CN103550357B - A kind of control muscae volitantes collyrium and its production and use - Google Patents
A kind of control muscae volitantes collyrium and its production and use Download PDFInfo
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Abstract
A kind of control muscae volitantes collyrium and its production and use, belongs to technical field of Chinese medicine.It is characterized in that the following material containing parts by weight: Pericarpium Citri Reticulatae 0.3 ~ 1.0 part, Flos Chrysanthemi 0.3 ~ 1.1 part, 0.8 ~ 1.8 part, Folium Mori, 0.6 ~ 1.5 part, sodium chloride, Rhizoma Coptidis 0.1 ~ 1.0 part, Cortex Phellodendri 0.3 ~ 1.1 part, Radix Notoginseng 0.2 ~ 1.2 part, Herba Menthae 0.5 ~ 1.3 part, Borneolum Syntheticum 0.4 ~ 1.3 part, vitamin B2? 0.3 ~ 1.2 part, distilled water 85-96 part.Above-mentioned one control muscae volitantes collyrium, has bactericidal antiphlogistic, heat clearing away and internal heat reducing, moistens eyeball, refrigerant improving eyesight effect, effectively can alleviate ophthalmic uncomfortable that muscae volitantes causes and dry etc. problem; This formula safety is gentle, containing the multiple nutritional labeling to eye health protection, manufacturing cost, effective simultaneously, has specially good effect to muscae volitantes, and without any side effects, can use as eye long-term care liquid medicine.
Description
Technical field
The invention belongs to technical field of Chinese medicine, be specially a kind of control muscae volitantes collyrium and its production and use.
Background technology
Collyrium is the liquid medicine for the treatment of disease of eye, and its composition has numerous species, such as steroid, antibiotic, antihistaminic, beta-blocker, non-steroidal anti-inflammatory analgesic etc. according to the difference of effect.General collyrium with the addition of the antiseptic of trace in order to preserve for a long time, can not impact under normal use to human body.If but life-time service contains the collyrium of antiseptic, be easier to cause cornea injured, occur the symptoms such as one's eyes became bloodshot, photophobia.Different collyrium has respective purposes, such as treat eye infection, reduce intraocular pressure, anti-inflammatory analgetic or eyes of releiving dry and astringent.As other drug, many collyrium all have the side effect of some degree.
Muscae volitantes refers in the visual field floating shadow, more obvious under the setting off of bright or white background.The record of motherland's medical science to muscae volitantes and similar symptoms is very long.In Sui's Chao Yuanfang (550-630 A.D.) writes " General Treatise on the Cause and Symptoms of Diseases ", just have the record of " the boundless and indistinct time of order ", " all orders is sick, if deficiency of liver-QI, double breast stand tall and upright wind-phlegm consumptive fever; then order can not hypermetropia, then boundless and indistinct also misty depending on thing, if insufficiency of heart-QI; also make order boundless and indistinct, or dislike see flame, depending on seeing that roach fly is yellow also black " river.Namely the sick deficiency of liver-QI of order can visual deterioration, depending on seeing little winged insect (roach is little winged insect) and fly sample shadow.Thereafter, the description such as " soon black flower ", " cloud and mist moves fine " and " muscae volitantes " is had in the ancient mat of the successive dynasties traditional Chinese medical science.Also have in Japan and west and be called " muscae volitantes ".Namely general muscae volitantes is that it occurs caning be fast or slow, different, and degree weight differs with the disease that is chief complaint of shadow of floating at the moment, simple eye or eyes can occur, is one of clinical ophthalmology common sympton, accounts for the 5%-10% of out-patient main suit.Mild mainly causes patient to look thing discomfort and long-term Mental health problem; Severe one can be the prodroma of some serious retinopathy such as detachment of retina, can cause serious consequence.
To the treatment of muscae volitantes and similar symptom, the successive dynasties traditional Chinese medical science has many records, is summed up: what 1. belong to that weakened body resistance mistake supports focuses on reinforcing tonification.As " silver-colored Nereid is micro-" thinks that primary disease is caused by deficiency of both the liver and kidney, control suitable liver and kidney tonifying, side's Bushen Pills." Precious Book of Ophthalmology " thinks that primary disease is for edema with the liver involved of can not helping of suffering from a deficiency of the kidney, available swallow core pill for curing." Zhang Shi doctor is logical " thinks that shadow is that gallbladder kidney is certainly sick, with the kidney invigorating Magnetitum ball.Have and the void of this disease point deficiency of both the liver and kidney and deficiency of qi and blood two type card are controlled.The former uses Radix Rehmanniae Pilulae for Improving Eyesight, ball in scape, Radix Stephaniae Tetrandrae noctilucence ball etc., and latter BAZHEN TANG, Chinese herbaceous peony return blood-enriching soup.2. belong to that turbid damp is not changed, the treatment of addiction blood inner stopper removes small house blood so that removing dampness is turbid.Namely think as " Long Mu's Secret Treatise on Ophthalmology " " the common black flower of eye as rope the person of leading ... the reality of this kidney is also ... should use secret recipe pig an aromatic plant metioned in ancient books soup, kuh-seng soup." doctor trained in Western medicine thinks, the great majority in muscae volitantes are the symptoms occurred in ageing process, and itself can not cause serious harm to vision, particularly occurs unconsciously, and the single mosquito that flies belongs to muscae volitantes mostly, without the need to special treatment.If but find myopia, should go rectifications, and mydriasis conscientiously checks whether peripheral retina degeneration, dryness ceasma, if having, then preventative laser photocoagulation of should going treatment.For the muddiness comparatively having a strong impact on vision, then need set about from expeling cause of disease, 2%-10% dionin eye drop eye etc. can be adopted in local simultaneously.Still lack effective Prevention and Curation medicine at present.
Summary of the invention
In view of problems of the prior art, the object of the invention is to design provides a kind of technical scheme of preventing and treating muscae volitantes collyrium and its production and use, and its cost is low, effective and effectively can prevent and treat muscae volitantes.
Described one control muscae volitantes collyrium, it is characterized in that the following material containing parts by weight: Pericarpium Citri Reticulatae 0.3 ~ 1.0 part, Flos Chrysanthemi 0.3 ~ 1.1 part, 0.8 ~ 1.8 part, Folium Mori, 0.6 ~ 1.5 part, sodium chloride, Rhizoma Coptidis 0.1 ~ 1.0 part, Cortex Phellodendri 0.3 ~ 1.1 part, Radix Notoginseng 0.2 ~ 1.2 part, Herba Menthae 0.5 ~ 1.3 part, Borneolum Syntheticum 0.4 ~ 1.3 part, vitamin B2 0.3 ~ 1.2 part, distilled water 85-96 part.
Described one control muscae volitantes collyrium, it is characterized in that: Pericarpium Citri Reticulatae 0.4 ~ 0.9 part, Flos Chrysanthemi 0.4 ~ 0.9 part, 1.0 ~ 1.6 parts, Folium Mori, 0.7 ~ 1.3 part, sodium chloride, Rhizoma Coptidis 0.2 ~ 0.9 part, Cortex Phellodendri 0.4 ~ 1.0 part, Radix Notoginseng 0.4 ~ 1.1 part, Herba Menthae 0.6 ~ 1.1 part, Borneolum Syntheticum 0.5 ~ 1.1 part, vitamin B2 0.5 ~ 1.1 part, distilled water 89-92 part.
Described one control muscae volitantes collyrium, it is characterized in that: Pericarpium Citri Reticulatae 0.5 ~ 0.7 part, Flos Chrysanthemi 0.5 ~ 0.8 part, 1.2 ~ 1.4 parts, Folium Mori, 0.8 ~ 1.1 part, sodium chloride, Rhizoma Coptidis 0.5 ~ 0.6 part, Cortex Phellodendri 0.5 ~ 0.8 part, Radix Notoginseng 0.5 ~ 0.8 part, Herba Menthae 0.8 ~ 1.0 part, Borneolum Syntheticum 0.8 ~ 1.0 part, vitamin B2 0.6 ~ 0.8 part, distilled water 90-91 part.
Described a kind of preparation method of preventing and treating muscae volitantes collyrium, is characterized in that comprising the following steps:
1) Pericarpium Citri Reticulatae, Flos Chrysanthemi, Folium Mori, sodium chloride, Rhizoma Coptidis, Cortex Phellodendri, Radix Notoginseng, Herba Menthae, Borneolum Syntheticum, vitamin B2, distilled water is taken according to ratio described in claim 1, for subsequent use;
2) Pericarpium Citri Reticulatae, Flos Chrysanthemi, Folium Mori, Rhizoma Coptidis, Cortex Phellodendri, Radix Notoginseng, Herba Menthae powder are broken to below 200 orders, distilled water is divided into equivalent two parts, first get a copy of it distilled water by all medical material dipping 8-15h, then 85-95 DEG C of heating 15-25min, last filter paper filtering carries out solid-liquid separation, collect filtering residue and filtrate respectively, for subsequent use;
3) by step 2) in add second half distilled water again in gained filtering residue, then repeat step one under similarity condition, finally merge twice filtrate, for subsequent use;
4) filtrate after being merged by gained in step 3), add sodium chloride, Borneolum Syntheticum and vitamin B2, vibration is uniformly dissolved, and at 125-130 DEG C, sterilizing 3-4h, obtains final products.
Described a kind of muscae volitantes collyrium of preventing and treating is preparing the application in control muscae volitantes, anti-inflammation and sterilization, alleviation eye strain, ophthalmic preparations.
Above-mentioned one control muscae volitantes collyrium, by by multiple there is bactericidal antiphlogistic, heat clearing away and internal heat reducing, moisten eyeball, the medical material of refrigerant improving eyesight refiningly by a certain percentage forms, and effectively can alleviate ophthalmic uncomfortable that muscae volitantes causes and dry etc. problem; This formula safety is gentle, containing the multiple nutritional labeling to eye health protection, manufacturing cost, effective simultaneously, has specially good effect to muscae volitantes, and without any side effects, can use as eye long-term care liquid medicine.
The percentage composition related in present specification unless otherwise indicated, other the weight percentage being pure material.
Detailed description of the invention
Now in conjunction with embodiments of the invention and the test of pesticide effectiveness, further illustrate beneficial effect of the present invention.
Embodiment 1
By 0.4 part of Pericarpium Citri Reticulatae, 0.4 part of Flos Chrysanthemi, 1.0 parts of Folium Mori, 0.2 portion of Rhizoma Coptidis, 0.4 portion of Cortex Phellodendri, 0.4 portion of Radix Notoginseng, 0.6 part of Herba Menthae powder is broken to below 200 orders, 89.0 parts of distilled water are divided into equivalent two parts, first get a copy of it distilled water by all medical material dipping 8h, then 85 DEG C of heating 15min, filter paper filtering carries out solid-liquid separation, collect filtering residue and filtrate respectively, and then in filtering residue, add second half distilled water dipping 8h again, then 85 DEG C of heating 15min, filter paper filtering carries out solid-liquid separation and collects filtrate, merge twice filtrate, again in the filtrate after the merging of gained, add 0.7 part of sodium chloride, 0.5 part of Borneolum Syntheticum and 0.5 part of vitamin B2, vibration is uniformly dissolved, sterilizing 3h at 125 DEG C, sealing Refrigerator store.
Embodiment 2
By 0.9 part of Pericarpium Citri Reticulatae, 0.9 part of Flos Chrysanthemi, 1.6 parts of Folium Mori, 0.9 portion of Rhizoma Coptidis, 1.0 portions of Cortex Phellodendris, 1.1 portions of Radix Notoginseng, 1.1 parts of Herba Menthae powders are broken to below 200 orders, 94.9 parts of distilled water are divided into equivalent two parts, first get a copy of it distilled water by all medical material dipping 15h, then 95 DEG C of heating 25min, filter paper filtering carries out solid-liquid separation, collect filtering residue and filtrate respectively, and then in filtering residue, add second half distilled water dipping 15h again, then 95 DEG C of heating 25min, filter paper filtering carries out solid-liquid separation and collects filtrate, merge twice filtrate, again in the filtrate after the merging of gained, add 1.3 parts of sodium chloride, 1.1 parts of Borneolum Syntheticums and 1.1 parts of vitamin Bies, vibration is uniformly dissolved, sterilizing 3h at 125 DEG C, sealing Refrigerator store.
Embodiment 3
By 0.5 part of Pericarpium Citri Reticulatae, 0.5 part of Flos Chrysanthemi, 1.1 parts of Folium Mori, 0.3 portion of Rhizoma Coptidis, 0.5 portion of Cortex Phellodendri, 0.5 portion of Radix Notoginseng, 0.7 part of Herba Menthae powder is broken to below 200 orders, 90.0 parts of distilled water are divided into equivalent two parts, first get a copy of it distilled water by all medical material dipping 9h, then 87 DEG C of heating 17min, filter paper filtering carries out solid-liquid separation, collect filtering residue and filtrate respectively, and then in filtering residue, add second half distilled water dipping 9h again, then 87 DEG C of heating 17min, filter paper filtering carries out solid-liquid separation and collects filtrate, merge twice filtrate, again in the filtrate after the merging of gained, add 0.8 part of sodium chloride, 0.7 part of Borneolum Syntheticum and 0.6 part of vitamin B2, vibration is uniformly dissolved, sterilizing 3h at 125 DEG C, sealing Refrigerator store.
Embodiment 4
By 0.6 part of Pericarpium Citri Reticulatae, 0.6 part of Flos Chrysanthemi, 1.2 parts of Folium Mori, 0.4 portion of Rhizoma Coptidis, 0.6 portion of Cortex Phellodendri, 0.6 portion of Radix Notoginseng, 0.8 part of Herba Menthae powder is broken to below 200 orders, 91 parts of distilled water are divided into equivalent two parts, first get a copy of it distilled water by all medical material dipping 10h, then 89 DEG C of heating 18min, filter paper filtering carries out solid-liquid separation, collect filtering residue and filtrate respectively, and then in filtering residue, add second half distilled water dipping 10h again, then 89 DEG C of heating 18min, filter paper filtering carries out solid-liquid separation and collects filtrate, merge twice filtrate, again in the filtrate after the merging of gained, add 0.9 part of sodium chloride, 0.8 part of Borneolum Syntheticum and 0.7 part of vitamin B2, vibration is uniformly dissolved, sterilizing 3h at 125 DEG C, sealing Refrigerator store.
Embodiment 5
By 0.7 part of Pericarpium Citri Reticulatae, 0.7 part of Flos Chrysanthemi, 1.3 parts of Folium Mori, 0.5 portion of Rhizoma Coptidis, 0.7 portion of Cortex Phellodendri, 0.7 portion of Radix Notoginseng, 0.9 part of Herba Menthae powder is broken to below 200 orders, 92 parts of distilled water are divided into equivalent two parts, first get a copy of it distilled water by all medical material dipping 12h, then 91 DEG C of heating 20min, filter paper filtering carries out solid-liquid separation, collect filtering residue and filtrate respectively, and then in filtering residue, add second half distilled water dipping 12h again, then 91 DEG C of heating 20min, filter paper filtering carries out solid-liquid separation and collects filtrate, merge twice filtrate, again in the filtrate after the merging of gained, add 1.0 parts of sodium chloride, 0.9 part of Borneolum Syntheticum and 0.8 part of vitamin B2, vibration is uniformly dissolved, sterilizing 3h at 125 DEG C, sealing Refrigerator store.
Embodiment 6
By 0.8 part of Pericarpium Citri Reticulatae, 0.8 part of Flos Chrysanthemi, 1.5 parts of Folium Mori, 0.8 portion of Rhizoma Coptidis, 0.9 portion of Cortex Phellodendri, 0.9 portion of Radix Notoginseng, 1.0 parts of Herba Menthae powders are broken to below 200 orders, 93 parts of distilled water are divided into equivalent two parts, first get a copy of it distilled water by all medical material dipping 14h, then 93 DEG C of heating 23min, filter paper filtering carries out solid-liquid separation, collect filtering residue and filtrate respectively, and then in filtering residue, add second half distilled water dipping 14h again, then 93 DEG C of heating 23min, filter paper filtering carries out solid-liquid separation and collects filtrate, merge twice filtrate, again in the filtrate after the merging of gained, add 1.2 parts of sodium chloride, 1.0 parts of Borneolum Syntheticums and 1.0 parts of vitamin Bies, vibration is uniformly dissolved, sterilizing 3h at 125 DEG C, sealing Refrigerator store.
Beneficial effect of the present invention is further illustrated below by way of test
Test one:
Each process selects 15 routine muscae volitantes patients to test respectively, wherein man 7 example, female 8 example; 45 ~ 87 years old age, average 56.8 years old; Average course of disease 3.2 years.Therapeutic Method: the collyrium of Example 1-6 gained one bottle, every bottle of about 10ml, often drips once inferior to the morning, noon and afternoon, every day at least three times, also number of times can be increased, not establishing the upper limit, 30 days is 1 course for the treatment of, advises patient to strike a proper balance between work and rest simultaneously, at ordinary times as far as possible less with eye, have a rest more, see TV, computer etc. less, strengthen physical training, wine for giving off smoking.Test and check after 1 month, add up effective, effective, invalid sufferer number, calculate its total effective rate (%), simultaneously observe clinical symptoms and with or without generation complication.Criterion of therapeutical effect: 1. effective: muscae volitantes disappears; 2. effective: muscae volitantes takes a turn for the better gradually, ophthalmic uncomfortable obviously alleviates; 3. invalid: not alleviate or increase the weight of.Result of the test is in table 1.
Table 1 embodiment 1-6 is to the test effect of muscae volitantes patient
| Process | Sufferer (example) | Effective | Effectively | Invalid | Total effective rate (%) |
| Embodiment 1 | 15 | 2 | 13 | 0 | 100 |
| Embodiment 2 | 15 | 3 | 12 | 0 | 100 |
| Embodiment 3 | 15 | 2 | 13 | 0 | 100 |
| Embodiment 4 | 15 | 3 | 12 | 0 | 100 |
| Embodiment 5 | 15 | 3 | 12 | 0 | 100 |
| Embodiment 6 | 15 | 2 | 13 | 0 | 100 |
Result of the test shows: embodiment 1-6 all has good curative effect to muscae volitantes patient, and embodiment 2 is better than embodiment 1, and embodiment 4 is better than embodiment 3, and embodiment 6 is better than embodiment 5, and none example develops complications.
Claims (3)
1. prevent and treat a preparation method for muscae volitantes collyrium, it is characterized in that comprising the following steps:
1) according to Pericarpium Citri Reticulatae 0.3 ~ 1.0 part, Flos Chrysanthemi 0.3 ~ 1.1 part, 0.8 ~ 1.8 part, Folium Mori, 0.6 ~ 1.5 part, sodium chloride, Rhizoma Coptidis 0.1 ~ 1.0 part, Cortex Phellodendri 0.3 ~ 1.1 part, Radix Notoginseng 0.2 ~ 1.2 part, Herba Menthae 0.5 ~ 1.3 part, Borneolum Syntheticum 0.4 ~ 1.3 part, vitamin B2 0.3 ~ 1.2 part, the ratio of distilled water 85-96 part takes each component, for subsequent use;
2) Pericarpium Citri Reticulatae, Flos Chrysanthemi, Folium Mori, Rhizoma Coptidis, Cortex Phellodendri, Radix Notoginseng, Herba Menthae powder are broken to below 200 orders, distilled water is divided into equivalent two parts, first get a copy of it distilled water by all medical material dipping 8-15h, then 85-95 DEG C of heating 15-25min, last filter paper filtering carries out solid-liquid separation, collect filtering residue and filtrate respectively, for subsequent use;
3) by step 2) in add second half distilled water again in gained filtering residue, dipping 8-15h, then 85-95 DEG C of heating 15-25min, filter paper filtering carries out solid-liquid separation, collects filtering residue and filtrate, last combining step 2) and the filtrate that obtains of step 3), for subsequent use;
4) filtrate after being merged by gained in step 3), add sodium chloride, Borneolum Syntheticum and vitamin B2, vibration is uniformly dissolved, and at 125-130 DEG C, sterilizing 3-4h, obtains final products.
2. a kind of preparation method of preventing and treating muscae volitantes collyrium as claimed in claim 1, it is characterized in that: Pericarpium Citri Reticulatae 0.4 ~ 0.9 part, Flos Chrysanthemi 0.4 ~ 0.9 part, 1.0 ~ 1.6 parts, Folium Mori, 0.7 ~ 1.3 part, sodium chloride, Rhizoma Coptidis 0.2 ~ 0.9 part, Cortex Phellodendri 0.4 ~ 1.0 part, Radix Notoginseng 0.4 ~ 1.1 part, Herba Menthae 0.6 ~ 1.1 part, Borneolum Syntheticum 0.5 ~ 1.1 part, vitamin B2 0.5 ~ 1.1 part, distilled water 89-92 part.
3. a kind of preparation method of preventing and treating muscae volitantes collyrium as claimed in claim 1, it is characterized in that: Pericarpium Citri Reticulatae 0.5 ~ 0.7 part, Flos Chrysanthemi 0.5 ~ 0.8 part, 1.2 ~ 1.4 parts, Folium Mori, 0.8 ~ 1.1 part, sodium chloride, Rhizoma Coptidis 0.5 ~ 0.6 part, Cortex Phellodendri 0.5 ~ 0.8 part, Radix Notoginseng 0.5 ~ 0.8 part, Herba Menthae 0.8 ~ 1.0 part, Borneolum Syntheticum 0.8 ~ 1.0 part, vitamin B2 0.6 ~ 0.8 part, distilled water 90-91 part.
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| 从郁论治眼病的经验介绍;卢丙辰等;《中医杂志》;19851231(第12期);第9-10页，尤其是第10页例5 * |
| 眼科名家张望之;梁润英等;《河南中医学院学报》;20051130;第20卷(第6期);第9-11页，尤其是第11页左栏第3.1节，第4节 * |
| 麦粒肿外敷验方;李神羲;《中医杂志》;19861231(第10期);第45页，尤其是第45页右栏最后一段 * |
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