CN111297948B - Eye patch for treating demodex blepharitis and preparation method - Google Patents
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Abstract
The invention discloses an eye patch for treating demodex blepharitis and a preparation method thereof, and relates to the technical field of traditional Chinese medicine preparations, wherein the eye patch is prepared from the following raw materials in parts by weight: 5-20% of tea tree essential oil, 0.1-4% of wormwood, 0.1-4% of wrinkled gianthyssop herb, 0.1-4% of pine needle, 0.1-3% of borneol, 0.1-3% of sodium hyaluronate and the balance of water. The tea tree essential oil in the eye patch for treating demodex blepharitis can inhibit the reproduction of demodex and eliminate the demodex, and the Chinese herbal medicine extracts of wormwood, wrinkled gianthyssop and pine needle are added to play roles in dispelling wind, promoting blood circulation, improving eyesight, detoxifying, relieving itching and the like, and the eye patch has a treatment effect on blepharitis, meibomian gland dysfunction, xerophthalmia and the like caused by demodex infection.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine preparations, in particular to an eye patch for treating demodex blepharitis and a preparation method thereof.
Background
Demodex mites colonize the eyelashes, with symptoms ranging from no ocular discomfort to various ocular lesions of varying nature and extent, and can also lead to a series of keratoconjunctival complications. Demodex blepharitis is a common but clinically overlooked infectious ocular surface disease.
The existing treatment method of demodex blepharitis comprises physical treatment and drug treatment, wherein cotton swabs are usually used for dipping physiological saline in the physical treatment to clean the root of eyelashes and remove scabs and the like, 5% of tea tree oil can block the demodex and influence the life cycle of the demodex, so the 5% of tea tree oil is usually used for carrying out blepharitis massage, but the treatment method has the defect that the demodex cannot be directly killed. Common drug treatment methods include: (1) the temporarily prepared eye drops or eye ointment with 2 percent of metronidazole is coated on the eyelid margin, the discomfort symptom of a patient is obviously relieved after 1 month, the quantity of mites is reduced, and the patient can achieve negative effect after continuously taking the medicine for 6 months, but the treatment method has the defects of large side effect and adverse reaction of the medicine, inconvenient use, long treatment period and no finished medicine at present; (2) the tea tree oil with the content of 50% is directly used for wiping and coating, has larger irritation and is not widely applied; (3) the levofloxacin ophthalmic gel, the eye drops of the western acid or the tobramycin dexamethasone eye ointment and other anti-inflammatory western medicines are used, but the treatment method has the defect that the treatment method can only treat the inflammatory reaction caused by the infection of the demodex and can not kill the demodex.
Therefore, a medicine which can effectively relieve the clinical symptoms of demodex blepharitis, can safely and effectively treat the demodex blepharitis and various complications caused by demodex infection, has small irritation to eyes, less adverse reaction, convenient use and good patient compliance and is suitable for family treatment is urgently needed.
Disclosure of Invention
Therefore, the invention provides an eye patch for treating demodex blepharitis and a preparation method thereof, and aims to solve the problems that the method for treating demodex blepharitis in the prior art cannot effectively relieve clinical symptoms of demodex blepharitis, cannot safely and effectively treat the demodex blepharitis and various complications caused by demodex infection, has large stimulation to eyes, has adverse reaction, is inconvenient to use and the like.
In order to achieve the above purpose, the invention provides the following technical scheme:
according to the first aspect of the invention, the eye patch for treating demodex blepharitis consists of the following raw materials in parts by weight: 5-20% of tea tree essential oil, 0.1-4% of wormwood, 0.1-4% of wrinkled gianthyssop herb, 0.1-4% of pine needle, 0.1-3% of borneol, 0.1-3% of sodium hyaluronate and the balance of water.
Further, the eye patch is composed of the following raw materials in parts by weight: tea tree essential oil 6%, wormwood 1%, agastache 1%, pine needle 1%, borneol 0.1%, sodium hyaluronate 0.5% and water 90.4%.
Further, the eye patch is composed of the following raw materials in parts by weight: tea tree essential oil 6%, wormwood 2%, wrinkled gianthyssop 2%, pine needle 2%, borneol 0.5%, sodium hyaluronate 1% and water 86.5%.
Further, the tea tree essential oil is made of FDA certified natural medical raw materials.
According to a second aspect of the present invention, the preparation method of the eye patch comprises the following steps:
weighing the raw materials in parts by weight for later use;
air drying folium Artemisiae Argyi, folium Pini, and herba Agastaches, pulverizing, soaking in 70-80% ethanol for 12-24 hr, extracting at 50-70 deg.C under reflux, and recovering under reduced pressure to obtain Chinese medicinal extract;
mixing the traditional Chinese medicine extract with tea tree essential oil, borneol, sodium hyaluronate and water, soaking the mixture into irradiated and sterilized non-woven fabric, and packaging and storing to obtain the eye patch.
Further, the average radiation dose of the radiation sterilization is 3-10 KGy.
The drug effect of the raw materials selected by the invention is as follows:
tea tree essential oil is extract of tea tree. Has antibacterial, antiinflammatory, pore astringing, common cold, cough, rhinitis, asthma treating, dysmenorrhea improving, menoxenia and genital infection relieving effects. It is suitable for oily and acne skin, and can be used for treating suppurative wound, burn, sunburn, tinea pedis, and dandruff. Refreshing brain, restoring vitality and resisting depression.
Mugwort is a plant of Artemisia of Compositae, and is perennial herb or slightly half-shrub. Bitter and pungent in flavor, warm in nature and entering liver, spleen and kidney meridians. The whole herb is used as a medicine and has the functions of warming channels, removing dampness, dispelling cold, stopping bleeding, diminishing inflammation, relieving asthma, relieving cough, preventing miscarriage, resisting allergy and the like.
Agastache rugosus, also known as: hexiang, cang Ji and shan Feng Zi are perennial herbs of Labiatae, Agastaches, Labiatae, pungent and slightly warm. It enters spleen, stomach and lung meridians. Has effects of eliminating turbid pathogen with aromatics, regulating the middle warmer, relieving vomit, relieving exterior syndrome and clearing summer-heat, and can be used for treating damp stagnation, abdominal distention emesis, summer-heat and dampness exterior syndrome, early stage of damp-warm syndrome, fever and listlessness, chest distress and discomfort, cold-dampness and summer-heat, abdominal pain, vomiting and diarrhea, nasosinusitis and headache.
Pine needles, also known as pine leaves, pine leaves with bristles, pine hairs or pine whiskers, are leaves of plants of the genus pinus of the family pinaceae, are needle-like in shape, and are one of the main byproducts of plants of the genus pinus. Bitter and astringent taste, warm nature and no toxicity. The pine needles have the following effects: the pine needles have the efficacies of dispelling wind and eliminating dampness, killing parasites, relieving itching, dispelling wind and activating blood, improving eyesight, soothing nerves, detoxifying, removing halitosis and removing dry mouth and tongue, are mainly used for treating rheumatism flaccidity and arthralgia, traumatic injury, insomnia, edema, eczema, mange and constipation, and are used for treating influenza, rheumatic arthralgia, traumatic swelling and pain, nyctalopia, hypertension, neurasthenia and external chilblain; and can be used for preventing and treating epidemic cerebrospinal meningitis, influenza, and ancylostomiasis.
Borneolum, named as Borneolum, pericarpium Citri Tangerinae, folium Artemisiae Argyi, Borneolum Syntheticum, Serissa, Borneolum Syntheticum, and Borneolum Syntheticum, is prepared from stems and leaves of blumea balsamifera of Compositae or branches and leaves of Cinnamomum camphora of Lauraceae by steam distillation and recrystallization. Also can be obtained by a series of chemical processes using turpentine. Fragrant smell, pungent and cool taste. It can be used for treating block pattern of coma, conjunctival congestion with swelling and pain, pharyngitis, aphtha, sore and ulcer with swelling and pain, and unhealed ulcer.
The invention has the following advantages:
the tea tree essential oil in the eye patch for treating demodex blepharitis can inhibit the reproduction of demodex and eliminate the demodex, and the Chinese herbal medicine extracts of wormwood, wrinkled gianthyssop and pine needle are added to play roles in dispelling wind, promoting blood circulation, improving eyesight, detoxifying, relieving itching and the like, and the eye patch has a treatment effect on blepharitis, meibomian gland dysfunction, xerophthalmia and the like caused by demodex infection.
The eye patch for treating the demodex blepharitis can effectively relieve the clinical symptoms of the demodex blepharitis, reduce the parasitic number of the demodex at the eyes and safely and effectively treat the demodex blepharitis. And the eye-care product has small irritation to eyes, less adverse reaction, convenient use and good patient compliance, and is suitable for family treatment.
The eye patch for treating demodex blepharitis has the advantages of simple preparation method and low cost.
Detailed Description
The present invention is described in terms of particular embodiments, other advantages and features of the invention will become apparent to those skilled in the art from the following disclosure, and it is to be understood that the described embodiments are merely exemplary of the invention and that it is not intended to limit the invention to the particular embodiments disclosed. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The eye patch for treating demodex blepharitis comprises the following raw materials in parts by weight: 10% of tea tree essential oil, 1% of wormwood, 1% of wrinkled gianthyssop herb, 1% of pine needle, 1% of borneol, 1% of sodium hyaluronate and 85% of water. The tea tree essential oil is made of FDA certified natural medical raw materials.
The preparation method of the eye patch comprises the following steps:
weighing the raw materials in parts by weight for later use;
air drying folium Artemisiae Argyi, folium Pini, and herba Agastaches, pulverizing, soaking in 70-80% ethanol for 12-24 hr, extracting at 50-70 deg.C under reflux, and recovering under reduced pressure to obtain Chinese medicinal extract;
and mixing the traditional Chinese medicine extract with tea tree essential oil, borneol, sodium hyaluronate and water, immersing the mixture into non-woven fabric subjected to radiation sterilization, and packaging and storing to obtain the eye patch, wherein the average radiation dose of the radiation sterilization is 3-10 KGy.
Example 2
The eye patch for treating demodex blepharitis comprises the following raw materials in parts by weight: 20% of tea tree essential oil, 4% of wormwood, 4% of wrinkled gianthyssop herb, 4% of pine needle, 3% of borneol, 3% of sodium hyaluronate and 62% of water.
The preparation method of the eye patch is the same as that of example 1.
The tea tree essential oil is made of FDA certified natural medical raw materials.
Example 3
The eye patch for treating demodex blepharitis comprises the following raw materials in parts by weight: 5% of tea tree essential oil, 0.1% of wormwood, 0.1% of wrinkled gianthyssop herb, 0.1% of pine needle, 0.1% of borneol, 0.1% of sodium hyaluronate and 94.5% of water.
The preparation method of the eye patch is the same as that of example 1.
The tea tree essential oil is made of FDA certified natural medical raw materials.
Example 4
The eye patch for treating demodex blepharitis comprises the following raw materials in parts by weight: 8% of tea tree essential oil, 0.5% of wormwood, 0.5% of wrinkled gianthyssop herb, 0.5% of pine needle, 0.5% of borneol, 0.5% of sodium hyaluronate and 89.5% of water.
The preparation method of the eye patch is the same as that of example 1.
The tea tree essential oil is made of FDA certified natural medical raw materials.
Example 5
The eye patch for treating demodex blepharitis comprises the following raw materials in parts by weight: 15% of tea tree essential oil, 3% of wormwood, 3% of wrinkled gianthyssop herb, 3% of pine needle, 2% of borneol, 2% of sodium hyaluronate and 72% of water.
The preparation method of the eye patch is the same as that of example 1.
The tea tree essential oil is made of FDA certified natural medical raw materials.
Example 6
The eye patch for treating demodex blepharitis comprises the following raw materials in parts by weight: tea tree essential oil 6%, wormwood 1%, agastache 1%, pine needle 1%, borneol 0.1%, sodium hyaluronate 0.5% and water 90.4%.
The preparation method of the eye patch is the same as that of example 1.
The tea tree essential oil is made of FDA certified natural medical raw materials.
Example 7
The eye patch for treating demodex blepharitis comprises the following raw materials in parts by weight: tea tree essential oil 6%, wormwood 2%, wrinkled gianthyssop 2%, pine needle 2%, borneol 0.5%, sodium hyaluronate 1% and water 86.5%.
The preparation method of the eye patch is the same as that of example 1.
The tea tree essential oil is made of FDA certified natural medical raw materials.
The eye patch for treating the demodex blepharitis has an excellent treatment effect on the demodex blepharitis, tea tree essential oil in raw materials can inhibit the propagation of the demodex and eliminate the demodex and Chinese herbal medicine extracts are added to play roles in dispelling wind, promoting blood circulation, improving eyesight, detoxifying, relieving itching and the like, clinical symptoms of the demodex blepharitis can be effectively relieved, the parasitic number of the demodex at the eye is reduced, various complications caused by the demodex infection are treated, the eye patch has a treatment effect on the blepharitis, meibomian gland dysfunction, xerophthalmia and the like caused by the demodex infection, and meanwhile, the eye patch has small stimulation to the eye, few adverse reactions and convenient use, can safely and effectively treat the demodex blepharitis, solves the problems of toxic reaction and large adverse reaction of the existing western medicines to the eye surface, and the efficacy of the eye patch preparation is illustrated through clinical data.
1. General data
45 patients with squamous blepharitis who were seen in traditional Chinese medicine hospitals in the vogue region from 4 months to 9 months in 2019 were selected, the average age was (48.7 +/-13.7) years, and the microscopic examination of the eyelash demodex mites of all the patients was positive and accompanied by different degrees of eye discomfort. The selected 45 patients have high treatment compliance, and the basic data of the age, the disease course, the disease type and the like are statistically processed and analyzed by SPSS 19.0, have no statistical significance (P is more than 0.05) and are comparable.
The ocular discomfort is represented by ocular surface symptom integral, and the ocular discomfort symptoms comprise 12 items of eye itching, photophobia, burning sensation, foreign body sensation in eyes, dryness sensation, eye secretion increase, eye redness, eyelash falling off, acupuncture sensation, soreness, asthenopia and lacrimation according to the complaints of patients. Each score was calculated as symptom duration, severity: dividing into 0 parts: none; 1, dividing into: occasionally, not obvious; thirdly, 2 min: often, moderate discomfort; fourthly, 3 points are: symptoms are present for most of the time, and seriously affect life. Ocular surface symptom integral calculation: the sum of the 12-topic scores, which vary from 0 to 36, with higher scores indicating a greater degree of ocular surface discomfort.
2. Method of treatment
The eye patch of the present invention, example 6, was applied 2 times a day for treatment, followed 1 time every 2 weeks, and the efficacy was evaluated 4 weeks after treatment.
3. Criteria for efficacy assessment
Drafted according to 'standard of curative effect for diagnosing Chinese medical diseases' published by State administration of traditional Chinese medicine
The effect is shown: the symptoms such as burning foreign body sensation and photophobia of eyes disappear, and eyelids have no red or red symptom and no ulcer;
the method has the following advantages: the symptoms such as burning foreign body sensation and photophobia of eyes are obviously improved, the red and red symptoms of eyelid margin are relieved, and the ulcer is obviously improved;
and (4) invalidation: the symptoms such as burning foreign body sensation and photophobia of eyes are not obviously improved and are repeatedly attacked.
4. Observation of therapeutic effects
Clinical results show that 32 patients in 45 patients have obvious effects, accounting for 71.1 percent, 8 patients have effects, accounting for 17.8 percent, 5 patients have no effects, accounting for 11.1 percent, and the total effective rate reaches 88.9 percent.
Statistical analysis is carried out on data such as improvement condition of ocular surface discomfort symptoms, demodex count, eyelid margin cleanliness and occurrence condition of adverse events before and after treatment of effective patients and 45 patients by adopting SPSS 19.0, the measurement data is expressed by x + s, P <0.05 is used as difference, the statistical significance is achieved, and a pairing t test is adopted, and the comparison result is as follows: the integral of the ocular surface symptoms before treatment is (8.7 +/-3.6) points, the integral of the ocular surface symptoms after treatment for 4 weeks is reduced to (1.0 +/-2.4) points, and the difference has statistical significance (t is 14.83, and P is less than 0.00); 39 patients (86.6%) had clean eyelid margin; the demodex microscopic count before treatment is (7.2 +/-3.0) per 4 eyelashes, and the demodex microscopic count after treatment is reduced to (0.8 +/-1.0) per 4 eyelashes, wherein the difference is statistically significant (t is 16.36, and P is less than 0.00); no allergic or adverse reactions occurred in all patients.
The demodex counting method comprises the following steps: randomly drawing 4 nonadjacent eyelashes from each eyelid and placing the eyelashes on a glass slide, and drawing 16 eyelashes from one eyelid; adding a drop of water on the eyelashes, and then covering a cover glass; demodex was counted under microscope.
Evaluation criteria for eyelid margin cleanliness: scales and secretions at the eyelid margin and the root of the eyelashes which are visible under the slit lamp are judged to be unclean, and the scales and the secretions which are not visible are judged to be clean.
According to the clinical tests, the eye patch prepared from the composition for treating the demodex blepharitis can effectively relieve the clinical symptoms of the demodex blepharitis, reduce the parasitic number of the demodex at the eyes, has small stimulation to the eyes and no adverse reaction, and is a safe and effective method for treating the demodex blepharitis.
Typical case
Case one
The female, 65 years old, is treated with photophobia and lacrimation for 2 weeks in both eyes. Ophthalmic examination: redness of both eyelid margins with scales, sleeveless changes in the base of eyelashes, and conjunctival congestion. Demodex mite count: 6/4. After the eye patch is used for treatment for 2 months, the patient feels photophobia and lacrimation are obviously improved. The redness of the double eyelid margin is reduced and the eyelid margin is cleaned. Demodex mite count: 0/4.
Case two
The patient is a female, aged 58 years old, and is treated for 1 month due to itching of the eyelids. Ophthalmic examination: redness and wrinkles of eyelid skin of both eyes with scales, changes in the shape of sleeves at the root of eyelashes, and conjunctival congestion. Demodex mite count: 8/4. The eye patch is used for the treatment of the eye after 2 months, and the eyelid of the patient is not itchy. The eyes are not red and swollen, and the eyelid margin is clean. Demodex mite count: 0/4.
Case three
The male, 31 years old, will be treated with "dry eyes and burning sensation for more than half a year". Ophthalmic examination: redness with scales of both eyelid margins, sleevelike changes in the base of eyelashes, conjunctival hyperemia, BUT (tear film rupture time) < 5S, detachment of corneal punctate epithelium. Demodex mite count: 4/4. After the eye patch is used for treatment for 2 months, the patient has better dry eyes without burning sensation. The double lid margins are cleaned. Demodex mite count: 0/4.
Although the invention has been described in detail above with reference to a general description and specific examples, it will be apparent to one skilled in the art that modifications or improvements may be made thereto based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.
Claims (3)
1. The eye patch for treating demodex blepharitis is characterized by being prepared from the following raw materials in parts by weight: the eye patch is composed of the following raw materials in parts by weight: tea tree essential oil 6%, wormwood 1%, agastache 1%, pine needle 1%, borneol 0.1%, sodium hyaluronate 0.5% and water 90.4%;
the eye patch for treating demodex blepharitis is prepared by the following steps:
weighing the raw materials in parts by weight for later use;
air drying folium Artemisiae Argyi, folium Pini, and herba Agastaches, pulverizing, soaking in 70-80% ethanol for 12-24 hr, extracting at 50-70 deg.C under reflux, and recovering under reduced pressure to obtain Chinese medicinal extract;
mixing the traditional Chinese medicine extract with tea tree essential oil, borneol, sodium hyaluronate and water, soaking the mixture into irradiated and sterilized non-woven fabric, and packaging and storing to obtain the eye patch.
2. The eye patch according to claim 1, wherein the tea tree essential oil is natural medical grade material approved by FDA.
3. The eye patch according to claim 1, wherein the average radiation dose for radiation sterilization is 3 to 10 KGy.
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| CN114366788B (en) * | 2022-01-12 | 2023-06-02 | 河南安进生物工程有限公司 | Mite-killing composition and preparation process thereof |
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| CN101795700A (en) * | 2007-08-29 | 2010-08-04 | 蒂休特赫公司 | compositions and methods for treating demodex infestations |
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| 5%茶树油眼膏治疗蠕形螨相关鳞屑性睑缘炎;高莹莹等;《中华眼视光学与视觉科学杂志》;20160131;第18卷(第1期);50-53 * |
| 眼部蠕形螨的研究进展;沈满意等;《复旦学报(医学版)》;20180731;第45卷(第04期);585-589 * |
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