CN104288335A - Traditional Chinese medicine eye drop for relieving eyestrain and preparation method thereof - Google Patents
Traditional Chinese medicine eye drop for relieving eyestrain and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the field of traditional Chinese medicine preparations and particularly relates to traditional Chinese medicine eye drop for relieving eyestrain and a preparation method thereof. The eye drop contains the following drugs in parts by weight: 5-10 parts of astragalus root, 2-3 parts of angelica sinensis, 5-10 parts of cassia seed, 3-5 parts of rhizoma Chuanxiong, 10-15 parts of wolfberry, 5-8 parts of ginkgo, 2-3 parts of pearl powder, 0.1-1 part of vitamin A and 0.1-1 part of vitamin E. The eye drop disclosed by the invention is prepared by adopting modern advanced medicine pharmaceutical technologies, has the effects of clearing heat and purging fire, relieving spasm and removing nephelium and nourishing the liver to improve visual acuity, and is used for treating impaired vision and adolescent pseudomyopia and relieving symptoms, such as conjunctival congestion and eye itching, caused by eye visual fatigue and eyestrain, and the selected medicinal materials are appropriate in combination, remarkable in treatment effect, high in safety performance, free from side effect and low in cost, so that the eye drop is worthy of extensive popularization and application.
Description
Technical field
The invention belongs to field of traditional Chinese, be specifically related to asthenopic traditional Chinese medicine eye drops of a kind of alleviation and preparation method thereof.
Background technology
Eyestrain is a kind of ophthalmology common disease, and the eye caused by it is dry, eye is puckery, eye is sour swollen, and blurred vision even visual deterioration directly affects work and the life of people.Eyestrain mainly due to people concentrate at ordinary times to see computer screen time, eyes number of winks reduces, and causes tear Secretion to reduce, and the fluorescent screen intense stimulus eyes of simultaneously glimmering cause.It can cause the corresponding sites such as the neck of people, shoulder to occur pain, also can cause and increase the weight of various oculopathy.
Along with the quickening of modern cultural rhythm of life, work, study hypertonicity, over-burden for psychological diathesis, in addition ecological environment unclean pollution, as the impact of the air quality such as dirt in air, smog and self psychentonia, it is improper that work and rest is coordinated, long-term excess eye-using or eyes can not get taking good care of fully and having a rest, the eyes pathological changes that factors brings out simultaneously gets more and more, pathological changes in various degree can cause eye vision and decline, form myopia, amblyopia, asthenopia or occur the diseases such as eye is aching and tired, eye frame pain, blurred vision, dim eyesight seriously can be made even blind.According to the incomplete statistics of social medicine newspapers and periodicals interrelated data, in the large, medium and small student in the whole nation, eye vision decline and rate of myopia account for 40% ~ 60%, its students in middle and primary schools' rate of myopia is 4.9%, just, in high school student rate of myopia is 52%, and myopia, amblyopia, asthenopia disease sickness rate rise with the speed of annual 5%.Heredity and developing myopia have become the current serious problem of society today affecting teenager vision health.Therefore, seek effective anti-eyestrain's pharmaceutical preparation, pre-myopia prevention, eliminate asthenopia, recover vision health, control and prevention ophthalmic disease, be problem and the direction of domestic and international ophthalmology academia joint research discussion always.
Summary of the invention
According to above the deficiencies in the prior art, the invention provides and a kind of alleviate asthenopic traditional Chinese medicine eye drops and preparation method thereof, it is evident in efficacy, safe and reliable, have no side effect, there is wide potential applicability in clinical practice.
One of the present invention alleviates asthenopic traditional Chinese medicine eye drops, according to weight parts, comprise following ingredient: the Radix Astragali 5 ~ 10 parts, Radix Angelicae Sinensis 2 ~ 3 parts, Semen Cassiae 5 ~ 10 parts, Rhizoma Chuanxiong 3 ~ 5 parts, Fructus Lycii 10 ~ 15 parts, Semen Ginkgo 5 ~ 8 parts, Margarita powder 2 ~ 3 parts, vitamin A 0.1 ~ 1 part and vitamin E 0.1 ~ 1 part.
Wherein, preferred version is as follows:
According to weight parts, comprise following ingredient: the Radix Astragali 8 parts, Radix Angelicae Sinensis 2 parts, Semen Cassiae 10 parts, Rhizoma Chuanxiong 3 parts, Fructus Lycii 15 parts, Semen Ginkgo 5 parts, Margarita powder 2 parts, vitamin A 0.5 part and vitamin E 1 part.
The preparation method of the asthenopic traditional Chinese medicine eye drops of alleviation of the present invention, during preparation, carry out according to following steps:
(1) first the Radix Astragali, Radix Angelicae Sinensis, Semen Cassiae, Rhizoma Chuanxiong, Fructus Lycii, Semen Ginkgo, Margarita powder are added water 5000 milliliters, slow fire boils 1 hour, gets filtrate;
(2) residue adds water 5000 milliliters again, and slow fire boils 1 hour, twice filtrate is merged;
(3) above-mentioned filtrate is concentrated into 125 milliliters, adds the ethanol mixing that 375 milliliters of mass fractions are 95% after cooling, place after 24 hours with filter paper filtering;
(4), after filtrate being waved most or recovery ethanol, vitaminize A and vitamin E powder, stir evenly adding distil water to 1000 ~ 5000 milliliter again and obtain medicinal liquid;
(5) adjust medicinal liquid and be equivalent to the osmotic pressure that mass fraction is the sodium chloride of 0.8 ~ 1.2%, adding preservative agent cyanogen Mercury difluoride. in medicinal liquid, wherein, the volume ratio of cyanogen Mercury difluoride. and medicinal liquid is 1:1500, then adjusts pH value to 7.0 with the sodium hydroxide that mass fraction is 10%;
(6) last medicinal liquid is through filter paper filtering, seals, autoclave sterilization, subpackage 8 mls/branch.
During use, every day 3 ~ 5 times, each 1 ~ 2.
Pharmacology analysis:
The Radix Astragali: gas in tonifying the spleen and stomach, and can yang-energy be promoted, QI and blood can arrive brain smoothly, put forward shake spirit, brains is clear, and can strengthen the ability of body surface resistance to colds.
Radix Angelicae Sinensis: enrich blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.Cure mainly all cards of blood deficiency; Menoxenia; Amenorrhea; Dysmenorrhea; Lump in the abdomen knot is poly-; Metrorrhagia; Asthenia cold abdominalgia; Flaccidity syndrome and arthralgia syndrome; Numbness of the skin; Dryness of the intestine dyschezia; Heavy after bloody dysentery; Ulcer sores; Injury from falling down.
Semen Cassiae: the function of tool clearing away heat to improve acuity of vision, loosening bowel to relieve constipation.Removing heat from the liver is longer than by raw Semen Cassiae, and intestine moistening is dry.For conjunctival congestion and swelling pain, constipation.
Rhizoma Chuanxiong: containing ligustrazine, ligustrazine energy coronary artery dilator, increases coronary artery blood flow, improves the blood oxygen supply of cardiac muscle, and reduces the oxygen consumption of cardiac muscle; The expansible cerebrovascular of ligustrazine, reduces vascular resistance, significantly increases brain and LBF amount, improves microcirculation; Can surface activity of blood platelet be reduced, suppress platelet aggregation, the formation of pre-preventing thrombosis; The neutral compound low dose of contained ferulic acid promotes, heavy dose of suppression uterine smooth muscle; Water decoction has sedation to animal central nervous systems, and has obvious and lasting hypotensive effect; The absorption of fracture local hematoma can be accelerated, promote callus formation; There is the effect of vitamin antagonist E shortage; Multiple bacillus can be suppressed; There are antihistaminic and choleretic effect.
Fructus Lycii: cure mainly nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.Containing 14 seed amino acids in Fructus Lycii, and containing special dietary compositions such as betanin, beautiful another name for Sichuan Province flavin, physalins, make it have outstanding health-care effect.Fructus Lycii contains the required nutrient substance of abundant carotene, multivitamin and the healthy eye such as calcium, ferrum, therefore has the merit of improving eyesight, is commonly called as " bright eye ".What ancient Chinese medicine doctor treatment deficiency of liver-blood, deficiency of kidney-YIN caused looks thing duskization and nyctalopia, usually uses Fructus Lycii.Famous prescription " QIJU DIHUANG WAN " is just key agents with Fructus Lycii.
Semen Ginkgo: property is put down, sweet in the mouth is pained, slightly poisonous; Enter lung, kidney channel.Folium Ginkgo extract principle active component is flavonoid and bilobalide-like biological active substances, referred to as Folium Ginkgo extract (GBE), ocular angiogenesis can be expanded, suppress platelet aggregation, reduce the permeability of blood capillary, antioxidation, scavenging activated oxygen, improve the activity of SOD, improve microcirculation with this.
Margarita powder: Margarita powder has the effect of heat-clearing and toxic substances removing, can clearing away liver-fire.The liver being in charge of the eyes, the raw nebula of hot-tempered then order, blurred vision.Find through research, the selenium in Margarita powder can strengthen the conduction of optic nerve, improves eyesight status simultaneously; Zinc in trace element can promote the axonal transport of optic nerve, improves metabolism and the function of retina and retinal pigment epithelium.The Pharmacopoeia of the People's Republic of China describes: " Margarita has the function of improving eyesight removing nebula, cures mainly the raw nebula of order ", so Margarita powder becomes " ophthalmology panacea " by a lot of scholar.
Vitamin A: also known as retinol (its aldehyde derivatives retinal) or antiophthalmic factor, be a unsaturated monohydric alcohol with alicyclic ring, comprising retinol1, the A2 two kinds in animal food source, is that a class has the bioactive material of retinol.Retinol1 is stored in the liver of mammal and saltwater fish more, and dehydroretinol is often stored in the liver of fresh-water fishes.Because the expression activitiy of dehydroretinol is low, so usually said vitamin A refers to retinol1.Vitamin A maintains normal visual performance, and vitamin A is sufficient, then soon and completely, dark adaptation is short for recovery time in the regeneration of rhodopsin.Vitamin A can treat xerophthalmia, keratomalacia, xerosis cutis and nyctalopia etc.In addition, to scald, cold injury and ulcer also effective in cure.
Vitamin E: vitamin E can suppress the lipid peroxidation in eye lens to react, and makes end slightly vasodilation, improves blood circulation, pre-myopia prevention occurs and development.
Eye drop of the present invention adopts modern advanced medical pharmaceutical technology to make, there is clearing away heat-fire, spasmolytic removing nebula, the effect of nourishing the liver to improve visual acuity, is used for the treatment of the symptom such as conjunctival congestion, ophthalmic pruritus that visual deterioration, teenage pseudomyopia, alleviation eye visual fatigue and eyestrain cause, selected medical material compatibility is suitable, evident in efficacy, security performance is high, has no side effect, cheap, should be widely promoted application.
Outcome measure:
1, case selection
As asthenopic collyrium of releiving, select the routine clinical observation of corresponding patient with sympotoms 160.
2, treatment group patient uses collyrium of the present invention, instillation ophthalmic, every day 3 ~ 5 times, each 1 ~ 2.
3, efficacy determination:
(1) effective: eye visual recovers completely, the symptoms such as pseudomyopia, conjunctival congestion, ophthalmic pruritus are cured;
(2) effective: eye strain is alleviated to some extent;
(3) invalid: disease is unchanged.
4, result: effective 128 examples, effective 27 examples, invalid 5 examples, total effective rate 96.875%.
Below enumerate several model case:
Chen, man, 12 years old, people from Shijiazhuang, Hebei, student, because learning anxiety, frequent studying at night, make eyes form pseudomyopia, after using eye drop of the present invention, treat after 20 days, vision restoration was normal, does not recur so far.
Beam, female, 26 years old, Zhengzhou, henan people, white collar, because of job demand, used computer overlong time, and eyes suffer from serious visual fatigue disease, and use eye drop of the present invention after 3 days, visual fatigue recovers to some extent, continues to use, and eye recovers normal.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described.
Embodiment 1:
The asthenopic traditional Chinese medicine eye drops of a kind of alleviation, according to weight parts, comprises following ingredient: the Radix Astragali 8 parts, Radix Angelicae Sinensis 2 parts, Semen Cassiae 10 parts, Rhizoma Chuanxiong 3 parts, Fructus Lycii 15 parts, Semen Ginkgo 5 parts, Margarita powder 2 parts, vitamin A 0.5 part and vitamin E 1 part.
Embodiment 2:
Embodiment 1 is prepared according to following steps:
(1) first the Radix Astragali, Radix Angelicae Sinensis, Semen Cassiae, Rhizoma Chuanxiong, Fructus Lycii, Semen Ginkgo, Margarita powder are added water 5000 milliliters, slow fire boils 1 hour, gets filtrate;
(2) residue adds water 5000 milliliters again, and slow fire boils 1 hour, twice filtrate is merged;
(3) above-mentioned filtrate is concentrated into 125 milliliters, adds the ethanol mixing that 375 milliliters of mass fractions are 95% after cooling, place after 24 hours with filter paper filtering;
(4), after filtrate being waved most or recovery ethanol, vitaminize A and vitamin E powder, stir evenly adding distil water to 3000 milliliter again and obtain medicinal liquid;
(5) adjust medicinal liquid and be equivalent to the osmotic pressure that mass fraction is the sodium chloride of 0.8%, adding preservative agent cyanogen Mercury difluoride. in medicinal liquid, wherein, the volume ratio of cyanogen Mercury difluoride. and medicinal liquid is 1:1500, then adjusts pH value to 7.0 with the sodium hydroxide that mass fraction is 10%;
(6) last medicinal liquid is through filter paper filtering, seals, autoclave sterilization, subpackage 8 mls/branch.
Claims (3)
1. alleviate asthenopic traditional Chinese medicine eye drops for one kind, it is characterized in that according to weight parts, comprise following ingredient: the Radix Astragali 5 ~ 10 parts, Radix Angelicae Sinensis 2 ~ 3 parts, Semen Cassiae 5 ~ 10 parts, Rhizoma Chuanxiong 3 ~ 5 parts, Fructus Lycii 10 ~ 15 parts, Semen Ginkgo 5 ~ 8 parts, Margarita powder 2 ~ 3 parts, vitamin A 0.1 ~ 1 part and vitamin E 0.1 ~ 1 part.
2. one according to claim 1 alleviates asthenopic traditional Chinese medicine eye drops, it is characterized in that according to weight parts, comprise following ingredient: the Radix Astragali 8 parts, Radix Angelicae Sinensis 2 parts, Semen Cassiae 10 parts, Rhizoma Chuanxiong 3 parts, Fructus Lycii 15 parts, Semen Ginkgo 5 parts, Margarita powder 2 parts, vitamin A 0.5 part and vitamin E 1 part.
3. a preparation method for the asthenopic traditional Chinese medicine eye drops of alleviation according to claim 1, when it is characterized in that preparation, carry out according to following steps:
(1) first the Radix Astragali, Radix Angelicae Sinensis, Semen Cassiae, Rhizoma Chuanxiong, Fructus Lycii, Semen Ginkgo, Margarita powder are added water 5000 milliliters, slow fire boils 1 hour, gets filtrate;
(2) residue adds water 5000 milliliters again, and slow fire boils 1 hour, twice filtrate is merged;
(3) above-mentioned filtrate is concentrated into 125 milliliters, adds the ethanol mixing that 375 milliliters of mass fractions are 95% after cooling, place after 24 hours with filter paper filtering;
(4), after filtrate being waved most or recovery ethanol, vitaminize A and vitamin E powder, stir evenly adding distil water to 1000 ~ 5000 milliliter again and obtain medicinal liquid;
(5) adjust medicinal liquid and be equivalent to the osmotic pressure that mass fraction is the sodium chloride of 0.8 ~ 1.2%, adding preservative agent cyanogen Mercury difluoride. in medicinal liquid, wherein, the volume ratio of cyanogen Mercury difluoride. and medicinal liquid is 1:1500, then adjusts pH value to 7.0 with the sodium hydroxide that mass fraction is 10%;
(6) last medicinal liquid is through filter paper filtering, seals, autoclave sterilization, subpackage 8 mls/branch.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108175806A (en) * | 2018-01-23 | 2018-06-19 | 贵州康琦药械有限公司 | A kind of Chinese medicine eye paste and preparation method thereof |
| CN112972583A (en) * | 2021-03-11 | 2021-06-18 | 王睿超 | Natural herbal eye drops and preparation method and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103393969A (en) * | 2013-08-03 | 2013-11-20 | 吴春子 | Eye drop used for releasing eye fatigue and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103393969A (en) * | 2013-08-03 | 2013-11-20 | 吴春子 | Eye drop used for releasing eye fatigue and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108175806A (en) * | 2018-01-23 | 2018-06-19 | 贵州康琦药械有限公司 | A kind of Chinese medicine eye paste and preparation method thereof |
| CN112972583A (en) * | 2021-03-11 | 2021-06-18 | 王睿超 | Natural herbal eye drops and preparation method and application thereof |
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Application publication date: 20150121 |