CN105726768A - Traditional Chinese medicine eye drops for easing eye strain and preparation method thereof - Google Patents

Abstract

The invention belongs to the field of a traditional Chinese medicine preparation, and specifically relates to traditional Chinese medicine eye drops for easing eye strain and a preparation method of the traditional Chinese medicine eye drops. The traditional Chinese medicine eye drops comprise the following medical components, by weight part, 5-10 parts of astragalus roots, 2-3 parts of radix angelicae sinensis, 5-10 parts of cassia seeds, 3-5 parts of rhizoma ligustici chuanxiong, 10-15 parts of Chinese wolfberry fruits, 5-8 parts of ginkgo nuts, 2-3 parts of pearl powder, 0.1-1 part of vitamin A, and 0.1-1 part of vitamin E. The eye drops are prepared through adoption of advanced modern pharmaceutical technology, have the function of clearing heat and purging fire, arresting convulsions and removing nebula, and nourishing the live and improving vision, and are used for treating visual impairment and teenage pseudomyopia, and alleviating symptoms, such as conjunctival congestion and eye itching, due to visual fatigue and eye strain. Medicines appropriately match each other, so that the eye drops are significant in therapeutic effect, high in safety, and low in price, have no side effect, and are worthy of wide popularization and application.

Description

Asthenopic traditional Chinese medicine eye drops of a kind of alleviation and preparation method thereof

Technical field

The invention belongs to field of traditional Chinese, be specifically related to asthenopic traditional Chinese medicine eye drops of a kind of alleviation and preparation method thereof.

Background technology

Eyestrain is a kind of ophthalmology common disease, and its caused eye is dry, eye is puckery, eye is sour swollen, and blurred vision even visual deterioration directly affects work and the life of people.When eyestrain concentrates to see computer screen at ordinary times mainly due to people, eyes number of winks reduce, cause tear Secretion to reduce, simultaneously flicker fluorescent screen intense stimulus eyes and cause.It can cause that pain occur in the corresponding sites such as the neck of people, shoulder, also can cause and increase the weight of various oculopathy.

Quickening along with modern cultural rhythm of life, work, study hypertonicity, over-burden for psychological diathesis, in addition ecological environment unclean pollution, such as the impact of the air quality such as dirt in air, smog and self psychentonia, it is improper that work and rest is coordinated, long-term excess eye-using or eyes can not get taking good care of fully and having a rest, the eyes pathological changes that factors brings out simultaneously gets more and more, pathological changes in various degree can cause eye vision and decline, form myopia, amblyopia, asthenopia or the diseases such as aching and tired, the eye frame pain of eye occur, blurred vision, dim eyesight seriously can be made even blind.According to social medicine newspapers and periodicals relevant information incomplete statistics, in the large, medium and small student in the whole nation, eye vision decline and rate of myopia account for 40%～60%, its students in middle and primary schools' rate of myopia is 4.9%, just, rate of myopia is 52% in high school student, and myopia, amblyopia, asthenopia disease sickness rate rise with the speed of annual 5%.Heredity and developing myopia have become as the serious problem of society today currently affecting teenager vision health.Therefore, seek effective anti-eyestrain's pharmaceutical preparation, pre-myopia prevention, eliminate asthenopia, recover vision health, control and prevention ophthalmic disease, be always up problem and direction that domestic and international ophthalmology academia joint research is inquired into.

Summary of the invention

According to above the deficiencies in the prior art, the present invention provides a kind of and alleviates asthenopic traditional Chinese medicine eye drops and preparation method thereof, and it is evident in efficacy, safe and reliable, have no side effect, and has wide potential applicability in clinical practice.

The asthenopic traditional Chinese medicine eye drops of a kind of alleviation of the present invention, according to parts by weight meter, including following ingredient: the Radix Astragali 5～10 parts, Radix Angelicae Sinensis 2～3 parts, Semen Cassiae 5～10 parts, Rhizoma Chuanxiong 3～5 parts, Fructus Lycii 10～15 parts, Semen Ginkgo 5～8 parts, Margarita powder 2～3 parts, vitamin A 0.1～1 part and vitamin E 0.1～1 part.

Wherein, it is preferable that scheme is as follows:

According to parts by weight meter, including following ingredient: the Radix Astragali 8 parts, Radix Angelicae Sinensis 2 parts, Semen Cassiae 10 parts, Rhizoma Chuanxiong 3 parts, Fructus Lycii 15 parts, Semen Ginkgo 5 parts, Margarita powder 2 parts, vitamin A 0.5 part and vitamin e1 part.

The preparation method of the asthenopic traditional Chinese medicine eye drops of alleviation of the present invention, during preparation, carries out according to following steps:

(1) first the Radix Astragali, Radix Angelicae Sinensis, Semen Cassiae, Rhizoma Chuanxiong, Fructus Lycii, Semen Ginkgo, Margarita powder being added water 5000 milliliters, slow fire boils 1 hour, takes filtrate；

(2) residue adds water 5000 milliliters, and slow fire boils 1 hour, twice filtrate is merged；

(3) above-mentioned filtrate is concentrated into 125 milliliters, adds the ethanol mixing that 375 milliliters of mass fractions are 95% after cooling, after placing 24 hours, use filter paper filtering；

(4) after filtrate being waved to the greatest extent or reclaiming ethanol, add vitamin A and vitamin E powder, stir evenly and add distilled water again and obtain medicinal liquid to 1000～5000 milliliters；

(5) adjust medicinal liquid and be equivalent to the osmotic pressure of the sodium chloride that mass fraction is 0.8～1.2%, adding preservative agent cyanogen Mercury difluoride. in medicinal liquid, wherein, the volume ratio of cyanogen Mercury difluoride. and medicinal liquid is 1:1500, then adjusts pH value to 7.0 with the sodium hydroxide that mass fraction is 10%；

(6) last medicinal liquid is through filter paper filtering, seals, autoclave sterilization, subpackage 8 mls/branch.

During use, every day 3～5 times, each 1～2.

Pharmacology analysis:

The Radix Astragali: gas in tonifying the spleen and stomach, and yang-energy can be promoted, it is possible to QI and blood arrives brain smoothly, puies forward shake spirit, and brains is clear, and can strengthen the ability of body surface resistance to colds.

Radix Angelicae Sinensis: enrich blood；Invigorate blood circulation；Menstruction regulating and pain relieving；Moisturize laxation.Cure mainly all cards of blood deficiency；Menoxenia；Amenorrhea；Dysmenorrhea；Lump in the abdomen knot is poly-；Metrorrhagia；Asthenia cold abdominalgia；Flaccidity syndrome and arthralgia syndrome；Numbness of the skin；Dryness of the intestine dyschezia；Weight after bloody dysentery；Ulcer sores；Injury from falling down.

Semen Cassiae: have the function of clearing away heat to improve acuity of vision, loosening bowel to relieve constipation.Raw Semen Cassiae is longer than removing heat from the liver, and intestine moistening is dry.For conjunctival congestion and swelling pain, constipation.

Rhizoma Chuanxiong: containing ligustrazine, ligustrazine energy coronary artery dilator, increase coronary artery blood flow, improves the blood oxygen supply of cardiac muscle, and reduces the oxygen consumption of cardiac muscle；The expansible cerebrovascular of ligustrazine, reduces vascular resistance, dramatically increases brain and LBF amount, improve microcirculation；Surface activity of blood platelet can be reduced, it is suppressed that platelet aggregation, the formation of pre-preventing thrombosis,；The neutral compound low dose of contained ferulic acid promotes, heavy dose of suppression uterine smooth muscle；Animal central nervous systems is had sedation by water decoction, and has obvious and lasting hypotensive effect；The absorption of fracture local hematoma can be accelerated, promote callus formation；There is vitamin antagonist E shortage effect；Multiple bacillus can be suppressed；There are antihistaminic and choleretic effect.

Fructus Lycii: cure mainly nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.Containing 14 seed amino acids in Fructus Lycii, and containing special dietary compositions such as glycine betaine, beautiful another name for Sichuan Province flavin, physalins so that it is have outstanding health-care effect.Fructus Lycii contains the required nutrient substance of abundant carotene, multivitamin and the healthy eye such as calcium, ferrum, therefore has the merit of improving eyesight, is commonly called as " bright eye ".What ancient Chinese medicine doctor treatment deficiency of liver-blood, deficiency of kidney-YIN caused looks thing dusk and nyctalopia, is frequently used Fructus Lycii.Famous prescription " QIJU DIHUANG WAN ", just with Fructus Lycii for key agents.

Semen Ginkgo: property is put down, sweet in the mouth is pained, slightly poisonous；Enter lung, kidney channel.Folium Ginkgo extract principle active component is flavonoid and bilobalide-like biological active substances, referred to as Folium Ginkgo extract (GBE), ocular angiogenesis can be expanded, suppress platelet aggregation, reduce the permeability of blood capillary, antioxidation, scavenging activated oxygen, improve the activity of SOD, improve microcirculation with this.

Margarita powder: Margarita powder has the effect of heat-clearing and toxic substances removing, it is possible to clearing away liver-fire.The liver being in charge of the eyes, the raw nebula of hot-tempered then order, blurred vision.Finding through research, the selenium in Margarita powder can strengthen the conduction of optic nerve, improves eyesight status simultaneously；Zinc in trace element can promote the axonal transport of optic nerve, improves metabolism and the function of retina and retinal pigment epithelium.The Pharmacopoeia of the People's Republic of China describes: " Margarita has the function of improving eyesight removing nebula, cures mainly the raw nebula of order ", so Margarita powder is become " ophthalmology panacea " by a lot of scholar.

Vitamin A: also known as retinol (its aldehyde derivatives retinal) or antiophthalmic factor, is a unsaturated monohydric alcohol with alicyclic ring, including the retinol1 in animal food source, A2 two kinds, is that a class has the bioactive material of retinol.Retinol1 is stored in the liver of mammal and saltwater fish more, and dehydroretinol is often stored in the liver of fresh-water fishes.Owing to the specific activity of dehydroretinol is relatively low, so usually said vitamin A refers to retinol1.Vitamin A maintains normal visual performance, and vitamin A is sufficient, then soon and completely, dark adaptation is short for recovery time in the regeneration of rhodopsin.Vitamin A can treat xerophthalmia, keratomalacia, xerosis cutis and nyctalopia etc..Additionally, boiling hot, cold injury and ulcer is also effective in cure.

Vitamin E: vitamin E can suppress the lipid peroxidation in ocular lens body to react, and makes end slightly vasodilation, improves blood circulation, pre-myopia prevention occurs and development.

Eye drop of the present invention adopts modern advanced medical pharmaceutical technology to make, there is clearing away heat-fire, spasmolytic removing nebula, the effect of nourishing the liver to improve visual acuity, for treating the symptoms such as visual deterioration, teenage pseudomyopia, alleviation eye visual be tired and eyestrain causes conjunctival congestion, ophthalmic pruritus, selected medical material compatibility is suitable, evident in efficacy, security performance is high, has no side effect, cheap, should be widely promoted application.

Outcome measure:

1, case selection

As asthenopic collyrium of releiving, select corresponding patient with sympotoms 160 example clinical observation.

2, treatment group patient uses collyrium of the present invention, instills ophthalmic, every day 3～5 times, each 1～2.

3, efficacy determination:

(1) effective: eye visual recovers completely, the symptom such as pseudomyopia, conjunctival congestion, ophthalmic pruritus is cured；

(2) effective: eye strain is alleviated to some extent；

(3) invalid: disease is unchanged.

4, result: effective 128 examples, effective 27 examples, invalid 5 examples, total effective rate 96.875%.

It is exemplified below several model case:

Chen, man, 12 years old, people from Shijiazhuang, Hebei, student, because learning anxiety, frequent studying at night, make eyes form pseudomyopia, after using eye drop of the present invention, after treating 20 days, vision restoration is normal, does not recur so far.

Beam, female, 26 years old, Zhengzhou, henan people, white collar, because of job demand, use computer overlong time, eyes suffer from serious visual fatigue disease, use eye drop of the present invention after 3 days, and visual fatigue recovers to some extent, is continuing with, and eye recovers normal.

Detailed description of the invention

Below in conjunction with embodiment, the invention will be further described.

Embodiment 1:

The asthenopic traditional Chinese medicine eye drops of a kind of alleviation, according to parts by weight meter, including following ingredient: the Radix Astragali 8 parts, Radix Angelicae Sinensis 2 parts, Semen Cassiae 10 parts, Rhizoma Chuanxiong 3 parts, Fructus Lycii 15 parts, Semen Ginkgo 5 parts, Margarita powder 2 parts, vitamin A 0.5 part and vitamin e1 part.

Embodiment 2:

Embodiment 1 is prepared according to following steps:

(1) first the Radix Astragali, Radix Angelicae Sinensis, Semen Cassiae, Rhizoma Chuanxiong, Fructus Lycii, Semen Ginkgo, Margarita powder being added water 5000 milliliters, slow fire boils 1 hour, takes filtrate；

(2) residue adds water 5000 milliliters, and slow fire boils 1 hour, twice filtrate is merged；

(3) above-mentioned filtrate is concentrated into 125 milliliters, adds the ethanol mixing that 375 milliliters of mass fractions are 95% after cooling, after placing 24 hours, use filter paper filtering；

(4) after filtrate being waved to the greatest extent or reclaiming ethanol, add vitamin A and vitamin E powder, stir evenly and add distilled water again and obtain medicinal liquid to 3000 milliliters；

(5) adjusting medicinal liquid and be equivalent to the osmotic pressure of the sodium chloride that mass fraction is 0.8%, adding preservative agent cyanogen Mercury difluoride. in medicinal liquid, wherein, the volume ratio of cyanogen Mercury difluoride. and medicinal liquid is 1:1500, then adjusts pH value to 7.0 with the sodium hydroxide that mass fraction is 10%；

(6) last medicinal liquid is through filter paper filtering, seals, autoclave sterilization, subpackage 8 mls/branch.

Claims (3)

1. alleviate asthenopic traditional Chinese medicine eye drops for one kind, it is characterized in that according to parts by weight meter, including following ingredient: the Radix Astragali 5～10 parts, Radix Angelicae Sinensis 2～3 parts, Semen Cassiae 5～10 parts, Rhizoma Chuanxiong 3～5 parts, Fructus Lycii 10～15 parts, Semen Ginkgo 5～8 parts, Margarita powder 2～3 parts, vitamin A 0.1～1 part and vitamin E 0.1～1 part.

2. the asthenopic traditional Chinese medicine eye drops of a kind of alleviation according to claim 1, it is characterized in that according to parts by weight meter, including following ingredient: the Radix Astragali 8 parts, Radix Angelicae Sinensis 2 parts, Semen Cassiae 10 parts, Rhizoma Chuanxiong 3 parts, Fructus Lycii 15 parts, Semen Ginkgo 5 parts, Margarita powder 2 parts, vitamin A 0.5 part and vitamin e1 part.

3. the preparation method alleviating asthenopic traditional Chinese medicine eye drops described in a claim 1, it is characterised in that during preparation, carry out according to following steps:

(1) first the Radix Astragali, Radix Angelicae Sinensis, Semen Cassiae, Rhizoma Chuanxiong, Fructus Lycii, Semen Ginkgo, Margarita powder being added water 5000 milliliters, slow fire boils 1 hour, takes filtrate；

(2) residue adds water 5000 milliliters, and slow fire boils 1 hour, twice filtrate is merged；

(3) above-mentioned filtrate is concentrated into 125 milliliters, adds the ethanol mixing that 375 milliliters of mass fractions are 95% after cooling, after placing 24 hours, use filter paper filtering；

(4) after filtrate being waved to the greatest extent or reclaiming ethanol, add vitamin A and vitamin E powder, stir evenly and add distilled water again and obtain medicinal liquid to 1000～5000 milliliters；

(5) adjust medicinal liquid and be equivalent to the osmotic pressure of the sodium chloride that mass fraction is 0.8～1.2%, adding preservative agent cyanogen Mercury difluoride. in medicinal liquid, wherein, the volume ratio of cyanogen Mercury difluoride. and medicinal liquid is 1:1500, then adjusts pH value to 7.0 with the sodium hydroxide that mass fraction is 10%；

(6) last medicinal liquid is through filter paper filtering, seals, autoclave sterilization, subpackage 8 mls/branch.