CN105770506A - Traditional Chinese medicine eye drops for alleviating asthenopia and preparation method thereof - Google Patents

Traditional Chinese medicine eye drops for alleviating asthenopia and preparation method thereof Download PDF

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Publication number
CN105770506A
CN105770506A CN201410781393.4A CN201410781393A CN105770506A CN 105770506 A CN105770506 A CN 105770506A CN 201410781393 A CN201410781393 A CN 201410781393A CN 105770506 A CN105770506 A CN 105770506A
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parts
eye drops
vitamin
chinese medicine
traditional chinese
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卢彦敏
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Qingdao Huangdao Hospital of Traditional Chinese Medicine
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Qingdao Huangdao Hospital of Traditional Chinese Medicine
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Abstract

The invention belongs to the field of a traditional Chinese medicine preparation, and more specifically relates to traditional Chinese medicine eye drops for alleviating asthenopia and a preparation method thereof. The eye drops comprise the following medicine components in parts by weight: 20-30 parts of dendrobium, 20-30 parts of Digitaria sanguinalis, 5-10 parts of Chinese wolfberry fruits, 20-30 parts of cassia seeds, 20-30 parts of gingkoes, 3-5 parts of licorice, 5-10 parts of honeysuckle flowers, 5-10 parts of mints, 3-5 parts of fresh rehmannia roots, 3-5 parts of rhizome atractylodis, 20-30 parts of camomile, 10-15 parts of Szechuan lovage rhizome, 0.1-1 parts of vitamin B1, and 0.1-1 parts of vitamin E. The eye drops are prepared by using modern and advanced medical pharmacy technology, and the eye drops have the effects for clearing heat, purging fire, resolving tetany, removing slight corneal opacity, nourishing liver and improving eyesight; the eye drops are used for treating impaired vision and adolescent pseudomyopia as well as alleviating conjunctival congestion, eye itching and other symptoms due to asthenopia; the eye drops have the advantages of appropriate compatibility of medicinal materials, substantial curative effects, high safety performance without side-effects, low cost, and wide promotion and application.

Description

Asthenopic traditional Chinese medicine eye drops of a kind of alleviation and preparation method thereof
Technical field
The invention belongs to field of traditional Chinese, be specifically related to asthenopic traditional Chinese medicine eye drops of a kind of alleviation and preparation method thereof.
Background technology
Eyestrain is a kind of ophthalmology common disease, and its caused eye is dry, eye is puckery, eye is sour swollen, and blurred vision even visual deterioration directly affects work and the life of people.When eyestrain concentrates to see computer screen at ordinary times mainly due to people, eyes number of winks reduce, cause tear Secretion to reduce, simultaneously flicker fluorescent screen intense stimulus eyes and cause.It can cause that pain occur in the corresponding sites such as the neck of people, shoulder, also can cause and increase the weight of various oculopathy.
Quickening along with modern cultural rhythm of life, work, study hypertonicity, over-burden for psychological diathesis, in addition ecological environment unclean pollution, such as the impact of the air quality such as dirt in air, smog and self psychentonia, it is improper that work and rest is coordinated, long-term excess eye-using or eyes can not get taking good care of fully and having a rest, the eyes pathological changes that factors brings out simultaneously gets more and more, pathological changes in various degree can cause eye vision and decline, form myopia, amblyopia, asthenopia or the diseases such as aching and tired, the eye frame pain of eye occur, blurred vision, dim eyesight seriously can be made even blind.According to social medicine newspapers and periodicals relevant information incomplete statistics, in the large, medium and small student in the whole nation, eye vision decline and rate of myopia account for 40%~60%, its students in middle and primary schools' rate of myopia is 4.9%, just, rate of myopia is 52% in high school student, and myopia, amblyopia, asthenopia disease sickness rate rise with the speed of annual 5%.Heredity and developing myopia have become as the serious problem of society today currently affecting teenager vision health.Therefore, seek effective anti-eyestrain's pharmaceutical preparation, pre-myopia prevention, eliminate asthenopia, recover vision health, control and prevention ophthalmic disease, be always up problem and direction that domestic and international ophthalmology academia joint research is inquired into.
Summary of the invention
According to above the deficiencies in the prior art, the present invention provides a kind of and alleviates asthenopic traditional Chinese medicine eye drops and preparation method thereof, and it is evident in efficacy, safe and reliable, have no side effect, and has wide potential applicability in clinical practice.
The asthenopic traditional Chinese medicine eye drops of a kind of alleviation of the present invention, according to parts by weight meter, including following ingredient: Herba Dendrobii 20~30 parts, Herba Digitariae 20~30 parts, Fructus Lycii 5~10 parts, Semen Cassiae 20~30 parts, Semen Ginkgo 20~30 parts, 3~5 parts of Radix Glycyrrhizae, Flos Lonicerae 5~10 parts, Herba Menthae 5~10 parts, 3~5 parts of the Radix Rehmanniae, Rhizoma Atractylodis 3~5 parts, Flos Chrysanthemi 20~30 parts, Rhizoma Chuanxiong 10~15 parts, vitamin B10.1~1 part and vitamin E 0.1~1 part.
Wherein, it is preferable that scheme is as follows:
According to parts by weight meter, including following ingredient: Herba Dendrobii 25 parts, Herba Digitariae 25 parts, Fructus Lycii 10 parts, Semen Cassiae 25 parts, Semen Ginkgo 25 parts, 3 parts of Radix Glycyrrhizae, Flos Lonicerae 8 parts, Herba Menthae 5 parts, 3 parts of the Radix Rehmanniae, Rhizoma Atractylodis 3 parts, Flos Chrysanthemi 25 parts, Rhizoma Chuanxiong 10 parts, vitamin B11 part and vitamin e1 part.
The preparation method of the asthenopic traditional Chinese medicine eye drops of alleviation of the present invention, during preparation, carries out according to following steps:
(1) first Herba Dendrobii, Herba Digitariae, Fructus Lycii, Semen Cassiae, Semen Ginkgo, Radix Glycyrrhizae, Flos Lonicerae, Herba Menthae, the Radix Rehmanniae, Rhizoma Atractylodis, Flos Chrysanthemi, Rhizoma Chuanxiong being added water 5000 milliliters, slow fire boils 1 hour, takes filtrate;
(2) residue adds water 5000 milliliters, and slow fire boils 1 hour, twice filtrate is merged;
(3) above-mentioned filtrate is concentrated into 125 milliliters, adds the ethanol mixing that 375 milliliters of mass fractions are 95% after cooling, after placing 24 hours, use filter paper filtering;
(4), after filtrate being waved to the greatest extent or reclaiming ethanol, vitamin B is added1And vitamin E powder, stir evenly and add distilled water again and obtain medicinal liquid to 1000~5000 milliliters;
(5) adjust medicinal liquid and be equivalent to the osmotic pressure of the sodium chloride that mass fraction is 0.8~1.2%, adding preservative agent cyanogen Mercury difluoride. in medicinal liquid, wherein, the volume ratio of cyanogen Mercury difluoride. and medicinal liquid is 1:1500, then adjusts pH value to 7.0 with the sodium hydroxide that mass fraction is 10%;
(6) last medicinal liquid is through filter paper filtering, seals, autoclave sterilization, subpackage 8 mls/branch.
During use, every day 3~5 times, each 1~2.
Pharmacology analysis:
Herba Dendrobii: for Chinese medicine, derives from the orchid family Herba Dendrobii, belongs to the stem of Dendrobium various plants, cold nature.Effect reinforcing stomach reg fluid, clearing away heat and nourishing YIN, cure mainly consumption of body fluid caused by febrile disease, xerostomia excessive thirst, after being ill deficiency-heat, that the moon hinders order is dark.Containing multiple alkaloid, polysaccharide, aminoacid and starch etc. in stem of Dendrobium, there is certain antipyretic effect;Gastric secretion can be promoted, aid digestion;There are enhancing metabolism, the anti-ageing effect of waiting for a long time.The traditional Chinese medical science is thought, the vital essence of the vital organs of the human body is all passed through to note in eyes on blood vessels, and liver " having one's ideas straightened out in order ", the physiological and pathological of eyes and the cloudy essence of liver fill whether contain in close relations.The cloudy essence of liver fills Sheng, then eye is fair bright and eagle-eyed, rotates flexibly, and full of vigor, people also seems hale and hearty;If cloudy insufficiency of essence, eye is fine will be intense darkness without light, or two are dry and astringent, or blurring of vision, or nyctalopia etc..Radix Stephaniae Tetrandrae has the function of YIN nourishing nourishing the liver, therefore is used as the good merchantable brand of eye-protecting by ancient Chinese medicine doctor.
Herba Digitariae: sweet in the mouth, cold.Enter liver, spleen two warp.Improving eyesight lung moistening.Control poor vision, cough due to lung-heat.
Fructus Lycii: cure mainly nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.Containing 14 seed amino acids in Fructus Lycii, and containing special dietary compositions such as glycine betaine, beautiful another name for Sichuan Province flavin, physalins so that it is have outstanding health-care effect.Fructus Lycii contains the required nutrient substance of abundant carotene, multivitamin and the healthy eye such as calcium, ferrum, therefore has the merit of improving eyesight, is commonly called as " bright eye ".What ancient Chinese medicine doctor treatment deficiency of liver-blood, deficiency of kidney-YIN caused looks thing dusk and nyctalopia, is frequently used Fructus Lycii.Famous prescription " QIJU DIHUANG WAN ", just with Fructus Lycii for key agents.
Semen Cassiae: have the function of clearing away heat to improve acuity of vision, loosening bowel to relieve constipation.Raw Semen Cassiae is longer than removing heat from the liver, and intestine moistening is dry.For conjunctival congestion and swelling pain, constipation.
Semen Ginkgo: property is put down, sweet in the mouth is pained, slightly poisonous;Enter lung, kidney channel.Folium Ginkgo extract principle active component is flavonoid and bilobalide-like biological active substances, referred to as Folium Ginkgo extract (GBE), ocular angiogenesis can be expanded, suppress platelet aggregation, reduce the permeability of blood capillary, antioxidation, scavenging activated oxygen, improve the activity of SOD, improve microcirculation with this.
Radix Glycyrrhizae: sweet, flat.GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, extremity contraction urgency pain, carbuncle sore tumefacting virus, cushion toxicity, strong.
Flos Lonicerae: cold in nature, sweet in the mouth, enter lung, the heart, stomach warp, there is heat-clearing and toxic substances removing, antiinflammatory, qi-restoratives treat effect of wind, cure mainly disease under distension, epidemic febrile disease heating, the disease such as pyretic toxicity carbuncle and ulcer and tumor.It all has certain curative effect for diseases such as dizzy dizzy, xerostomia is made yearningly, hyperhidrosis unhappiness, enteritis, bacillary dysentery, measles, pneumonia, encephalitis b, epidemic encephalitis, acute mastitis, septicemia, appendicitis, skin infection, carbuncle furuncle, erysipelas, parotitis, suppurative tonsillitiss.
Herba Menthae: children's tender stem point can make vegetable edible, and herb can be used as medicine again, cure cold heating laryngalgia, headache, conjunctival congestion with ophthalmalgia, myalgia, and the diseases such as skin rubella is scratched where it itches, measles without adequate eruption are also effective to carbuncle, cellulitis, scabies, tinea, dermatitis rhus in addition.Herba Menthae contains menthol, this material can fresh breath there is the multiple property of medicine, stomachache, gallbladder problem such as spasm can be alleviated, also there is antisepsis and sterilization, diuresis, reduce phlegm, stomach invigorating and the effect such as aid digestion.
The Radix Rehmanniae: have anastalsis, has again blood coagulation resisting function, also has antifungic action, and the growth of the multiple funguses such as trichophyton mentagrophytes, Gypsum Fibrosum sample microspore tinea bacterium, ulotrichy microspore tinea bacterium and Du big belly microspore tinea bacterium difficult to understand is had inhibitory action.
Rhizoma Atractylodis: have drying damp and strengthening spleen, it is turbid to ward off dirtyization, expelling wind and cold, effect of improving eyesight;Curing mainly the spleen and stomach being stranded by dampness, gastral cavity painful abdominal mass abdominal distention, vomiting and nausea is had loose bowels, leukorrhagia stranguria with turbid discharge, pestilence, communicable subtropical diseases, malaria, and cholera is rheumatism exogenous, cold-damp damp arthralgia, beriberi, flaccidity, nyctalopia.
Flos Chrysanthemi: dissipate wind heat clearing away, suppressing the hyperactive liver improving eyesight.For anemopyretic cold, dizziness of having a headache, conjunctival congestion and swelling pain, eyes is dim-sighted.
Rhizoma Chuanxiong: containing ligustrazine, ligustrazine energy coronary artery dilator, increase coronary artery blood flow, improves the blood oxygen supply of cardiac muscle, and reduces the oxygen consumption of cardiac muscle;The expansible cerebrovascular of ligustrazine, reduces vascular resistance, dramatically increases brain and LBF amount, improve microcirculation;Surface activity of blood platelet can be reduced, it is suppressed that platelet aggregation, the formation of pre-preventing thrombosis,;The neutral compound low dose of contained ferulic acid promotes, heavy dose of suppression uterine smooth muscle;Animal central nervous systems is had sedation by water decoction, and has obvious and lasting hypotensive effect;The absorption of fracture local hematoma can be accelerated, promote callus formation;There is vitamin antagonist E shortage effect;Multiple bacillus can be suppressed;There are antihistaminic and choleretic effect.
Vitamin B1: being primarily present in crust and the plumule of seed, in Testa oryzae and wheat bran, content is very abundant, and in yeast, content is also extremely abundant.In lean meat, Chinese cabbage and Herba Apii graveolentis, content is also abundanter.Presently used vitamin B1All products of chemosynthesis.In vivo, vitamin B1Participate in catabolism of carbohydrate with co-enzyme form, have the neural effect of protection;Enterogastric peristalsis can also be promoted, increase appetite.Vitamin B1It is one of optic nerve and perineural source of nutrition, it is possible to improve ophthalmoplegia, nystagmus and asthenopia.
Vitamin E: vitamin E can suppress the lipid peroxidation in ocular lens body to react, and makes end slightly vasodilation, improves blood circulation, pre-myopia prevention occurs and development.
Eye drop of the present invention adopts modern advanced medical pharmaceutical technology to make, there is clearing away heat-fire, spasmolytic removing nebula, the effect of nourishing the liver to improve visual acuity, for treating the symptoms such as visual deterioration, teenage pseudomyopia, alleviation eye visual be tired and eyestrain causes conjunctival congestion, ophthalmic pruritus, selected medical material compatibility is suitable, evident in efficacy, security performance is high, has no side effect, cheap, should be widely promoted application.
Outcome measure:
1, case selection
As asthenopic collyrium of releiving, select corresponding patient with sympotoms 100 example clinical observation.
2, treatment group patient uses collyrium of the present invention, instills ophthalmic, every day 3~5 times, each 1~2.
3, efficacy determination:
(1) effective: eye visual recovers completely, the symptom such as pseudomyopia, conjunctival congestion, ophthalmic pruritus is cured;
(2) effective: eye strain is alleviated to some extent;
(3) invalid: disease is unchanged.
4, result: effective 82 examples, effective 16 examples, invalid 2 examples, total effective rate 98%.
It is exemplified below several model case:
Zhang, female, 12 years old, people from Qingdao, student, because learning anxiety, frequent studying at night, make eyes form pseudomyopia, after using eye drop of the present invention, after treating 20 days, vision restoration is normal, does not recur so far.
Liu, female, 26 years old, people from Qingdao, white collar, because of job demand, use computer overlong time, eyes suffer from serious visual fatigue disease, use eye drop of the present invention after 3 days, and visual fatigue recovers to some extent, is continuing with, and eye recovers normal.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described.
Embodiment 1:
The asthenopic traditional Chinese medicine eye drops of a kind of alleviation, according to parts by weight meter, including following ingredient: Herba Dendrobii 25 parts, Herba Digitariae 25 parts, Fructus Lycii 10 parts, Semen Cassiae 25 parts, Semen Ginkgo 25 parts, 3 parts of Radix Glycyrrhizae, Flos Lonicerae 8 parts, Herba Menthae 5 parts, 3 parts of the Radix Rehmanniae, Rhizoma Atractylodis 3 parts, Flos Chrysanthemi 25 parts, Rhizoma Chuanxiong 10 parts, vitamin B11 part and vitamin e1 part.
Embodiment 2:
Embodiment 1 is prepared according to following steps:
(1) first Herba Dendrobii, Herba Digitariae, Fructus Lycii, Semen Cassiae, Semen Ginkgo, Radix Glycyrrhizae, Flos Lonicerae, Herba Menthae, the Radix Rehmanniae, Rhizoma Atractylodis, Flos Chrysanthemi, Rhizoma Chuanxiong being added water 5000 milliliters, slow fire boils 1 hour, takes filtrate;
(2) residue adds water 5000 milliliters, and slow fire boils 1 hour, twice filtrate is merged;
(3) above-mentioned filtrate is concentrated into 125 milliliters, adds the ethanol mixing that 375 milliliters of mass fractions are 95% after cooling, after placing 24 hours, use filter paper filtering;
(4), after filtrate being waved to the greatest extent or reclaiming ethanol, vitamin B is added1And vitamin E powder, stir evenly and add distilled water again and obtain medicinal liquid to 1000~5000 milliliters;
(5) adjust medicinal liquid and be equivalent to the osmotic pressure of the sodium chloride that mass fraction is 0.8~1.2%, adding preservative agent cyanogen Mercury difluoride. in medicinal liquid, wherein, the volume ratio of cyanogen Mercury difluoride. and medicinal liquid is 1:1500, then adjusts pH value to 7.0 with the sodium hydroxide that mass fraction is 10%;
(6) last medicinal liquid is through filter paper filtering, seals, autoclave sterilization, subpackage 8 mls/branch.

Claims (3)

1. alleviate asthenopic traditional Chinese medicine eye drops for one kind, it is characterized in that according to parts by weight meter, including following ingredient: Herba Dendrobii 20~30 parts, Herba Digitariae 20~30 parts, Fructus Lycii 5~10 parts, Semen Cassiae 20~30 parts, Semen Ginkgo 20~30 parts, 3~5 parts of Radix Glycyrrhizae, Flos Lonicerae 5~10 parts, Herba Menthae 5~10 parts, 3~5 parts of the Radix Rehmanniae, Rhizoma Atractylodis 3~5 parts, Flos Chrysanthemi 20~30 parts, Rhizoma Chuanxiong 10~15 parts, vitamin B10.1~1 part and vitamin E 0.1~1 part.
2. the asthenopic traditional Chinese medicine eye drops of a kind of alleviation according to claim 1, it is characterized in that according to parts by weight meter, including following ingredient: Herba Dendrobii 25 parts, Herba Digitariae 25 parts, Fructus Lycii 10 parts, Semen Cassiae 25 parts, Semen Ginkgo 25 parts, 3 parts of Radix Glycyrrhizae, Flos Lonicerae 8 parts, Herba Menthae 5 parts, 3 parts of the Radix Rehmanniae, Rhizoma Atractylodis 3 parts, Flos Chrysanthemi 25 parts, Rhizoma Chuanxiong 10 parts, VB11 part and vitamin e1 part.
3. the preparation method alleviating asthenopic traditional Chinese medicine eye drops described in a claim 1, it is characterised in that during preparation, carry out according to following steps:
(1) first Herba Dendrobii, Herba Digitariae, Fructus Lycii, Semen Cassiae, Semen Ginkgo, Radix Glycyrrhizae, Flos Lonicerae, Herba Menthae, the Radix Rehmanniae, Rhizoma Atractylodis, Flos Chrysanthemi, Rhizoma Chuanxiong being added water 5000 milliliters, slow fire boils 1 hour, takes filtrate;
(2) residue adds water 5000 milliliters, and slow fire boils 1 hour, twice filtrate is merged;
(3) above-mentioned filtrate is concentrated into 125 milliliters, adds the ethanol mixing that 375 milliliters of mass fractions are 95% after cooling, after placing 24 hours, use filter paper filtering;
(4), after filtrate being waved to the greatest extent or reclaiming ethanol, vitamin B is added1And vitamin E powder, stir evenly and add distilled water again and obtain medicinal liquid to 1000~5000 milliliters;
(5) adjust medicinal liquid and be equivalent to the osmotic pressure of the sodium chloride that mass fraction is 0.8~1.2%, adding preservative agent cyanogen Mercury difluoride. in medicinal liquid, wherein, the volume ratio of cyanogen Mercury difluoride. and medicinal liquid is 1:1500, then adjusts pH value to 7.0 with the sodium hydroxide that mass fraction is 10%;
(6) last medicinal liquid is through filter paper filtering, seals, autoclave sterilization, subpackage 8 mls/branch.
CN201410781393.4A 2014-12-16 2014-12-16 Traditional Chinese medicine eye drops for alleviating asthenopia and preparation method thereof Pending CN105770506A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107362285A (en) * 2017-09-07 2017-11-21 西安雅顿生物科技有限公司 A kind of radioresistance visual function improving liquid and preparation method thereof
CN107412590A (en) * 2017-05-25 2017-12-01 马玉玲 A kind of traditional Chinese medicine reagent prevented and mitigate myopia
CN113456724A (en) * 2021-06-10 2021-10-01 天津科技大学 Pure plant compound medlar eyesight-improving nanometer eye protection patch and preparation method thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107412590A (en) * 2017-05-25 2017-12-01 马玉玲 A kind of traditional Chinese medicine reagent prevented and mitigate myopia
CN107362285A (en) * 2017-09-07 2017-11-21 西安雅顿生物科技有限公司 A kind of radioresistance visual function improving liquid and preparation method thereof
CN113456724A (en) * 2021-06-10 2021-10-01 天津科技大学 Pure plant compound medlar eyesight-improving nanometer eye protection patch and preparation method thereof

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Application publication date: 20160720