CN109581693A - A kind of plant crystal room temperature gasification glasses preventing near-sighted cataract - Google Patents

Abstract

The present invention is a kind of plant crystal room temperature gasification glasses for preventing near-sighted cataract, by plant crystal room temperature gasification lens body；Right activity eyeglass, movable eyeglass shelves card slot；Flexible nose-pad, left movable eyeglass, eyesight hole；The composition such as movable eyeglass shelves card, right drug box body, venthole.Gasification medicine material includes lycorine part, and a- asarone, asarinin, Pogostone, plant crystal room temperature gasification glasses are made in asarol, for 1 to 16 cataract, myopia, macular degeneration initial phase course for the treatment of, treated effect 99%.Shed tears to presbyopia, false view, eye, xerophthalmia, 1 to 3 course for the treatment of have and increase view, efficient 99%；Glasses, which are worn to gasifying 40 minutes on cataractous eye, myopia, presbyopia and eye-blurred eye, can make that eyes are comfortable, obviously number increases, sees that Dong Xi Ming is bright, improves the effect of sleep eyesight degree, effective percentage 100%.The generation that can prevent eye disease often is worn, anti-eye strain has special efficacy.

Description

A kind of plant crystal room temperature gasification glasses preventing near-sighted cataract

Technical field

The plant crystal room temperature that near-sighted cataract is prevented the present invention relates to a kind of gasifies glasses, in particular in a kind of plant The crystallographic extracted, plant crystal are put into glasses, and room temperature has the prevention and treatment myopia cataract of successive gasification function Plant crystal gasification glasses and preparation method thereof.

Background technique

China human mortality aging is increasingly severe, and cataract is that muddiness occurs for crystalline lens in eyes, becomes impermeable by transparent It is bright, hinder light to enter intraocular, to affect eyesight.The initial stage muddiness of cataract is little to eyesight influence, then can be gradually It aggravates, finally significantly affects eyesight to blindness.Cataract patient shows as unilateral or bilateral more, and two morbidities can have successively, Eyesight declines, and since lens cortex muddiness causes crystalline lens different parts refractive power different, generates dazzle sense or simple eye multiple Depending on, myopia degree increases etc..Cataract of old people clinically divides the fourth phase i.e. initial phase, the phase of expansion, maturity period and overripe stage.It is existing It there has been relatively advanced operative treatment to maturity period cataract of old people for medicine, but since operative treatment will wait until cataract Maturity period or overdone stage operation, and the expense performed the operation is costly, and the unsatisfactory curative effect at initial stage and the phase of expansion for cataract, This lengthy procedure from initial phase to maturity period, it is significantly inconvenient undoubtedly to bring to patient and its family.Cataract hair Disease is more common in 45 years old or more, and disease incidence increases with the age and increased, and the disease incidence of 45-60 years old at present cataract of old people is 60-70%, 70 years old or more up to 80%, 80 years old or more the elderly is almost up to 100%.Worldwide cataract is blinding One of the primary cause of disease, about 5 million peoples are blinding due to cataract in the world now, separately there is 1.5 hundred million cataract trouble Person needs surgery recovery eyesight, at least accounts for the half of blind person, China 45-89 in most of Africa and Asian countries, cataract Year, the cataract blindness person of age bracket accounted for the 95.10% of all cataract blindness.Cataract patient accounts for the 46.7% of person with visual disabilities, Cataract of old people occupies first of various eye disease in the elderly is with visual disabilities.At present in modern medicine, pathogenesis is still unknown Really, do not have specific therapeutic agent and means yet, do not find the good method for preventing this disease disease progression yet, be at present in treatment It only, is still very difficult.Therefore, develop effectively Prevention cataract in initial stage easy to use seems more for patient Important, research manufacture medicine crystal gasification glasses have significant realistic meaning.

Myopia brings many inconvenience, and correction can be played the role of by getting the right lensses for one's eyeglasses, but cannot be obtained medical treatment, Near-sighted degree is generally lower than 6 diopters (- 600 degree), stops development by 20 years old or so.But childhood makes much progress, to 13~ 20 years old progress more rapidly, slow down, such myopia is often higher than 6 diopters, can reach 20 or 30 diopters, both later Eyeglass -2000~-3000 degree.This myopia is known as laser high myopia or progressive myopia, also referred to as pathological myopia.This myopia, Retrogression pathological changes can occur to old age, eyesight is faded, and can not be corrected defects of vision with mirror, and most of such eyes are last all It causes to blind.Myopia is listed in one of big disease in the world three, China's myopia number nearly 4.5 hundred million, and wherein teenager is about 3.5 hundred million people, 2, center broadcasting on June 5th, 2018, university student's myopia have 88.77%, high school student to have 88.3%, junior school student to have 74.4%, pupil has 45.7%, and newly-increased myopia is about 9% every year.Having become China for the prevention and treatment of myopia is To the urgent need of the people of the world, teenager's low vision has become serious society and medical problem.

Myopia corneal clouding shows as the albefaction of normal hyaline cornea.The loss of the transparency of this cornea can be caused Complaint domain is from eye-blurred to blindness.Myopia and the treatment method of amblyopia generally comprise at present: mist regard therapy, Bates therapy, Wearing spectacles, laser surgey, Chinese traditional massage and acupuncture.When mist depending on therapy is at near-sighted initial stage or not near-sighted, wears orthoptoscope and see Nearby things mainly serves pre- myopic-preventing；Bates therapy is far to see close training by seeing to sighting target, adjusts eye circumference flesh Meat, but the method treatment time is longer, and effect is unobvious；Though wearing spectacles can see things clearly, the degree that will lead to eyes is continuous Increase, no therapeutic effect；Laser surgey is cut to cornea, changes the angle that light enters eyes by force, has to eyes Injury, facts proved that there are sequelae；Chinese traditional massage and acupuncture and moxibustion treatment are limited by technology, complicated for operation, technical relatively strong, effect Rate is lower, and can rebound.

Currently, the method for prevention and treatment myopia, acupuncture and moxibustion therapy, ear acupuncture therapy, acupuncture therapeutic, point massage method, Electromagnetotherapy, instrument, etc. varied, poor, using trouble that medicine liquid heating vaporization glasses dose lacks effect, and wear near-sighted glasses It can play the role of correction, but cannot obtain medical treatment, be unable to retarding myopia degree, macular degeneration, cataract, close can not be prevented Depending on effect, with according to age increase only aggravate eyesight degree.It is existing hundreds for the treatment of myopia drug it is practical to no effect, It is especially very big to haveing the defects that in teen-age myopia effect.

In modern medicine, the medicine of western medicine cataract mainly uses C16H8N2O5, and the field of Chinese medicines prevents and treats the system of cataract Agent pharmacopeia is recorded not yet.Intravitreal injection preparation is expensive, and every price is in thousands of members to tens of thousands of members etc..And And intravitreal injection preparation is primary using frequently, generally monthly needing to inject, and also has and injects within 2~3 months once, Huan Zhenai Poor by property, damage that in use can be certain caused by eyeball has certain risk.Due to directly acting on administration portion Position, for intravitreal injection preparation while effective, side effect is also relatively large.

Document report prevention and treatment macular degeneration, cataract, myopia etc. in control and to control Chinese medicine therapeutic agent outside as follows: inside control master There are oral solution, decoction, electuary, pill, granule, tablet, capsule etc..Inside controlling mainly has;Hinder clear oral solution, compound ginseng fruit Liquid, promoting blood circulation dispel hinder soup, disappear hinder electuary, electuary of recovering lost eyesight, control barrier ball 1, exempt from screen ball, Fuming Tablet, basis-reinforcing eyesight-improving capsule, disappearing hinders spirit Ball, disappearing hinders the clear oral solution of pills for improving acuity of sight, JINHUA MINGMU WAN, cataract or glaucoma, the bright particle of compound sugar barrier, bear gall pill etc..These effect of drugs are poor Or it is invalid, side effect is larger.

External therapy is mainly powder, eye drops.Furthermore the document of Chinese medicinal film agent, injection for treating cataract is seen also.Such as, musk deer Pearl eyesight improvement powder medicine, ZYM eye drops, C16H8N2O5 (Catalin Eye Drops) eye drops, ophthalmically acceptable freeze-dried ZIAOZHANGSU INJECTION hinder drop of recovering lost eyesight Ocular fluid, making compound leech eye drip, herbal mixture eye drops, QUZHANGLING DIYANYE, scattered eye drops of hiding from view (are made and hide from view scattered, face use Shi Peicheng) etc..These topical eye drops drugloading rates are small, and patient, which needs frequently to use, is just able to satisfy needs；Topical eye drops by Then liquid preparation, bioadhesive is poor, and the time retained in eyes is too short, although eyedrops uses more convenient, toner It is too short to measure the time that is small and acting on eyes, is easily eliminated, control efficiency is too poor or invalid.Topical eye drops are extremely difficult to be worn Eye position after the physiological structure of through hole ball reaches, topical eye drops also have certain toxic side effect.

In recent years, is permeated by rouge and is placed in glasses for the gasification of prevention and treatment macular degeneration, cataract, myopia both at home and abroad and matched It wears and uses and the extensive concern by researcher, many experts and scholars want to study, but studied successfully without a people, even to this day Domestic and international preparation pharmacopeia records registration and the paper by wearing plant crystalline substance glasses room temperature evaporating therapy myopia eye cataract not yet Report and patent registration, so, prevent the plant crystal room temperature gasification glasses of near-sighted cataract both at home and abroad or blank.

Summary of the invention

In order to overcome domestic and international existing glasses that cannot control the eye disease such as myopia, cataract, presbyopia, drug in advance in room temperature Shi Buneng, which successively gasifies to cornea, vitreum, retina and vitreous opacity, to be repaired, and wearing glasses cannot delay to regard Power, wear glasses cannot pre- Anti-myopic eye, be unable to prevention initial phase, can not delay eyesight aging, wear glasses only plus The high defect problem of attention dynamics number, intravitreal injection somewhat expensive, surgery cost.

The invention reside in provide a kind of plant crystal room temperature gasification glasses for preventing near-sighted cataract, the plant crystal room temperature It is continuous in room temperature that gasification glasses are not applied to eye, eye no pain, non-stimulated, without side-effects, easy to use, drug directly Constantly vaporization aggravates, effectively to cornea, vitreum, retina, efficient repairing complex crystal shape muddiness, effective retarding myopia eye vision Delay cataract eyesight to aggravate, effectively delays macular degeneration eyesight to aggravate, effectively green light eye vision is delayed to aggravate, effectively delay to move back Row eye disease has effects that permeating screen of dispelling, cure rate height, control efficiency significantly, with one kind curative for effect prevents myopia white The plant crystal room temperature gasification glasses of cataract or glaucoma.

The present invention is a kind of plant crystal room temperature gasification glasses, by plant crystal room temperature gasification lens body；Right flexible mirror Piece, movable eyeglass shelves card slot；Flexible nose-pad, left movable eyeglass, eyesight hole；Movable eyeglass shelves card, right drug box body, penetrating gas Hole, preceding spectacle frame, preceding spectacle frame and rear spectacle frame cage knob, preceding spectacle frame and rear spectacle frame seam, rear spectacle frame, left medicine kit sheet Body, drug cassette, preceding mirror holder powder charge object box body hole, medicine kit bulk drug gasification hole, gasification drug, gasification drug hole, gas Chemical drug object eyesight hole composition.

Plant crystal room temperature gasifies lens body as human head shapes, and there are spectacle frame before the arcuation of garden, the rear part in front There is spectacle frame after corresponding garden arcuation；There are preceding spectacle frame and rear spectacle frame lock 1, spectacle frame before being adjusted in the middle part of spectacle frame afterwards It is separated and closed and locked with rear spectacle frame in preceding spectacle frame and rear spectacle frame seam crossing；

The flexible nose support in the lower part in the middle position of preceding spectacle frame；

There is the movable eyeglass shelves card slot interlocking garden You Yikuai arcuation activity eyeglass shelves card in the outermost middle section of preceding spectacle frame；

There are left movable eyeglass and right flexible mirror 2 behind movable eyeglass shelves card；

It is corresponding behind left activity eyeglass and right movable eyeglass that there are two preceding mirror holder powder charge object box body holes；

Preceding mirror holder powder charge object box body is corresponding with right drug box body and left drug box body behind hole；

Right drug box body and left drug box body are by drug cassette, medicine kit bulk drug gasification hole, gasification drug, gasification medicine Object hole；Gasify drug eyesight hole composition；Uniformly there is gasification drug hole on gasification drug, there is gasification drug eyesight at in-between position Hole；

There is penetrating stomata in the front of preceding spectacle frame two sides；One end of penetrating stomata is communicated with outside, the other end of penetrating stomata It is communicated with preceding mirror holder powder charge object box body hole.

Another object of the present invention is it is characterized in that provide a kind of above-mentioned plant crystal room temperature for preventing near-sighted cataract The preparation method of gasification glasses gasification drug, it is characterised in that: therapeutic agent raw material proportion group based on following parts by weight At, preparing raw material includes 1-6 parts of lycorine, and 1-8 parts of a- asarone, 1-6 parts of asarinin, 3-11 parts of Pogostone, asarum It is 2-5 parts oily.

A kind of preparation method of above-mentioned plant crystal room temperature gasification glasses gasification drug for preventing near-sighted cataract, including Following steps:

Short-tube lycoris alkali preparation method

Short-tube lycoris stem powder is taken, is extracted for 24 hours with alcohol reflux, cooled and filtered takes filtrate to be concentrated to dryness, it is concentrated to dryness, dissolving with hydrochloric acid, Filter to take filtrate, soda ash, chloroform recovery, among chloroform buck layer is added in filtrate chloroform, the filtrate after chloroform Lycorine solid is precipitated, alkene dissolving with hydrochloric acid is used after filter, concentration precipitates crystal, dry lycorine.

Asarone preparation method

The drystone calamus for taking 20kg extracts 4 each 3h of with 80L alcohol reflux.Obtained extract is concentrated by evaporation after merging and obtains Obtain the rhizoma acori graminei extract of 2.2kg.It is dissolved again with 12L distilled water, repeats three in triplicate with n-butanol 9L with ethyl acetate 13L Secondary separation obtains a- asarone then with removal organic solvent is evaporated in vacuo.

Pogostone preparation method

Pogostemon cablin 11Kg is taken, steam distillation extracts volatile oil to the greatest extent, separates volatile oil, the ether of 1.3 times of its volume amounts is added The NaOH solution of the 1mol/L measured with 2 times, extraction separate water layer, and repetitive operation 4 times, combining water layer is added dilute hydrochloric acid and adjusts PH4 is stood overnight, and filtration takes filter residue, is washed to neutrality, and n-hexane dissolution is added, and refrigerates crystallization, separation crystallization, and washing is done Dry Pogostone to obtain the final product.

Asarinin preparation method

Asarum is dried, crushes to obtain asarum coarse powder, asarum coarse powder is placed in the extraction kettle of supercritical CO 2 extraction device, is sealed, Extraction kettle, separating still are respectively heated, when extraction kettle temperature reaches 49 DEG C, separating still I and II temperature of separating still reach 45 DEG C, extraction kettle valve is opened, exhaust valve is opened when pressure is equal with sump pressure in extraction kettle and empties air, pass through high pressure Pump pressurizes to system, when extraction kettle pressure, which reaches 35Mpa, separating still I and separating still II, reaches 6.8Mpa, controls CO2 Flow is 45L/h, starts the cycle over extraction, extracts to obtain asarum total volatile oil;By asarum total volatile oil, low temperature is quiet under the conditions of -3 DEG C 28h is set, decompression filters, and obtains asarinin crude product;Take asarinin crude product that the anhydrous of 4 times of volumes of asarinin crude product is added Ethyl alcohol is dissolved, and is placed in low temperature recrystallization, is obtained asarinin.

A kind of plant crystal room temperature gasification glasses and preparation method thereof preventing near-sighted cataract:

The raw material weight number meter ratio range that most preferably selects of preparation plant crystal is: 5 parts of lycorine, 7.5 parts of a- asarone, carefully Pungent 3.5 parts, 8.6 parts of Pogostone, 5 parts of asarol of rouge element;

By 5 parts of lycorine, 7.5 parts of a- asarone, 3.5 parts of asarinin, 8.6 parts of Pogostone are incorporated in one → crushing, powder 5 parts of asarol are added in particle, is thoroughly mixed → plant crystalloid fluid inflow spectacle case → cooling after heating melting → melting Crystallize → be cooled to room temperature after, with plastic film sealed package, obtain plant crystal room temperature gasification glasses.

The application method of plant crystal room temperature gasification glasses:

1, plant crystal room temperature gasification glasses are worn to eye, wears smoked treatment in one time 30-60 minutes morning, wears a 30-60 at night Minute smoked treatment, one day 2-3 times, 1 month is 1 course for the treatment of;

2, for 1 to 16 cataract, myopia, macular degeneration initial phase course for the treatment of, treated effect 95-99%.

3, low to teenager's eyesight, amblyopia, visual impairment, shed tears to presbyopia, eye, xerophthalmia, 1 to 3 course for the treatment of have Increase view, efficient 93-98%；

4, it cannot fully recover to macular degeneration, cataract, near-sighted mid-term, the effect that eyesight can only be delayed no longer to aggravate；

5, to the eyes disease such as bacterial keratitis, uveitis, staphylococcus, streptococcus, sclerotitis, optic neuritis, iritis Disease can be cured with 6 days to 30 days.Plant crystal room temperature gasification glasses effectively prevent various eye disease generations and anti-eye strain With the effect for removing toxin；

6, plant crystal room temperature gasification glasses can often have on the generation of prevention eye disease and the effect of anti-eye strain.

The pharmacological treatment effect of plant crystal room temperature gasification glasses:

Plant crystal gasification drug is placed in plant crystal room temperature gasification glasses, gasification drug is using a variety of extracted form natural plants Lycorine, a- asarone, asarinin, Pogostone, the above several drugs are re-refined as plant crystal, and plant crystal has Room temperature gasification function, plant crystal gasification nanometer ester molecule amount is small, is changed into nanometer grade liposome, plant crystal through chemical reaction Nanometer rouge tool gasify around successive gasification to cornea, nano liposomes are reacted with lysozyme dissolution in tears, make to receive Meter level liposome smoothly penetrates and Deiter's cells is promoted to act on, and cornea, vitreum, view are crossed in nanometer grade liposome infiltration Nethike embrane and blood-brain barrier and play drug effect, the nanometer grade liposome factor reach eye kill virus infection, inhibit lens Protein denaturation and vitreous opacity play curative effect, make the effect of the fine quick light of eye.

Plant crystal long term toxicity test:

Plant crystal of the present invention is object, selects adult rat 50, is randomly divided into 5 groups, one group of control group and four groups of test groups, Every group 10, half male and half female.Test group each group dosage is respectively 0.1(500m/K part BW of LD50), 0.15(750m/K parts of BW), 0.22(1100m/K parts of BW), 0.34(1700m/K parts of BW), daily stomach-filling is primary, continuous 20 days.Then it observes 7 days.Inspection Result each group is surveyed without death, each dosage group does not show death without dose-response relationship yet, this drug does not have obvious accumulation Toxicity, long-term use will not generate side effect.

The test of plant Phacoanaphylaxis;

Using plant crystal of the present invention as object, 30 healthy guinea pigs is taken to be tested, male and female half-and-half carries out back two before administration The processing of side unhairing, is randomly divided into five groups, every group 6, respectively control group, the high 1 multiple dose 0.5mg of damaged skin, 2 times of low dosage Dosage 1mg group, the high 1 multiple dose 0.5mg of intact skin, 2 multiple dose 1mg group of low dosage.Four groups below are subcutaneously used respectively After medicine, once a day, continuous 7 days, each group situation is observed, as a result cavy all survives, and the skin of the cavy of each group does not go out Existing any discomfort, and obvious exception does not occur for feeding, activity, breathing and the weight etc. of cavy.The results show that the drug does not have There is sensitization.Pharmacology pharmacodynamic test display, the medicine do not have any toxic effect, sensitization and adverse reaction, clinical use Safety.

One, cataract clinical test is treated:

Subjects 430 are suffered from the identical patient of cataract degree, are divided into three groups according to cataract type, wear plant crystal room temperature Gasify glasses.

Experimental method, three groups of patients all wear plant crystal room temperature gasification glasses, the treatment results of the 3-12 course for the treatment of: treatment Cataract type experimental result table 1

The effective percentage that clinical test shows to treat cataract is 100%, rapid-action, short treating period, curative for effect, not only cure rate Height, and speed of fully recovering is fast, will not generate any side effect.

Typical treatment case:

1, Hu, male, 53 years old, people from Dayu County suffered from the initial stage patient of cataract conditions, and blurred vision is easy to produce slur or more Shadow phenomenon.Totally 3 patients, are middle-aging male, and it is white to wear the gasification glasses treatment of plant crystal room temperature for long campaigns housework It is cured completely after 3 courses for the treatment of of cataract or glaucoma.

2, Zhang, male, 46 years old, people from Ganzhou City suffered from cataract conditions, and the heavier patient of the state of an illness in short term.Specific symptom It is fuzzy for the visual field, and slightly dim phenomenon, colour vision occur abnormal.Totally 4 patients, wherein 2 middle-aged male patients, 2 middle ages Female patient, the state of an illness is controlled substantially after wearing plant crystal room temperature gasification 6 courses for the treatment of of glasses, and needs to continue to wear plant crystal Room temperature gasification glasses are cured.

3, Liang, male, 61 years old, people from Ruijin City initial stage suffered from the patient of cataract, and specific symptom can occur to be before eyes There is exception, affect vision in the dotted or sheet shade of position shape invariance, colour vision.Totally 2 patients wear plant crystal room temperature gas Symptom is eased after changing 6 courses for the treatment of of glasses, is controlled after continuing plant crystal room temperature gasification 6 courses for the treatment of of glasses, and need Continue to wear plant crystal room temperature gasification glasses to be cured.

Two, myopia clinical test is treated;

Subjects 566 are suffered from the identical patient of myopia degree, are divided into three groups according to myopia type, wear plant crystal room temperature Gasify glasses.

Experimental method, three groups of patients all wear plant crystal room temperature gasification glasses, the treatment results of the 2-12 course for the treatment of: treatment Near-sighted ocular form experimental result table 2:

Clinical test shows that treating myopia effective percentage is 100%, and rapid-action, short treating period, curative for effect, not only cure rate is high, And speed of fully recovering is fast, will not generate any side effect.

Myopia typical case:

Hu XX, female, 12 years old, Ganzhou people from city, left vision was 0.8 before treating, right vision 1.1, in the People's Hospital, city Massage therapy 1 year without obvious curative effects.After being worn plant crystal room temperature gasification glasses 4 courses for the treatment of of treatment, her left vision is 1.5, right vision is completely recovered for 1.2.

Xu XX, male, 21 years old, Ganzhou people from city played games all night, and physical examination uncorrected visual acuity is 0.7, and junior middle school starts to wear It wears glasses, existing eyeglass degree or so is 200 degree, and hospital regards as pseudo-myopia, relies on drug eye drops and ocular region massaging afterwards Device is treated, and nothing is clearly better.After wearing the gasification of plant crystal room temperature glasses 4 weeks, eyeglass degree drops to 100 degree, continues After wearing plant crystal room temperature gasification 3 courses for the treatment of of glasses, eyesight is returned to normal, and patient is adhered to so far using title alleviates eyesight Tired effect is very good.

Hu XX, male 15 years old, Ganzhou people from city myopia 3 years, uncorrected visual acuity are left eye 08, and right eye 0.7 never matches mirror It corrects defects of vision, habit narrows eye view object, and eyes are dry and astringent, fatiguability, do the difficult maintenance eyesight of eye exercises throughout the year, but can only make to regard Power transience is restored.Begin to use and wear plant crystal room temperature gasification glasses and feels to regard the raising of object clarity after two weeks, feeling of fatigue disappears It loses, without dry and astringent, after continuing to use 2 courses for the treatment of, uncorrected visual acuity is restored to 1.5, and right vision restores to 1.2, and eyesight is still tieed up so far It holds.

Rely XX, female, Jiangxi people from Yudu County, 13 years old, five classmans, 200 degree near-sighted, astigmatism.The myopia since Third school grade Rise, parent goes around countless hospitals in order not to allowing her to wear glasses, ear point massaging, eye sticker, acupuncture etc. almost with time, family is bought The various equipment for controlling myopia be also it is complete, can eyesight fluctuated at 0.8 always, eyes make a line depending on object.By After wearing plant crystal room temperature gasification glasses 4 courses for the treatment of of treatment, binocular vision has been restored to naked view 1.5.

Three, keratitis clinical test is treated;

Subjects 288 are suffered from the identical patient of keratitis degree, are divided into three groups according to keratitis type, wear plant crystal room temperature Gasify glasses.

Experimental method, three groups of patients all wear plant crystal room temperature gasification glasses, 1-8 course of therapy keratitis experiment effect Fruit.

Treat keratitis type experimental result table 3:

The effective percentage that clinical test shows to treat keratitis is 100%, rapid-action, short treating period, curative for effect, not only cure rate Height, and speed of fully recovering is fast, will not generate any side effect.

Typical case,

1, beam XX, female, 41 years old, causes three months left sides of ulcer of the cornea after Ganzhou City, Jiangxi Province illness symptom right eye is scratched by branch The right side is not shown through certain hospital with various therapy effects, and by the agency of is sought medical advice on June 17th, 2018 to examine.It checks, systemic conditions are good It is good.Eye conditions, eyesight are the right side 0.5, are shed tears, photophobia, pain, ciliary congestion (thirty), and cornea is in muddiness entirely, and there is a strip in center Deeper ulcer, eyeground cannot be pried through.It is diagnosed as cornea of right eye ulcer (corneal ulcer).Plant crystal room temperature gasification glasses are worn in treatment, It wears smoked treatment in one time 40 minutes morning, wears smoked treatment in one time 30-40 minutes at night, 3 times a day, after 5 days, irritation disappears, ulcer Healing, cornea form nubecula, and eyesight rises to 1.2, and the disease is cured.

2, Lee XX, female, 35 years old, Ganzhou City, Jiangxi Province illness symptom, right eye suffers from ulcer of the cornea nearly five months, through various treatments In vain, in first visit on March 21 in 2018.It checks, ordinary circumstance is fair, and left eye is normal.Right vision 0.1, light sensation are shed tears, shy Bright, headache, mesh pain is most very.Mixed congestion, cornea lesser ring of Merkel deep layer ulcer, front empyema, liquid level are parallel with the hole Pupil lower edge.It examines It is disconnected, right eye hypopyon ulcer (upward rushing of yellow fluid, hypopyon).Treatment is worn plant crystal room temperature gasification glasses, is worn morning one time 40 Smoked treatment in one time 30-40 minutes is worn in minute smoked treatment at night, and 3 times a day, irritation disappearance after 7 days, hypopyon absorbs, ulcer Healing, eyesight are accused and are cured up to 0.9.

3, week XX, male, 46 years old, Ganzhou City, Jiangxi Province illness symptom, leads to cornea after patient's private prosecution left eye is scratched by nail The ulcer a few days examines after certain hospitalize is invalid on March 13rd, 2018.It checks, whole body is without discomfort.Eye, eyesight are the right side 0.08, it sheds tears, photophobia, pain, ciliary congestion (thirty), cornea is in muddiness entirely, and center has the deeper ulcer eyeground of a strip that cannot peep Depending on.It is diagnosed as cornea of right eye ulcer.Plant crystal room temperature gasification glasses are worn in treatment, are worn smoked treatment in one time 40 minutes morning, are worn at night Smoked treatment in one time 30-40 minutes, 3 times a day, after 9 days, irritation all disappears, ulcer healing, and cornea forms nubecula, and eyesight mentions Height is all removed to 1.1 all diseases and is cured.

4, XX, female, 50 years old are opened, Ganzhou City, Jiangxi Province illness symptom, patient's right eye suffers from ulcer of the cornea nearly three months, through multi-party Treatment is invalid, on July 3rd, 2018 and come to see a doctor.It checks, ordinary circumstance is fair.Right vision, light sensation are shed tears, photophobia, head Bitterly, mesh pain most very.Mixed congestion, cornea lesser ring of Merkel deep layer ulcer, front empyema, liquid level are parallel with the hole Pupil lower edge.Diagnose right eye Hypopyon ulcer (upward rushing of yellow fluid, hypopyon).Plant crystal room temperature gasification glasses are worn in treatment, wear smoked treatment in one time 40 minutes morning, Smoked treatment in one time 30-40 minutes is worn at night, and 3 times a day, after 6 days, irritation disappears, and hypopyon absorbs, and ulcer disappears and is cured.

The beneficial effect of plant crystal room temperature gasification glasses of the present invention is:

One, in treatment, the eyes of people no longer make the eye of people cover invisible thing as previous treatment, and the present invention can be with According to different patient's eye degrees, different lenses fitted, near-sighted concave lens, long sight hyperopic lens, normal is worn People uses plano lens etc..

Two, plant crystal room temperature gasification glasses are worn to smoked on cataractous eye, myopia, presbyopia, eye-blurred eye and are treated After 30-60 minutes, it can make that eyes are comfortable, obviously number increases, sees that Dong Xi Ming is bright, improves the effect of sleep eyesight degree, it is efficient 100%.Have substantive distinguishing features outstanding.

Three, the unexpected technical effect plant crystal gasification of plant crystal room temperature gasification glasses can penetrate eyeball barrier Eye position after arrival and work, with natural lycorine, a- asarone, asarinin, Pogostone is the Tissue distribution of index It the results show that it can not only be measured in cornea, can also be measured in vitreum and retina, illustrate plant crystal gas of the present invention Change the creativeness that eye after can smoothly reaching generates drug effect, has substantive distinguishing features outstanding.

Four, plant crystal room temperature gasification glasses are unexpected can delay cataract eyesight to aggravate, delay macular degeneration eyesight It aggravates, green light eye vision is delayed to aggravate, retarding myopia eye vision aggravates, inhibits lens protein denaturation and muddiness occurs New breakthrough.

Five, plant crystal room temperature gasification glasses key solves both painless without performing the operation, not being applied to eye, eye directly Advantage bitter, non-stimulated, without side-effects, easy to use, and spontaneous vaporization can be played and successively gasified the new original creation of administration.

Six, it breaches and becomes over the past thousands of years without plant crystal room temperature gasification glasses energy room temperature gasification prevention and treatment cataract, macula lutea Property, the global problem of myopia, glaucoma treatment without specific medicament.

Seven, plant crystal room temperature gasification glasses are solved without operative treatment initial phase cataract, macular degeneration, green light Eye, myopia cure rate are high, fireballing new creation of fully recovering.

Eight, the plant crystal room temperature gasification glasses plant crystal factor directly acts on eye, can effectively improve maculopathy, Rapid-action, the plant crystal factor has the function of intervention experiment retinosis, and cure rate is high, control efficiency is significant, has Certain social economic value and practicability, with the application having a extensive future.

Nine, plant crystal room temperature gasifies glasses to eye, and the nanometer ester factor that gasifies tool is discharged in efficient activation tears toxin External significant role, the protein for human body mood caused by capable of excluding human body emotion pressure of shedding tears and the benzene neighbour two accumulated The salt biochemistry toxin of phenol and amine effect will be to health very not if these toxin stay in the body not by discharge of shedding tears Benefit.So the characteristics of can only being flowed out by tears, the chemical substance of this harmful toxins could be discharged.

The present invention is described in further detail with reference to the accompanying drawings and detailed description by the present invention.

Detailed description of the invention:

Fig. 1 is preceding schematic perspective view of the invention；

Fig. 2 is rear schematic perspective view of the invention；

Fig. 3 is preceding schematic view of the front view of the invention；

Schematic view of the front view before when Fig. 4 is removal activity eyeglass shelves card of the invention；

Fig. 5 is the structural schematic diagram of left and right drug box body of the invention；

Fig. 6 is the schematic cross-sectional view of drug box body of the invention.

In Fig. 1-6,1. plant crystal room temperatures gasification lens body；2. right activity eyeglass；3. movable eyeglass shelves card slot；4. bullet Property nose support；5. left activity eyeglass；6. eyesight hole；7. movable eyeglass shelves card；8. right drug box body；9. penetrating stomata；Eye before 10. Mirror holder；11. preceding spectacle frame and rear spectacle frame cage knob；12. preceding spectacle frame and rear spectacle frame seam；Spectacle frame after 13.；14. left medicine Object box body；15. drug cassette；Mirror holder powder charge object box body hole before 16.；The hole 17. medicine kit bulk drug gasifies；18. gasification Drug；19. drug hole of gasifying；20. drug eyesight hole of gasifying.

Specific embodiment:

Embodiment one: the present invention is a kind of plant crystal room temperature gasification glasses for preventing near-sighted cataract, by plant crystal room temperature Gasify lens body 1；Right activity eyeglass 2, movable eyeglass shelves card slot 3；Flexible nose-pad 4, left movable eyeglass 5, eyesight hole 6；Activity Eyeglass shelves card 7, right drug box body 8, penetrating stomata 9, preceding spectacle frame 10, preceding spectacle frame and rear spectacle frame cage knob 11, preceding glasses Frame and rear spectacle frame seam 12, rear spectacle frame 13, left drug box body 14, drug cassette 15, preceding mirror holder powder charge object box body hole 16, medicine kit bulk drug gasification hole 17, gasification drug 18, gasification drug hole 19, gasification drug eyesight hole 20 form.

Plant crystal room temperature gasifies lens body 1 as human head shapes, and there is spectacle frame 10 before the arcuation of garden in front, thereafter There is spectacle frame 13 after corresponding garden arcuation in portion；There are preceding spectacle frame and rear spectacle frame cage knob 11 in the middle part of spectacle frame 13 afterwards, adjustable Save preceding spectacle frame 10 and rear spectacle frame 13 separated at preceding spectacle frame and rear spectacle frame seam 12 with it is closed and locked；

The flexible nose support 4 in the lower part in the middle position of preceding spectacle frame 10；

The outermost middle section of preceding spectacle frame 10 has movable eyeglass shelves card slot 3 to rabbet the garden You Yikuai arcuation activity eyeglass shelves card 7；

There are left movable eyeglass 5 and right movable eyeglass 2 behind movable eyeglass shelves card 7；

It is corresponding behind left activity eyeglass 5 and right movable eyeglass 2 that there are two preceding mirror holder powder charge object box body holes 16；

Right drug box body 8 and left drug box body 14 are corresponding with behind preceding mirror holder powder charge object box body hole 16；

Right drug box body 8 and left drug box body 14 are by drug cassette 15, medicine kit bulk drug gasification hole 17, gasification drug 18, gasification drug hole 19；Gasify the composition of drug eyesight hole 20；Uniformly there is gasification drug hole 19 on gasification drug 18, among it There is gasification drug eyesight hole 20 at position；

There is penetrating stomata 9 in the front of preceding 10 two sides of spectacle frame；One end of penetrating stomata 9 is communicated with outside, and penetrating stomata 9 is in addition One end is communicated with preceding mirror holder powder charge object box body hole 16.

Another object of the present invention is it is characterized in that provide a kind of above-mentioned plant crystal room temperature for preventing near-sighted cataract The preparation method of gasification glasses gasification drug, it is characterised in that: therapeutic agent raw material proportion group based on following parts by weight At, preparing raw material includes 1-6 parts of lycorine, and 1-8 parts of a- asarone, 1-6 parts of asarinin, 3-11 parts of Pogostone, asarum It is 2-5 parts oily.

A kind of preparation method of above-mentioned plant crystal room temperature gasification glasses gasification drug for preventing near-sighted cataract, including Following steps:

Short-tube lycoris alkali preparation method

Short-tube lycoris stem powder is taken, is extracted for 24 hours with alcohol reflux, cooled and filtered takes filtrate to be concentrated to dryness, it is concentrated to dryness, dissolving with hydrochloric acid, Filter to take filtrate, soda ash, chloroform recovery, among chloroform buck layer is added in filtrate chloroform, the filtrate after chloroform Lycorine solid is precipitated, alkene dissolving with hydrochloric acid is used after filter, concentration precipitates crystal, dry lycorine.

Asarone preparation method

The drystone calamus for taking 20kg extracts 4 each 3h of with 80L alcohol reflux.Obtained extract is concentrated by evaporation after merging and obtains Obtain the rhizoma acori graminei extract of 2.2kg.It is dissolved again with 12L distilled water, repeats three in triplicate with n-butanol 9L with ethyl acetate 13L Secondary separation obtains a- asarone then with removal organic solvent is evaporated in vacuo.

Pogostone preparation method

Pogostemon cablin 11Kg is taken, steam distillation extracts volatile oil to the greatest extent, separates volatile oil, the ether of 1.3 times of its volume amounts is added The NaOH solution of the 1mol/L measured with 2 times, extraction separate water layer, and repetitive operation 4 times, combining water layer is added dilute hydrochloric acid and adjusts PH4 is stood overnight, and filtration takes filter residue, is washed to neutrality, and n-hexane dissolution is added, and refrigerates crystallization, separation crystallization, and washing is done Dry Pogostone to obtain the final product.

Asarinin preparation method

Asarum is dried, crushes to obtain asarum coarse powder, asarum coarse powder is placed in the extraction kettle of supercritical CO 2 extraction device, is sealed, Extraction kettle, separating still are respectively heated, when extraction kettle temperature reaches 49 DEG C, separating still I and II temperature of separating still reach 45 DEG C, extraction kettle valve is opened, exhaust valve is opened when pressure is equal with sump pressure in extraction kettle and empties air, pass through high pressure Pump pressurizes to system, when extraction kettle pressure, which reaches 35Mpa, separating still I and separating still II, reaches 6.8Mpa, controls CO2 Flow is 45L/h, starts the cycle over extraction, extracts to obtain asarum total volatile oil;By asarum total volatile oil, low temperature is quiet under the conditions of -3 DEG C 28h is set, decompression filters, and obtains asarinin crude product;Take asarinin crude product that the anhydrous of 4 times of volumes of asarinin crude product is added Ethyl alcohol is dissolved, and is placed in low temperature recrystallization, is obtained asarinin.

A kind of plant crystal room temperature gasification glasses and preparation method thereof preventing near-sighted cataract:

The raw material weight number meter ratio range that most preferably selects of preparation plant crystal is: 5 parts of lycorine, 7.5 parts of a- asarone, carefully Pungent 3.5 parts, 8.6 parts of Pogostone, 5 parts of asarol of rouge element;

By 5 parts of lycorine, 7.5 parts of a- asarone, 3.5 parts of asarinin, 8.6 parts of Pogostone are incorporated in one → crushing, powder 5 parts of asarol are added in particle, is thoroughly mixed → plant crystalloid fluid inflow spectacle case → cooling after heating melting → melting Crystallize → be cooled to room temperature after, with plastic film sealed package, obtain plant crystal room temperature gasification glasses.

Claims (2)

1. a kind of plant crystal room temperature gasification glasses for preventing near-sighted cataract, it is characterised in that: gasified by plant crystal room temperature Lens body (1)；Right activity eyeglass (2), movable eyeglass shelves card slot (3)；Flexible nose-pad (4), left movable eyeglass (5), eyesight hole (6)；Movable eyeglass shelves card (7), right drug box body (8), penetrating stomata (9), preceding spectacle frame (10), preceding spectacle frame and rear glasses Frame cage knob (11), preceding spectacle frame and rear spectacle frame seam (12), rear spectacle frame (13), left drug box body (14), drug cassette (15), preceding mirror holder powder charge object box body hole (16), medicine kit bulk drug gasification hole (17), gasification drug (18), gasification drug Hole (19), gasification drug eyesight hole (20) composition；

Plant crystal room temperature gasifies lens body (1) as human head shapes, and there is spectacle frame (10) before the arcuation of garden in front, thereafter There is spectacle frame (13) after corresponding garden arcuation in portion；There are preceding spectacle frame and rear spectacle frame cage knob in the middle part of spectacle frame (13) afterwards (11), preceding spectacle frame (10) is adjusted to separate and be closed at preceding spectacle frame and rear spectacle frame seam (12) with rear spectacle frame (13) Locking；

The flexible nose support in lower part (4) in the middle position of preceding spectacle frame (10)；

There are movable eyeglass shelves card slot (3) the interlocking garden You Yikuai arcuation activity eyeglass shelves in the outermost middle section of preceding spectacle frame (10) Block (7)；

There are left movable eyeglass (5) and right movable eyeglass (2) behind movable eyeglass shelves card (7)；

Left activity eyeglass (5) is corresponding with behind right movable eyeglass (2), and there are two preceding mirror holder powder charge object box body holes (16)；

Right drug box body (8) and left drug box body (14) are corresponding with behind preceding mirror holder powder charge object box body hole (16)；

Right drug box body (8) and left drug box body (14) by drug cassette (15), medicine kit bulk drug gasification hole (17), Gasify drug (18), gasification drug hole (19)；Gasify drug eyesight hole (20) composition；Uniformly there is gasification in gasification drug (18) There is gasification drug eyesight hole (20) at drug hole (19), in-between position；

The front of preceding spectacle frame (10) two sides has penetrating stomata (9)；One end of penetrating stomata (9) is communicated with outside, penetrating stomata (9) other end is communicated with preceding mirror holder powder charge object box body hole (16).

2. a kind of preparation method for the plant crystal room temperature gasification glasses gasification drug for preventing near-sighted cataract, it is characterised in that: The therapeutic agent raw material matches composition based on following parts by weight, and preparing raw material includes 1-6 parts of lycorine, a- asarone 1- 8 parts, 1-6 parts of asarinin, 3-11 parts of Pogostone, 2-5 parts of asarol；

The following steps are included:

Short-tube lycoris alkali preparation method

Short-tube lycoris stem powder is taken, is extracted for 24 hours with alcohol reflux, cooled and filtered takes filtrate to be concentrated to dryness, it is concentrated to dryness, dissolving with hydrochloric acid, Filter to take filtrate, soda ash, chloroform recovery, among chloroform buck layer is added in filtrate chloroform, the filtrate after chloroform Lycorine solid is precipitated, alkene dissolving with hydrochloric acid is used after filter, concentration precipitates crystal, dry lycorine；

A- asarone preparation method

The drystone calamus for taking 20kg is extracted 4 times, each 3h with 80L alcohol reflux, and obtained extract is concentrated by evaporation after merging and obtains The rhizoma acori graminei extract of 2.2kg is obtained, then is dissolved with 12L distilled water, repeats three in triplicate with n-butanol 9L with ethyl acetate 13L Secondary separation obtains a- asarone then with removal organic solvent is evaporated in vacuo；

Pogostone preparation method

Pogostemon cablin 11Kg is taken, steam distillation extracts volatile oil to the greatest extent, separates volatile oil, the ether of 1.3 times of its volume amounts is added The NaOH solution of the 1mol/L measured with 2 times, extraction separate water layer, and repetitive operation 4 times, combining water layer is added dilute hydrochloric acid and adjusts PH4 is stood overnight, and filtration takes filter residue, is washed to neutrality, and n-hexane dissolution is added, and refrigerates crystallization, separation crystallization, and washing is done Dry Pogostone to obtain the final product；

Asarinin preparation method

Asarum is dried, crushes to obtain asarum coarse powder, asarum coarse powder is placed in the extraction kettle of supercritical CO 2 extraction device, is sealed, Extraction kettle, separating still are respectively heated, when extraction kettle temperature reaches 49 DEG C, separating still I and II temperature of separating still reach 45 DEG C, extraction kettle valve is opened, exhaust valve is opened when pressure is equal with sump pressure in extraction kettle and empties air, pass through high pressure Pump pressurizes to system, when extraction kettle pressure, which reaches 35Mpa, separating still I and separating still II, reaches 6.8Mpa, controls CO2 Flow is 45L/h, starts the cycle over extraction, extracts to obtain asarum total volatile oil;By asarum total volatile oil, low temperature is quiet under the conditions of -3 DEG C 28h is set, decompression filters, and obtains asarinin crude product;Take asarinin crude product that the anhydrous of 4 times of volumes of asarinin crude product is added Ethyl alcohol is dissolved, and is placed in low temperature recrystallization, is obtained asarinin；

The raw material weight number meter ratio range that most preferably selects of preparation plant crystal is: 5 parts of lycorine, 7.5 parts of a- asarone, carefully Pungent 3.5 parts, 8.6 parts of Pogostone, 5 parts of asarol of rouge element;

By 5 parts of lycorine, 7.5 parts of a- asarone, 3.5 parts of asarinin, 8.6 parts of Pogostone are incorporated in one → crushing, powder 5 parts of asarol are added in particle, is thoroughly mixed → plant crystalloid fluid inflow spectacle case → cooling after heating melting → melting Crystallize → be cooled to room temperature after, with plastic film sealed package, obtain plant crystal room temperature gasification glasses.