CN105106318A - Traditional Chinese medicine composition for treating xerophthalmia and preparation method of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for treating xerophthalmia and preparation method of traditional Chinese medicine composition Download PDFInfo
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- CN105106318A CN105106318A CN201510587464.1A CN201510587464A CN105106318A CN 105106318 A CN105106318 A CN 105106318A CN 201510587464 A CN201510587464 A CN 201510587464A CN 105106318 A CN105106318 A CN 105106318A
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Abstract
The invention discloses traditional Chinese medicine composition and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from mulberry leaves, chrysanthemum indicum and mint. The prepared traditional Chinese medicine composition is used for being prepared into frequently-seen stifling bags, the preparation process is simple, and the stifling bags are obtained only by smashing raw materials of components into rough powder, subpackaging the rough powder into the stifling bags and conducting sterilization. The traditional Chinese medicine composition can be used for treating xerophthalmia, is particularly effective for xerophthalmia caused by meibomian gland dysfunction, and is simple and feasible in treatment process and good in effect.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine pharmacy, relate to a kind of Chinese medicine composition for the treatment of xerophthalmia and preparation method thereof.
Background technology
The tear film instability that the exception of xerophthalmia tear quality and quantity caused by any reason or the dynamic (dynamical) exception of tear cause and eye surface damage, thus cause a class disease of ophthalmic uncomfortable symptom.Patients with dry eye main manifestations is eye sensation of dryness, foreign body sensation, eyestrain, eye are ached and burn feeling, and the person of being in a bad way can cause the obvious decline of vision and affect work and life.
Along with the raising of socioeconomic development and people's living standard, the incidence rate of xerophthalmia has the trend of increase, and has the trend of rejuvenation.Due to the quickening of people's reading method and rhythm of life, its sickness rate is in the trend raised year by year.Xerophthalmia is one of common eye surface diseases of ophthalmology, and according to statistics, China's xerophthalmia sickness rate is 10.71%-12.91%.
Xerophthalmia belongs to the dry astringent eye, xerosis conjunctivitis category of TCM Ophthalmology, and Chinese medicine thinks that assertive evidence is because pathogenic heat are reluctant to leave, lack of lung-YIN, retention of heat in the spleen and stomach and hepatic and renal YIN deficiency, YIN fluid being insufficient and causing caused by eyes losing nutrition.From modern medicine angle, according to etiology, xerophthalmia can be divided into: the imbalance xerophthalmia of Environmental xerophthalmia, gonadal hormone, meibomian gland dysfunction xerophthalmia, dry eye syndrome (autoimmunity), the dyskinetic xerophthalmia of nerve conduction (afferent and spread out of obstacle), mixed type xerophthalmia.Although cause the cause of disease of xerophthalmia different, its pathophysiological change is similar, once enter developmental stage, inflammation becomes the factor of most critical in xerophthalmia pathogeny.
Current multiplex eye drop clinically etc. treats xerophthalmia.Because organizing of eye is more responsive, these medicines are larger for the injury of part tissue of eye, and usually can produce the problem of drug resistance.
Western medical treatment is based on local, a kind of common western medicine therapy is as supplementary artificial tears, this artificial tears can play a protective role to normal eyes, eliminate ophthalmic uncomfortable, moistening eyeball alleviates local symptom, but the potential cause of disease of this artificial tears to xerophthalmia does not give treatment, plays the effect of curing the symptoms, not the disease; When serious symptom dry eye patients conventional treatments unsatisfactory curative effect, and when likely causing vision to be badly damaged, generally adopt operative treatment, as implanted the operative treatments such as lacrimal passage stopper, puncta block technique and submaxillary gland transplanting.
Chinese traditional treatment with a long history, Therapeutic Method is various, as oral medicinal herb, acupuncture and moxibustion therapy, massaging and physiotherapeutical and traditional Chinese medical science eye drip etc.Publication number is that the Chinese patent application of 102145126A discloses a kind of pharmaceutical composition profound wheat profit order granule for the treatment of xerophthalmia, said composition is made up of the crude drug of following mass parts: Radix Rehmanniae 6-30, Radix Scrophulariae 10-40, Radix Ophiopogonis 5-30, Herba Dendrobii 5-30, Rhizoma Anemarrhenae 10-20, Radix Trichosanthis 10-20, Flos Chrysanthemi 5-30, Folium Mori 5-30, Flos Eriocauli 5-20, Radix Saposhnikoviae 10-30, this compositions is made granule form, patient can carry out brewing for oral administration.Publication number is that the Chinese patent application of 104367832A provides a kind of compound recipe Herba Dendrobii eye drop for the treatment of xerophthalmia and preparation method thereof, and this prescription is formed by following preparation of raw material: Herba Dendrobii 80-120g, Radix Trichosanthis 80-120g, Folium Isatidis 80-120g, VITAMIN B15 0-100g and Mel 10-20ml.Herba Dendrobii, Radix Trichosanthis, Folium Isatidis etc. are first smashed to pieces and boil by it, filter to obtain medicinal liquid, first add antiseptic ethyl hydroxybenzoate and vitamin B1 and Mel in backward gained medicinal liquid, adopt distilled water to regulate medicinal liquid osmotic pressure to be equivalent to the osmotic pressure of 0.8-1.2 sodium chloride concentration, then filter subpackage and obtain eye drop.Although these Therapeutic Method also can Yin-nourishing and body fluid promoting, moistening eyes, treat and improve the symptom of xerophthalmia, still have and attend to one thing and lose sight of another, and if any larger side effect, treatment cycle is long, medical material is of a great variety or preparation process very complicated etc., and effect differs.Modern's rhythm of life is fast, and conventional Therapeutic Method condition is restricted, and patient Duo Yin can not adhere to, gives up halfway and causes affecting its curative effect.Thus, develop a kind of therapeutic effect comparatively definite, therapeutic process is simple and have the medicine of less side effect to seem very important.
The Chinese medicine composition for the treatment of xerophthalmia of the present invention fully realizes the pathogenetic of xerophthalmia based on Chinese medicine and pharmacy, be prepared from by re-starting scientific composition to Folium Mori, Flos Chrysanthemi Indici and Herba Menthae, with the wild Chinese crude drug of pure natural for raw material, have no side effect, preparation process and using method simple, it can dredging the meridian, dispelling wind and heat pathogens and liver heat removing and eyesight improving, reaches the effect for the treatment of xerophthalmia.
Summary of the invention
Primary and foremost purpose of the present invention provides a kind of Chinese medicine composition for the treatment of xerophthalmia and preparation method thereof for the problems referred to above.The cause of disease that this Chinese medicine composition is formed for xerophthalmia and pathogenesis, utilize the mutual synergism of the active component of plurality of Chinese, wind-dispelling heat-dissipating, heat-clearing and toxic substances removing, liver heat removing and eyesight improving, diminishes inflammation, thus reach the object for the treatment of xerophthalmia.
For realizing object of the present invention, one aspect of the present invention provides a kind of Chinese medicine composition for the treatment of xerophthalmia, mainly comprises following raw material: Folium Mori, Flos Chrysanthemi Indici and Herba Menthae.
Wherein, the weight of described traditional Chinese medicine composite is: Folium Mori 0.5-2, Flos Chrysanthemi Indici 0.5-2, Herba Menthae 0.5-2.
Particularly, the weight of described raw material is: Folium Mori 0.5-1.5, Flos Chrysanthemi Indici 0.5-1.5, Herba Menthae 0.5-1.5.
Especially, the weight of described raw material is preferably: Folium Mori 1, Flos Chrysanthemi Indici 1, Herba Menthae 1.
Chinese medicine composition of the present invention selects Folium Mori, Flos Chrysanthemi Indici, Herba Menthae carries out combination and is prepared from, and has effect of wind-dispelling heat-dissipating, heat-clearing and toxic substances removing, liver heat removing and eyesight improving.For the eyelid caused by wind heat visitor network and white of the eye blood vessel indistinct, ophthalmic pruritus is dry and astringent, and mill pain is scorching hot, and being unable to see for a long time, watching for a long time is ached.
In prescription of the present invention, monarch drug Folium Mori bitter in the mouth is cold in nature, has effect of dispelling wind and heat pathogens, liver heat removing and eyesight improving, and interior energy clear internal organs lung is hot and suffocating, the heresy of external enwergy dispelling wind and heat pathogens.Wind heat is clear, and stasis is fallen apart, then white of the eye, born of the same parents' eyelid are red redly moves back, and puckery twinge of itching can disappear.In side, ministerial drug Flos Chrysanthemi Indici toil is slightly cold, and enters lung liver two warp, heat-clearing and toxic substances removing, has the merit of moving back conjunctival congestion, going pruritus; In side, ministerial drug Herba Menthae is pungent in flavor and cool in property, enters liver lung meridian, have soothing the liver stagnant, remove stagnant heat, antipruritic effect, the two and monarch drug are harmonious, and are aided with removing heat from the liver, move back red nebula, effect of antipruritic puckery, bright eyes.
Folium Mori, for moraceae plants Mulberry through white leaves, Chinese medicine and pharmacy is thought, Folium Mori nature and flavor are bitter, sweet, cold, double enter Liver Channel, have the effect of pancake liver-yang, it can gently be evacuated clearly, external enwergy dispelling wind and heat pathogens, interior can lung heat clearing, treatment excessive rising of liver-YANG, improving eyesight, conventional control anemopyretic cold, dryness-heat impairing the lung, excessive rising of liver-YANG and wind heat or liver-fire conjunctival congestion flu, dryness-heat impairing the lung, excessive rising of liver-YANG and wind heat or liver-fire conjunctival congestion and swelling pain, deficiecny of liver-YIN eyes dim-sighted; In addition, again can cooling blood for hemostasis.Arrange with liver heat removing and eyesight improving such as Flos Chrysanthemi, Spica Prunellae, Semen Plantaginiss, available treatment wind-heat of liver channel, the excess syndrome such as liver-fire is attacked caused conjunctival congestion, puckery pain, shed tears; Coordinate the Semen Sesami Nigrum of nourishing essence-blood, i.e. mulberry hemp pill, can be used for deficiecny of liver-YIN again, the deficiency syndrome that eyes is dim-sighted.
Modern Chinese and western medicine uses Folium Mori and Folium Mori biological preparation as the medicine improving various difficult miscellaneous diseases, think that its drug effect is very extensive.There are clearing away lung-heat and moistening for dryness, cough-relieving, reduce phlegm and internal heat, reduce phlegm, control night sweat; Tonifying liver, liver heat removing and eyesight improving, treatment dizziness and blurred vision, insomnia, elimination eye strain, subside a swelling, purify the blood; Treatment dysentery, stomachache, fat-reducing, except beriberi, sharp large and small intestinal; Anti-stress, removing heat from blood, blood pressure lowering, blood fat reducing, prevention myocardial infarction, cerebral hemorrhage, dispel headache, long hair; Blood sugar lowering, anti-sugar are sick.
Flos Chrysanthemi Indici, property is pungent, and bitter in the mouth is slightly cold, and returns liver, heart channel, and primary efficacy is heat-clearing and toxic substances removing.Cure mainly carbuncle, furuncle, conjunctival congestion, scrofula, pemphigus, eczema etc.Because the power of heat-clearing and toxic substances removing is contained in Flos Chrysanthemi, it is good at the disease for the treatment of all kinds of furuncle carbuncle.
Modern medicine finds Flos Chrysanthemi Indici, main component is yejuhua lactone, chrysanthemol, flavonoid glycoside etc., tool subduing swelling and detoxicating, infection, antiviral effect, epidemic cerebrospinal meningitis can be prevented and treated, prevention influenza, flu, treatment hypertension, hepatitis, dysentery, carbuncle furuncle treatment skin ulcer have positive effect.The immersion of Flos Chrysanthemi Indici is to killing wriggler and fly larvae is also very effective.
Flos Chrysanthemi Indici has effect of heat-clearing and toxic substances removing, dispelling wind suppressing the hyperactive liver.Be used for the treatment of anemopyretic cold, laryngopharynx swelling and pain, conjunctival congestion and swelling pain, dizzy and furuncle carbuncle disease of having a headache.Flos Chrysanthemi Indici water extract and volatile oil all have antiviral, antibacterial activity.Flos Chrysanthemi Indici water extract has stronger inhibitory action to staphylococcus aureus, diphtheria corynebacterium, Bacillus typhi, escherichia coli, Bacillus proteus, dysentery bacterium, escherichia coli, Pseudomonas aeruginosa, Fu Shi he bacterium.Flos Chrysanthemi Indici volatile oil is comparatively strong to staphylococcus aureus effect, effective to Staphylococcus albus.Flos Chrysanthemi Indici water extract and volatile oil have significant antiinflammatory, immunosuppressive action, but volatile oil is better to the Inflammatory effects caused by chemicals, and water extract is better to the inflammatory effect caused by foreign preteins pro-inflammatory cytokine; By in Flos Chrysanthemi Indici the chrysanthemol that is separated to of lipophilic moieties there is obvious antiinflammatory action.Flos Chrysanthemi Indici decoct has the effect promoting phagocytic activity of leukocytes, and in vitro tests shows the Flos Chrysanthemi Indici decoct of 1:1280 concentration, has and promotes that human leukocytes engulfs the effect of staphylococcus aureus, also have the effect of resisting pathogenic microbes.
Herba Menthae is acrid in the mouth, cool in nature, nontoxic.Return lung, Liver Channel, have and disperse wind heat, the clear general clearing throat of upperization, rash is detoxified, dispersing the stagnated live-QI to relieve the stagnation of QI and the effect such as antipruritic, be applicable to cold, fever, headache, laryngopharynx swelling and pain, lossless, wind-fire acute conjunctivitis, rubella, skin are itched, colic, fire-toxin become the diseases such as skin ulcer, dysentery and scrofula, external has slight analgesic effect, for neuralgia etc.Wind dispels the heat, and also can draw heat and go out, therefore under controlling hectic fever due to YIN-deficiency consumptive disease (pulmonary tuberculosis), children's's mania and irritation, large heat etc., often uses it as priming.
Modern pharmacological research proves, mentha leave has following several functions: 1, stimulate and suppress neural.Herba Menthae has the effect stimulating nervus centralis, and acting on skin has bright sense and creeping chill simultaneously, and it has again the effect of suppression and paralysis to sensory nerve ending.2, antiphlogistic antibacterial.Herba Menthae has desensitization, antiinflammatory and antibacterial effect to mosquito bite skin; Also obvious cough-relieving, antiinflammatory and bacteriostasis is had to upper respiratory tract infection; Hemorrhoid, anal fissure are had to the effect of reducing swelling and alleviating pain, antiphlogistic antibacterial.3. stomach invigorating is dispeled the wind.Herba Menthae has big gun hotness and stimulation to oral mucosa, can promote the amount of blood supply of oral cavity sialorrhea, appetite stimulator, increase gastric mucosa, improves digestive function.In addition, Herba Menthae also has good wind dispelling effect in intestinal, can alleviate intestinal inflation, speed slow myenteron wriggle, have slow down enterocele pain effect.4. fragrant seasoning.Mainly utilize refrigerant throat-moistening specific to Herba Menthae and some senses of discomfort having abnormal flavour and be difficult to the medicine swallowed are covered up and improved to the pleasant abnormal smells from the patient of fragrance.
The present invention provides a kind of preparation method of this Chinese medicine composition on the other hand, comprises the steps:
1, raw material is prepared according to following weight:
Flos Chrysanthemi Indici 0.5-2, Folium Mori 0.5-2, Herba Menthae 0.5-2
2, Folium Mori, Flos Chrysanthemi Indici, Herba Menthae are pulverized respectively, obtained Folium Mori, Flos Chrysanthemi Indici, Herba Menthae powder;
3, Folium Mori, Flos Chrysanthemi Indici, Herba Menthae powder mix homogeneously, to obtain final product.
Wherein, the weight of the raw material described in step 1 is preferably: Flos Chrysanthemi Indici 0.5-1.5, Folium Mori 0.5-1.5, Herba Menthae 0.5-1.5, more preferably: Flos Chrysanthemi Indici 1, Folium Mori 1, Herba Menthae 1.
Particularly, granularity >=40 order of the powder described in step 2, is preferably 40-60 orders, and preferred powder size is 50 orders further.
It should be noted that, adopt disintegrating machine to shatter by the component of said composition, then blender is adopted to carry out stirring and evenly mixing, filter paper bag (such as teabag tea filter paper bag etc.) is adopted to carry out subpackage after mixing fully, every bag of subpackage 1-5g makes stifling bag, and carries out sterilization treatment.
Particularly, obtained stifling bag is adopted ethylene oxide sterilizing method process sterilizing.
Wherein, the conditional parameter arranged in described sterilisation process is: ethylene oxide concentration is 450mg/L, and temperature is 45 DEG C, and sterilization time is 5h.
The stifling bag using method of described said composition: get the water tumbler that a life is common, cleaned by water tumbler, puts into stifling bag, then pours certain amount of boiling water into fumigating bag submergence completely, be put in by water tumbler near eyes, adopts vapours to smoke eye treatment.Every day fumigates number of times 1-3 time, and the fumigation treatment time is 10-30min/ time, each use 1 bag, every bag of 3g.
Particularly, stifling the wrapping in obtained by described Chinese medicine composition is prevented or/and can have good application in treatment xerophthalmia.
The Chinese medicine composition tool for the treatment of xerophthalmia prepared by the present invention has the following advantages:
The source of each crude drug of the compositions 1, in the present invention is easy, and preparation technology is simple, and be easy to realize, the toxicity of drug regimen is little, and be suitable for crowd extensive, determined curative effect is remarkable.
2, patient is simple for use, uses stainless-steel pan or fumigation instrument heating.
3, stifling bag is convenient to storage, and normal temperature environment, effect duration is permanent.
4, the present invention treats xerophthalmia compositions prescription compatibility science, and determined curative effect, safety is high, quality controllable.
5, the present invention treats effect that xerophthalmia compositions has wind and heat dispersing, nourshing Yin and drynsessmoistening prescription, liver heat removing and eyesight improving, can be used for prevention and therapy xerophthalmia, and treatment xerophthalmia, eliminates tarsal glands inflammation.
Detailed description of the invention
Further describe the present invention below in conjunction with specific embodiment, advantage and disadvantage of the present invention will be more clear along with description.But these embodiments are only exemplary, do not form any restriction to scope of the present invention.It will be understood by those skilled in the art that and can modify to the details of technical solution of the present invention and form or replace down without departing from the spirit and scope of the present invention, but these amendments and replacement all fall within the scope of protection of the present invention.
Embodiment 1
1, raw material (× 1000g) is prepared according to following weight
Flos Chrysanthemi Indici 1, Folium Mori 1, Herba Menthae 1
2, adopt pulverizer to carry out pulverization process respectively Folium Mori, Flos Chrysanthemi Indici, Herba Menthae, then cross 50 mesh sieves, obtain Flos Chrysanthemi Indici powder, Mulberry Leaf, Herba Menthae powder respectively;
3, Flos Chrysanthemi Indici powder, Mulberry Leaf, Herba Menthae powder are joined in blender and stir, obtained Flos Chrysanthemi Indici-Folium Mori-Herba Menthae compositions;
4, the Flos Chrysanthemi Indici-Folium Mori-Herba Menthae compositions of mix homogeneously be sub-packed in after being weighed by quantifier (filter paper bag that such as conventional teabag uses) in packaging bag, every bag of 1-5g, is preferably 3g;
5, the medicated bag after subpackage is positioned over ethylene oxide sterilizing cabinet (ethylene oxide sterilizing cabinet, model is ZMW-500L, Shenyang City's modern medical instrument institute) sterilization, the parameter of setting is ethylene oxide concentration is 450mg/L, temperature is 45 DEG C, sterilization time 5h;
6, be packaged in outer packaging bag after sterilizing medicated bag being cooled, obtain final product.
The traditional Chinese medicine fumigating steamed bun for the treatment of xerophthalmia of the present invention uses 1 bag at every turn, and every day fumigates 2-3 time.
Embodiment 2
1, raw material (× 1000g) is prepared according to following weight
Flos Chrysanthemi Indici 0.5, Folium Mori 1.0, Herba Menthae 1.0
2, adopt pulverizer to carry out pulverization process respectively Folium Mori, Flos Chrysanthemi Indici, Herba Menthae, then cross 40 mesh sieves, obtain Flos Chrysanthemi Indici powder, Mulberry Leaf, Herba Menthae powder respectively;
3, Flos Chrysanthemi Indici powder, Mulberry Leaf, Herba Menthae powder are joined in blender and stir, obtained Flos Chrysanthemi Indici-Folium Mori-Herba Menthae compositions;
4, the Flos Chrysanthemi Indici-Folium Mori-Herba Menthae compositions of mix homogeneously be sub-packed in after being weighed by quantifier (filter paper bag that such as conventional teabag uses) in packaging bag, every bag of 1-5g, is preferably 1g;
5, the medicated bag after subpackage is positioned over ethylene oxide sterilizing cabinet (ethylene oxide sterilizing cabinet, model is ZMW-500L, Shenyang City's modern medical instrument institute) sterilization, the parameter of setting is ethylene oxide concentration is 450mg/L, temperature is 45 DEG C, sterilization time 5h;
6, be packaged in outer packaging bag after sterilizing medicated bag being cooled, obtain final product.
The traditional Chinese medicine fumigating steamed bun for the treatment of xerophthalmia of the present invention uses 1 bag at every turn, stifling 2-3 times of every day.
Embodiment 3
1, raw material (× 1000g) is prepared according to following weight
Flos Chrysanthemi Indici 1.5, Folium Mori 0.5, Herba Menthae 0.5
2, adopt pulverizer to carry out pulverization process respectively Folium Mori, Flos Chrysanthemi Indici, Herba Menthae, then cross 60 mesh sieves, obtain Flos Chrysanthemi Indici powder, Mulberry Leaf, Herba Menthae powder respectively;
3, Flos Chrysanthemi Indici powder, Mulberry Leaf, Herba Menthae powder are joined in blender and stir, obtained Flos Chrysanthemi Indici-Folium Mori-Herba Menthae compositions;
4, the Flos Chrysanthemi Indici-Folium Mori-Herba Menthae compositions of mix homogeneously be sub-packed in after being weighed by quantifier (filter paper bag that such as conventional teabag uses) in packaging bag, every bag of 1-5g, is preferably 5g;
5, the medicated bag after subpackage is positioned over ethylene oxide sterilizing cabinet (ethylene oxide sterilizing cabinet, model is ZMW-500L, Shenyang City's modern medical instrument institute) sterilization, the parameter of setting is ethylene oxide concentration is 450mg/L, temperature is 45 DEG C, sterilization time 5h;
6, be packaged in outer packaging bag after sterilizing medicated bag being cooled, obtain final product.
The traditional Chinese medicine fumigating steamed bun for the treatment of xerophthalmia of the present invention uses 1 bag at every turn, stifling 2-3 times of every day.
Embodiment 4
1, raw material (× 1000g) is prepared according to following weight
Flos Chrysanthemi Indici 2, Folium Mori 0.5, Herba Menthae 2
2, adopt pulverizer to carry out pulverization process respectively Folium Mori, Flos Chrysanthemi Indici, Herba Menthae, then cross 50 mesh sieves, obtain Flos Chrysanthemi Indici powder, Mulberry Leaf, Herba Menthae powder respectively;
3, Flos Chrysanthemi Indici powder, Mulberry Leaf, Herba Menthae powder are joined in blender and stir, obtained Flos Chrysanthemi Indici-Folium Mori-Herba Menthae compositions;
4, the Flos Chrysanthemi Indici-Folium Mori-Herba Menthae compositions of mix homogeneously be sub-packed in after being weighed by quantifier (filter paper bag that such as conventional teabag uses) in packaging bag, every bag of 1-5g, is preferably 3g;
5, the medicated bag after subpackage is positioned over ethylene oxide sterilizing cabinet (ethylene oxide sterilizing cabinet, model is ZMW-500L, Shenyang City's modern medical instrument institute) sterilization, the parameter of setting is ethylene oxide concentration is 450mg/L, temperature is 45 DEG C, sterilization time 5h;
6, be packaged in outer packaging bag after sterilizing medicated bag being cooled, obtain final product.
The traditional Chinese medicine fumigating steamed bun for the treatment of xerophthalmia of the present invention uses 1 bag at every turn, stifling 2-3 times of every day.
Embodiment 5
1, raw material (× 1000g) is prepared according to following weight
Flos Chrysanthemi Indici 0.5, Folium Mori 1.5, Herba Menthae 0.5
2, adopt pulverizer to carry out pulverization process respectively Folium Mori, Flos Chrysanthemi Indici, Herba Menthae, then cross 40 mesh sieves, obtain Flos Chrysanthemi Indici powder, Mulberry Leaf, Herba Menthae powder respectively;
3, Flos Chrysanthemi Indici powder, Mulberry Leaf, Herba Menthae powder are joined in blender and stir, obtained Flos Chrysanthemi Indici-Folium Mori-Herba Menthae compositions;
4, the Flos Chrysanthemi Indici-Folium Mori-Herba Menthae compositions of mix homogeneously be sub-packed in after being weighed by quantifier (filter paper bag that such as conventional teabag uses) in packaging bag, every bag of 1-5g, is preferably 3g;
5, the medicated bag after subpackage is positioned over ethylene oxide sterilizing cabinet (ethylene oxide sterilizing cabinet, model is ZMW-500L, Shenyang City's modern medical instrument institute) sterilization, the parameter of setting is ethylene oxide concentration is 450mg/L, temperature is 45 DEG C, sterilization time 5h;
6, be packaged in outer packaging bag after sterilizing medicated bag being cooled, obtain final product.
The traditional Chinese medicine fumigating steamed bun for the treatment of xerophthalmia of the present invention uses 1 bag at every turn, stifling 2-3 times of every day.
The clinical observation on the therapeutic effect of test example one traditional Chinese medicine composition for treating xerophthalmia of the present invention
1, test objective
By studying the clinical observation of 80 routine patients with dry eyes, verify the clinical efficacy of this traditional Chinese medicine fumigating steamed bun.
2, Chinese and western medicine diagnostic criteria and foundation thereof
Xerophthalmia belongs to the category of " dry astringent eye, xerosis conjunctivitis " at ophthalmology of Chinese medicine, with reference to the relevant CM syndrome differentiation criterion of Zeng Qinghua chief editor " ophthalmology of Chinese medicine ".Its Symptoms is: trouble eye is dry and astringent not well, again and again twinkles, or micro-photophobia; White of the eye blood vessel is indistinct, maybe can look into and see a black eyeball point-like star an ancient unit of weight equal to 20 or 24 *taels of silver; Red tongue.Thin fur, rapid pulse or count accurately.Western medicine diagnose standard is with reference to the diagnostic criteria of the Diagnosis and Treat progress formulation of national xerophthalmia in 2004.This diagnostic criteria is: 1, patient has obvious subjective symptoms, as foreign body sensation, sensation of dryness, burn feeling, ophthalmic bloated sense, photophobia, furious, wherein with eyestrain, foreign body sensation, sensation of dryness 3 symptoms for leading indicator; 2, tear film shows as unstability, and breakup time of tear film shortening is less than 10 seconds; 3, lacrimal secretion reduces, and Schimer's test is less than or equal to 10mm/5min; 4, eye surface damage, adopts corneal fluorescein dyeing to strengthen diagnosis.
3, case inclusion criteria
Meet Chinese and western medicine diagnostic criteria, and the age is below 70 one full year of life, sex is unrestricted.
4, case exclusion standard
A be accompanied with have a strong impact on visual function other oculopathy as the disease such as glaucoma, cataract that can not cure simultaneously.
B has obvious organic oculopathy (hypophasis; Eyelid malposition; Thyroid correlation immunity oculopathy; Corneal scarring; Conjunctiva trace etc.).
C has the oculopathy (anaphylaxis keratoconjunctivitis etc.) of strong interference to primary disease
D has the decorum diseases such as serious connective tissue disease, rheumatoid arthritis, scleroderma, lupus erythematosus.
E merges the severe primary diseases such as the heart, liver, kidney, hemopoietic system, psychotic.
F allergic constitution person.
5, criterion of therapeutical effect and foundation thereof
" the disease of tcm Standardization of diagnosis and curative effect " issued with reference to State Administration of Traditional Chinese Medicine is drafted
A cures: transference cure, and corneal dyeing disappears, and lacrimal secretion experiment repetitive measurement is greater than 10mm/5min.
B takes a turn for the better: symptom alleviates, and corneal dyeing reduces, and lacrimal secretion experiment repeatedly measures lacrimal secretion to be increased to some extent.
C is not healed: symptom is without improvement, and corneal dyeing is unchanged or increase, and lacrimal secretion experiment repetitive measurement lacrimal secretion is without increase.
6, test method
(1) all Eligible subjects meeting case diagnosis standard, inclusive criteria and exclusion standard adopt " random digits table " to be assigned randomly to this herbal fumigation bag treatment group A (40 example) and matched group B (40 example).
(2) medicine
A treatment group uses: the stifling bag of Chinese medicine composition prepared by the embodiment of the present invention 1
The auspicious pearl eye drop of choice of drug (Hubei Grand Everyday Bright Eyes Pharmaceutical Co., Ltd., 0.8 milliliter: 11.2 milligrams (with polyvinyl alcohol)) that b matched group uses
(3) medication
A gets the common water tumbler of a life, water tumbler is cleaned, put into stifling bag, then certain amount of boiling water is poured into fumigating bag submergence completely, water tumbler is put near eyes, adopts vapours to smoke eye and treat, each use 1 bag, every day fumigates number of times 2-3 time, and the fumigation treatment time is 10-30min/ time.Treating 4 weeks is 1 course for the treatment of.Medication was checked after 2 weeks, carried out the mensuration of the test of tear basal secretion and breakup time of tear film.
B matched group gives control drug auspicious pearl eye drop, when eyes are felt dry and astringent, drips auspicious pearl eye drop, each 1, every day 4 times to trouble eye.Treating 4 weeks is 1 course for the treatment of.Medication was checked after 2 weeks, carried out the mensuration of the test of tear basal secretion and breakup time of tear film.
(4) clinical observation content
A, eye symptom; B, ocular signs (corneal fluorescein dyeing, lacrimal secretion); C, tongue fur, pulse condition.
(5) clinical experiment observed result
| Group | Cure | Take a turn for the better | Do not heal | Total effective rate (%) |
| Treatment group | 8 | 31 | 1 | 97.5 |
| Matched group | 2 | 25 | 13 | 67.5 |
Result shows:
On inspection, the routine patient for the treatment of group 40 after the treatment total effective rate reach 97.5%.Patients symptomatic disappears, and corneal dyeing disappears, and lacrimal secretion is greater than patient's number 8 example of 10mm/5min, and cure rate reaches 20%; Symptom alleviates, and corneal dyeing reduces, and the patient that lacrimal secretion increases to some extent has 31 examples, and improvement effective percentage reaches 77.5%; Patients symptomatic does not have clear improvement, and the patient that lacrimal secretion is not significantly increased has 1 example, and more rate is not 2.5%.
Medicament fumigating bag of the present invention in use experimenter, without any anaphylaxis and other untoward reaction, illustrates that the compositions for the treatment of xerophthalmia of the present invention has no adverse effects to human body.
Rebound phenomena is not had to occur in the observation of 6 months after using product of the present invention to experimenter.
Test example two Chinese medicine composition of the present invention fumigates bag toxicological test
Embodiment 1 is obtained traditional Chinese medicine fumigating steamed bun toxicity test is carried out to mice: stifling bag is placed in boiled water and fully soaks, per os gastric infusion and by described Chinese medicine composition through ultrasonic atomizatio administration, day by day observe, and record each treated animal poisoning manifestations and dead animal number to 14 day, result shows two kinds of medication equal LD50 > 5000ml/kg (body weight), true border innocuous substance.
The toxicity test of stifling bag to lagophthalmos nose: the traditional Chinese medicine fumigating steamed bun prepared according to embodiment 1 is placed in water tumbler, adopts after soaking completely in boiled water, is then placed in by water tumbler in semi-enclosed rabbit-hutch of top-open, opposite side with the boiled distilled water that seethes with excitement for contrast.Subsequently 1,6,24, the reaction (having the symptom such as anophthalmia nasal congestion, rhinorrhea, cough) of 48h and 4 day observer's rabbit conjunctival, iris and cornea and nasal mucosa, acquired results reaction integration is 0, belongs to without comparatively strong and stimulating and toxicity.
Case 1
Patient Lee, man, 32 years old, people from Baoding, private prosecution eyes sense of discomfort and eyes 3 years bitterly, ophthalmic pruritus, eye is dry, before vision is much worse than, double eyeball conjunctival congestion is checked when coming medical, breakup time of tear film (BUT) right eye 4S, left eye 5S, SchimmerI tests right eye 3mm/5min, left eye 2mm/5min, corneal fluorescein dyeing right eye+, left eye ++ be diagnosed as xerophthalmia (liver-kidney yin deficiency), 2 courses for the treatment of of treatment are guaranteed to cure through this herbal fumigation, wherein 4 weeks each courses for the treatment of, conjunctiva of both eyes hyperemia is disappeared, feel that eye is dry to be clearly better, eyes are moistening, namely after 1 course for the treatment of, eye is dry disappears with ophthalmic pruritus, recheck Dual-eyelid chemosis after two courses for the treatment of to disappear, SchimmerI test checks tear 15mm/5min (two), breakup time of tear film (BUT) 20S.
Case 2
Patient Chen, female, 57 years old, people from Beijing; Readme eye is dry, puckery 1 year of eye, undesirable by sodium hyaluronate eye drops effect.Check time medical that conjunctiva of both eyes is congested, corneal transparency, pupil 3mm, breakup time of tear film (BUT) right eye 3S, left eye 4S, SchimmerI test checks tear 2mm/5min (two), corneal fluorescein dyeing right eye+, left eye ++, be diagnosed as xerophthalmia (liver-kidney yin deficiency), after adopting traditional Chinese medicine fumigating steamed bun of the present invention to carry out 2 courses for the treatment of of fumigation treatment, wherein 4 weeks each courses for the treatment of, eyelid, eyeball, conjunctival congestion disappear, eye is dry to disappear with ophthalmic pruritus, breakup time of tear film (BUT) 15s.SchimmerI test checks tear 14mm/5min (two), and all inadaptations are eliminated and fully recover.
Case 3
Patient Lee, female, 40 years old, people from Heilungkiang, dry and astringent 1 year of eyes distending pain, was envious sometimes.Check time medical that Dual-eyelid is without exception, conjunctiva mild hyperaemia, corneal transparency, dark in anterior chamber, pupil 3mm, sensitive to luminous reflectance, breakup time of tear film (BUT) right eye 3S, left eye 2S, SchimmerI test checks that tear eyes are 0, corneal fluorescein dyeing right eye ++, left eye+, be diagnosed as xerophthalmia (liver-kidney yin deficiency).Through this traditional Chinese medicine fumigating steamed bun two the fumigation treatment course for the treatment of, wherein each course for the treatment of surrounding, dry eye condition all disappears, the unassured dye of corneal fluorescein dyeing, breakup time of tear film (BUT) right eye 12s, left eye 15s.SchimmerI tests right eye 13mm/5min, left eye 14mm/5min.
Case 4
Patient Zhao, man, 38 years old, people from Liaoning, eyes were dry and astringent, can not watching for a long time more than 2 years.The conjunctival congestion of inspection double eyeball+, cornea of both eyes is transparent, dark in anterior chamber, pupil 3mm, luminous reflectance is sensitive, breakup time of tear film (BUT) right eye 3S, left eye 2S, SchimmerI test right eye 1mm/5min, left eye 4mm/5min, corneal fluorescein dyeing right eye ++, left eye ++, be diagnosed as xerophthalmia (liver-kidney yin deficiency).Through the fumigation treatment of three courses for the treatment of of this traditional Chinese medicine fumigating steamed bun, each course for the treatment of surrounding, eyes dry eye condition all disappears, and conjunctiva of both eyes is without hyperemia, corneal transparency, dark in anterior chamber, pupil 3mm, sensitive to luminous reflectance, breakup time of tear film (BUT) right eye 18s, left eye 16s.SchimmerI tests right eye 25mm/5min, and left eye 20mm/5min, cornea of both eyes fluorescent staining all nowhere contaminates, and dry eye condition all disappears.
Case 5
Patient fiber crops certain, female, 70 years old, people from Beijing, the dry and astringent twinge of eyes, can not watching for a long time 3 months.Check that conjunctiva of both eyes is without hyperemia, corneal transparency, dark in anterior chamber, pupil 3mm is sensitive to luminous reflectance, breakup time of tear film (BUT) right eye 4S, left eye 4S, SchimmerI test right eye 7mm/5min, left eye 8mm/5min, corneal fluorescein dyeing has no and contaminates, and is diagnosed as eyes xerophthalmia (liver-kidney yin deficiency).Through this traditional Chinese medicine fumigating steamed bun one the fumigation treatment course for the treatment of, wherein each course for the treatment of surrounding, patient's dry eye condition disappears, breakup time of tear film (BUT) right eye 15s, left eye 17s.SchimmerI tests right eye 13mm/5min, left eye 15mm/5min.
Claims (10)
1. treat a Chinese medicine composition for xerophthalmia, it is characterized in that, comprise following raw material: Folium Mori, Flos Chrysanthemi Indici, Herba Menthae.
2. Chinese medicine composition as claimed in claim 1, it is characterized in that, the weight of described raw material is: Folium Mori 0.5-2, Flos Chrysanthemi Indici 0.5-2, Herba Menthae 0.5-2.
3. Chinese medicine composition as claimed in claim 2, is characterized in that, the weight of described raw material is preferably: Folium Mori 0.5-1.5, Flos Chrysanthemi Indici 0.5-1.5, Herba Menthae 0.5-1.5.
4. Chinese medicine composition as claimed in claim 2, is characterized in that, the weight of described raw material is preferably: Folium Mori 1, Flos Chrysanthemi Indici 1, Herba Menthae 1.
5. treat a preparation method for the Chinese medicine composition of xerophthalmia, it is characterized in that, carry out step in the following order:
1) raw material is prepared according to following weight:
Flos Chrysanthemi Indici 0.5-2, Folium Mori 0.5-2, Herba Menthae 0.5-2
2) Folium Mori, Flos Chrysanthemi Indici, Herba Menthae are pulverized respectively, obtained Folium Mori, Flos Chrysanthemi Indici, Herba Menthae powder;
3) Folium Mori, Flos Chrysanthemi Indici, Herba Menthae powder mix homogeneously, to obtain final product.
6. preparation method as claimed in claim 5, is characterized in that, step 1) described in the weight of raw material be preferably: Folium Mori 0.5-1.5, Flos Chrysanthemi Indici 0.5-1.5, Herba Menthae 0.5-1.5.
7. preparation method as claimed in claim 5, is characterized in that, step 1) described in the weight of raw material be preferably: Folium Mori 1, Flos Chrysanthemi Indici 1, Herba Menthae 1.
8. preparation method as claimed in claim 5, is characterized in that, step 2) described in Folium Mori, Flos Chrysanthemi Indici, Herba Menthae powder granularity >=40 order.
9. preparation method as claimed in claim 8, is characterized in that, step 2) described in Folium Mori, Flos Chrysanthemi Indici, Herba Menthae powder particle size range be 40-60 order.
10. Chinese medicine composition as arbitrarily described in claim 1-4 in prevention or/and treat the application in xerophthalmia.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112107623A (en) * | 2020-10-12 | 2020-12-22 | 北京市眼科研究所 | Traditional Chinese medicine composition for improving meibomian gland function |
| CN112704705A (en) * | 2021-02-05 | 2021-04-27 | 广州新锐视光学科技有限公司 | Traditional Chinese medicine eye patch for relieving visual fatigue and preparation method thereof |
| CN112933163A (en) * | 2021-02-05 | 2021-06-11 | 广州新锐视光学科技有限公司 | Method for classifying traditional Chinese medicine composition for treating asthenopia by external application and traditional Chinese medicine eye patch |
| CN116211916A (en) * | 2023-05-05 | 2023-06-06 | 广州白云山星群(药业)股份有限公司 | Application of grass mulberry chrysanthemum extract in preparing medicament for treating hypertonic xerophthalmia |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112107623A (en) * | 2020-10-12 | 2020-12-22 | 北京市眼科研究所 | Traditional Chinese medicine composition for improving meibomian gland function |
| CN112107623B (en) * | 2020-10-12 | 2023-03-31 | 首都医科大学附属北京同仁医院 | Traditional Chinese medicine composition for improving meibomian gland function |
| CN112704705A (en) * | 2021-02-05 | 2021-04-27 | 广州新锐视光学科技有限公司 | Traditional Chinese medicine eye patch for relieving visual fatigue and preparation method thereof |
| CN112933163A (en) * | 2021-02-05 | 2021-06-11 | 广州新锐视光学科技有限公司 | Method for classifying traditional Chinese medicine composition for treating asthenopia by external application and traditional Chinese medicine eye patch |
| CN116211916A (en) * | 2023-05-05 | 2023-06-06 | 广州白云山星群(药业)股份有限公司 | Application of grass mulberry chrysanthemum extract in preparing medicament for treating hypertonic xerophthalmia |
| CN116211916B (en) * | 2023-05-05 | 2023-12-15 | 广州白云山星群(药业)股份有限公司 | Application of grass mulberry chrysanthemum extract in preparing medicament for treating hypertonic xerophthalmia |
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| CN105106318B (en) | 2018-10-19 |
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