CN104288334A - Traditional Chinese medicine eye drop for relieving eyestrain and preparation method thereof - Google Patents
Traditional Chinese medicine eye drop for relieving eyestrain and preparation method thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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Abstract
The invention belongs to the field of traditional Chinese medicine preparations and particularly relates to a traditional Chinese medicine eye drop for relieving eyestrain and a preparation method thereof. The eye drop contains the following drugs in parts by weight: 10-20 parts of flos chrysanthemi, 5-8 parts of honeysuckle flower, 2-3 parts of borneol, 10-15 parts of cassia seed, 5-8 parts of rose, 3-5 parts of mint, 10-20 parts of wolfberry, 0.1-1 part of vitamin A and 0.1-1 part of vitamin E. The eye drop disclosed by the invention is prepared by adopting modern advanced medicine pharmaceutical technologies, has the effects of clearing heat and purging fire, relieving spasm and removing nephelium and nourishing the liver to improve visual acuity, and is used for treating impaired vision and adolescent pseudomyopia and relieving symptoms, such as conjunctival congestion and eye itching, caused by eye visual fatigue and eyestrain, and the selected medicinal materials are appropriate in combination, remarkable in treatment effect, high in safety performance, free from side effect and low in cost, so that the eye drop is worthy of extensive popularization and application.
Description
Technical field
The invention belongs to field of traditional Chinese, be specifically related to asthenopic traditional Chinese medicine eye drops of a kind of alleviation and preparation method thereof.
Background technology
Eyestrain is a kind of ophthalmology common disease, and the eye caused by it is dry, eye is puckery, eye is sour swollen, and blurred vision even visual deterioration directly affects work and the life of people.Eyestrain mainly due to people concentrate at ordinary times to see computer screen time, eyes number of winks reduces, and causes tear Secretion to reduce, and the fluorescent screen intense stimulus eyes of simultaneously glimmering cause.It can cause the corresponding sites such as the neck of people, shoulder to occur pain, also can cause and increase the weight of various oculopathy.
Along with the quickening of modern cultural rhythm of life, work, study hypertonicity, over-burden for psychological diathesis, in addition ecological environment unclean pollution, as the impact of the air quality such as dirt in air, smog and self psychentonia, it is improper that work and rest is coordinated, long-term excess eye-using or eyes can not get taking good care of fully and having a rest, the eyes pathological changes that factors brings out simultaneously gets more and more, pathological changes in various degree can cause eye vision and decline, form myopia, amblyopia, asthenopia or occur the diseases such as eye is aching and tired, eye frame pain, blurred vision, dim eyesight seriously can be made even blind.According to the incomplete statistics of social medicine newspapers and periodicals interrelated data, in the large, medium and small student in the whole nation, eye vision decline and rate of myopia account for 40% ~ 60%, its students in middle and primary schools' rate of myopia is 4.9%, just, in high school student rate of myopia is 52%, and myopia, amblyopia, asthenopia disease sickness rate rise with the speed of annual 5%.Heredity and developing myopia have become the current serious problem of society today affecting teenager vision health.Therefore, seek effective anti-eyestrain's pharmaceutical preparation, pre-myopia prevention, eliminate asthenopia, recover vision health, control and prevention ophthalmic disease, be problem and the direction of domestic and international ophthalmology academia joint research discussion always.
Summary of the invention
According to above the deficiencies in the prior art, the invention provides and a kind of alleviate asthenopic traditional Chinese medicine eye drops and preparation method thereof, it is evident in efficacy, safe and reliable, have no side effect, there is wide potential applicability in clinical practice.
One of the present invention alleviates asthenopic traditional Chinese medicine eye drops, according to weight parts, comprise following ingredient: Flos Chrysanthemi 10 ~ 20 parts, Flos Lonicerae 5 ~ 8 parts, Borneolum Syntheticum 2 ~ 3 parts, Semen Cassiae 10 ~ 15 parts, Flos Rosae Rugosae 5 ~ 8 parts, Herba Menthae 3 ~ 5 parts, Fructus Lycii 10 ~ 20 parts, vitamin A 0.1 ~ 1 part and vitamin E 0.1 ~ 1 part.
Wherein, preferred version is as follows:
According to weight parts, comprise following ingredient: Flos Chrysanthemi 15 parts, Flos Lonicerae 6 parts, Borneolum Syntheticum 2 parts, Semen Cassiae 10 parts, Flos Rosae Rugosae 5 parts, Herba Menthae 3 parts, Fructus Lycii 15 parts, vitamin A 0.5 part and vitamin e1 part.
The preparation method of the asthenopic traditional Chinese medicine eye drops of alleviation of the present invention, during preparation, carry out according to following steps:
(1) first Flos Chrysanthemi, Flos Lonicerae, Semen Cassiae, Flos Rosae Rugosae, Herba Menthae, Fructus Lycii are added water 5000 milliliters, slow fire boils 1 hour, gets filtrate;
(2) residue adds water 5000 milliliters again, and slow fire adds Borneolum Syntheticum after boiling 1 hour, twice filtrate is merged after Borneolum Syntheticum dissolves;
(3) above-mentioned filtrate is concentrated into 125 milliliters, adds the ethanol mixing that 375 milliliters of mass fractions are 95% after cooling, place after 24 hours with filter paper filtering;
(4), after filtrate being waved most or recovery ethanol, vitaminize A and vitamin E powder, stir evenly adding distil water to 1000 ~ 5000 milliliter again and obtain medicinal liquid;
(5) adjust medicinal liquid and be equivalent to the osmotic pressure that mass fraction is the sodium chloride of 0.8 ~ 1.2%, adding preservative agent cyanogen Mercury difluoride. in medicinal liquid, wherein, the volume ratio of cyanogen Mercury difluoride. and medicinal liquid is 1:1500, then adjusts pH value to 7.0 with the sodium hydroxide that mass fraction is 10%;
(6) last medicinal liquid is through filter paper filtering, seals, autoclave sterilization, subpackage 8 mls/branch.
During use, every day 3 ~ 5 times, each 1 ~ 2.
Pharmacology analysis:
Flos Chrysanthemi: loose wind heat clearing away, suppressing the hyperactive liver improving eyesight.For anemopyretic cold, have a headache dizzy, conjunctival congestion and swelling pain, eyes is dim-sighted.
Flos Lonicerae: cold in nature, sweet in the mouth, enters lung, the heart, stomach warp, has heat-clearing and toxic substances removing, antiinflammatory, tonify deficiency treat effect of wind, cures mainly disease under distension, epidemic febrile disease heating, the diseases such as pyretic toxicity carbuncle and ulcer and tumor.The diseases such as it is dizzy for giddy, xerostomia is done yearningly, hyperhidrosis is unhappy, enteritis, bacillary dysentery, measles, pneumonia, encephalitis b, epidemic encephalitis, acute mastitis, septicemia, appendicitis, skin infection, carbuncle furuncle, erysipelas, parotitis, suppurative tonsillitis all have certain curative effect.
Borneolum Syntheticum: main loose stagnated fire, can deep warm, controls infantile convulsion, expectorant fan, sore throat, and swelling of the tongue, toothache, deafness, breath, conjunctival congestion cataract, pox poison cave in, parasite killing, hemorrhoid, expedite the emergence of, and property is walked and do not keep, also can granulation promoting pain relieving.So loose and easily exhaust, be that YIN-cold is also after all.
Semen Cassiae: the function of tool clearing away heat to improve acuity of vision, loosening bowel to relieve constipation.Removing heat from the liver is longer than by raw Semen Cassiae, and intestine moistening is dry.For conjunctival congestion and swelling pain, constipation.
Flos Rosae Rugosae: sweet and slightly bitter taste, slightly warm in nature, returns liver, spleen, stomach warp.Turbid clearly and not, and and violent, easing the affected liver is waken up stomach, and thin gas is invigorated blood circulation, and a surname is logical stops up stagnant and absolutely not pungent temperature is just dry fraud.
Herba Menthae: young tender stem point can make vegetable edible, and herb can be used as medicine again, cure cold heating laryngalgia, and headache, conjunctival congestion with ophthalmalgia, myalgia, skin rubella is scratched where it itches, the diseases such as measles without adequate eruption, also effective to carbuncle, cellulitis, scabies, tinea, dermatitis rhus in addition.Herba Menthae contains menthol, and this material can fresh breath have the multiple property of medicine, can alleviate stomachache, gallbladder problem as spasm, also have antisepsis and sterilization, diuresis, reduces phlegm, stomach invigorating and the effect such as aid digestion.
Fructus Lycii: cure mainly nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.Containing 14 seed amino acids in Fructus Lycii, and containing special dietary compositions such as betanin, beautiful another name for Sichuan Province flavin, physalins, make it have outstanding health-care effect.Fructus Lycii contains the required nutrient substance of abundant carotene, multivitamin and the healthy eye such as calcium, ferrum, therefore has the merit of improving eyesight, is commonly called as " bright eye ".What ancient Chinese medicine doctor treatment deficiency of liver-blood, deficiency of kidney-YIN caused looks thing duskization and nyctalopia, usually uses Fructus Lycii.Famous prescription " QIJU DIHUANG WAN " is just key agents with Fructus Lycii.
Vitamin A: also known as retinol (its aldehyde derivatives retinal) or antiophthalmic factor, be a unsaturated monohydric alcohol with alicyclic ring, comprising retinol1, the A2 two kinds in animal food source, is that a class has the bioactive material of retinol.Retinol1 is stored in the liver of mammal and saltwater fish more, and dehydroretinol is often stored in the liver of fresh-water fishes.Because the expression activitiy of dehydroretinol is low, so usually said vitamin A refers to retinol1.Vitamin A maintains normal visual performance, and vitamin A is sufficient, then soon and completely, dark adaptation is short for recovery time in the regeneration of rhodopsin.Vitamin A can treat xerophthalmia, keratomalacia, xerosis cutis and nyctalopia etc.In addition, to scald, cold injury and ulcer also effective in cure.
Vitamin E: vitamin E can suppress the lipid peroxidation in eye lens to react, and makes end slightly vasodilation, improves blood circulation, pre-myopia prevention occurs and development.
Eye drop of the present invention adopts modern advanced medical pharmaceutical technology to make, there is clearing away heat-fire, spasmolytic removing nebula, the effect of nourishing the liver to improve visual acuity, is used for the treatment of the symptom such as conjunctival congestion, ophthalmic pruritus that visual deterioration, teenage pseudomyopia, alleviation eye visual fatigue and eyestrain cause, selected medical material compatibility is suitable, evident in efficacy, security performance is high, has no side effect, cheap, should be widely promoted application.
Outcome measure:
1, case selection
As asthenopic collyrium of releiving, select the routine clinical observation of corresponding patient with sympotoms 100.
2, treatment group patient uses collyrium of the present invention, instillation ophthalmic, every day 3 ~ 5 times, each 1 ~ 2.
3, efficacy determination:
(1) effective: eye visual recovers completely, the symptoms such as pseudomyopia, conjunctival congestion, ophthalmic pruritus are cured;
(2) effective: eye strain is alleviated to some extent;
(3) invalid: disease is unchanged.
4, result: effective 85 examples, effective 12 examples, invalid 3 examples, total effective rate 97%.
Below enumerate several model case:
Pacify certain, man, 30 years old, Bay, Ningde, Fujian Province people, civil servant, because of frequent contact lens, there is conjunctival hemorrhage in eye.Use eye drop of the present invention after five days, remission, continue to use to ten days, eye recovers normal.
High certain, female, 61 years old, people from Hefei ,Anhui, retired worker, was in after retirement and has nothing to do, often see TV, play games, and eyes suffer from serious eyestrain symptoms, and after using eye drop of the present invention, visual fatigue alleviates, and vision restoration is normal.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described.
Embodiment 1:
The asthenopic traditional Chinese medicine eye drops of a kind of alleviation, according to weight parts, comprise following ingredient: Flos Chrysanthemi 15 parts, Flos Lonicerae 6 parts, Borneolum Syntheticum 2 parts, Semen Cassiae 10 parts, Flos Rosae Rugosae 5 parts, Herba Menthae 3 parts, Fructus Lycii 15 parts, vitamin A 0.5 part and vitamin e1 part.
Embodiment 2:
Embodiment 1 is prepared according to following steps:
(1) first Flos Chrysanthemi, Flos Lonicerae, Semen Cassiae, Flos Rosae Rugosae, Herba Menthae, Fructus Lycii are added water 5000 milliliters, slow fire boils 1 hour, gets filtrate;
(2) residue adds water 5000 milliliters again, and slow fire adds Borneolum Syntheticum after boiling 1 hour, twice filtrate is merged after Borneolum Syntheticum dissolves;
(3) above-mentioned filtrate is concentrated into 125 milliliters, adds the ethanol mixing that 375 milliliters of mass fractions are 95% after cooling, place after 24 hours with filter paper filtering;
(4), after filtrate being waved most or recovery ethanol, vitaminize A and vitamin E powder, stir evenly adding distil water to 4000 milliliter again and obtain medicinal liquid;
(5) adjust medicinal liquid and be equivalent to the osmotic pressure that mass fraction is the sodium chloride of 1.0%, adding preservative agent cyanogen Mercury difluoride. in medicinal liquid, wherein, the volume ratio of cyanogen Mercury difluoride. and medicinal liquid is 1:1500, then adjusts pH value to 7.0 with the sodium hydroxide that mass fraction is 10%;
(6) last medicinal liquid is through filter paper filtering, seals, autoclave sterilization, subpackage 8 mls/branch.
Claims (3)
1. alleviate asthenopic traditional Chinese medicine eye drops for one kind, it is characterized in that according to weight parts, comprise following ingredient: Flos Chrysanthemi 10 ~ 20 parts, Flos Lonicerae 5 ~ 8 parts, Borneolum Syntheticum 2 ~ 3 parts, Semen Cassiae 10 ~ 15 parts, Flos Rosae Rugosae 5 ~ 8 parts, Herba Menthae 3 ~ 5 parts, Fructus Lycii 10 ~ 20 parts, vitamin A 0.1 ~ 1 part and vitamin E 0.1 ~ 1 part.
2. the asthenopic traditional Chinese medicine eye drops of alleviation according to claim 1, it is characterized in that according to weight parts, comprise following ingredient: Flos Chrysanthemi 15 parts, Flos Lonicerae 6 parts, Borneolum Syntheticum 2 parts, Semen Cassiae 10 parts, Flos Rosae Rugosae 5 parts, Herba Menthae 3 parts, Fructus Lycii 15 parts, vitamin A 0.5 part and vitamin e1 part.
3. a preparation method for the asthenopic traditional Chinese medicine eye drops of alleviation according to claim 1, when it is characterized in that preparation, carry out according to following steps:
(1) first Flos Chrysanthemi, Flos Lonicerae, Semen Cassiae, Flos Rosae Rugosae, Herba Menthae, Fructus Lycii are added water 5000 milliliters, slow fire boils 1 hour, gets filtrate;
(2) residue adds water 5000 milliliters again, and slow fire adds Borneolum Syntheticum after boiling 1 hour, twice filtrate is merged after Borneolum Syntheticum dissolves;
(3) above-mentioned filtrate is concentrated into 125 milliliters, adds the ethanol mixing that 375 milliliters of mass fractions are 95% after cooling, place after 24 hours with filter paper filtering;
(4), after filtrate being waved most or recovery ethanol, vitaminize A and vitamin E powder, stir evenly adding distil water to 1000 ~ 5000 milliliter again and obtain medicinal liquid;
(5) adjust medicinal liquid and be equivalent to the osmotic pressure that mass fraction is the sodium chloride of 0.8 ~ 1.2%, adding preservative agent cyanogen Mercury difluoride. in medicinal liquid, wherein, the volume ratio of cyanogen Mercury difluoride. and medicinal liquid is 1:1500, then adjusts pH value to 7.0 with the sodium hydroxide that mass fraction is 10%;
(6) last medicinal liquid is through filter paper filtering, seals, autoclave sterilization, subpackage 8 mls/branch.
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| CN105125630A (en) * | 2015-09-08 | 2015-12-09 | 内江市药城宗玉医学研究所 | Eye drops and preparation method thereof |
| CN105726698A (en) * | 2016-03-25 | 2016-07-06 | 甘肃东方天润玫瑰科技发展有限公司 | Rose composition and eye mask for relieving visual fatigue and preparation method thereof |
| CN105726697A (en) * | 2016-03-25 | 2016-07-06 | 甘肃东方天润玫瑰科技发展有限公司 | Anti-asthenopia rose composition, eye drop and preparation method of anti-asthenopia rose composition |
| CN105902686A (en) * | 2016-06-15 | 2016-08-31 | 郑州人造金刚石及制品工程技术研究中心有限公司 | In-situ gel eyewash containing nano-carbon crystals and preparation method thereof |
| CN107929580A (en) * | 2017-11-20 | 2018-04-20 | 艾因特丽（苏州）生物科技有限公司 | It is a kind of that there is novel compound preparation for alleviating eye strain and its preparation method and application |
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| CN109010761A (en) * | 2018-08-15 | 2018-12-18 | 王小平 | A kind of eye externally applied drug and preparation method thereof alleviated visual fatigue and improve eyesight |
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Application publication date: 20150121 |