absorbing and cooling temperature.
Specific embodiment
Have effects that refresh oneself eye-catching Chinese medicine composition, ophthalmically acceptable compound medicinal formulation and be sprayed on eye the present invention provides a kind of
The easypro eye water of skin includes：Mint extract, Honegsukle flower P.E, cassia seed extract and borneol.
Peppermint is the dry aerial parts of Lamiaceae plant peppermint, according to《Compendium of Materia Medica》Record, peppermint start with it is lunar, foot faint
Yin, property is pungent cool, pungent to dissipate, and the cool clear benefit of energy, specially in Xiaofeng San heat, therefore headache intermittent headache, all diseases of eyes, throat, ability to speak, children shy
Heat and scrofula scabies are key medicine.Modern pharmacology research finds that 8 kinds of catechu naphthols acid contained in peppermint are effective anti-inflammatory agents.
Cassia seed is the dry mature seed of legume cassia or little cassia tora,《Sheng Nong's herbal classic》On through recording：Cassia
Son, main optic atrophy, mesh is excessive, and skin is red, tunica albuginea, swelling ophthalmalgia, lacrimation.Modern pharmacology research finds that cassia seed main component is rheum officinale
Phenol, Chrysophanol have very good bactericidal effect for alpha streptococcus, influenza bacteroid.
The pharmacological action of borneol includes：There are significant analgesia, sedation；Anti-inflammatory effect；It is true to some pathogenic skins
Bacterium has inhibiting effect.Since borneol can make corneal epithelial cell phospholipid bilayer motion more orderly, to increase cell membrane
Permeability, i.e. " efficacy-enhancing ingredient " effect of borneol, therefore borneol can promote the Transdermal absorption of other drugs, improve the blood of other drugs
Concentration and bioavilability.Said from modern medicine angle, peppermint, cassia seed and borneol reasonable compatibility, have anti-inflammatory, antibacterial,
It is antibacterial, refrigerant and the effect of refresh oneself.
The present invention is not particularly limited the source of mint extract and cassia seed extract, using those skilled in the art
It is known, such as commercial source；Or the extract being prepared using conventional technical means in the art.Further
, the mint extract is preferably peppermint oil dementholized, and the cassia seed extract is preferably cassia seed ethanol extract, the gold
Honeysuckle flower extract is preferably honeysuckle ethanol extract.
The content of contained active constituent is easy the influence of factors such as to be subject to processing, transport, store and pack in the prepared slices of Chinese crude drugs,
Unstable quality.Therefore, the cassia seed uses cassia seed granule in the present invention, and the honeysuckle is matched using honeysuckle
Square particle.Related pharmacology equivalence trial data show that the cassia seed granule totality drug effect of anthraquinone component enrichment is better than
Water decoction.The present invention replaces the prepared slices of Chinese crude drugs using Chinese medicinal granule or plants essential oil, under the premise of guaranteeing clinical equivalent,
Greatly simplifie operating procedure.
Technical solution of the present invention is clearly and completely described below in conjunction with the specific embodiment of the invention, it is clear that
Described embodiment is a part of the embodiment of the present invention, instead of all the embodiments.Those skilled in the art should manage
Solution, modifies to specific embodiments of the present invention or is replaced on an equal basis to some technical characteristics, without departing from the present invention
The spirit of technical solution should all cover in the scope of protection of the invention.
Honeysuckle dispensing granule employed in following embodiment is purchased from Guangdong Yifang Pharmaceutical Co., Ltd；Cassia seed formula
Particle is purchased from Tianjiang Pharmaceutical Industry Co., Ltd., Jiangyin；Peppermint oil dementholized is purchased from Jian County natural perfume material oil extract Co., Ltd；Borneol purchase
From three Borneolum of the village Bao Chang Tai Yuan, Hong Kong.
Embodiment 1
According to parts by weight, easypro eye water provided in the present embodiment includes：4 parts of Honegsukle flower P.E, cassia seed extract
0.4 part of object, 6 parts of peppermint oil dementholized, 3 parts of borneol, Tween-80 are 9 parts, 37 parts of ethyl alcohol.The following are specific preparation process：
(1) borneol is taken, ethyl alcohol dissolution is added, ultrasound mixes, spare.
(2) it takes peppermint oil dementholized and cosolvent Tween-80 to mix, step (1) is added and is made in middle borneol solution, side edged is pressed
Same direction stirring, obtains the borneol solutions of mint oil as made from solubilising-double solvents method.
(3) extracting honeysuckle granule and cassia seed granule, add ethyl alcohol to infiltrate, and sonic oscillation 5 minutes, cross 0.22 μm
Organic phase miillpore filter, collect filtrate to get honeysuckle cassia seed alcohol extract, it is spare.
(4) borneol solutions of mint oil obtained in step (2) is slowly added to honeysuckle cassia seed obtained in step (3)
Alcohol extract in, while be stirred at same direction to get easypro eye water magma 1, it is spare；
(5) easypro eye water magma 1 obtained in 1mL step (4) is drawn, is slowly added in the purified water of 19mL, side edged stirs
It mixes, mixes to get easypro eye water finished product 1.
The application method of the easypro eye water of the present embodiment is：Close eyes, using nanospray instrument by this product be sprayed on eyelid and
Around eye socket.
Embodiment 2
According to parts by weight, easypro eye water provided in the present embodiment includes：2 parts of Honegsukle flower P.E, cassia seed extract
0.2 part of object, 2 parts of peppermint oil dementholized, 1 part of borneol, Tween-80 are 1 part, 37 parts of ethyl alcohol.Its specific preparation process and application method are such as
Shown in embodiment 1.
Embodiment 3
According to parts by weight, easypro eye water provided in the present embodiment includes：6 parts of Honegsukle flower P.E, cassia seed extract
2 parts of object, 8 parts of peppermint oil dementholized, 4 parts of borneol, Tween-80 are 9 parts, 37 parts of ethyl alcohol.Its specific preparation process and application method are strictly according to the facts
It applies shown in example 1.
It should be pointed out that specific embodiment is the more representational example of the present invention, it is clear that skill of the invention
Art scheme is not limited to the above embodiments, and can also have many variations.Those skilled in the art define public affairs with the present invention
Written description open or according to file is undoubted to be obtained, and this patent scope of the claimed is considered as.
Claims (10)
1. a kind of Chinese medicine composition, which is characterized in that including：Mint extract, Honegsukle flower P.E, cassia seed extract and ice
Piece.
2. Chinese medicine composition according to claim 1, which is characterized in that the mint extract is peppermint oil dementholized.
3. Chinese medicine composition according to claim 1, which is characterized in that the Honegsukle flower P.E is the ethyl alcohol of honeysuckle
Extract；
The cassia seed extract is the ethanol extract of cassia seed.
4. Chinese medicine composition according to claim 1, which is characterized in that by weight, the mint extract be 2~
8 parts；
The cassia seed extract is 0.2~2 part；
The Honegsukle flower P.E is 2~6 parts；
The borneol is 1~4 part.
5. Chinese medicine composition according to claim 1, which is characterized in that by weight, the mint extract is 6
Part；
The cassia seed extract is 0.4 part；
The Honegsukle flower P.E is 4 parts；
The borneol is 3 parts.
6. a kind of ophthalmically acceptable compound medicinal formulation, which is characterized in that include Chinese medicine described in 1 to 5 any one of the claims
Composition and pharmaceutically acceptable auxiliary material.
7. ophthalmically acceptable compound medicinal formulation according to claim 6, which is characterized in that its dosage form is Alevaire, aqua, injection
Preparation, syrup, solid particle, pill or tablet.
8. a kind of easypro eye water for being sprayed on eyelid, which is characterized in that by weight, including：
9. easypro eye water according to claim 8, which is characterized in that preparation method includes：
(1) borneol is taken, the ethyl alcohol dissolution is added, ultrasound mixes, and obtains borneol ethanol solution；
(2) it takes the peppermint oil dementholized and the Tween-80 to mix, is added in the borneol ethanol solution of step (1), side edged is by same
The stirring of one direction, obtains borneol peppermint oil ethanol solution；
(3) extracting honeysuckle granule and cassia seed granule, add ethyl alcohol to infiltrate, and sonic oscillation 5 minutes, filter was collected in filtering
Liquid to get honeysuckle cassia seed ethanol extract；
(4) borneol peppermint oil ethanol solution obtained in step (2) is slowly added to honeysuckle cassia seed obtained in step (3)
Ethanol extract in, side edged is stirred at same direction to get easypro eye water magma；
(5) easypro eye water magma and water that step (4) obtains are mixed in proportion, obtains the easypro eye water.
10. easypro eye water according to claim 9, which is characterized in that ratio described in step (5) is volume ratio 1:(18~
20)。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710321572.3A CN108853187A (en) | 2017-05-09 | 2017-05-09 | A kind of Chinese medicine composition, ophthalmically acceptable compound medicinal formulation and the easypro eye water for being sprayed on eyelid |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710321572.3A CN108853187A (en) | 2017-05-09 | 2017-05-09 | A kind of Chinese medicine composition, ophthalmically acceptable compound medicinal formulation and the easypro eye water for being sprayed on eyelid |
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| CN108853187A true CN108853187A (en) | 2018-11-23 |
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| CN201710321572.3A Pending CN108853187A (en) | 2017-05-09 | 2017-05-09 | A kind of Chinese medicine composition, ophthalmically acceptable compound medicinal formulation and the easypro eye water for being sprayed on eyelid |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111905023A (en) * | 2020-07-28 | 2020-11-10 | 成都蜜儿堂职业技能培训学校有限公司 | Cold and hot medicinal moxibustion with effects of relieving fatigue, reducing fine lines and protecting eyes and preparation method thereof |
| CN112704705A (en) * | 2021-02-05 | 2021-04-27 | 广州新锐视光学科技有限公司 | Traditional Chinese medicine eye patch for relieving visual fatigue and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1394596A (en) * | 2002-06-30 | 2003-02-05 | 丛繁滋 | Peroral and pernasal administration compound, spray and auxiliary preparation and its preparation method |
| CN101564375A (en) * | 2008-04-25 | 2009-10-28 | 北京和润创新医药科技发展有限公司 | Chinese medicinal in situ forming eye gel |
| CN104288334A (en) * | 2014-09-17 | 2015-01-21 | 张道敬 | Traditional Chinese medicine eye drop for relieving eyestrain and preparation method thereof |
-
2017
- 2017-05-09 CN CN201710321572.3A patent/CN108853187A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1394596A (en) * | 2002-06-30 | 2003-02-05 | 丛繁滋 | Peroral and pernasal administration compound, spray and auxiliary preparation and its preparation method |
| CN101564375A (en) * | 2008-04-25 | 2009-10-28 | 北京和润创新医药科技发展有限公司 | Chinese medicinal in situ forming eye gel |
| CN104288334A (en) * | 2014-09-17 | 2015-01-21 | 张道敬 | Traditional Chinese medicine eye drop for relieving eyestrain and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111905023A (en) * | 2020-07-28 | 2020-11-10 | 成都蜜儿堂职业技能培训学校有限公司 | Cold and hot medicinal moxibustion with effects of relieving fatigue, reducing fine lines and protecting eyes and preparation method thereof |
| CN112704705A (en) * | 2021-02-05 | 2021-04-27 | 广州新锐视光学科技有限公司 | Traditional Chinese medicine eye patch for relieving visual fatigue and preparation method thereof |
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Application publication date: 20181123 |