CN105726767A - Traditional Chinese medicine eye drops for easing eye strain and preparation method of traditional Chinese medicine eye drops - Google Patents

Abstract

The invention belongs to the field of a traditional Chinese medicine preparation, and specifically relates to traditional Chinese medicine eye drops for easing eye strain and a preparation method of the traditional Chinese medicine eye drops. The traditional Chinese medicine eye drops comprise the following medical components, by weight part, 10-20 parts of chrysanthemum flowers, 5-8 parts of honeysuckle flowers, 2-3 parts of borneol, 10-15 parts of cassia seeds, 5-8 parts of rose flowers, 3-5 parts of mint, 10-20 parts of Chinese wolfberry fruits, 0.1-1 part of vitamin A, and 0.1-1 part of vitamin E. The eye drops are prepared through adoption of advanced modern pharmaceutical technology, have the function of clearing heat and purging fire, arresting convulsions and removing nebula, and nourishing the live and improving vision, and are used for treating visual impairment and teenage pseudomyopia, and alleviating symptoms, such as conjunctival congestion and eye itching, due to visual fatigue and eye strain. Medicines appropriately match each other, so that the eye drops are significant in therapeutic effect, high in safety, and low in price, have no side effect, and are worthy of wide popularization and application.

Description

Alleviate asthenopic traditional Chinese medicine eye drops and preparation method thereof

Technical field

The invention belongs to field of traditional Chinese, be specifically related to asthenopic traditional Chinese medicine eye drops of a kind of alleviation and preparation method thereof.

Background technology

Eyestrain is a kind of ophthalmology common disease, and its caused eye is dry, eye is puckery, eye is sour swollen, and blurred vision even visual deterioration directly affects work and the life of people.When eyestrain concentrates to see computer screen at ordinary times mainly due to people, eyes number of winks reduce, cause tear Secretion to reduce, simultaneously flicker fluorescent screen intense stimulus eyes and cause.It can cause that pain occur in the corresponding sites such as the neck of people, shoulder, also can cause and increase the weight of various oculopathy.

Quickening along with modern cultural rhythm of life, work, study hypertonicity, over-burden for psychological diathesis, in addition ecological environment unclean pollution, such as the impact of the air quality such as dirt in air, smog and self psychentonia, it is improper that work and rest is coordinated, long-term excess eye-using or eyes can not get taking good care of fully and having a rest, the eyes pathological changes that factors brings out simultaneously gets more and more, pathological changes in various degree can cause eye vision and decline, form myopia, amblyopia, asthenopia or the diseases such as aching and tired, the eye frame pain of eye occur, blurred vision, dim eyesight seriously can be made even blind.According to social medicine newspapers and periodicals relevant information incomplete statistics, in the large, medium and small student in the whole nation, eye vision decline and rate of myopia account for 40%～60%, its students in middle and primary schools' rate of myopia is 4.9%, just, rate of myopia is 52% in high school student, and myopia, amblyopia, asthenopia disease sickness rate rise with the speed of annual 5%.Heredity and developing myopia have become as the serious problem of society today currently affecting teenager vision health.Therefore, seek effective anti-eyestrain's pharmaceutical preparation, pre-myopia prevention, eliminate asthenopia, recover vision health, control and prevention ophthalmic disease, be always up problem and direction that domestic and international ophthalmology academia joint research is inquired into.

Summary of the invention

According to above the deficiencies in the prior art, the present invention provides a kind of and alleviates asthenopic traditional Chinese medicine eye drops and preparation method thereof, and it is evident in efficacy, safe and reliable, have no side effect, and has wide potential applicability in clinical practice.

The asthenopic traditional Chinese medicine eye drops of a kind of alleviation of the present invention, according to parts by weight meter, including following ingredient: Flos Chrysanthemi 10～20 parts, Flos Lonicerae 5～8 parts, Borneolum Syntheticum 2～3 parts, Semen Cassiae 10～15 parts, Flos Rosae Rugosae 5～8 parts, Herba Menthae 3～5 parts, Fructus Lycii 10～20 parts, vitamin A 0.1～1 part and vitamin E 0.1～1 part.

Wherein, it is preferable that scheme is as follows:

According to parts by weight meter, including following ingredient: Flos Chrysanthemi 15 parts, Flos Lonicerae 6 parts, Borneolum Syntheticum 2 parts, Semen Cassiae 10 parts, Flos Rosae Rugosae 5 parts, Herba Menthae 3 parts, Fructus Lycii 15 parts, vitamin A 0.5 part and vitamin e1 part.

The preparation method of the asthenopic traditional Chinese medicine eye drops of alleviation of the present invention, during preparation, carries out according to following steps:

(1) first Flos Chrysanthemi, Flos Lonicerae, Semen Cassiae, Flos Rosae Rugosae, Herba Menthae, Fructus Lycii being added water 5000 milliliters, slow fire boils 1 hour, takes filtrate；

(2) residue adds water 5000 milliliters, and slow fire adds Borneolum Syntheticum after boiling 1 hour, and twice filtrate is merged after dissolving by Borneolum Syntheticum；

(3) above-mentioned filtrate is concentrated into 125 milliliters, adds the ethanol mixing that 375 milliliters of mass fractions are 95% after cooling, after placing 24 hours, use filter paper filtering；

(4) after filtrate being waved to the greatest extent or reclaiming ethanol, add vitamin A and vitamin E powder, stir evenly and add distilled water again and obtain medicinal liquid to 1000～5000 milliliters；

(5) adjust medicinal liquid and be equivalent to the osmotic pressure of the sodium chloride that mass fraction is 0.8～1.2%, adding preservative agent cyanogen Mercury difluoride. in medicinal liquid, wherein, the volume ratio of cyanogen Mercury difluoride. and medicinal liquid is 1:1500, then adjusts pH value to 7.0 with the sodium hydroxide that mass fraction is 10%；

(6) last medicinal liquid is through filter paper filtering, seals, autoclave sterilization, subpackage 8 mls/branch.

During use, every day 3～5 times, each 1～2.

Pharmacology analysis:

Flos Chrysanthemi: dissipate wind heat clearing away, suppressing the hyperactive liver improving eyesight.For anemopyretic cold, dizziness of having a headache, conjunctival congestion and swelling pain, eyes is dim-sighted.

Flos Lonicerae: cold in nature, sweet in the mouth, enter lung, the heart, stomach warp, there is heat-clearing and toxic substances removing, antiinflammatory, qi-restoratives treat effect of wind, cure mainly disease under distension, epidemic febrile disease heating, the disease such as pyretic toxicity carbuncle and ulcer and tumor.It all has certain curative effect for diseases such as dizzy dizzy, xerostomia is made yearningly, hyperhidrosis unhappiness, enteritis, bacillary dysentery, measles, pneumonia, encephalitis b, epidemic encephalitis, acute mastitis, septicemia, appendicitis, skin infection, carbuncle furuncle, erysipelas, parotitis, suppurative tonsillitiss.

Borneolum Syntheticum: main dissipate stagnated fire, can deep heat, control infantile convulsion, expectorant fan, sore throat, swelling of the tongue, toothache, deafness, breath, conjunctival congestion cataract, pox poison cave in, parasite killing, hemorrhoid, expedite the emergence of, and property is walked and do not kept, also can granulation promoting pain relieving.So dissipate and easily exhaust, be that YIN-cold is also after all.

Semen Cassiae: have the function of clearing away heat to improve acuity of vision, loosening bowel to relieve constipation.Raw Semen Cassiae is longer than removing heat from the liver, and intestine moistening is dry.For conjunctival congestion and swelling pain, constipation.

Flos Rosae Rugosae: sweet and slightly bitter taste, slightly warm in nature, returns liver, spleen, stomach warp.Turbid clearly and not, and and violent, easing the affected liver is waken up stomach, and thin gas is invigorated blood circulation, and a surname is led to and stopped up stagnant and that absolutely not pungent temperature is just dry fraud.

Herba Menthae: children's tender stem point can make vegetable edible, and herb can be used as medicine again, cure cold heating laryngalgia, headache, conjunctival congestion with ophthalmalgia, myalgia, and the diseases such as skin rubella is scratched where it itches, measles without adequate eruption are also effective to carbuncle, cellulitis, scabies, tinea, dermatitis rhus in addition.Herba Menthae contains menthol, this material can fresh breath there is the multiple property of medicine, stomachache, gallbladder problem such as spasm can be alleviated, also there is antisepsis and sterilization, diuresis, reduce phlegm, stomach invigorating and the effect such as aid digestion.

Fructus Lycii: cure mainly nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.Containing 14 seed amino acids in Fructus Lycii, and containing special dietary compositions such as glycine betaine, beautiful another name for Sichuan Province flavin, physalins so that it is have outstanding health-care effect.Fructus Lycii contains the required nutrient substance of abundant carotene, multivitamin and the healthy eye such as calcium, ferrum, therefore has the merit of improving eyesight, is commonly called as " bright eye ".What ancient Chinese medicine doctor treatment deficiency of liver-blood, deficiency of kidney-YIN caused looks thing dusk and nyctalopia, is frequently used Fructus Lycii.Famous prescription " QIJU DIHUANG WAN ", just with Fructus Lycii for key agents.

Vitamin A: also known as retinol (its aldehyde derivatives retinal) or antiophthalmic factor, is a unsaturated monohydric alcohol with alicyclic ring, including the retinol1 in animal food source, A2 two kinds, is that a class has the bioactive material of retinol.Retinol1 is stored in the liver of mammal and saltwater fish more, and dehydroretinol is often stored in the liver of fresh-water fishes.Owing to the specific activity of dehydroretinol is relatively low, so usually said vitamin A refers to retinol1.Vitamin A maintains normal visual performance, and vitamin A is sufficient, then soon and completely, dark adaptation is short for recovery time in the regeneration of rhodopsin.Vitamin A can treat xerophthalmia, keratomalacia, xerosis cutis and nyctalopia etc..Additionally, boiling hot, cold injury and ulcer is also effective in cure.

Vitamin E: vitamin E can suppress the lipid peroxidation in ocular lens body to react, and makes end slightly vasodilation, improves blood circulation, pre-myopia prevention occurs and development.

Eye drop of the present invention adopts modern advanced medical pharmaceutical technology to make, there is clearing away heat-fire, spasmolytic removing nebula, the effect of nourishing the liver to improve visual acuity, for treating the symptoms such as visual deterioration, teenage pseudomyopia, alleviation eye visual be tired and eyestrain causes conjunctival congestion, ophthalmic pruritus, selected medical material compatibility is suitable, evident in efficacy, security performance is high, has no side effect, cheap, should be widely promoted application.

Outcome measure:

1, case selection

As asthenopic collyrium of releiving, select corresponding patient with sympotoms 100 example clinical observation.

2, treatment group patient uses collyrium of the present invention, instills ophthalmic, every day 3～5 times, each 1～2.

3, efficacy determination:

(1) effective: eye visual recovers completely, the symptom such as pseudomyopia, conjunctival congestion, ophthalmic pruritus is cured；

(2) effective: eye strain is alleviated to some extent；

(3) invalid: disease is unchanged.

4, result: effective 85 examples, effective 12 examples, invalid 3 examples, total effective rate 97%.

It is exemplified below several model case:

Pacifying certain, man, 30 years old, Bay, Ningde, Fujian Province people, civil servant, because of frequent contact lens, there is conjunctival hemorrhage in eye.Use eye drop of the present invention after five days, remission, it is continuing with to ten days, eye recovers normal.

High certain, female, 61 years old, people from Hefei ,Anhui, retired worker, be in after retirement and have nothing to do, often see TV, play game, eyes suffer from serious eyestrain symptoms, and after using eye drop of the present invention, visual fatigue alleviates, and vision restoration is normal.

Detailed description of the invention

Below in conjunction with embodiment, the invention will be further described.

Embodiment 1:

The asthenopic traditional Chinese medicine eye drops of a kind of alleviation, according to parts by weight meter, including following ingredient: Flos Chrysanthemi 15 parts, Flos Lonicerae 6 parts, Borneolum Syntheticum 2 parts, Semen Cassiae 10 parts, Flos Rosae Rugosae 5 parts, Herba Menthae 3 parts, Fructus Lycii 15 parts, vitamin A 0.5 part and vitamin e1 part.

Embodiment 2:

Embodiment 1 is prepared according to following steps:

(1) first Flos Chrysanthemi, Flos Lonicerae, Semen Cassiae, Flos Rosae Rugosae, Herba Menthae, Fructus Lycii being added water 5000 milliliters, slow fire boils 1 hour, takes filtrate；

(2) residue adds water 5000 milliliters, and slow fire adds Borneolum Syntheticum after boiling 1 hour, and twice filtrate is merged after dissolving by Borneolum Syntheticum；

(3) above-mentioned filtrate is concentrated into 125 milliliters, adds the ethanol mixing that 375 milliliters of mass fractions are 95% after cooling, after placing 24 hours, use filter paper filtering；

(4) after filtrate being waved to the greatest extent or reclaiming ethanol, add vitamin A and vitamin E powder, stir evenly and add distilled water again and obtain medicinal liquid to 4000 milliliters；

(5) adjusting medicinal liquid and be equivalent to the osmotic pressure of the sodium chloride that mass fraction is 1.0%, adding preservative agent cyanogen Mercury difluoride. in medicinal liquid, wherein, the volume ratio of cyanogen Mercury difluoride. and medicinal liquid is 1:1500, then adjusts pH value to 7.0 with the sodium hydroxide that mass fraction is 10%；

(6) last medicinal liquid is through filter paper filtering, seals, autoclave sterilization, subpackage 8 mls/branch.

Claims (3)

1. alleviate asthenopic traditional Chinese medicine eye drops for one kind, it is characterized in that according to parts by weight meter, including following ingredient: Flos Chrysanthemi 10～20 parts, Flos Lonicerae 5～8 parts, Borneolum Syntheticum 2～3 parts, Semen Cassiae 10～15 parts, Flos Rosae Rugosae 5～8 parts, Herba Menthae 3～5 parts, Fructus Lycii 10～20 parts, vitamin A 0.1～1 part and vitamin E 0.1～1 part.

2. the asthenopic traditional Chinese medicine eye drops of alleviation according to claim 1, it is characterized in that according to parts by weight meter, including following ingredient: Flos Chrysanthemi 15 parts, Flos Lonicerae 6 parts, Borneolum Syntheticum 2 parts, Semen Cassiae 10 parts, Flos Rosae Rugosae 5 parts, Herba Menthae 3 parts, Fructus Lycii 15 parts, vitamin A 0.5 part and vitamin e1 part.

3. the preparation method alleviating asthenopic traditional Chinese medicine eye drops described in a claim 1, it is characterised in that during preparation, carry out according to following steps:

(1) first Flos Chrysanthemi, Flos Lonicerae, Semen Cassiae, Flos Rosae Rugosae, Herba Menthae, Fructus Lycii being added water 5000 milliliters, slow fire boils 1 hour, takes filtrate；

(2) residue adds water 5000 milliliters, and slow fire adds Borneolum Syntheticum after boiling 1 hour, and twice filtrate is merged after dissolving by Borneolum Syntheticum；

(3) above-mentioned filtrate is concentrated into 125 milliliters, adds the ethanol mixing that 375 milliliters of mass fractions are 95% after cooling, after placing 24 hours, use filter paper filtering；

(4) after filtrate being waved to the greatest extent or reclaiming ethanol, add vitamin A and vitamin E powder, stir evenly and add distilled water again and obtain medicinal liquid to 1000～5000 milliliters；

(5) adjust medicinal liquid and be equivalent to the osmotic pressure of the sodium chloride that mass fraction is 0.8～1.2%, adding preservative agent cyanogen Mercury difluoride. in medicinal liquid, wherein, the volume ratio of cyanogen Mercury difluoride. and medicinal liquid is 1:1500, then adjusts pH value to 7.0 with the sodium hydroxide that mass fraction is 10%；

(6) last medicinal liquid is through filter paper filtering, seals, autoclave sterilization, subpackage 8 mls/branch.