CN101279008A - Chinese medicine pad pasting for preventing and controlling myopic eye, eyestrain symptoms and eyebase ischemia - Google Patents
Chinese medicine pad pasting for preventing and controlling myopic eye, eyestrain symptoms and eyebase ischemia Download PDFInfo
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Abstract
Short sight, visual fatigue and ischemic ophthalmopathy belong to the cataract diseases of oculopathy and are mostly caused by emotion problems or body fluid loss, blood shortage, weak kidney and liver which lead to the disorder of entrails, no moistening of eyes, blood stasis, etc., thus causing the loss of sight and even other neopathy. The treatment principle is that the traditional Chinese medicine components which can strengthen the liver and the kidney, supplement blood and body fluid, activate blood circulation to dissipate blood stasis, invigorate the spleen, and be beneficial for moistening are selected; the medicinal materials are extracted (63 percent of effective components, 30 percent of film-forming agent and 7 percent of plasticizer) and blended evenly to make the Chinese medicinal plaster with the thickness of 0.08 to 0.12cm and the plaster is then dried at the normal temperature (the temperature is controlled below 40 DEG C), cut and packaged into a finished product. The medicine can be applied to the skin around the eye and be finally acted on the target area in the ocular fundus after being absorbed by capillary vessels of the skin into the blood circulation of the eye.
Description
Technical field
The present invention relates to a kind of Chinese medicine pad pasting of myopia, asthenopia disease and optical fundus ischemic eye disease and its preparation process of this pad pasting prevented and treated.
Technical background
The human lives is in the world of light, and the information that enters brain is accepted by eyes more than 80%.Bathomorphic distant vision obstacle, apparent distance shortening have not only limited people and have been engaged in a lot of work, influence importing into of extraneous more information simultaneously, to bringing inconvenience orthobiosis.More fearful is the degeneration of complication optical fundus, has a strong impact on visual function, is between twenty and fifty blinding one of the main reasons.According to AAO's statistics in 1989, the whole world had 1/4 promptly to have 1,000,000,000 people to suffer from myopia in 4,000,000,000 populations, and particularly Chinese's prevalence is higher in Aisan.Bathomorphic control is numerous for centuries medical experts and the interested problem of business circles' common concern, also is a very complicated difficult problem.So far the existing unnumbered method of preventing and treating.The U.S., Japan, the Soviet Union, the West Europe utmost point pay attention to modern science and technology as: medicine, optical correction, operation or the like method is prevented and treated.So, these methods are all cured the symptoms, not the disease, and can only temporarily improve certain vision, and can not prevent and treat the optical fundus degeneration, improve the bad and nervous dysfunction of ophthalmic nutrition, dysbolismus and microcirculation.Motherland's medical science is a great treasure-house, and the cause of disease, pathological change and the treatment to oculopathy for thousands of years accumulated rich practice experience, and leaves over a large amount of oculopathy monographs, has established rich basis for the descendants of Chinese nation research prevents and treats oculopathy.
Eye is a relatively independent organ, has the barrier of self, and Drug therapy adopts three kinds of methods to ocular disease is normal: 1. dripping eyedrop or be coated with spongaion; 2. muscle or intravenous injection; 3. intraocular drug injection.
Cornea is divided into five layers, that is: epithelial layer → lamina elastica corneae anterior → hypothallus → descemet's membrane → endodermis.Wherein epithelial layer, hypothallus and endodermis are the barriers of drug absorption.Epithelial layer mainly is the barrier that water soluble drug absorbs, and hypothallus and endodermis are the barriers that fat-soluble medicine absorbs.Some fat-soluble prodrug are by epithelial layer and in this deposition, in case also can and be entered eye by the endodermis barrier gradually in the hypothallus deposition by the lipase hydrolysis.Conjunctival surface has a large amount of abundant blood capillaries, and medicine is big at the osmotic coefficient ratio cornea of conjunctiva; Sclera is than the easy medicine that sees through of cornea, and its permeability ratio cornea is big.But dripping eyedrop or unction, the concentration that the concentration ratio eye rear portion tissue (crystalline lens, vitreous body, retina) of preocular tissue (cornea, sclera, conjunctiva, aqueous humor, corpus ciliare) drug absorption absorbs want high.Therefore the surperficial dripping eyedrop of eye or be coated with the disease that spongaion is difficult to reach treatment eye rear portion tissue, having only small part medicine (5%-10%) to enter cornea, sclera, conjunctiva simultaneously is absorbed, and most of medicine absorbs through nasolacrimal duct system and nasal mucosa, gastric mucosa and enters the body circulation, have in addition may cause the whole body toxicity.Medicine needs certain technical operation, and is not suitable for prolonged application through all possible harmed eye inner tissue of eye subconjunctival injection, intravitreal injection and retrobulbar injection.
Therefore, at present there is certain problem in clinical ophthalmology medicine dosage form, and a lot of experts propose: the approach of the ophthalmic administration preparation of design ideal that medicine is thought according to reason enters the target area acceptor site more accurately, and the raising medicine is at the therapeutic effect of ophthalmic administration.
Summary of the invention
Purpose of the present invention has promptly provided a kind of Chinese medicine pad pasting of effectively preventing and treating myopia, asthenopia disease and optical fundus ischemic eye disease.
Another purpose of the present invention is the manufacture method of preventing and treating myopia, asthenopia disease and optical fundus ischemic eye disease Chinese medicine pad pasting.
The present invention prevents and treats the Chinese medicine pad pasting of myopia, asthenopia disease and optical fundus ischemic eye disease, is by the backing layer material, and medicated layer and protective film are formed.Wherein medicated layer is that (the matrix type adjuvant is natural polysaccharide and synthetic polymer, as preferably polyethylene alcohol 30% one or more in polyvinyl alcohol, Pioloform, polyvinyl acetal, polyvinylpyrrolidone, polyacrylate or the polyacrylamide) by matrix type adjuvant 23-65%; Middle pharmaceutically active ingredient 75%-20%; Preferred 63%; Plasticizer 2-15% (be in glycerol, three fat acid glyceride, ethylene glycol, the sorbitol phthalic acid ester one or more) preferably glycerine 7%.
The present invention selects the combination of kinds of traditional Chinese medicines for use, these Chinese medicines can directly grind to form superfine powder, also can carry middle pharmaceutically active ingredient by a part of water, distillating extracting oil, part alcohol extraction effective ingredient, then all effective ingredient are mixed mutually, utilize synergism between similar medicine and the inhomogeneity effective ingredient to heighten the effect of a treatment.
The Chinese medicine that the present invention selects for use mainly is: invigorating the liver and kidney, QI invigorating, blood, body fluid, simultaneously compatibility open Xuan Fu blood circulation promoting and blood stasis dispelling, causing resuscitation with aromatic drugs, activating QI to alleviate the depression and spleen invigorating, dampness removing, to calm the nerves, restrain astringent or styptic treatment for spontaneous sweating Chinese medicine collaborative mutually, thereby curative effect multiplication realization the present invention.Chinese herbs for tonifying liver and kidney: Fructus Lycii, Semen Cuscutae, Semen Cassiae, Fructus Rubi; Replenishing QI and blood Chinese medicine: Radix Rehmanniae Preparata, Radix Astragali Preparata, Radix Codonopsis, the Radix Polygoni Multiflori.These Chinese medicine amount ranges are: Fructus Lycii 15-375 part, Semen Cuscutae 12-300 part, Semen Cassiae 12-300 part, Fructus Rubi 12-300 part, Radix Rehmanniae Preparata 15-375 part, Radix Astragali Preparata 12-300 part, Radix Codonopsis 15-375 part, Radix Polygoni Multiflori 12-300 part.Preferably: 75 parts of Fructus Lycii, 60 parts of Semen Cuscutae, 60 parts of Fructus Rubies, 60 parts of Semen Cassiaes, 75 parts in Radix Rehmanniae Preparata, 60 parts of Radix Astragali Preparatas, 75 parts of Radix Codonopsis, 60 parts of the Radixs Polygoni Multiflori.
Blood-activating and stasis-removing: Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Notoginseng, Radix Paeoniae Rubra, Flos Caryophylli, Folium Ginkgo, Flos Carthami, Rhizoma Cyperi.Their amount ranges is respectively: Radix Angelicae Sinensis 12-300 part, Rhizoma Chuanxiong 10-250 part, Radix Salviae Miltiorrhizae 12-300 part, Radix Notoginseng 12-300 part, Radix Paeoniae Rubra 12-300 part, Flos Caryophylli 15-375 part, Folium Ginkgo 15-375 part, Flos Carthami 10-250 part, Rhizoma Cyperi 12-300 part.Preferably: 60 parts of Radix Angelicae Sinensis, 50 parts of Rhizoma Chuanxiongs, 60 parts of Radix Salviae Miltiorrhizaes, 60 parts of Radix Notoginseng, 60 parts of Radix Paeoniae Rubra, 75 parts of Flos Caryophyllis, 75 parts of Folium Ginkgos, 50 parts on Flos Carthami, 60 parts of Rhizoma Cyperis.
Causing resuscitation with aromatic drugs: Borneolum Syntheticum, Rhizoma Acori Graminei, Radix Bupleuri.Their amount ranges: Borneolum Syntheticum 1-5 part, Rhizoma Acori Graminei 12-300 part, Radix Bupleuri 12-300 part.Preferably: 1 part of Borneolum Syntheticum, 60 parts of Rhizoma Acori Graminei, 60 parts of Radix Bupleuri.
Restrain astringent or styptic treatment for spontaneous sweating Chinese medicine: Rhizoma Atractylodis Macrocephalae (parched), Radix Polygalae, Poria cum Radix Pini, Fructus Schisandrae Chinensis.Their amount ranges: Rhizoma Atractylodis Macrocephalae (parched) 12-300 part, Radix Polygalae 12-300 part, Poria cum Radix Pini 12-300 part, Fructus Schisandrae Chinensis 10-250 part.Preferably: 60 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 60 parts of Radix Polygalaes, 60 parts of Poria cum Radix Pinis, 50 parts of Fructus Schisandrae Chinensis.
The effective ingredient that the maximum feature of this method processing technology is its Chinese medicine patch film is pure Chinese medicine, and content of dispersion does not add any Western medicine or Percutaneous absorption enhancer up to 63%; Auxiliary type agent substitutes macromolecule glue with film former 30%, and therefore, not only the big percutaneous absorbtivity of content of dispersion is many for pad pasting, the blood drug level height, and good effect, and also the medicine film is affixed on the skin not and the skin adhesion, and ventilative, do not influence the eliminating of local skin homergy and secretions.Their manufacture method is:
One, manufacture method 1
1. pharmaceutically active ingredient in the water extraction, boil distillating extracting oil:
Chinese crude drug Radix Codonopsis, Radix Angelicae Sinensis, Rhizoma Acori Graminei, Rhizoma Chuanxiong, Fructus Schisandrae Chinensis, Poria cum Radix Pini are put into extraction pot to be added 6-8 hour post-heating of water logging bubble that 3-5 doubly measures and boils distillating extracting oil to carrying fully to the greatest extent, water cooking liquid filters, filtrate is condensed into thick paste, and (relative density is 1.18-1.20,60 ℃) add 1.7 times of 95% ethanol and make that to contain alcohol amount be 60%, fully stir fully evenly, leave standstill and drew supernatant in 20 hours, the precipitation part filters, decompression filtrate recycling ethanol is condensed into thick paste (1.18-1.20,60 ℃) standby, medicinal residues are retained standby, collect volatile oil.
2. alcohol extraction effective ingredient
The Chinese crude drug Radix Rehmanniae of alcohol extraction, Fructus Lycii, Semen Cuscutae, Semen Cassiae, Fructus Rubi, Radix Salviae Miltiorrhizae, the Radix Astragali, Radix Polygalae and item 1. the medicinal residues behind the water extraction mix and put into the alcohol extraction jar, add 9 times of amount ethanol, twice of 2-4 hour post-heating reflux, extract, (90% ethanol for the first time that soaks, 80% ethanol for the second time, each 1.5-2 hour) filter, twice filtrate is merged reclaim under reduced pressure ethanol (about 60 ℃ of temperature), medicinal residues are condensed into thick paste (relative density is 1.18-1.20,60 ℃).
Borneol and grinding becomes fine powder or dissolves with 75% ethanol, and its solution is with powder-beta-dextrin powder enclose, and is standby.
The volatile oil that 1. item distills out is with powder-beta-dextrin powder enclose, and is standby.
The configuration of 5. middle pharmaceutically active ingredient compound
Get 1. 2. 3. 4. volatile oil → whole mixing and stirring of Borneolum Syntheticum+item of thick paste+item of thick paste+item of item, leave standstill 20-30 minute, promptly get middle pharmaceutically active ingredient compound to the minute bubbles complete obiteration.
6. Chinese medicine patch film production
(get item 5. compound 63%)+(10% film former PVA30%)+(plasticizer glycerol 7%) → stir leaves standstill promptly to get to the minute bubbles complete obiteration in 15-20 minute and makes the film compound.
7. get and 6. make the film compound, put in the film-making machine medicine groove → system film → room temperature under (in 40 ℃) dry → cut into little medicine bulk → put and add protective film on the non-woven fabrics medicine film that contains glue and cover → add exterior and interior packing.
Two, manufacture method 2
1. water is carried middle pharmaceutically active ingredient, boils distillating extracting oil
The Chinese crude drug Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Rhizoma Acori Graminei, Rhizoma Chuanxiong, Fructus Schisandrae Chinensis, Poria cum Radix Pini, Rhizoma Cyperi, Radix Bupleuri, Folium Ginkgo, Radix Paeoniae Rubra, the Rhizoma Atractylodis Macrocephalae, Flos Carthami, Flos Caryophylli is put into the water extraction jar, add 6-8 hour post-heating of water logging bubble that 3-5 doubly measures and boil distillating extracting oil to carrying fully to the greatest extent, water cooking liquid filtration filtrate is condensed into thick paste, and (relative density is 1.18-1.20,60 ℃), add 1.7 times of 95% ethanol and make that to contain alcohol amount be 60%, fully stir fully evenly, left standstill 20 hours, draw supernatant, the precipitation part filters decompression filtrate recycling ethanol, (relative density is 1.18-1.20 to be condensed into thick paste, 60 ℃) standby, medicinal residues are retained standby, collect volatile oil.
2. alcohol extraction effective ingredient
The Chinese crude drug Radix Rehmanniae of alcohol extraction, Fructus Lycii, Semen Cuscutae, Semen Cassiae, Fructus Rubi, Radix Salviae Miltiorrhizae, the Radix Astragali, Radix Polygalae, the Radix Polygoni Multiflori and item 1. the medicinal residues behind the water extraction mix and put into the alcohol extraction jar, add 9 times of amount soak with ethanol, twice of 2-4 hour post-heating reflux, extract, (90% ethanol for the first time, 80% ethanol for the second time) each 1.5-2 hour, filter, twice filtrate is merged reclaim under reduced pressure ethanol (60 ℃ of temperature) medicinal liquid be condensed into thick paste (relative density is 1.18-1.20,60 ℃).
3. borneol and grinding becomes fine powder or with the dissolving of 75% ethanol, uses beta-schardinger dextrin-powder enclose standby, and Radix Notoginseng powder is standby.
4. a volatile oil that 1. extracts beta-schardinger dextrin-powder enclose is standby.
The configuration of middle pharmaceutically active ingredient compound
Get 1. 2. 3. 4. volatile oil → whole mixing and stirring of Borneolum Syntheticum, Radix Notoginseng+item of thick paste+item of thick paste+item of item, leave standstill 20-30 minute, promptly get middle pharmaceutically active ingredient compound to the minute bubbles complete obiteration.
6. Chinese medicine patch film production
Get (item 5. compound 63%)+(10%PVA solution 30%)+(glycerol 7%) → stir, leave standstill 15-20 minute to minute bubbles complete obiteration → promptly get and make the film compound.
7. get and 6. make the film compound, put in the film-making machine medicine groove → system film → room temperature under (in 40 ℃) dry → cut into little medicine piece → place on the non-woven fabrics that contains glue, add protective film on the medicine film and cover → add exterior and interior packing.
Three, " Chinese medicine pad pasting " treatment oculopathy feasibility analysis:
1. " Chinese medicine pad pasting " is modern novel form through the skin administration, and medicine directly enters the target area acceptor site and brings into play local therapeutic effects to blood capillary through the local skin Transdermal absorption.The pad pasting external application is skin near the eyes, and this one is the weak part of whole skin, the easiest infiltration of medicine, diffuses into ophthalmic blood capillary, little blood vessel, lymphatic vessel, by fast Absorption and be distributed to ophthalmic each tissue, particularly fundus tissue.
2. internal carotid artery is told ophthalmic artery forward after going into cranium, Zinn's artery and the blood supply of arteria ciliares system that tissue such as optic nerve and ophthalmic retina, choroid is produced by ophthalmic artery.The abundant blood capillary of anterior ocular segment eyelid, conjunctiva then derives from the ophthalmic artery branch (comprising nose, back of the body tremulous pulse, supraorbital artery, lacrimal artery) that the facial artery of external carotid artery props up (comprising facial artery, superficial temporal artery and infraorbital artery) and internal carotid artery.Therefore facial enclose near the eyes percutaneous dosing very fast can be by coincideing the vasoganglion infiltration, be diffused into ophthalmic and absorb and particularly enter fundus tissue.
3. " Chinese medicine pad pasting " external application near the eyes the time of staying long, medicine continue to ophthalmic discharge many more, absorption many more, ophthalmic blood drug level is high more, effectively therapeutic effect is just good more.
4. most department of Chinese materia medica are fat-soluble, easily penetrate the eye barrier.
For these reasons, the Chinese medicine pad pasting is a treatment ocular disease ideal novel form, in the development and application of ophthalmology great space will be arranged.
Four, the foundation in prescription source
1, myopia, asthenopia disease and optical fundus ischemic eye disease pathogenic factor
Motherland's medical science is divided into external oculopathy and cataracta ophthalmopathy two large divisions to ophthalmic diseases, distinguishes that in conjunction with the whole body situation disease executing control according to the cause of disease, pathological change, disease performance.Cataracta ophthalmopathy is many because of internal injury caused by excess of seven emotions or the consumption essence is overtaxed one's nerves, deficiency of the liver and kindey, deficiency of both QI and blood etc. cause the imbalance of internal organs meridians, eye to lose moistening foster, qi depression to blood stasis, sweat pore obstruction.
Myopia, asthenopia disease and optical fundus ischemic eye disease belong to ophthalmic barrier disease category.Myopia is divided into congenital myopia and acquired myopia again.
1. congenital myopia mainly is congenital heredity gene chromosome recessive inheritance HLA
B8Anti-first increase frequency, congenital malformation, Liver and kidney two void, gas, blood, Tianjin, liquid deficiency, ciliary muscle, sclera, venation arteries and veins, retinal development cause axis oculi unusually and prolong ametropia.
2. acquired myopia, asthenopia disease, how too much because of long-term close eye, labor is raved to exhaust and is looked, and damages liver blood, qi depression to blood stasis in the order, irritability stasis, meridians are not smooth, and profound mansion is obstructed.
3. a retinopathy part is because of outside ophthalmic self pathological changes, and another part is seen more general disease, as: diseases such as diabetes, ocular fundus arteriosclerosis, hypertension cause the optical fundus blood vessel ischemia.
2, myopia pathology, physiological change
1. the eyeball axle is elongated, resembles a pear in shape or egg type;
2. CC attenuation, radius of curvature diminishes, and the descemet's membrane attenuation is easily broken;
3. sclera collagen fiber structure is unclear, arrange loose, can not form firm crosslinked, sclera attenuation, softness, fragility, irreversible elongation;
4. choroid attenuation, atrophy, pigment cell and elastic fiber disappear, and are the lacquer shape and split, and breach has connective tissue proliferation, and combines together with retina, and glass-film is ended, and sclera exposes, and forms white conus;
5. retina cell swelling, discrete, pigment epithelium cell reduces, glass-film breaks, conus forms;
6. look the nipple color and bleach, become vertically or oval by circle, the atrophia choroideae et retinae of nipple side forms the first quarter moon conus, and conus forms annular speckle around one week of nipple when serious, the blood vessel of visible atrophy around the speckle;
7. eyeball: occur microcirculation disturbance in early days, arteria retina and eye muscle sarcocyte small artery and vein generation limitation are destroyed, and cause choroid trunk thrombosis at last.Retinal vascular occlusion, choroid-atrophy of retina popularity and degeneration;
8. because microcirculation disturbance causes ophthalmic metabolism and optic nerve function disorder, and visual cell is in the hypoallergenic state, and optic nerve imports hypofunction into, the Brodmann area resolving ability weakens;
9. muscle group spasm: shoulder cervical muscle, scalenus spasm, influence sympathetic nerve, eyeball lateral rectus contraction spasm, tractive eyeball pressurized, ophthalmic ciliary muscle group spasm has changed crystal shape, and angle, tractive retina room influences corneal curvature.
In a word, muscle group spasm → eyeball axle is elongated → microcirculation disturbance → metabolism and nervous dysfunction → optical fundus degeneration, influence develops complications at last each other.
3, complication (myopia complication)
1. lenticular opacity, posterior subcapsular cataract (mostly occurring after 40 years old);
2. vitreous opacity;
3. glaucoma (20%, intraocular pressure increases);
4. macula lutea portion hemorrhage (45%, after seeing 40 years old) more;
5. macular hole;
6. retinal hole;
7. detachment of retina (78-81%).
4, Therapeutic Principle
The clinical treatment ophthalmic disease adopts " benefit ", " leading to " double controlling more, " leads to " more important than mending sometimes.Facts have proved that tonic adds drug for invigorating blood circulation and eliminating stasis and awaking drug, the collaborative compatibility of QI regulating medicine, can make the curative effect multiplication.We's rule of treatment is based on the invigorating the liver and kidney replenishing QI and blood; Vital energy regualting and blood circulation-promoting, causing resuscitation with aromatic drugs are auxilliary.
(1) invigorating the liver and kidney, replenishing QI and blood
The traditional Chinese medical science is thought Liver and kidney storage essence and blood, for life provides matter and energy.Kidney is received the essence of five ZANG-organs and six FU-organs and is hidden it, and eye can photopic vision rely the essence of five ZANG-organs and six FU-organs gas to nourish.Order is the liver key, and blood stored in the liver master, order are subjected to the blood can photopic vision.If bar is lost in the liver catharsis, in the order sweat pore obstruction then look not clear, so more than control it from invigorating the liver and kidney.Recent studies, invigorating the liver and kidney can enliven hepatic and renal function, the resistance against diseases that has additional nutrients, strengthen tissue of enhancing metabolism, vision is improved or recovers; Neuroendocrine regulatory function be can strengthen, physical stress ability and immunologic function regulated; Improve hemopoietic system, improve the ophthalmic microcirculation; Remove spasm of ocular muscles; Improve the content of trace element, particularly zinc in the body.(trace element zinc, magnesium, calcium reduce in the person who suffer from deficiency of kidney Yang body), and trace element plays an important role to the physiological function of eye, a lot of oculopathy are hanged down relevant with zinc content.This method is selected for use: Radix Rehmanniae, Semen Cuscutae, Fructus Lycii, Fructus Rubi.
Traditional Chinese medical science yin-yang theory is thought, positive main gas (representative function), and gas is then refreshing entirely prosperous, and cloudy main blood (representative species) blood contains that then shape is strong.Illustrate that QI and blood is necessary material and a power among the human life activity.Blood moistens the order network, grows the optical fundus for supporting the source of order, the refreshing light of Rong Ying, and blood can carry QI can promote blood operation.Qi-blood-body fluid is with coming from the vascular, and the circumfluence whole body has guaranteed the health that nourishing that blood supply makes eye obtain gas, blood, body fluid could keep, brings into play and looks the function that thing is debated color.
Blood deficiency comprises two aspects, the one, and oligemia, the 2nd, blood matter impure (or lacking certain material), the generation of blood and operation be unable to do without gas, " the gas promoting the circulation of blood is then gone, qi depression to blood stasis ", and the deficiency of vital energy is many from blood deficiency, and the deficiency of vital energy also can cause blood deficiency under certain condition.Blood deficiency causes the oculopathy multiterminal more, and QI and blood is connected with each other, so clinical being everlasting wanted QI invigorating when enriching blood.We select for use: the Radix Polygoni Multiflori, Radix Rehmanniae Preparata, Radix Codonopsis, Radix Astragali Preparata etc.
Filling blood is applicable to myopia, asthenopia disease, achromatopsia, the various oculopathy of nyctalopia and degenerative disease and various chronic inflammatory disease, acute inflammation convalescent period or wound convalescent period.
(2) blood circulation promoting and blood stasis dispelling, depressed liver-energy dispersing and QI regulating
It is less that clinical ophthalmology common disease belongs to pure deficient syndrome person, mostly is simulataneous insufficiency and excessive or excess syndrome, therefore the generally speaking not outer two big classes that are divided into of treatment: the one, and reinforcement, the 2nd, logical method." benefit " be tonification internal organs vital essence to make eye bright, " leading to " promptly opens profound Fu Qiaodao to make eye bright, logical sometimes method is even more important than the reinforcement meaning.
Common medication of opening profound Fu Qiaodao: 1, drug for invigorating blood circulation and eliminating stasis, 2, drugs of causing resuscitation by administering aromatic drugs, 3, the depressed liver-energy dispersing and QI regulating medicine, 4, suffering distributes medicine administered to bring out the cold, 5, damp-excreting medicinal reduces phlegm.Usually when using tonic, add with opening its curative effect multiplication of key road, profound mansion medicine.
QI and blood is necessary material and a power in human life activity's process, always has ubiquitously under the normal condition, if a certain position of body or whole body generation qi and blood circulation freely are not qi depression to blood stasis part or whole body pathological changes can not take place.Stagnation of QI-blood is normal relevant with the endocrine nervous dysfunction.Meridians are that the passage of QI and blood is again the tie that internal organs and body surface organ are got in touch.Eye is that numerous meridians converge through part, if the meridian function of its this one of eye stagnation of QI-blood also functional disorder can take place, spasm of ocular muscles or paralysis and many diseases often occur.
The pathological product that the blood flow stasis of blood stagnates promptly and to become sweat pore obstruction again and caused as the major reason that causes sweat pore obstruction in the order is so blood circulation promoting and blood stasis dispelling is significant to make eye bright to opening profound Fu Qiaodao.The reason of forefathers' meaning " promoting the circulation of blood is for controlling the guiding principle of order ".We adopt and to invigorate blood circulation, nourish blood, the Chinese medicine of promoting the circulation of blood, blood stasis dispelling, as: Rhizoma Chuanxiong, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Radix Notoginseng, Flos Caryophylli, Radix Paeoniae Rubra, Folium Ginkgo, Rhizoma Cyperi.
Order is the liver key, and irritability is led to order and can be debated the five colors.Irritability stasis causes the principal element of sweat pore obstruction often, so dispersing the stagnated live-QI to relieve the stagnation of QI is the ophthalmology method that makes eye bright commonly used with Xuan Fu in the Caytoniales.As: Rhizoma Cyperi, Fructus Aurantii ... the smooth Liver Channel mechanism of qi of all kind accent.Often join the product of invigorating blood circulation, nourishing blood.
(3) causing resuscitation with aromatic drugs
Awaking drug mainly is that the treatment key closes the medicine of coma.Its acrid in the mouth, property fragrance are walked to scurry and are open to the custom, can penetrating key road unfavorable, the heap soil or fertilizer over and around the roots of reaching meridians exhausts, and is the product that are used as the refreshment of having one's ideas straightened out.Facts have proved in order to Xuan Fu in the Caytoniales, fluent vital essence, refreshing light, increase to look and make eye bright, quite see tall and erect the effect.
Eye is one of seven apertures, it is common that key closes coma person, so awaking drug is more common in ophthalmic applications, be used for cataracta ophthalmopathy, not having the inaccessible suddenly and person that causes sudden blindness of obvious improvement or order key as the visual function in therapeutic process of Recovery Phase of diseases at the bottom of the chronic eye all can be at the dialectical compatibility logical profound mansion medicine of having one's ideas straightened out of executing on the basis of controlling medication more.We select Rhizoma Acori Graminei, Borneolum Syntheticum, Radix Bupleuri for use.
(4) the astringent or styptic treatment for spontaneous sweating and invigorating spleen to remove dampness sedative of convergence
Astringent drug is meant to have that the medicine of function is taken off in convergence admittedly, the most nature and flavor of this type of medicine are sour and astringent, has effects such as arresting sweating, antidiarrheal, arresting seminal emission are with admittedly, improving inspiration by invigorating kidney-QI Dingchuan respectively.Be used for more weakness due to chronic disease, healthy energy solid due to the person.Clinical normal with QI invigorating, enrich blood, compatibility of drugs uses such as YIN nourishing, YANG invigorating.Can obtain good effect.As: Fructus Schisandrae Chinensis, Rhizoma Atractylodis Macrocephalae (parched), Radix Polygalae, Poria cum Radix Pini.
Five, clinical verification data:
The present invention once made Chinese powder medicine and packed in the cloth bag, i.e. eye nose bag clinical practice is in the control of juvenile myopia, wear before sleeping every night, morning, time-out was removed, wear every night about 6-8 hour, two weeks of logotype are a course of treatment, shared two courses of treatment of (other any medicine for treatment of stopping using during the treatment, check a vision when finish each course of treatment, and the record result.
Data one
The big outpatient service ophthalmology of Anhui medical courses in general Guo Shiyue doctor observes
1, observes 30 routine patients and be man in juvenile myopia and ametropia (based on the pupil) 30 examples, each 15 people of woman, maximum 24 years old of age, minimum 9 years old.30 routine patients are functional myopia eye and ametropia, have an eyesight test before and after the Drug therapy, and platycoria optometry (looking into diopter) also is recorded as radix.
2, advise all patients in evening h.d. wear Chinese medicine eye nose bag, morning, time-out was extractd, and wore every night 6-8 hour, two weeks were a course of treatment, checked a vision when finish each course of treatment totally two courses of treatment (other any medicine for treatment of stopping using during the treatment), and interrecord structure.
3,14 examples are 5 grades pupils registrations of laying foundations in 30 examples, prepare long-term follow-up study (tentative a year) and observe late result.
4, result
1. curative effect is commented the system standard: adopt domestic general logarithmic visual acuity chart at present, check the definite curative effect rank in back:
Produce effects: the vision raising reaches triplex row or the above person of triplex row;
Effectively: the vision raising reaches 1-2 passerby;
Invalid: the vision no change.
2. result
46 76.7% of 60 eye produce effects; Effective 8 13.3%; Invalid 6 10%.
| Myopia | Oculopathy number (only) | Obvious effective rate (%) | Effective percentage (%) | Inefficiency (%) | Total effective rate (%) |
| 54 | 43 | 7 | 4 | ||
| 6 | 3 | 1 | 2 | ||
| Add up to | 60 | 46(76.7％) | 8(13.3％) | 6(10％) | 54(90％) |
3. wherein 6 refraction of eye degree not just, 3 eye produce effects after the medication, 1 eye is effective, 2 eyes are invalid, total effective rate is 66.6%.
Data two
The ophthalmology outpatient service of the attached institute of Anhui Chinese Medicine College
" case selection ": 50 routine patients (based on middle school student) are carried out medication observe.Male's 22 examples, women's 28 examples, the oldest 20 years old, minimum 9 years old, the course of disease is the longest 6 years, and was the shortest 3 months, and wherein most patients are defined as just receiving treatment after the myopia all through the examination of refraction of strictness.This organizes this example patient's 32 examples of wearing glasses, and the topnotch number reaches-6 diopters.
" Therapeutic Method ": all patients h.d. every night put on Chinese medicine eye nose bag, morning time-out to extract (about 6-8 hour) two weeks of logotype be a course of treatment, 2 courses of treatment of sustainable usefulness, inactive other any medicine during the treatment, check a vision when finish each course of treatment, and the record result.
" observation of curative effect ":
1. curative effect is accurate, adopts domestic general logarithmic visual acuity chart inspection at present, and it is effectively that all process treatment visions are promoted a passerby, and vision improves three passerbys and is produce effects, and it is invalid that vision does not have enhancement person.
2. observed result, this organizes 50 examples totally 100 eyes, counts 90 eyes through clinical observation vision enhancement person, and total effective rate is 90%, in 90 eyes, wherein promotes and reaches 3 passerbys totally 59 eyes, and the produce effects case is 66% of effective case.
Model case:
Example 1: Wang Junbo, man, 14 years old, this city 48 middle school student.Private prosecution: binocular vision descended 1 year, did not wear mirror.First visit checks that binocular vision is 0.25, examination of refraction: the right side-1.25D ball, a left side-1.00D ball.Wear with the back check of one week of eye pouch, right vision 1.2, left vision 1.0, treatment finishes the back check, and binocular vision is the same.
Example 2: Wang Ying, the woman, 14 years old, middle school student, did not get the right lensses for one's eyeglasses at eyes myopia half a year.First visit checks that binocular vision is 0.5, and near vision is 1.2, dioptrics selective examination, right eye :-200D ball, left eye-2.50D ball is checked back eyes fixing upward nose bag Chinese medicine in time, week back further consultation, right vision 1.2, left eye 1.0 continues treatment further consultation in back month, and binocular vision is 1.5.
Subordinate list:
| Name | Sex | Age | The course of disease | Once do not wear mirror | Vision before the treatment | Diopter before the treatment | Treatment back vision |
| Wang Ying | The woman | 14 | Half a year | Not | A left side: 0.5 right side: 0.5 | The a left side :-2.00D ball right side :-2.50D ball | A left side: 1.5 right sides: 1.5 |
| The red legend monarch | The man | 13 | 1 year | Not | A left side: 0.8 right side: 0.5 | The a left side :-1.00D ball right side :-1.50D ball | A left side: 1.2 right sides: 1.2 |
| Wang Junbo | The man | 14 | 1 year | Not | A left side: 0.25 right side: 0.25 | The a left side :-1.25D ball right side :-1.00D ball | A left side: 1.0 right sides: 1.2 |
| Hu Kai | The man | 9 | 1 year | Not | A left side: 0.6 right side: 0.8 | The a left side :-1.25D ball right side :-1.00D ball | A left side: 1.0 right sides: 1.2 |
| Chen Le | The man | 13 | 1 year | Not | A left side: 0.6 right side: 0.8 | The a left side :-1.00D ball right side :-1.00D ball | A left side: 1.0 right sides: 1.2 |
| Xu Wei | The woman | 14 | Half a year | Not | A left side: 0.8 right side: 0.8 | The a left side :-1.00D ball right side :-1.00D ball | A left side: 1.2 right sides: 1.5 |
| Lu Qiong | The woman | 13 | 2 years | {。##.##1}, | A left side: 0.3 right side: 0.4 | The a left side :-2.50D ball right side :-2.50D ball | A left side: 0.8 right side: 0.5 |
| Xu Shushi | The man | 13 | March | Not | A left side: 0.8 | A left side :-1.00D ball | A left side: 1.5 |
| Right: 0.8 | Right :-1.00D ball | Right: 1.0 | |||||
| Zhang Qiong | The woman | 11 | 2 years | {。##.##1}, | A left side: 0.3 right side: 0.3 | The a left side :-3.00D ball right side :-3.00D ball | A left side: 1.0 right sides: 1.2 |
| Huang Xin | The woman | 12 | 2 years | {。##.##1}, | A left side: 0.2 right side: 0.15 | The a left side :-2.50D ball right side :-3.00D ball | A left side: 1.0 right sides: 1.2 |
| Fructus Myricae rubrae | The woman | 12 | 2 years | {。##.##1}, | A left side: 0.25 right side: 0.25 | The a left side :-1.50D ball right side :-1.50D ball | A left side: 0.8 right side: 1.0 |
| Liu Guangjuan | The woman | 13 | 2 years | {。##.##1}, | A left side: 0.15 right side: 0.15 | The a left side :-2.50D ball right side :-2.50D ball | A left side: 0.8 right side: 0.8 |
| Zhang Xiang | The woman | 13 | 4 years | {。##.##1}, | A left side: 0.1 right side: 0.15 | The a left side :-3.50D ball right side :-3.25D ball | A left side: 0.4 right side: 1.0 |
| Liang Zhuotao | The man | 14 | -year | {。##.##1}, | A left side: 0.15 right side: 0.1 | The a left side :-4.00D ball right side :-4.00D ball | A left side: 0.5 right side: 0.5 |
| Fei Wei | The man | 13 | August | {。##.##1}, | A left side: 0.4 right side: 0.5 | The a left side :-2.00D ball right side :-2.00D ball | A left side: 0.5 right side: 0.5 |
| Yin Run | The woman | 13 | Half a year | {。##.##1}, | A left side: 0.8 right side: 0.8 | The a left side :-2.50D ball right side :-2.50D ball | A left side: 0.8 right side: 0.8 |
| Xia Di | The man | 13 | 1 year | {。##.##1}, | A left side: 0.12 right side: 0.15 | The a left side :-2.50D ball right side :-2.50D ball | A left side: 1.5 right sides: 1.2 |
| Tang Zhenyu | The man | 13 | 1 year | Not | A left side: 0.6 right side: 0.3 | The a left side :-1.50D ball right side :-1.50D ball | A left side: 1.5 right sides: 1.0 |
| Sun Liang | The man | 14 | 1 year | Not | A left side: 0.3 right side: 0.3 | The a left side :-2.00D ball right side :-2.00D ball | A left side: 1.0 right sides: 0.5 |
| Wu Limin | The woman | 13 | 2 years | {。##.##1}, | A left side: 0.2 right side: 0.25 | The a left side :-3.00D ball right side :-2.50D ball | A left side: 0.8 right side: 1.0 |
| Zhang Ying | The woman | 13 | 3 years | {。##.##1}, | A left side: 0.1 | A left side :-2.00D ball | A left side: 0.5 |
| Right: 0.1 | Right :-3.50D ball | Right: 0.8 | |||||
| Chen Yanyan | The woman | 13 | 1 year | {。##.##1}, | A left side: 0.12 right side: 0.12 | The a left side :-1.50D ball right side :-1.75D ball | A left side: 0.8 right side: 0.5 |
| Qin Hening | The woman | 14 | Half a year | {。##.##1}, | A left side: 0.4 right side: 0.3 | The a left side :-2.00D ball right side :-2.00D ball | A left side: 1.0 right sides: 0.8 |
| Put in Shen | The man | 14 | 2 years | Not | A left side: 0.15 right side: 0.15 | The a left side :-2.00D ball right side :-2.00D ball | A left side: 0.3 right side: 0.4 |
| Feng Lei | The man | 13 | 1 year | Not | A left side: 0.5 right side: 0.8 | The a left side :-1.75D ball right side :-1.25D ball | A left side: 0.8 right side: 1.0 |
| Wang Yuanyuan | The woman | 13 | 1 year | {。##.##1}, | A left side: 0.4 right side: 0.3 | The a left side :-2.00D ball right side :-2.00D ball | A left side: 0.5 right side: 0.8 |
| A left side is all | The man | 13 | 4 years | {。##.##1}, | A left side: 0.3 right side: 0.25 | The a left side :-4.00D ball right side :-4.00D ball | A left side: 0.4 right side: 0.4 |
| Wang Jing | The woman | 14 | 4 years | {。##.##1}, | A left side: 0.2 right side: 0.15 | The a left side :-4.00D ball right side :-5.00D ball | A left side: 0.3 right side: 0.3 |
| Liu Yanhong | The woman | 14 | August | {。##.##1}, | A left side: 0.25 right side: 0.25 | The a left side :-2.75D ball right side :-2.75D ball | A left side: 0.3 right side: 0.3 |
| Zheng Xiaohui | The woman | 13 | Half a year | {。##.##1}, | A left side: 0.8 right side: 0.5 | The a left side :-1.50D ball right side :-1.75D ball | A left side: 1.0 right sides: 0.5 |
| Hu Lei | The man | 14 | 1 year | {。##.##1}, | A left side: 0.3 right side: 0.3 | The a left side :-2.50D ball right side :-2.50D ball | A left side: 0.5 right side: 0.5 |
| Jia Xiaojie | The woman | 14 | 1 year | {。##.##1}, | A left side: 0.15 right side: 0.15 | The a left side :-2.50D ball right side :-3.50D ball | A left side: 0.25 right side: 0.2 |
| Zhang Jianjun | The man | 14 | 1 year | {。##.##1}, | A left side: 0.2 right side: 0.25 | The a left side :-2.00D ball right side :-2.50D ball | A left side: 0.4 right side: 0.3 |
| Yang Yuanyuan | The woman | 13 | 3 years | Not | A left side: 0.6 | A left side :-0.75D ball | A left side: 0.8 |
| Right: 0.4 | Right :-1.00D ball | Right: 0.8 | |||||
| Shi Xin | The man | 14 | 3 years | {。##.##1}, | A left side: 0.12 right side: 0.12 | The a left side :-3.50D ball right side :-4.00D ball | A left side: 0.3 right side: 0.3 |
| Li Yang | The woman | 13 | 2 years | Not | A left side: 0.3 right side: 0.2 | The a left side :-2.50D ball right side :-2.75D ball | A left side: 0.4 right side: 0.4 |
| Vast sea | The woman | 15 | Half a year | {。##.##1}, | A left side: 0.4 right side: 0.4 | The a left side :-1.50D ball right side :-2.00D ball | A left side: 0.8 right side: 0.8 |
| Pei Li | The woman | 13 | 2 years | Not | A left side: 0.25 right side: 0.5 | The a left side :-3.00D ball right side :-2.50D ball | A left side: 0.4 right side: 0.5 |
| Chen Juan | The woman | 13 | 2 years | {。##.##1}, | A left side: 0.12 right side: 0.12 | The a left side :-3.50D ball right side :-3.50D ball | A left side: 0.3 right side: 0.5 |
| Chen Jian | The man | 14 | 1 year | {。##.##1}, | A left side: 0.12 right side: 0.1 | The a left side :-3.50D ball right side :-5.00D ball | A left side: 0.3 right side: 0.4 |
| Shen Xianbin | The man | 18 | 2 years | {。##.##1}, | A left side: 0.25 right side: 0.3 | The a left side :-2.25D ball right side :-2.50D ball | A left side: 0.3 right side: 0.6 |
| Xiang Kai | The man | 13 | 2 years | {。##.##1}, | A left side: 0.3 right side: 0.1 | The a left side :-3.75D ball right side :-3.50D ball | A left side: 0.4 right side: 0.3 |
| Yu Zhongjian | The man | 13 | 3 years | {。##.##1}, | A left side: 0.5 right side: 0.3 | The a left side :-1.50D ball right side :-3.50D ball | A left side: 0.6 right side: 0.4 |
| Gong Mingna | The woman | 18 | 1 year | Not | A left side: 0.25 right side: 0.4 | A left side: the right side: | A left side: 0.4 right side: 0.5 |
| The king is willing to | The woman | 13 | August | {。##.##1}, | A left side: 0.4 right side: 0.5 | The a left side :-2.00D ball right side :-2.00D ball | A left side: 0.4 right side: 0.5 |
| The discipline barge | The man | 14 | 1 year | Not | A left side: 0.5 right side: 0.15 | The a left side :-1.00D ball right side :-2.00D ball | A left side: 0.6 right side: 0.2 |
| Song Hong | The woman | 14 | Half a year | {。##.##1}, | A left side: 0.4 | A left side :-1.50D ball | A left side: 0.4 |
| Right: 0.25 | Right :-1.75D ball | Right: 0.4 | |||||
| Wang Qinghua | The woman | 14 | A year and a half | {。##.##1}, | A left side: 0.25 right side: 0.25 | The a left side :-3.50D ball right side :-3.50D ball | A left side: 0.2 right side: 0.2 |
| Chen Rui | The woman | 20 | 4 years | {。##.##1}, | A left side: 0.3 right side: 0.3 | The a left side :-3.25D ball right side :-3.00D ball | A left side: 0.3 right side: 0.3 |
| Tao Liang | The man | 13 | 6 years | {。##.##1}, | A left side :-0.4 right side: 0.25 | The a left side :-5.00D ball right side :-6.00D ball | A left side: 0.4 right side: 0.3 |
Data three
The department of eye outpatient service of Anhui Chinese Medicine College Affiliated Hospital
1, with eye nose Chinese medicine bag treatment nasal disease 93 examples, male's 42 examples wherein, women's 51 examples, 3 years old-61 years old age.
The sick kind has atrophic rhinitis's 31 examples, chronic rhinitis, sinusitis 31 examples, allergic rhinitis 31 examples.
2, Therapeutic Method
Wear in the eye nose with eye nose medicated bag, be not less than every day 2 hours, 2 weeks were a course of treatment, followed up a case by regular visits to one month after finishing for 1 course of treatment.During with this medicated bag, stop using other medicine treatment.
3, therapeutic outcome
1. criterion of therapeutical effect
Atrophic rhinitis's criterion of therapeutical effect:
A, healing: subjective symptoms is obviously improved, and incrustation disappears, and olfactory sensation improves, and nasal cavity is more preceding to be dwindled, and the mucosa color and luster is red and moistening;
B, improvement: nasal cavity before dwindles, and it is little to form a scab, and subjective symptoms take a favorable turn;
C, invalid: concha nasalis is atrophy still, and nasal cavity is still roomy, and it is still many to form a scab, and subjective symptoms is with before treating.
Other treatment of rhinitis standard:
A, healing: nasal obstruction, sneeze, headache, rhinorrhea disappear, and concha nasalis inferior recovers normal size, and middle nasal meatus's olfactory cleft does not have dense sexual secretion.
B, improvement: nasal obstruction, sneeze, headache, rhinorrhea improve, and slightly enlargement of concha nasalis inferior has a little viscous secretion at the bottom of the nose, and middle nasal meatus, olfactory cleft do not have purulent secretion.
C, invalid: before symptom is treated together with inspection.
2. therapeutic outcome
Eye nose Chinese medicine bag curative effect is seen attached list:
| Name of disease | The example number | Cure | Take a turn for the better | Invalid | Effective percentage (%) |
| The atrophic rhinitis | 31 | 8 | 20 | 3 | 90.3 |
| Chronic rhinitis, sinusitis | 31 | 10 | 17 | 4 | 87 |
| Allergic rhinitis | 31 | 3 | 23 | 5 | 83.8 |
| Add up to | 87％ |
Eye nose Chinese medicine bag is treated various rhinitis 93 examples as can be seen from the above table, and total effective rate reaches 87%, and wherein atrophic rhinitis's effective percentage is 90.3%, and chronic rhinitis, sinusitis effective percentage are 87%, and the allergic rhinitis effective percentage is 83.8%.
3. model case
Example 1, king so-and-so, woman, 20 years old, student.Tell dry nasal cavity, olfactory sensation is poor, has hemorrhage 2 years during nose stream crust piece.Through being coated with nose with chlorotetracycline eye ointment, the commentaries on classics of not getting better of 1% streptomycin solution paraffin oil collunarium.Check: two concha nasalis inferior dwindle, the middle nasal concha hypertrophy, and nasal cavity is roomy, and the crust piece is arranged in the meatus nasi communis, nasal membrane erosion, nasal cavity frowziness.
Diagnosis: atrophic rhinitis.Be not less than 2 hours every day through eyes fixing upward nose Chinese medicine bag, follow up a case by regular visits to after 7 days, tell the xeromycteria sense and alleviate, olfactory sensation takes a turn for the better, and the crust piece reduces.Check: the concha nasalis inferior atrophy lightens, and olfactory sensation takes a turn for the better, and the crust piece reduces, and the concha nasalis inferior atrophy lightens, and nasal cavity dwindles, and it is light red that the nasal mucosa color changes.Continue to wear the back check of two week of medicated bag, main suit's nasal cavity is moist, and olfactory sensation improves, and is not hemorrhage.Check: two concha nasalis inferior recover normal, and mucosa is ruddy, the nasal cavity normal size, and nasal cavity crust piece disappears.Fully recovered when following up a case by regular visits to a further consultation in month.
Case 2, Lee so-and-so, the woman, the shop assistant, time-out nasal obstruction, sneeze surplus the rhinorrhea three year, were once taken 30 of hismanal, the 1% ephedrine meticortelone drop nose curative effect of migrating and were not shown morning.Check: two hypertrophic inferior turbinates, the mucosal pallor edema, meatus nasi communis has small amount of water sample secretions.Diagnosis: be allergic rhinitis, give the treatment of a nose Chinese medicine bag, be not less than every day two hours, week back check tells that women's head-ornaments portion is comfortable, nasal obstruction, sneeze, snivel take a turn for the better.Check: two concha nasalis inferior are big slightly, and meatus nasi communis nasal mucosa color is light white, a further consultation in month: tell and play nasal obstruction, sneeze, snivel disappearance morning.Check: two concha nasalis inferior normal size, nasal cavity cleaning is followed up a case by regular visits to further consultation after one month and is fully recovered.
Case 3, Wang so-and-so, man, 18 years old, student.Main suit's nose, headache, the dense tears of stream 2 years.Once obeyed 5 bottles of HUODAN WAN, 1% ephedrine drop nose is not healed.Check: two hypertrophic inferior turbinates, the mucosa color is dark red, middle nasal meatus's empyema.Diagnosis: sinusitis, through one week of eyes fixing upward nose Chinese medicine bag, the check headache obviously improves, and nasal obstruction alleviates, and the nose rhinorrhea reduces.Check: two concha nasalis inferior are bigger, and middle nasal concha is normal, and it is dark red that middle nasal meatus's dope reduces the mucosa color, continues to wear medicated bag, and headache, nasal obstruction, rhinorrhea disappearance are told in the back further consultation of two weeks.Check: two concha nasalis inferior normal size, each nasal meatus cleaning, it is light red that the mucosa color changes, and follows up a case by regular visits to a recovery from illness in month.
Case 4, Jiao, the woman, 19 years old, first visit was told and was replaced the property nasal obstruction 3 years, once uses 5 bottles of naphazoline collunarium and rhinitis tablets, and curative effect does not show.Check: two hypertrophic inferior turbinates, the mucosa color is dark red, shrinks insensitive through the cotton sheet of 1% ephedrine liquid.Give eyes fixing upward nose Chinese medicine bag, be not less than every day 2 hours.The back further consultation of one week is told nasal obstruction and is obviously improved, and lies on one's side in bed and does not have a stuffy nose.Check: the slightly enlargement of two concha nasalis inferior, the mucosa color is light red.Two weeks back further consultation nasal obstruction disappears.Check: two concha nasalis inferior sizes are normal, and it is light red that the mucosa color changes, and checks after one month and fully recover.
Claims (11)
1. a Chinese medicine pad pasting of preventing and treating myopia, asthenopia disease and optical fundus ischemic eye disease is made up of back lining materials, medicated layer and protective film.Wherein medicated layer is that (the matrix type adjuvant is natural polysaccharide and synthetic polymer by matrix type adjuvant 23-65%, as: one or more in polyvinyl alcohol, Pioloform, polyvinyl acetal, polyvinylpyrrolidone, polyacrylate or the polyacrylamide), preferably polyethylene alcohol 30%; In pharmaceutically active ingredient 75%-20%, preferred 63% and plasticizer 2-15% (be in glycerol, triacetyl glycerine, ethylene glycol, the sorbitol phthalic acid ester one or more) preferably glycerine 7%.Middle pharmaceutically active ingredient is to select for use the prescription of following traditional Chinese medicines material to make:
Borneolum Syntheticum 1-5 part Fructus Lycii: 15-375 part Semen Cuscutae: 12-300 part
Fructus Rubi: 12-300 part Semen Cassiae: 12-300 part Radix Rehmanniae Preparata: 15-375 part.
2. according to claims 1 described external Chinese medicine pad pasting of preventing and treating myopia, asthenopia disease and optical fundus ischemic eye disease, wherein middle pharmaceutically active ingredient selects for use the prescription that contains the following traditional Chinese medicines material to make:
Borneolum Syntheticum: 1 part of Fructus Lycii: 75 parts of Semen Cuscutae: 60 parts
Fructus Rubi: 60 parts of Semen Cassiaes: 60 parts of Radix Rehmanniaes Preparata: 75 parts.
3. select for use the prescription that contains the following traditional Chinese medicines material to make according to claims 1 described wherein middle pharmaceutically active ingredient of external Chinese medicine pad pasting of preventing and treating myopia, asthenopia disease and optical fundus ischemic eye disease:
Borneolum Syntheticum: 1-5 part Fructus Lycii: 15-375 part Semen Cuscutae: 12-300 part
Fructus Rubi: 12-300 part Semen Cassiae: 12-300 part Radix Rehmanniae Preparata: 15-375 part
Radix Astragali Preparata: 12-300 part Rhizoma Chuanxiong: 10-250 part Radix Salviae Miltiorrhizae: 12-300 part
Radix Angelicae Sinensis: 12-300 part Radix Codonopsis: 15-375 part Poria cum Radix Pini: 12-300 part
Radix Polygalae: 12-300 part Rhizoma Acori Graminei: 12-300 part Fructus Schisandrae Chinensis: 10-250 part
4. according to claims 3 described external Chinese medicine pad pastings of preventing and treating myopia, asthenopia disease and optical fundus ischemic eye disease, wherein middle pharmaceutically active ingredient is to select for use the prescription of following traditional Chinese medicines material to make:
Borneolum Syntheticum: 1 part of Fructus Lycii: 75 parts of Semen Cuscutae: 60 parts
Fructus Rubi: 60 parts of Semen Cassiaes: 60 parts of Radix Rehmanniaes Preparata: 75 parts
Radix Astragali Preparata: 60 parts of Rhizoma Chuanxiongs: 50 parts of Radix Salviae Miltiorrhizaes: 60 parts
Radix Angelicae Sinensis: 60 parts of Radix Codonopsis: 75 parts of Poria cum Radix Pinis: 60 parts
Radix Polygalae: 60 parts of Rhizoma Acori Graminei: 60 parts of Fructus Schisandrae Chinensis: 50 parts
5. according to claims 3 described external Chinese medicine pad pastings of preventing and treating myopia, asthenopia disease and optical fundus ischemic eye disease, wherein middle pharmaceutically active ingredient is to select for use the prescription of following traditional Chinese medicines material to make:
Borneolum Syntheticum: 1-5 part Fructus Lycii: 15-375 part Semen Cuscutae: 12-300 part
Fructus Rubi: 12-300 part Semen Cassiae: 12-300 part Radix Rehmanniae Preparata: 15-375 part
Radix Astragali Preparata: 12-300 part Rhizoma Chuanxiong: 10-250 part Radix Salviae Miltiorrhizae: 12-300 part
Radix Angelicae Sinensis: 12-300 part Radix Codonopsis: 15-375 part Poria cum Radix Pini: 12-300 part
Radix Polygalae: 12-300 part Rhizoma Acori Graminei: 12-300 part Fructus Schisandrae Chinensis: 10-250 part
The Radix Polygoni Multiflori: 12-300 part Rhizoma Atractylodis Macrocephalae (parched): 12-300 part Radix Paeoniae Rubra: 12-300 part
Flos Carthami: 10-250 part Radix Notoginseng: 12-300 part Rhizoma Cyperi: 12-300 part
Radix Bupleuri: 12-300 part Folium Ginkgo: 15-375 part Flos Caryophylli: 15-375 part
6. make according to claims 5 described prescriptions of preventing and treating the external Chinese crude drug of myopia, asthenopia disease and optical fundus ischemic eye disease:
Borneolum Syntheticum: 1 part of Fructus Lycii: 75 parts of Semen Cuscutae: 60 parts
Fructus Rubi: 60 parts of Semen Cassiaes: 60 parts of Radix Rehmanniaes Preparata: 75 parts
Radix Astragali Preparata: 60 parts of Rhizoma Chuanxiongs: 50 parts of Radix Salviae Miltiorrhizaes: 60 parts
Radix Angelicae Sinensis: 60 parts of Radix Codonopsis: 75 parts of Poria cum Radix Pinis: 60 parts
Radix Polygalae: 60 parts of Rhizoma Acori Graminei: 60 parts of Fructus Schisandrae Chinensis: 50 parts
The Radix Polygoni Multiflori: 60 parts of Rhizoma Atractylodis Macrocephalae (parched)s: 60 parts of Radix Paeoniae Rubra: 60 parts
Flos Carthami: 50 portions of Radix Notoginseng: 60 portions of Rhizoma Cyperis: 60 parts
Radix Bupleuri: 60 parts of Folium Ginkgos: 75 portions of Flos Caryophyllis: 75 parts
7. according to claims 6 described external Chinese medicine pad pastings of preventing and treating myopia, asthenopia disease and optical fundus ischemic eye disease, wherein middle pharmaceutically active ingredient is to select for use the prescription of following traditional Chinese medicines material to make:
Borneolum Syntheticum: 0.2g Fructus Lycii: 15g Semen Cuscutae: 12g
Fructus Rubi: 12g Semen Cassiae: 12g Radix Rehmanniae Preparata: 15g
Radix Astragali Preparata: 12g Rhizoma Chuanxiong: 10g Radix Salviae Miltiorrhizae: 12g
Radix Angelicae Sinensis: 12g Radix Codonopsis: Poria cum Radix Pini 15g: 12g
Radix Polygalae: 12g Rhizoma Acori Graminei: 12g Fructus Schisandrae Chinensis: 10g
The Radix Polygoni Multiflori: 12g Rhizoma Atractylodis Macrocephalae (parched): 12g Rhizoma Cyperi: 12g
Flos Carthami: 10g Radix Notoginseng: 12g Radix Paeoniae Rubra: 12g
Radix Bupleuri: 12g Folium Ginkgo: 15g Flos Caryophylli: 15g
8. according to any one described external Chinese medicine pad pasting of preventing and treating myopia, asthenopia disease and optical fundus ischemic eye disease in claims 1-7 item, wherein middle pharmaceutically active ingredient is 63%, and polyvinyl alcohol (PVA) is 30%, glycerol 7%.
9. according to claims 1 or 2 described preparation methoies of preventing and treating the external Chinese medicine pad pasting of myopia, asthenopia disease and optical fundus ischemic eye disease, it is characterized in that it comprises the following steps:
1. alcohol extraction effective ingredient: five tastes medical materials such as Fructus Lycii, Semen Cuscutae, Fructus Rubi, Semen Cassiae, Radix Rehmanniae Preparata are added soak 2-4 hour reheat reflux, extract, 2 times of 9 amount ethanol, each 1.5-2 hour, filter, twice filtrate is merged decompression recycling ethanol, it is standby that medicinal liquid is condensed into thick paste;
2. borneol and grinding is become impalpable powder (10-12um) or dissolves the B-cyclodextrin inclusion compound with 75% ethanol;
3. thick paste that 1. item is extracted and item 2. the Borneolum Syntheticum fine powder be mixed and made into compound, stir, produce to there being minute bubbles, left standstill 20 minutes-30 minutes, to the minute bubbles complete obiteration;
4. get item 3. compound 63%+10%PVA30%+ glycerol 7% → mixing and stirring leave standstill disappear → promptly to get to minute bubbles in 15-20 minute and make the film compound;
5. get and 4. make the film compound, put in the film-making machine medicine groove → system film → room temperature under (in 40 ℃) drying → cutting frustillatum → put on the non-woven fabrics that contains glue, add protecting film on the medicine film and cover → add exterior and interior packing.
10. according to claims 3 or 4 described preparation methoies of preventing and treating the external Chinese medicine pad pasting of myopia, asthenopia disease and optical fundus ischemic eye disease, it is characterized in that it comprises the following steps:
1. water extraction effective components of Chinese medicinal, boil distillating extracting oil:
Chinese crude drug: Radix Codonopsis, Radix Angelicae Sinensis, Rhizoma Acori Graminei, Rhizoma Chuanxiong, Fructus Schisandrae Chinensis, Poria cum Radix Pini put into extraction pot and add 6-8 hour post-heating of water logging bubble that 3-5 doubly measures and boil distillating extracting oil to carrying fully to the greatest extent, water cooking liquid filters, filtrate is condensed into thick paste, and (relative density is 1.18-1.20,60 ℃), add 1.7 times of 95% ethanol and make that to contain alcohol amount be 60%, fully stir fully evenly, leave standstill and drew supernatant in 20 hours, the precipitation part filters, decompression filtrate recycling ethanol is condensed into thick paste (1.18-1.20,60 ℃) standby, medicinal residues are retained standby, collect volatile oil;
2. alcohol extraction effective ingredient
The Chinese crude drug of alcohol extraction: Radix Rehmanniae, Fructus Lycii, Semen Cuscutae, Semen Cassiae, Fructus Rubi, Radix Salviae Miltiorrhizae, the Radix Astragali, Radix Polygalae and the item 1. medicinal residues behind the water extraction mix and put into the alcohol extraction jar, add 9 times of amount ethanol, twice of 2-4 hour post-heating reflux, extract, (90% ethanol for the first time that soaks, 80% ethanol for the second time) each 1.5-2 hour, filter, twice filtrate is merged reclaim under reduced pressure ethanol (about 60 ℃ of temperature), medicinal residues are condensed into thick paste (relative density is 1.18-1.20,60 ℃);
3. borneol and grinding becomes fine powder, or dissolves with 75% ethanol, and its solution is with powder-beta-dextrin powder enclose, and is standby;
4. a volatile oil that 1. distills out is standby with beta-schardinger dextrin-powder enclose;
The preparation of 5. middle pharmaceutically active ingredient compound:
Get 1. 2. 3. 4. volatile oil → whole mixing and stirring of Borneolum Syntheticum+item of thick paste+item of thick paste+item of item, leave standstill 20-30 minute, promptly get middle pharmaceutically active ingredient compound to the minute bubbles complete obiteration;
6. Chinese medicine patch film production:
Get item 5. compound 63%+10%PVA solution 30%+ glycerol 7% → stir leave standstill 15-20 minute to minute bubbles complete obiteration → promptly get and make the film compound.
7. get and 6. make the film compound, put in the film-making machine medicine groove → system film → room temperature under (in 40 ℃) dry → cut into little medicine bulk → place on the non-woven fabrics that contains glue, add protective film on the medicine film and cover → add exterior and interior packing.
11., it is characterized in that it comprises the following steps: according to claims 5 or 6 described preparation methoies of preventing and treating the external Chinese medicine pad pasting of myopia, asthenopia disease and optical fundus ischemic eye disease
1. pharmaceutically active ingredient in the water extraction, boil distillating extracting oil:
Chinese crude drug: Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Rhizoma Acori Graminei, Rhizoma Chuanxiong, Fructus Schisandrae Chinensis, Poria cum Radix Pini, Rhizoma Cyperi, Radix Bupleuri, Folium Ginkgo, Radix Paeoniae Rubra, the Rhizoma Atractylodis Macrocephalae, Flos Carthami, Flos Caryophylli is put into extraction pot, add water logging bubble that 3-5 doubly measures after 6-8 hour, the heated and boiled distillating extracting oil is to carrying fully to the greatest extent, water cooking liquid filters, filtrate is condensed into thick paste, and (relative density is 1.18-1.20,60 ℃), add 1.7 times of 95% ethanol and make that to contain alcohol amount be 60%, fully stir fully evenly, left standstill 20 hours, draw supernatant, the precipitation part filters, decompression filtrate recycling ethanol, (relative density is standby for (1.18-1.20,60 ℃) to be condensed into thick paste; Medicinal residues are retained standby, collect volatile oil;
2. alcohol extraction effective ingredient:
The Chinese crude drug of alcohol extraction: Radix Rehmanniae, Fructus Lycii, Semen Cuscutae, Semen Cassiae, Fructus Rubi, Radix Salviae Miltiorrhizae, the Radix Astragali, Radix Polygalae, the Radix Polygoni Multiflori and the item 1. medicinal residues behind the water extraction mix and put into the alcohol extraction jar, add 9 times of amount ethanol, twice of 2-4 hour post-heating reflux, extract, (90% ethanol for the first time that soaks, 80% ethanol for the second time) each 1.5-2 hour, filter, twice filtrate is merged reclaim under reduced pressure ethanol (60 ℃ of temperature) medicinal liquid be condensed into thick paste (relative density is 1.18-1.20,60 ℃).
3. borneol and grinding becomes fine powder or with the dissolving of 75% ethanol, uses beta-schardinger dextrin-powder enclose standby, and Radix Notoginseng powder is standby.
4. a volatile oil that 1. extracts is standby with beta-schardinger dextrin-powder enclose;
The preparation of 5. middle pharmaceutically active ingredient compound:
Get 1. 2. 3. 4. volatile oil → whole mixing and stirring of Borneolum Syntheticum, Radix Notoginseng powder+item of thick paste+item of thick paste+item of item, leave standstill 20-30 minute, promptly get middle pharmaceutically active ingredient compound to the minute bubbles complete obiteration;
6. Chinese medicine patch film production:
Get 5. compound 63%+10%PVA solution 30%+ glycerol 7% → stir of item, leave standstill 15-20 minute to minute bubbles complete obiteration → promptly get and make the film compound;
7. get and 6. make the film compound, put in the film-making machine medicine groove → system film → room temperature under (in 40 ℃) dry → cut into little medicine piece → place on the non-woven fabrics that contains glue, add protective film on the medicine film and cover → add exterior and interior packing.
In a word:
1. application prevents and treats the right protection of the above prescription of myopia, asthenopia disease and optical fundus ischemic eye disease new drug Chinese medicine pad pasting.
2. application prevents and treats the protection of myopia, asthenopia disease and optical fundus ischemic new drug Chinese medicine patch membrane process manufacture method.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100651271A CN101279008A (en) | 2007-04-05 | 2007-04-05 | Chinese medicine pad pasting for preventing and controlling myopic eye, eyestrain symptoms and eyebase ischemia |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100651271A CN101279008A (en) | 2007-04-05 | 2007-04-05 | Chinese medicine pad pasting for preventing and controlling myopic eye, eyestrain symptoms and eyebase ischemia |
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| CN101279008A true CN101279008A (en) | 2008-10-08 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2007100651271A Pending CN101279008A (en) | 2007-04-05 | 2007-04-05 | Chinese medicine pad pasting for preventing and controlling myopic eye, eyestrain symptoms and eyebase ischemia |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101797314A (en) * | 2010-04-22 | 2010-08-11 | 田东华 | Medicinal composition for treating adolescent myopia and preparation method thereof |
| CN103705638A (en) * | 2013-12-30 | 2014-04-09 | 广西梧州制药（集团）股份有限公司 | Traditional Chinese medicine composition for relieving asthenopia and preparation method thereof |
| CN104383168A (en) * | 2014-11-03 | 2015-03-04 | 王青年 | Traditional Chinese medicine unguent for improving eyesight and preparation method thereof |
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| CN104997955A (en) * | 2015-07-09 | 2015-10-28 | 韩红卫 | External drug for improving myopia and its preparation method and use |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101797314A (en) * | 2010-04-22 | 2010-08-11 | 田东华 | Medicinal composition for treating adolescent myopia and preparation method thereof |
| CN104740644A (en) * | 2013-07-03 | 2015-07-01 | 郑州市新视明科技工程有限公司 | Preparation method of composition for promoting skin compliance and ingredient absorption of eye hydropathic compress agent |
| CN104740644B (en) * | 2013-07-03 | 2017-11-24 | 郑州市新视明科技工程有限公司 | Promote eye Wet-dressing agent skin compliance and the preparation method of ingredient draws composition |
| CN103705638A (en) * | 2013-12-30 | 2014-04-09 | 广西梧州制药（集团）股份有限公司 | Traditional Chinese medicine composition for relieving asthenopia and preparation method thereof |
| CN103705638B (en) * | 2013-12-30 | 2016-05-18 | 广西梧州制药（集团）股份有限公司 | Chinese medicine composition of a kind of alleviating asthenopia and preparation method thereof |
| CN104383168A (en) * | 2014-11-03 | 2015-03-04 | 王青年 | Traditional Chinese medicine unguent for improving eyesight and preparation method thereof |
| CN104383168B (en) * | 2014-11-03 | 2018-04-06 | 王青年 | A kind of Chinese medicine ointment for improving eyesight and preparation method thereof |
| CN104740150A (en) * | 2015-04-02 | 2015-07-01 | 黄文鹏 | Fermented ointment helpful for preventing and treating myopia and preparation method thereof |
| CN104997955A (en) * | 2015-07-09 | 2015-10-28 | 韩红卫 | External drug for improving myopia and its preparation method and use |
| CN105878627A (en) * | 2016-06-03 | 2016-08-24 | 马小英 | Traditional Chinese medicine formula for treating myopic disease |
| CN107412539A (en) * | 2017-04-14 | 2017-12-01 | 肖志远 | Prevent and treat the herbal application of myopia |
| CN107029121A (en) * | 2017-05-11 | 2017-08-11 | 李晴 | It is a kind of nurse one's health that Liver Channel kidney qi dredging the channel alleviates and improve eyesight stick ointment |
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Open date: 20081008 |