CN103705638B - Chinese medicine composition of a kind of alleviating asthenopia and preparation method thereof - Google Patents
Chinese medicine composition of a kind of alleviating asthenopia and preparation method thereof Download PDFInfo
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Abstract
The invention discloses Chinese medicine composition of a kind of alleviating asthenopia and preparation method thereof. Said composition is that raw material is prepared from by medicinal materials such as panoxadiol glycosides, cassia twig, Radix Angelicae Sinensis, the Radix Astragali, peach kernel, Ligusticum wallichii, the root of Dahurain angelica, matrimony vine, the seed of Chinese dodder, earthworms. The present invention also provides the preparation method of the Chinese medicine composition of this alleviating asthenopia. Composition provided by the invention can effectively improve visual fatigue symptom, improves distant vision, and improves duration of photopic vision, reaches the effect of alleviating asthenopia.
Description
Technical field
The present invention relates to pharmaceutical sanitary field, be specifically related to a kind of Chinese medicine composition and preparation side thereof of alleviating asthenopiaMethod.
Background technology
Visual fatigue is the common a kind of disease of current ophthalmology, and patient's symptom is varied, common are near workCan not be lasting, go out to lose face and eye socket around pain, blurred vision, eyes dry and astringent, shed tears etc., severe patient headache, dislikeThe heart, dizzy. It is not disease independently, but the one group of fatigue syndrome causing due to a variety of causes. Its generation is formerBecause being also diversified, common are: (l) reason of eyes itself, as the dioptrics such as myopia, long sight, astigmatism notIt is improper etc. that just, adjusting factor, eye muscle factor, conjunctivitis, keratitis, institute wear glasses; (2) systemic factor, asNeurasthenia, health overwork, hysteria or involutional women; (3) environmental factor, as not enough or excessively strong in illumination, lightSource distribution is inhomogeneous or glimpse, and the target of watching attentively is too small, meticulous or unstable etc.
Increasing " visual fatigue " crowd's generation is now also the table of modern way of life change and social progressExisting, its real reason is that people are to eyes, to the attention of self health. Expert claims, people under normal circumstances, eyeTear in socket of the eye can form a skim, covers the surface of Cornea and conjunctiva, is called tear film. After people blinks at every turn,Can form one deck tear film, can keep eyes moistening and comfortable, therefore be difficult for producing the eye symptom such as dry, tired. ButIf stare at for a long time a target (as used computer, reading), the duration is oversize, and blink reflex is fewer, can notForm in time tear film, will cause a dry tack free, cause visual fatigue. Eyedrops can not effect a radical cure kopiopia, althoughSome eyedrops really can fatigue-relieving symptom.
Then eyedrops is can only respite eyesight tired, cures the symptoms, not the disease. . alleviating asthenopic eyedrops mustUnder physician guidance, use. Because all contain anticorrisive agent in current 90% eyedrops, these materials can be to ocular surfaceCell produce infringement. Patients with dry eye is preferably selected the artificial tears of preservative free. From traditional Chinese medical science angle, depending on tiredLabor majority is by deficiency of qi and blood, and order apoplex involving the channels and collaterals is not smooth, lose in moisten support due to.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition of alleviating asthenopia;
Another object of the present invention is to provide a kind of Chinese medicine composition preparation method of alleviating asthenopia.
The object of the invention is to realize by following technical scheme:
The Chinese medicine composition of alleviating asthenopia of the present invention is to be prepared from by the raw material containing following weight portion:
Panoxadiol glycosides 1-4 part, cassia twig 5-15 part, Radix Angelicae Sinensis 5-15 part, Radix Astragali 10-30 part, the root of Dahurain angelica 20-40 parts, seed of Chinese dodder 20-40 part, earthworm 20-40 part, peach kernel 30-50 part, Ligusticum wallichii 30-50 part, matrimony vine30-50 part.
Preferably, be to be prepared from by the raw material containing following weight portion:
Panoxadiol glycosides 2-3 part, cassia twig 8-12 part, Radix Angelicae Sinensis 8-12 part, Radix Astragali 15-25 part, the root of Dahurain angelica 25-35 parts, seed of Chinese dodder 25-35 part, earthworm 25-35 part, peach kernel 35-45 part, Ligusticum wallichii 35-45 part, matrimony vine35-45 part.
More preferably, be to be prepared from by the raw material containing following weight portion:
3 parts of panoxadiol glycosides, 10 parts of cassia twig, 10 parts of Radix Angelicae Sinensis, 20 parts of the Radixs Astragali, 30 parts of the roots of Dahurain angelica, the seed of Chinese dodder 30Part, 30 parts of earthworms, 40 parts, peach kernel, 40 parts of Ligusticum wallichiis, 40 parts of matrimony vines.
Below crude drug source of the present invention:
PDS: the one that is ginsenoside. Ginsenoside (Ginsenoside) is a kind of steroidCompound, triterpenoid saponin. Mainly be present in Araliaceae Panax medicinal material, Panax majority is some rare traditional Chinese medicines,As pseudo-ginseng, ginseng, American Ginseng etc. Ginsenoside can be divided into three groups of two classes, a class according to the difference of sapogeninBe the Dammar methane series saponin(e of tetracyclic triterpene, wherein one group of acid hydrolysis end product is panoxadiol, as ginseng soapGlycosides Rb1, Rb2, Rb3, Rc, Rd, Rg3, Rh2 etc.
Cassia twig: this product is the dry spray of canella Chinese cassia tree CinnamomumcassiaPresl. Spring, Xia ErjiGather, except defoliation, dry, or section is dried. [nature and flavor] acrid, sweet, warm. [return through] thoughts of returning home, lung, wingGuang warp. [function cures mainly] sweating expelling pathogenic factors from muscles and skin, warming meridian, helps yang transforming qi, the flat gas that spins. For anemofrigid cold,Coldness and pain in the epigastrium, blood is cold through closing, joint pain, phlegm and retained fluid, oedema, palpitaition, globefish runs quickly.
Radix Angelicae Sinensis: this product is umbelliferae angelica Angelicasinensis(Oliv.) the dry root of Diels. Qiu MoExcavate, remove fibrous root and silt, after moisture slightly evaporates, be bundled into wisp, upper canopy, with slowly smoke-dried beancurd of pyrotechnics. [propertyTaste] sweet, acrid, warm. [return through] returns liver, the heart, the spleen channel. [function cures mainly] enriched blood and invigorated blood circulation, menstruction regulating and pain relieving,Relax bowel. Sallow for the deficiency of blood, dizzy palpitaition, irregular menstruation, through closing dysmenorrhoea, asthenia cold abdominalgia, the dry constipation of intestines,Arthralgia due to wind-dampness, injury from falling down, ulcer sores. Prepared RADIX ANGELICAE SINENSIS with yellow rice wine activating blood to promote menstruation. Be used for through closing dysmenorrhoea, arthralgia due to wind-dampness, fallsFlutter damage.
The Radix Astragali: be legume astragalus mongolicus Astragalusmembranaceus(Fisch.) Bge.var.Mongholicus(Bge.) Hsiao or Astragalus membranacus Astragalusmembranaceus(Fisch.) Bge.Dry root. Spring, Qiu Erji excavate, and remove fibrous root and root head, dry. [nature and flavor] are sweet, temperature. [return through] returnsLung, the spleen channel. [function cures mainly] invigorating qi for strengthening superficies, diuresis holder poison, apocenosis, expelling pus and promoting granulation. It is weak for the deficiency of vital energy,Anorexia and loose stool, the sinking of qi of middle-jiao, rushes down prolapse of the anus for a long time, the uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy oedema, ulcer is difficult bursts, for a long timeBurst and do not hold back, flaccidity of limbs due to deficiency of blood Huang, interior heat is quenched one's thirst; Chronic nephritis albuminuria, diabetes.
Peach kernel: this product is rosaceous plant peach Prunuspersica(L.) Batsch or mountain peach Prunusdavidiana(Carr.) dry mature seed of Franch.. After fruit maturation, gather, remove pulp and nucleocapsid, take out seed,Dry. [nature and flavor] bitter, sweet, flat. [return through] thoughts of returning home, liver, large intestine channel. [function cures mainly] promoting blood circulation,Relax bowel. Be used for through closing dysmenorrhoea ， wei lump in the abdomen lump in the abdomen, injury from falling down, the dry constipation of intestines.
Ligusticum wallichii: this product is samphire Ligusticum wallichii LigusticumchuanxiongHort.(or LigusticumwallichiiFranch.) dry rhizome. Showing outstanding when joint dish on stem summer, and slightly excavate when purple, removes silt,After shining, a heatable brick bed is dry, then removes fibrous root. [nature and flavor] are pungent, temperature. [return through] returns liver, courage, pericardium channel. [function cures mainly]Blood-activating and qi-promoting, wind-expelling pain-stopping. For irregular menstruation, through closing dysmenorrhoea, abdominal mass stomachache, the shouting pain of the chest side of body, tumbling and swelling,Headache, arthralgia due to wind-dampness.
The root of Dahurain angelica: this product is the plant root of Dahurain angelica Angelicadahurica(Fisch.exHoffm. of umbellate form section) Benth.etHook.f. or Radix angelicae dahuricae Angelicadahurica(Fisch.exHoffm.) Benth.etHook.f.var.formosana(Boiss.) the dry root of ShanetYuan. When leaf is yellow between summer, autumn, excavate, remove fibrous root and silt, dry orLow temperature drying. [nature and flavor] are pungent, temperature. [return through] returns stomach, large intestine, lung channel. [function cures mainly] loose wind dehumidifying,Understand things pain-stopping, detumescence and apocenosis. For cold headache, pain in the supra-orbital bone, nasal obstruction, nasosinusitis, toothache, leukorrhea, soreSwell and ache.
Matrimony vine: this product is the dry mature fruit of plant of Solanaceae lycium barbarum LyciumbarbarumL.. Summer, autumnWhen two seasons, fruit took on a red color, gather, hot-air seasoning, removes carpopodium. Or dry in the air to rhicnosis, dry, remove carpopodium. [propertyTaste] sweet, flat. [return through] returns liver, kidney channel. [function cures mainly] is nourishing liver and kidney, benefiting shrewd head. For consumptive disease essenceLose, soreness of waist and knee joint, dizzy tinnitus, interior heat is quenched one's thirst, and the deficiency of blood is sallow, and blurred vision is not clear.
The seed of Chinese dodder: this product is the dry mature seed of convolvulus cuscuta plant CuscutachinensisLam.. AutumnThe plant of gathering when fruit maturation in season, dries, and lays seed, removes impurity. [nature and flavor] are sweet, temperature. [return through]Return liver,kidney,spleen warp. [function cures mainly] is nourishing liver and kidney, and controlling nocturnal emission with astringent drugs contracting urine is antiabortive, improving eyesight, antidiarrheal. For sunImpotence seminal emission, dripping urination, enuresis frequent micturition, soreness and weakness of waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, fetal irritability, spleen kidneyVoid is rushed down; Externally treating leucoderma.
Earthworm: this product is the animal Pheretima aspergillum Pheretimaaspergillum(E.Perrier of Ju Yin section), popular ringHair earthworm PheretimavulgarisChen, William Pheretimatschiliensis Pheretimaguillelmi(Michaelsen) or comb blindThe dry body of Pheretimatschiliensis PheretimapectiniferaMichaelsen. Front a kind of habit claims " LUMBRICUS ", practises title for latter three kinds" Shanghai earthworm ". LUMBRICUS catches to autumn spring, and Shanghai earthworm catches summer, cuts in time belly open, removes internal organ and mudSand, cleans, and dries or low temperature drying. [nature and flavor] are salty, cold. [return through] returns liver, spleen, urinary bladder channel. [meritCan cure mainly] heat-clearing arresting convulsion, dredging collateral, relievings asthma, diuresis. For unconsciousness due to high fever, frightened epilepsy is twitched, joint pain, limbBody numbness, hemiplegia, dyspnea and cough due to lung-heat, oliguria oedema, hypertension.
Another aspect of the present invention has been to provide the preparation method of the active component of Chinese medicine composition of the present invention, and the method isAdopt the alcohol extract of water extraction or 40-80% concentration expressed in percentage by volume. Concrete preparation method is as follows:
Scheme one: get whole medicinal materials, extracting in water 2-3 time, each amount of water is equivalent to the 6-12 of medicinal material gross weightDoubly, each extraction time is 1-3 hour, merges extract, filters, and filtrate is condensed into liquid extract, obtains described workProperty composition.
Scheme two: get whole medicinal materials, extracting in water 2-3 time, each amount of water is equivalent to the 6-12 of medicinal material gross weightDoubly, each extraction time is 1-3 hour, merges extract, filters relative density when filtrate is concentrated into 70-80 DEG CFor the clear cream of 1.05-1.20, add ethanol, making containing alcohol amount is 40-70%, leaves standstill 12-24 hour, filters filtrateBe condensed into liquid extract, obtain described active component.
Scheme three: get whole medicinal materials, with 40-80% alcohol reflux extraction 2-3 time, each ethanol consumption is medicinal material total amount4-10 doubly, extraction time is 1-3 hour, merges extract, filters, filtrate is condensed into liquid extract, obtains instituteState active component.
The Chinese medicine composition of alleviating asthenopia of the present invention, can coordinate with pharmaceutically acceptable carrier, systemBecome various common dosage forms, as tablet, granule, capsule, syrup, mixture etc.
Pharmaceutically acceptable carrier of the present invention includes but not limited to following:
Diluent: starch, Icing Sugar, lactose, dextrin, microcrystalline cellulose, inorganic salts, glycitols etc.
Wetting agent and adhesive: purified water, ethanol, gelatin, polyethylene glycol, cellulose derivative etc.
Disintegrant: starch, sodium carboxymethyl starch, cellulose derivative, PVPP etc.
Lubricant: dolomol, superfine silica gel powder, talcum powder, polyethylene glycol etc.
Cosolvent: water, ethanol, glycerine, propane diols, liquid paraffin, plant wet goods.
Flavouring: sucrose, monose, aromatic etc.
Anticorrisive agent: benzoic acid, sorbic acid, methyl esters, ethyl ester, propyl ester etc.
Method 1: tablet
Get scheme one to one of scheme three gained active components, be dried to dried cream powder, add tablet to commonly use auxiliary material, by normalRule production method is prepared into tablet of the present invention.
The conventional auxiliary material of above-mentioned tablet comprises one of diluent, wetting agent, adhesive, disintegrant, lubricant or whole.
Method 2: granule
Get scheme one to one of scheme three gained active components, be dried to dried cream powder, add granule to commonly use auxiliary material, pressConventional production method is prepared into granule of the present invention.
The conventional auxiliary material of above-mentioned granule comprises one of diluent, wetting agent, adhesive, disintegrant or whole.
Method 3: capsule
Get scheme one to one of scheme three gained active components, be dried to dried cream powder, add capsule to commonly use auxiliary material, pressConventional production method is prepared into capsule of the present invention.
The conventional auxiliary material of above-mentioned capsule comprises one of diluent, wetting agent, adhesive, disintegrant, lubricant or whole.
Method 4: syrup
Get scheme one to one of scheme three gained active components, add syrup to commonly use auxiliary material, routinely producer legal systemFor obtaining syrup of the present invention.
The conventional auxiliary material of above-mentioned syrup comprises one of flavouring, anticorrisive agent, cosolvent or whole.
Method 5: mixture
Get scheme one to one of scheme three gained active components, add mixture to commonly use auxiliary material, production method preparation routinelyObtain mixture of the present invention.
The conventional auxiliary material of above-mentioned mixture comprises one of flavouring, anticorrisive agent or whole.
Fang Xie: we card is by deficiency of qi and blood, and order apoplex involving the channels and collaterals is not smooth, loses due to moisten and support. Disease opinion can not closely be looked for a long time,Palpitaition, forgetful, god is tired etc. Control and work as tonifying Qi and blood, promoting blood circulation and removing obstruction in channels. We's cassia twig warming meridian, a surname leads and invigorates blood circulation it againProduct and stagnation resolvation; Chinese angelica blood supplementing is invigorated blood circulation, and both virtual loss of enriching yin blood, invigorate blood circulation again and help dredging collateral, and two arrogate to oneself its merit; We reuse HuangStilbene tonifying Qi, is intended to make the prosperous blood of gas, and stasis of blood Xiaoluotong is all monarch drug in a prescription. Peach kernel, Ligusticum wallichii share blood-activating and qi-promoting, menstruation regulating,Association's Radix Angelicae Sinensis activating blood circulation and dissipating blood stasis, helps again cassia twig bar to reach passages through which vital energy circulates; The pungent row temperature of the root of Dahurain angelica is logical, is apt to away Yangming Channel, separates head's pain, allFor ministerial drug. We's assistant is with the fruit of Chinese wolfberry, the seed of Chinese dodder, earthworm, and the fruit of Chinese wolfberry and seed of Chinese dodder master enter liver, kidney channel, can nourish liver and kidneyThe moon, flat kidney tonifying essence liver blood, kindly controls hypopsia due to asthenia of essence and blood, has a dizzy spell; Earthworm master returns Liver Channel, propertyWalk to alter, be longer than current channels and collaterals, can fluent blood vessels and help Radix Angelicae Sinensis, Radix Astragali blood-activating and qi-promoting, make not smooth train of thought qi and blood full.
The present invention adds panoxadiol glycosides in above-mentioned side. Panoxadiol glycosides has the microcirculatory effect of improvement, thereby changesKind eye blood confession, improves eye metaboilic level, and its effect anti-oxidant, that remove free radical also has protection to eyes. WithTime panoxadiol glycosides also there is neuroprotection, can play protection to optic nerve. Above-mentioned side assists with panoxadiol glycosides,Its alleviating asthenopia, the health care of protection eyes is better.
Technical solution of the present invention meets the mechanism of tcm treatment according to syndrome differentiation, bases oneself upon the origin of disease, reasonable recipe science.
The Chinese medicine composition of a kind of alleviating asthenopia provided by the invention has the following advantages:
1, the Chinese medicine composition of alleviating asthenopia provided by the invention is invigorated blood circulation by dredging collateral, and blood yiqi is fundamentally slowSeparate visual fatigue. , can improve the asthenopic symptom of experimenter, the present invention is compared with control group, and it improves visual fatigue symptomFunction more excellent, be significantly better than control group (P < 0.05).
2, the present invention can improve experimenter's distant vision, has significant difference (P < 0.05) compared with control group, tableBright test group is better to visual fatigue experimenter's function.
3, Chinese medicine composition of the present invention can make the average duration of photopic vision raising of experimenter be greater than 10%, compared with control group,Duration of photopic vision of the present invention is higher, and two groups have significant difference (P < 0.05), show that medicine of the present invention has moreThe function of good raising duration of photopic vision. .
Detailed description of the invention
Further illustrate the present invention below by embodiment. It should be understood that embodiments of the invention are for explanationThe present invention instead of limitation of the present invention. The simple modifications that essence according to the present invention is carried out the present invention all belongs to thisInvent claimed scope.
Embodiment 1 syrup
Get panoxadiol glycosides 3g, cassia twig 10g, Radix Angelicae Sinensis 10g part, Radix Astragali 20g, root of Dahurain angelica 30g, seed of Chinese dodder 30g,Dragon 30g, peach kernel 40g, Ligusticum wallichii 40g, matrimony vine 40g. By above-mentioned whole medicinal materials, extracting in water 2 times, adds water for twiceAmount is respectively 10 times, 8 times of medicinal material gross weight, and the extracted twice time is respectively 2 hours, 1 hour, merges and extractsLiquid, filters, and filtrate is condensed into liquid extract. In medicinal extract, add syrup auxiliary material sucrose, honey, potassium sorbate, waterStir, make syrup.
Embodiment 2 tablets
Get panoxadiol glycosides 2g, cassia twig 8g, Radix Angelicae Sinensis 8g part, Radix Astragali 15g, root of Dahurain angelica 25g, seed of Chinese dodder 25g, earthworm25g, peach kernel 350g, Ligusticum wallichii 35g, matrimony vine 35g. By above-mentioned whole medicinal materials, with 40% alcohol reflux extraction 3 times,Each ethanol consumption is respectively 10 times, 8 times, 4 times of medicinal material total amount, 3 hours, 2 hours, 1 respectively extraction timeHour, merge extract, to filter, filtrate is condensed into after liquid extract, is dried to dried cream powder, adds supplementary product starch, secondAlcohol, talcum powder, make tablet.
Embodiment 3 mixture
Get panoxadiol glycosides 3g, cassia twig 12g, Radix Angelicae Sinensis 12g part, Radix Astragali 25g, root of Dahurain angelica 35g, seed of Chinese dodder 35g,Dragon 35g, peach kernel 45g, Ligusticum wallichii 45g, matrimony vine 45g. By above-mentioned whole medicinal materials, extracting in water 3 times, adds water for three timesAmount is equivalent to respectively 12 times, 8 times, 6 times of medicinal material gross weight, 3 hours, 2 hours, 1 respectively each extraction timeHour, merge extract, filter, the clear cream that when filtrate is concentrated into 70 DEG C, relative density is 1.20, adds ethanol,Making containing alcohol amount is 40%, leaves standstill 24 hours, filters, and filtrate is condensed into liquid extract, and adding purified water ad pond om is medicine3 times of material gross weight, filling, obtain mixture of the present invention.
Add mixture auxiliary material sucrose, ethyl ester, water, potassium sorbate to stir, make mixture.
Embodiment 4 tablets
Get panoxadiol glycosides 1g, cassia twig 5g, Radix Angelicae Sinensis 5g part, Radix Astragali 10g, root of Dahurain angelica 20g, seed of Chinese dodder 20g, earthworm20g, peach kernel 30g, Ligusticum wallichii 30g, matrimony vine 30g. Above-mentioned whole medicinal materials are extracted 2 times to each second with alcohol refluxDetermining alcohol is respectively 80%, 60%, and each ethanol consumption is respectively 10 times, 8 times of medicinal material total amount, and extraction time dividesBe not 4 hours, 3 hours, merge extract, filter, filtrate is condensed into after liquid extract, is dried to dried cream powder, addsEnter microcrystalline cellulose, Ac-Di-Sol, superfine silica gel powder, make tablet.
Embodiment 5 capsules
Get panoxadiol glycosides 4g, cassia twig 15g, Radix Angelicae Sinensis 15g part, Radix Astragali 30g, root of Dahurain angelica 40g, seed of Chinese dodder 40g,Dragon 40g, peach kernel 50g, Ligusticum wallichii 50g, matrimony vine 50g. By above-mentioned whole medicinal materials, extracting in water 3 times, adds water for three timesAmount is respectively 12 times, 8 times, 6 times of medicinal material gross weight, and three extraction times are respectively 3 hours, 2 hours, 1Hour, merge extract, filter, filtrate is condensed into after liquid extract, is dried to dried cream powder, adds supplementary product starch, secondAlcohol, dextrin, dolomol, incapsulate shell, make capsule.
Embodiment 6 granules
Get panoxadiol glycosides 1g, cassia twig 10g, Radix Angelicae Sinensis 5g part, Radix Astragali 15g, root of Dahurain angelica 30g, seed of Chinese dodder 20g,Dragon 35g, peach kernel 30g, Ligusticum wallichii 40g, matrimony vine 45g. By above-mentioned whole medicinal materials, extracting in water 2 times adds water at every turnAmount is equivalent to respectively 12 times, 10 times of medicinal material gross weight, and each extraction time is respectively 3 hours, 2 hours, closesAnd extract, filtering, filtrate is concentrated into the clear cream that at 80 DEG C, relative density is 1.05, adds ethanol, makes containing alcohol amountBe 70%, leave standstill 12 hours, filter, filtrate is condensed into after liquid extract, is dried to dried cream powder, add auxiliary material Icing Sugar,Starch, dextrin, ethanol, make granule.
Embodiment 7 pulvis
Take panoxadiol glycosides 4g, cassia twig 12g, Radix Angelicae Sinensis 15g part, Radix Astragali 25g, root of Dahurain angelica 20g, seed of Chinese dodder 25g,Earthworm 20g, peach kernel 40g, Ligusticum wallichii 50g, matrimony vine 35g. Medicinal material cleans, pulverizes, and crosses 80-100 mesh sieve, to obtain final productPulvis of the present invention.
Pharmacodynamics test: improve the evaluation of visual fatigue function assessment
Human feeding trial:
Take sample of the present invention front and back to the asthenopic impact of experimenter by investigation, the present invention is improved asthenopicHealth care carries out function assessment evaluation.
1 experimenter includes in and exclusion standard
(" the health food inspection and assessment technique enforcement of regulations handbook " issued with reference to the Ministry of Public Health)
1.1 experimenter's inclusive criterias
1.1.1 children and adolescents or adult.
1.1.2 long-term with eye, eyesight fatiguability person.
1.2 experimenter's exclusion standards
1.2.1 do not meet the experimenter who includes age criterion in; To health food allergy sufferers.
1.2.2 suffers from infectious eye disease person, the inside and outside eye disease patients such as nebula, circle pheasant cornea.
1.2.3 suffer from fundus oculi disease or be associated with the diseases such as cardiovascular, the cerebrovascular, liver, kidney, hemopoietic system.
1.2.4 take in a short time the article relevant with tested function, have influence on the judgement person to result.
1.2.5 other medicine about treatment eyesight of long-term taking or use other methods for the treatment of, fails terminator.
1.2.6 do not meet inclusive criteria, do not take in accordance with regulations, or data is not congruent affects effect or security judgement person.
1.3 observation index
1.3.1 safety indexes
1.3.1.1 blood, routine urianlysis, physical examination.
1.3.1.2 liver, kidney function test (children experimenter does not measure this).
1.3.1.3 (in pretest inspection once, children experimenter does not measure this for Chest X-rays, electrocardiogram, Abdominal B type ultrasonography inspection).
1.3.2 efficiency index (checking in the time of on-test and end)
1.3.2.1 eye examination, ophthalmodynia, swollen, the photophobia of eye, blurred vision, the symptom such as dry and astringent.
1.3.2.2 duration of photopic vision: assay method is shown in " health food inspection and assessment technique enforcement of regulations handbook " annex.
1.3.2.3 distant vision.
1.4 asthenopia symptom decision methods, in table 1
Table 1 asthenopia symptom decision method (sxemiquantitative integration method)
Note: " random thoughts " refer to 1-2 time/2 days; " time have " refers to 1-3 times/day; " often " refers to > 3 times/day
1.5 data processing and statistical analysis
By the data input database that experimental period is collected, analyze and statistical procedures. Symptom integral and photopic vision are lastingDegree is measurement data, and improvement rate and total effective rate are enumeration data, adopts respectively t inspection and inspection to carry out Χ2Relatively.All taking P < 0.05 or P < 0.01 be the standard of its significance of difference.
2 case selections and grouping
At 20～40 years old age, long-term with eye, asthenopia, is ready to accept 30 days experimenters. Adopt between self and group twoPlant control design. According to symptom and eye test situation, consider the factor such as age, sex, by random, two simultaneouslyBlind method is divided into test group and control group, every group of number 102 people.
3 give quadrat method
Experimental group: give embodiment 1 syrup, each 10ml, every day 2 times.
Control group: give QIJU DIHUANG KOUFUYE, Beijing Changcheng Pharmaceutical Factory produces, each 10ml, every day 2 times.
4 effect criterion
4.1 the symptoms of eye diseases
Symptom is improved: ophthalmodynia, swollen, the photophobia of eye, blurred vision, the dry and astringent arbitrary symptom of eye are improved more than 1 point and 1 pointBe improvement, 5 kinds of arbitrary improvement of symptom and other symptoms judge symptom improvement without worsening.
Effective: before and after symptom improvement and duration of photopic vision, differ by more than and equal 0.1, and comparing difference to have conspicuousness by statistics.
Invalid: not reach effective standard.
4.2 durations of photopic vision: average duration of photopic vision raising is more than or equal to 10%.
4.3 distant visions: eye vision contrast before and after test.
5 results
Experimental group most of patient take after the embodiment of the present invention 1, and ophthalmodynia, eye is swollen, photophobia, blurred vision, eye are dryThe symptom such as puckery has obtained improvement in various degree.
The impact of table 2 test sample on experimenter's visual fatigue symptom
Note: test group compared with control group, * P < 0.05.
As shown in Table 2, test group and the asthenopic symptom of control group experimenter have all obtained good improvement. TestGroup is compared with control group, and its function of improving visual fatigue symptom is more excellent, is significantly better than control group (P < 0.05).
The impact of table 3 test sample on experimenter's distant vision (n=102,±s）
Note: test group compared with control group, * P < 0.05.
As shown in Table 3, tested after, test group distant vision is improved obviously, has significant difference compared with control group(P < 0.05). Show that test group is better to visual fatigue experimenter's health care.
The impact of table 4 test sample on experimenter's duration of photopic vision (n=102,±s）
Note: test group compared with control group, * P < 0.05.
As shown in Table 4, test group and control group experimenter test rear average duration of photopic vision raising and are all greater than 10%,Think that two groups of durations of photopic vision are all improved. But test group is compared with control group, and the duration of photopic vision of test group moreHeight, two groups have significant difference (P < 0.05). Show that health products of the present invention have better raising duration of photopic visionFunction.
Conclusion: medicine of the present invention can effectively improve visual fatigue symptom, improves distant vision, and improve duration of photopic vision,Reach the effect of alleviating asthenopia.
Although, above use general explanation, detailed description of the invention and test, the present invention has been done to detailed retouchingState, but on basis of the present invention, can make some modifications or improvements it, this is aobvious to those skilled in the artAnd easily see. Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to thisBright claimed scope.
Claims (8)
1. a Chinese medicine composition for alleviating asthenopia, is characterized in that it is to be prepared from by the raw material of following weight portion: panoxadiol glycosides 1-4 part, cassia twig 5-15 part, Radix Angelicae Sinensis 5-15 part, Radix Astragali 10-30 part, root of Dahurain angelica 20-40 part, seed of Chinese dodder 20-40 part, earthworm 20-40 part, peach kernel 30-50 part, Ligusticum wallichii 30-50 part, matrimony vine 30-50 part.
2. the Chinese medicine composition of alleviating asthenopia as claimed in claim 1, is characterized in that it is to be prepared from by the raw material of following weight portion: panoxadiol glycosides 2-3 part, cassia twig 8-12 part, Radix Angelicae Sinensis 8-12 part, Radix Astragali 15-25 part, root of Dahurain angelica 25-35 part, seed of Chinese dodder 25-35 part, earthworm 25-35 part, peach kernel 35-45 part, Ligusticum wallichii 35-45 part, matrimony vine 35-45 part.
3. the Chinese medicine composition of alleviating asthenopia as claimed in claim 1, is characterized in that it is to be prepared from by the raw material of following weight portion: 3 parts of panoxadiol glycosides, 10 parts of cassia twig, 10 parts of Radix Angelicae Sinensis, 20 parts of the Radixs Astragali, 30 parts of the roots of Dahurain angelica, 30 parts of the seed of Chinese dodders, 30 parts of earthworms, 40 parts, peach kernel, 40 parts of Ligusticum wallichiis, 40 parts of matrimony vines.
4. the Chinese medicine composition as described in claim 1-3 any one, the active component that it is characterized in that it is to adopt the alcohol extract of water extraction or 40-80% concentration expressed in percentage by volume to be prepared from.
5. Chinese medicine composition as claimed in claim 4, the active component that it is characterized in that it is prepared from by the following method: get whole medicinal materials, extracting in water 2-3 time, each amount of water is equivalent to 6-12 times of medicinal material gross weight, each extraction time is 1-3 hour, merges extract, filters, filtrate is condensed into liquid extract, obtains described active component.
6. Chinese medicine composition as claimed in claim 4, the active component that it is characterized in that it is prepared from by the following method: get whole medicinal materials, extracting in water 2-3 time, each amount of water is equivalent to 6-12 times of medicinal material gross weight, each extraction time is 1-3 hour, merge extract, filter, the clear cream that when filtrate is concentrated into 70-80 DEG C, relative density is 1.05-1.20, adds ethanol, and making containing alcohol amount is 40-70%, leave standstill 12-24 hour, filter, filtrate is condensed into liquid extract, obtains described active component.
7. Chinese medicine composition as claimed in claim 4, the active component that it is characterized in that it is prepared from by the following method: get whole medicinal materials, with 40-80% alcohol reflux extraction 2-3 time, the 4-10 that each ethanol consumption is medicinal material total amount doubly, extraction time is 1-3 hour, merges extract, filters, filtrate is condensed into liquid extract, obtains described active component.
8. a Chinese medicine composition for alleviating asthenopia, is prepared and is formed by acceptable carrier in the Chinese medicine composition of the alleviating asthenopia of any one in claim 1-3 and pharmaceuticals industry.
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| CN104688931A (en) * | 2015-04-02 | 2015-06-10 | 张玉雯 | Medicine composition for relieving eyestrain and preparation method of medicine composition |
| CN105535258A (en) * | 2015-12-24 | 2016-05-04 | 兰州古驰生物科技有限公司 | Traditional Chinese medicine health-care preparation for regulating asthenopia |
| CN106344878A (en) * | 2016-10-25 | 2017-01-25 | 广西壮族自治区职业病防治研究院 | Zhuang medicine composition for treating asthenopia caused by view screen |
| CN110179966A (en) * | 2019-05-17 | 2019-08-30 | 严启新 | The preparation method and applications of traditional Chinese medicine composition for relieving asthenopia |
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| CN101279008A (en) * | 2007-04-05 | 2008-10-08 | 北京华恒汉方医药科技有限公司 | Chinese medicine pad pasting for preventing and controlling myopic eye, eyestrain symptoms and eyebase ischemia |
| CN101642511A (en) * | 2009-09-07 | 2010-02-10 | 林继华 | Traditional Chinese medicine composition for relieving visual fatigue and treating pseudomyopia and preparation method thereof |
| CN103417737A (en) * | 2013-08-12 | 2013-12-04 | 东北师范大学 | Eye protection liquid with ginsenoside Rg1 |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101279008A (en) * | 2007-04-05 | 2008-10-08 | 北京华恒汉方医药科技有限公司 | Chinese medicine pad pasting for preventing and controlling myopic eye, eyestrain symptoms and eyebase ischemia |
| CN101642511A (en) * | 2009-09-07 | 2010-02-10 | 林继华 | Traditional Chinese medicine composition for relieving visual fatigue and treating pseudomyopia and preparation method thereof |
| CN103417737A (en) * | 2013-08-12 | 2013-12-04 | 东北师范大学 | Eye protection liquid with ginsenoside Rg1 |
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