CN108578523A - Prevent the gasification infiltration fat glasses and preparation method thereof of macular degeneration cataract myopia - Google Patents
Prevent the gasification infiltration fat glasses and preparation method thereof of macular degeneration cataract myopia Download PDFInfo
- Publication number
- CN108578523A CN108578523A CN201810627433.8A CN201810627433A CN108578523A CN 108578523 A CN108578523 A CN 108578523A CN 201810627433 A CN201810627433 A CN 201810627433A CN 108578523 A CN108578523 A CN 108578523A
- Authority
- CN
- China
- Prior art keywords
- gasification
- fat
- glasses
- infiltration
- eye
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/83—Thymelaeaceae (Mezereum family), e.g. leatherwood or false ohelo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C11/00—Non-optical adjuncts; Attachment thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Vascular Medicine (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Optics & Photonics (AREA)
- General Physics & Mathematics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention is a kind of gasification infiltration fat glasses and preparation method thereof for preventing macular degeneration cataract myopia.By lens body, rubber seal eyeshade, lens body eyeglass, rubber nose support, eye frame protrusion card column, eye frame groove, gasification infiltration fat, gasification infiltration fat is ventilative, lenses fitted hole sleeve hole, lenses fitted, prevention raw material is brother king's general flavone, natural d-borneol, L-Borneol, gasification infiltration fat glasses made of Angelica oil etc..Different eyeglasses can be selected according to different myopia degrees, in treatment eyes no longer as previous treatment makes the eye of people cover invisible thing.It solves and neither performs the operation and be not applied to directly eye, eye no pain, non-stimulated, without side-effects, easy to use, successively gasification administration, to various eye illness control effective percentage 100%, significant effect.Breaching Qian Bai Lai No has gasification infiltration fat glasses that can prevent the global problem of cataract, macular degeneration, myopia, glaucoma treatment without specific medicament.
Description
Technical field
The invention belongs to field of medical device, more particularly to fat preparation method is permeated in a kind of gasification, and gasification infiltration fat is put into
Gasification infiltration fat glasses and preparation method thereof in glasses for preventing macular degeneration cataract myopia.
Background technology
A investigation report of the World Health Organization shows that age-related macular degeneration disease is after cataract, entirely
The third-largest blinding disease of ball.It can cause a disease in all age group, occur mainly in 45-50 years old or more crowd.The whole world
The lesion market survey report display of Age related macular portion, age-related macular degeneration disease are just increased with year multiple growth rate 9.62%.State
The interior newest investigation about age-related macular degeneration incidence is a investigation report delivered in 2010, and finding shows China
The illness rate of 45 years old or more crowds is 7.96%~25.13%.Population base of China is big, and aging of population is increasingly severe, always
The incidence of year macular degeneration is certain to be higher than above-mentioned statistics.So far, either age-related macular degeneration or juvenile macula lutea becomes
Property, at present in modern medicine, pathogenesis is still not clear, and does not also have specific medicine and means, does not also find prevention
The good method of this disease disease progression is still in treatment so far very difficult.
Cataract is that crystalline lens generation muddiness becomes opaque by transparent in eyes, hinders light to enter intraocular, to shadow
Eyesight is rung.The initial stage muddiness of cataract is little to eyesight influence, can then aggravate gradually, finally significantly affects eyesight to mistake
It is bright.There are many reason of causing cataract, have congenital, traumatic, concurrency, poisoning, radiation etc. crystalline lens can be caused to be metabolized
Disorder causes crystallins to be denaturalized and muddiness occurs, therefore referred to as cataract.Lens opacity is from crystalline lens centre, that is, embryo
Tire nuclear location starts density increase occur, gradually aggravates and slowly radiates out, and is in faint yellow in early days, as muddiness aggravates,
Color and luster is gradually deepened such as buff, dark brown yellow.Cataract patient shows as unilateral or bilateral more, and two morbidities can have successively,
Eyesight progressive declines, and since lens cortex muddiness causes crystalline lens different parts refractive power different, generates dazzle sense or simple eye
Diplopia, myopia degree increase etc..Pathogenesis of cataract is more common in 45 years old or more, and incidence increases with the age and increased, at present 45-
The incidence of 60 years old cataracts of old people be 60-70%, 70 years old or more up to 80%, 80 years old or more the elderly almost reaches
100%.Worldwide cataract is one of primary cause of disease of blinding, and about 5 million peoples are due to white interior in the world now
Hinder and blinding, separately there are 1.5 hundred million cataract patients to need surgery recovery eyesight, it is white interior in most of Africa and Asian countries
Barrier at least accounts for the half of blind person, and the cataract blindness person of the age bracket of China 45-89 Sui accounts for the 95.10% of all cataract blindness.
Cataract patient accounts for the 46.7% of person with visual disabilities, and cataract of old people occupies in the elderly is with visual disabilities first of various eye disease.
Timely and effectively prevention SC has become a top priority.
Up to the present, the drug for treating cataract has：Bevacizumab, Arastin, Macugen injection, Compaq
Western general, VEGF Trap, Ai Liya, Lucentis and promise are fitted.Also laser photocoagulation, through pupil thermotherapy, light power treat
Method is replanted into artificial lens, operation and radiotherapy etc..Cataract of old people clinically divides the fourth phase i.e. initial phase, the phase of expansion,
Maturity period and overripe stage.Modern medicine there has been maturity period cataract of old people relatively advanced operative treatment, but due to hand
Art therapy will wait until the maturity period of cataract or overdone stage operation, and the expense performed the operation is costly, and for the initial stage of cataract
And the effect of phase of expansion, is bad, this lengthy procedure from initial phase to maturity period, can undoubtedly be brought to patient and its family very big
The inconvenience of degree, therefore, develop effectively Prevention cataract in initial stage easy to use seems even more important for patient, grinds
Study carefully manufacture gasification infiltration fat glasses, there is significant realistic meaning.
Myopia brings many inconvenience, and correction can be played the role of by getting the right lensses for one's eyeglasses, but cannot be obtained medical treatment,
Near-sighted degree is generally lower than 6 diopters (- 600 degree), stops development by 20 years old or so.But childhood makes much progress, to 13~
20 years old progress more rapidly, slow down later, and such myopia is often higher than 6 diopters, can reach 20 or 30 diopters, both
Eyeglass -2000~-3000 are spent.This myopia is known as laser high myopia or progressive myopia, also referred to as pathological myopia.This myopia,
Retrogression pathological changes can occur to old age, eyesight is faded, and can not be corrected defects of vision with mirror, and most of such eyes are last all
It causes to blind.Myopia is listed in one of three big disease of the world, China's myopia number nearly 4.5 hundred million, and wherein teenager is about
3.5 hundred million people, 2, center broadcasting on June 5th, 2018, university student's myopia have 88.77%, high school student to have 88.3%, junior school student to have
74.4%, pupil has 45.7%, and newly-increased myopia is about 9% every year.Having become China for the prevention and treatment of myopia is
To the active demand of the people of the world, teenager's low vision has become serious society and medical problem.
Myopia corneal clouding shows as the albefaction of normal hyaline cornea.The loss of the transparency of this cornea can be caused
Complaint domain is from eye-blurred to blindness.The therapy of myopia and amblyopia generally comprises at present：Mist regard therapy, Bates therapy,
Wearing spectacles, laser surgey, Chinese traditional massage and acupuncture.When mist depending on therapy is at near-sighted initial stage or not near-sighted, wears orthoptoscope and see
Nearby things mainly serves pre- myopic-preventing；Bates therapy is far to see close training by being seen to sighting target, adjusts eye circumference flesh
Meat, but the method treatment time is longer, effect unobvious；Though wearing spectacles can see things clearly, the number of degrees of eyes can be caused continuous
Increase, no therapeutic effect；Laser surgey is cut to cornea, changes the angle that light enters eyes by force, has to eyes
Injury, facts proved that there are sequelae；Chinese traditional massage and acupuncture and moxibustion treatment are limited by technology, complicated for operation, technical relatively strong, effect
Rate is relatively low, and can rebound.
Currently, the method for prevention and treatment myopia, acupuncture and moxibustion therapy, ear acupuncture therapy, acupuncture therapeutic, point massage method,
Electromagnetotherapy, instrument, drug etc. are varied, and correction can be played the role of by wearing near-sighted glasses, but cannot obtain medical treatment, no
Energy retarding myopia degree, can not prevent, and the eyesight number of degrees are only aggravated with increasing according to age.Hundreds of existing treatment myopia
Drug is practical to no effect, especially to there is prodigious defects in teen-age myopia effect.
In modern medicine, the medicine of western medicine cataract mainly uses C16H8N2O5, and the field of Chinese medicines prevents the system of cataract
Agent pharmacopeia is recorded not yet.Intravitreal injection preparation is expensive, and every price is in thousands of members to tens of thousands of members etc..And
And intravitreal injection preparation uses frequently, generally monthly needs injection primary, also has and injects within 2~3 months once, Huan Zhenai
Poor by property, damage that in use can be certain caused by eyeball has certain risk.Due to directly acting on administration portion
Position, for intravitreal injection preparation while effective, side effect is also relatively large.
Document report prevention macular degeneration, cataract, myopia etc. in control and to control Chinese medicine medicine outside as follows：Inside control master
There are oral solution, decoction, electuary, pill, granule, tablet, capsule etc..Inside controlling mainly has;Hinder clear oral solution, compound ginseng fruit
Liquid, promoting blood circulation dispel barrier soup, disappear barrier electuary, electuary of recovering lost eyesight, control barrier ball 1, exempt from screen ball, Fuming Tablet, basis-reinforcing eyesight-improving capsule, disappear barrier spirit
Ball, disappear barrier pills for improving acuity of sight, JINHUA MINGMU WAN, the clear oral solution of cataract or glaucoma, compound sugar hinder bright particle, bear gall pill etc..These effect of drugs are poor
Or it is invalid, side effect is larger.
External therapy is mainly powder, eye drops.In addition see also Chinese medicinal film agent, injection for treating cataract document.Such as, musk deer
Pearl eyesight improvement powder medicine, ZYM eye drops, C16H8N2O5（Catalin Eye Drops）Eye drops, ophthalmically acceptable freeze-dried ZIAOZHANGSU INJECTION hinder drop of recovering lost eyesight
Ocular fluid, making compound leech eye drip, herbal mixture eye drops, QUZHANGLING DIYANYE, scattered eye drops of hiding from view（It is made and hides from view scattered, face use
Shi Peicheng）Deng.These topical eye drops drugloading rates are small, and patient needs frequently use that could meet needs；Topical eye drops by
Then liquid preparation, bioadhesive is poor, and the time retained in eyes is too short, although eyedrops uses more convenient, toner
It is too short to measure the time that is small and acting on eyes, is easily eliminated, control effect is too poor or invalid.Topical eye drops are extremely difficult to be worn
Eye position after the physiological structure of through hole ball reaches, topical eye drops also have certain toxic side effect.
In recent years, is permeated by fat and is placed in glasses for the gasification of prevention macular degeneration, cataract, myopia both at home and abroad and matched
It wears and uses by the extensive concern of researcher, many experts and scholars want to study, and Dan Shi No have a people to study successfully, even to this day
Domestic and international preparation pharmacopeia record not yet by gasification infiltration prevention macular degeneration of wearing glasses, cataract, myopia registration and
Paper report and patent registration, so, the domestic and international still blank of gasification infiltration fat glasses.
Invention content
In order to overcome domestic and international prior art prevention macular degeneration, myopia, the initial phase of cataract and the treatment of the phase of expansion
It imitates poor, intravitreal injection and somewhat expensive, surgery cost is expensive, drug cannot successively penetrate into cornea, vitreum, view
Film, blood-eye barrier using drug and wear glasses and cannot delay the defect of the eye disease such as eyesight and vitreous opacity.
It does not perform the operation to solve curing eye diseases, using Chinese and Western medicine and wear glasses and treating the chronic macular degeneration, cataract, close
Depending on eye weak curative effect, intravitreal injection somewhat expensive, surgery cost is expensive the problems such as.The invention reside in provide a kind of prevention macula lutea change
Property, cataract, myopia do not have to operation, be not applied to eye, eye no pain, non-stimulated, without side-effects, user directly
Just, efficient repairing answers crystalline lens and muddiness does not occur, effectively cataract eyesight is delayed to aggravate, macular degeneration eyesight is effectively delayed to aggravate,
Effective retarding myopia eye vision exacerbation effectively delays green light eye vision to aggravate, effectively delays degeneration eye disease, having and permeate screen of dispelling
Effect, cure rate are high, control effect is notable, fat glasses are permeated in prevention macular degeneration cataract myopia curative for effect gasification and
Preparation method.
The object of the present invention is to provide a kind of gasifications of prevention macular degeneration cataract myopia to permeate fat glasses, by glasses sheet
Body, rubber glasses frame body, rubber seal eyeshade, Rubber end cuff, lens body eyeglass, Rubber end cuff buckle, rubber nose
Support, eye frame protrusion card column, eye frame groove, eye frame are hooked with rubber glasses frame body connection card, gasification infiltration fat, and gasification infiltration fat is saturating
Gas, lenses fitted hole sleeve, lenses fitted hole sleeve hole, lenses fitted, lenses fitted frame, gasification infiltration fat ventilating cover center
Hole, gasify infiltration fat ventilating cover mesh, the fixing groove in rubber nose support, the fixing groove composition on rubber glasses frame body.
The front of lens body is rubber glasses frame body and lens body eyeglass；
Lens body eyeglass is made of organic glass, and the front is eyeglass, and there is a frame groove at middle part, has eye behind eye frame groove
Frame protrusion card column, eye frame protrusion card column have a frame to be hooked with rubber glasses frame body connection card by the side of nose support, eye frame protrusion card
Column and eye frame hook the fixation being nested on rubber glasses frame body in corresponding rubber nose support with rubber glasses frame body connection card
In fixing groove on slot and rubber glasses frame body.
The rear portion of lens body is rubber seal eyeshade；There are a Rubber end cuff in the both sides of lens body, in rubber headgear
Between have Rubber end cuff buckle.
There is rubber nose support in the middle part of lens body.
It is characterized in that：
The outermost interposition of lens body eyeglass is equipped with lenses fitted hole sleeve hole, and lenses fitted hole sleeve has wearing mirror on hole
Piece hole sleeve, lenses fitted hole sleeve can be set with the lenses fitted of the different number of degrees or zero diopter.
Lenses fitted and lenses fitted frame are integral casing, end of the lenses fitted in lenses fitted frame one end.
Centre inside lens body eyeglass be cased with it is corresponding with lenses fitted hole sleeve aperture have poroid gasification ooze
Saturating fat, gasification, which is permeated behind fat, is covered with corresponding gasification infiltration fat ventilating cover, and there is gas in the centre that fat ventilating cover is permeated in gasification
Change infiltration fat ventilating cover centre bore, the two sides of gasification infiltration fat ventilating cover is evenly equipped with gasification infiltration fat ventilating cover mesh.
Another object of the present invention is it is characterized in that provide the gasification infiltration of above-mentioned prevention macular degeneration cataract myopia
The preparation method of fat gasification infiltration fat, it is characterised in that：The medicine raw material matches composition based on following parts by weight,
It includes 3-13 parts of Wikstroemia indica general flavone, 35-65 parts of natural d-borneol, 30-58 parts of L-Borneol, Angelica oil 20- to prepare raw material
50 parts, 1-5 parts of lutein, -2 parts of vitamin B1.
Fat preparation method is permeated in above-mentioned gasification.Include the following steps：
Wikstroemia indica general flavone extracts
Step 1 is packed into extraction after the pulverizer of dry Wikstroemia indica 300g medicinal material good leak tightness is crushed the particle for 20 mesh
In batch can, extraction batch can is placed in extraction kettle, extraction kettle is sealed, is passed through carbon dioxide in a supercritical state and is extracted
It takes, and uses 200 milliliters of absolute ethyl alcohol as entrainer and participate in extraction, wherein extraction equipment process condition range, pressure 28,000,000
Pascal, temperature are 38 degrees Celsius, and carbon dioxide flow is 18 liters per hour, and extraction time is 2 hours,
Step 2,
Step 1 the method is prepared into gained Wikstroemia indica extract and is diluted to medicinal material, solution 1:Sample liquid is crossed polyamide by 1
Column, it is to be adsorbed completely after, first use the ethanol aqueous wash of pure water and 10-30% to remove decontamination, then water-soluble with the ethyl alcohol of 40-80%
Liquid elutes, and collects eluent, is concentrated under reduced pressure, and 70 DEG C of low-temperature vacuum drying obtains Wikstroemia indica general flavone.
The preparation method for preventing the gasification infiltration fat glasses gasification infiltration fat of macular degeneration cataract myopia is as follows：
Preparing the raw material weight number meter ratio range that most preferably selects of the gasification infiltration fat of the present invention is:Wikstroemia indica general flavone 3, naturally
41 parts of parts of d-Bomeol, L-Borneol 33, part, 17 parts of Angelica oil, 2 parts of lutein, 2 parts of vitamin B;
By 3 parts of Wikstroemia indica general flavone, 41 parts of natural d-borneol, 33 parts of L-Borneol, 2 parts of lutein, the conjunction of vitamin B2 part
And 17 parts of Angelica oil is added in one → crushing, crushed material, heating melting → being thoroughly mixed after melting → is gasified infiltration
Fat flows into spectacle case → crystallisation by cooling → and after being cooled to room temperature, is packed with plastic film, and must gasify infiltration fat glasses, using each
Kind curing eye diseases and prevention.
The application method of gasification infiltration fat glasses:
Gasification infiltration fat glasses are worn to eye, wear smoked treatment in one time 30-40 minutes morning, wears to smoke for one time 30-40 minutes at night and treat,
One day 2-3 times, 1 month is 1 course for the treatment of, and 1 to 16 course for the treatment of is cured for macular degeneration, cataract, near-sighted initial phase and the phase of expansion,
To that cannot fully recover after macular degeneration, cataract, near-sighted mid-term, the effect that eyesight can only be delayed no longer to aggravate, to regarding god
Through atrophy, uveitis, retinal pigment degeneration, xerophthalmia, retinopathy, retinal vein obstruction, retinal hole, sclera
Inflammation, preretinal membrane, fundus hemorrhage, optic neuritis, amblyopia, iritis, diabetic eye diseases, retinal detachment, visual impairment etc.
Eye disease can be cured with 1 to 10 course for the treatment of, and gasification infiltration fat glasses effectively prevent various eye disease generations and elimination eyes are tired
The effect of labor, gasification infiltration fat glasses can often have on the generation for preventing eye disease.
The pharmacological treatment effect of gasification infiltration fat:
1, Wikstroemia indica flavones, natural d-borneol, L-Borneol, Angelica oil are containing the drug combinations such as Ligustilide 70%, molecular weight
It is small, it is fat-soluble strong, penetrate and promote Deiter's cells effect, gasification infiltration fat can cross over cornea, glass with powerful
Glass body, retina and blood-brain barrier, eye position after arrival and play treatment move back the screen film triangular mass of mucous membrane growing from the inner corner of the eye and inhibit lens protein
It is denaturalized and muddy effect occurs;
2, gasification infiltration fat glasses form gasification after being applied to eyes, and gasification liquid successively penetrates cornea, vitreum, view
Film and blood-eye barrier will greatly improve ester concentration and extend in the action time of eye, accelerate cornea, vitreum reparation becomes clear
Effect;
3, gasification infiltration fat can assist active factors ingredient to be directed through eyeball barrier action in rear eye position, gasification infiltration fat
The factor gets over cell membrane into various types of cells, and eye kills virus infection and plays curative effect after can smoothly reaching;
4, the present invention relates to using Wikstroemia indica flavones, natural d-borneol, L-Borneol, Ligustilide as the Tissue distribution knot of index
Fruit shows, can not only be measured in cornea, can also be measured in vitreum and retina.With penetrate cornea, vitreum and
Retinal vessel enters the new breakthrough inside eye tissue.
Gasification infiltration fat long term toxicity test:
The present invention infiltration fat that gasifies is object, selects adult rat 50, is randomly divided into 5 groups, one group of control group and four groups of experiments
Group, every group 10, half male and half female.Test group each group dosage is respectively the 0.1 of LD50（500m/K parts of BW）、0.15（750m/K parts
BW）、0.22（1100m/K parts of BW）、0.34（1700m/K parts of BW）, daily gavage is primary, continuous 20 days.Then 7 are observed
It.Testing result each group is without death, and each dosage group does not show death without dose-response relationship yet, this drug does not have bright
Aobvious cumulative toxicity, long-term use not will produce side effect.
Gasification infiltration fat hypersensitive test;
Gasified using the present invention and permeate fat as object, takes 30 healthy guinea pigs to be tested, male and female half-and-half carries out back before administration
The processing of both sides unhairings, is randomly divided into five groups, every group 6, respectively control group, the high 1 multiple dose 0.5mg of damaged skin, low dosage 2
Multiple dose 1mg groups, the high 1 multiple dose 0.5mg of intact skin, 2 multiple dose 1mg groups of low dosage.It is subcutaneous to four groups of carry out below respectively
After medication, once a day, continuous 7 days, each group situation is observed, as a result cavy all survives, and the skin of the cavy of each group is not
There is any discomfort, and apparent exception does not occur for the searching for food of cavy, activity, breathing and weight etc..The results show that the drug is not
With sensitization.Pharmacology pharmacodynamic experiment display, the medicine do not have any toxic effect, sensitization and adverse reaction, and clinic makes
With safety.
One, macular degeneration clinical test is treated;
Diagnosis and treatment standard:
Macular degeneration diagnostic criteria uses《New Chinese medicine guideline of clinical investigations Ministry of Health of the People's Republic of China 1997,
205-207》Standard, 1. eyesight decline rapidly, 2. macula area glass-film wart, depigmentation, bleeding, exudation, detachment of retina
Or fibre machine film, 3. macular area subretinal Neovascularization, the uniform hyperfluorescence area of clear border, early stage, its periphery was by weak glimmering
Light area is surrounded to middle and advanced stage, and phosphor persistence leakage, lesion boundary is obscured.
Best inspection of correcting defects of vision, is detected by two doctors using international standard visual chart, two times result exists respectively
Average in error range, the error range of permission is≤0.1.
Eyesight the standard of curative effect evaluation;
It is effective, it most preferably corrects defects of vision and improves 4 rows or 4 rows or more, effectively, most preferably correct defects of vision and improve 2 to 3 rows, stablize, it is best to rectify
The fluctuation up and down in 1 row of positive eyesight, in vain, decline of most preferably correcting defects of vision.
362 patients are treated, gasification infiltration fat glasses, the treatment results of the 3-16 course for the treatment of are worn:
Treat macular degeneration type experimental result table 1
The effective percentage that clinical test shows to treat macular degeneration is 100%, rapid-action, short treating period, curative for effect, not only cure rate
Height, and speed of fully recovering is fast, not will produce any side effect.
Model case
1, Zhang Mounv, 53 years old, five years ago eyes were diagnosed as senile atrophy type macular degeneration, there is central plate-like dim spot in the visual field,
Macula area has the rigid glass-film wart than comparatively dense.Once various treatments were attempted, all kinds of Chinese and Western medicines are taken, eyesight does not carry not only
Height is gradually reduced instead, right vision 0.3 when coming to go to a doctor, left eye 0.4, after wearing gasification infiltration fat 2 courses for the treatment of of glasses, right eye
Eyesight reaches 0.7, and up to 0.9, drusen reduction melanin increases left eye under retina after fundus photograph display treatment, is that lesion is extensive
Multiple performance.
2, Guo, man, 62 years old, people from Ganzhou City, eye-blurred, central scotoma, metamorphopsia started to wear in September, 2017
Gasification infiltration fat glasses wear smoked treatment in one time 30-40 minutes morning, wear to smoke for one time 30-40 minutes at night and treat, 2 times a day, a course for the treatment of
Eyesight improves afterwards, continues recovery from illness after wearing gasification infiltration fat two courses for the treatment of of glasses and stops wearing.
3, Hu, female, 35 years old, there is yellow-white exudation in retina deep layer in people from Dayu County, and gasification was worn in 2 months 2017
Fat glasses are permeated, wear smoked treatment in one time 30-40 minutes morning, wear smoked treatment in one time 30-40 minutes, 2 times a day, a course for the treatment of backsight at night
Power improves, and continues recovery from illness after wearing gasification infiltration fat two courses for the treatment of of glasses and stops wearing.
4. Liu, man, 53 years old, electric welder did manual work outdoors for a long time.Often there is ghost image at the moment in readme symptom, depending on
Wild smudgy, eyes are dry and astringent, and can also be with the decline of eyesight.After wearing gasification infiltration fat 4 courses for the treatment of of glasses, visual field overlapping
Phenomenon disappears, and the dry and astringent phenomenon of eyes swelling is eased, and eyesight is steady in a long-term.
5. Liu, male 62 years old peasant, are engaged in manual labor outdoors for a long time.Left vision is gradual the year before for readme symptom
Decline, the visual field is fuzzy, blackspot is will appear before long-time fixating eye, and then right vision starts to decline, and ghost image often occurs in the visual field,
Phenomena such as things is overlapped, left eye is more serious compared with right eye.After wearing gasification infiltration fat 2 courses for the treatment of of glasses, right eye perspective overlapping phenomenon
It disappears, eyesight level is stablized, and left eye ghost phenomena is eased, and blackspot phenomenon is thoroughly eliminated, and eyes overall vision is basic
Stablized.
Two, cataract clinical test is treated:
Subjects 503 suffer from the identical patient of cataract degree, are divided into three groups according to cataract type, wear gasification infiltration fat eye
Mirror.
Experimental method, three groups of patients all wear gasification infiltration fat glasses, the treatment results of the 3-12 course for the treatment of:Treat cataract
Type experimental result table 2
The effective percentage that clinical test shows to treat cataract is 100%, rapid-action, short treating period, curative for effect, not only cure rate
Height, and speed of fully recovering is fast, not will produce any side effect.
Typical treatment case:
1, clock, female, 45 years old, people from Yudu County suffered from the patient at cataract initial stage, and sight gradually obscures, and felt light week sometimes
The color for crossing existing aperture and object is not bright enough.Totally 5 patients are middle-aged male, wear gasification infiltration fat glasses treatment
It is cured completely after 4 courses for the treatment of of cataract.
2, clock, man, 49 years old, Ningdu County people suffered from the short-term patient of cataract conditions, and blurred vision easy tos produce slur
Or more shadow phenomenons.Totally 3 patients, are middle-aging male, and it is white interior to wear gasification infiltration fat glasses treatment for long campaigns housework
It is cured completely after 3 courses for the treatment of of barrier.
3, Liang, man, 56 years old, people from Ruijin City suffered from cataract conditions, and the patient that the state of an illness is heavier in short term.Specific symptom
It is fuzzy for the visual field, and slightly dim phenomenon, colour vision occur abnormal.Totally 4 patients, wherein 2 middle-aged male patients, 2 middle ages
Female patient, the state of an illness is controlled substantially after wearing gasification infiltration fat 6 courses for the treatment of of glasses, and needs to continue to wear gasification infiltration fat glasses
It is cured.
4, Liang, man, 63 years old, people from Ruijin City suffered from the patient of cataract for a long time, and specific symptom can occur to be before eyes
Position fixes, the dotted or sheet shade of shape invariance, affects vision.Totally 2 patients wear gasification infiltration fat 6 courses for the treatment of of glasses
Symptom is eased afterwards, is controlled after persistently wearing gasification infiltration fat 6 courses for the treatment of of glasses, and needs to continue to wear gasification infiltration fat eye
Mirror is cured.
5, permitted certain, female 55 years old, suffers from cataract, because not too much taking notice of at that time, has only taken some common on the market
Drug, but symptom never improves after going to hospital to check, doctor shows that the success rate cured is less high, to lean on
Operation excision and then the Chinese herbal medicine for having taken treatment cataract of the invention are checked again for by 3 courses for the treatment of to hospital later
When cataract be completely recovered.
Three, myopia clinical test is treated;
Subjects 300 suffer from the identical patient of myopia degree, are divided into three groups according to myopia type, wear gasification infiltration fat eye
Mirror.
Experimental method, three groups of patients all wear gasification infiltration fat glasses, the treatment results of the 2-12 course for the treatment of:Treat myopia
Type experimental result table 3:
Clinical test shows that it is 100% to treat myopia effective percentage, and rapid-action, short treating period, curative for effect, not only cure rate is high,
And speed of fully recovering is fast, not will produce any side effect.
Myopia typical case:
Clock XX, female, 13 years old, Ganzhou people from city, left vision was 0.3 before treating, right vision 1.1, in the People's Hospital of city
Massage therapy 1 year is without obvious curative effects.After wearing gasification infiltration fat glasses 2 courses for the treatment of of treatment, her left vision is 1.5, right eye
Eyesight is completely recovered for 1.3.
Guo XX, man, 19 years old, Ganzhou people from city played games all night, and physical examination uncorrected visual acuity is 4.8, and junior middle school starts to wear
It wears glasses, existing eyeglass number of degrees or so are 400 degree, and hospital regards as pseudo-myopia, rely on drug eye drops and ocular region massaging afterwards
Device is treated, and nothing is clearly better.Gasification infiltration fat glasses are worn after 4 weeks, the eyeglass number of degrees drop to 200 degree, continue to wear gasification
After permeating fat one course for the treatment of of glasses, eyesight returns to normal, and patient adheres to using so far, claims to alleviate asthenopia effect very
It is good.
Hu XX, man 18 years old, Guangdong Hui Zhoushi people myopia 3 years, uncorrected visual acuity is left eye 4.1, and right eye 4.4 is never matched
Mirror is corrected defects of vision, and custom narrows eye and regards object, and eyes are dry and astringent, fatiguability, do the difficult maintenance eyesight of eye exercises throughout the year, but can only make
Eyesight transience is restored.Begin to use wear gasification infiltration fat glasses feels after two weeks regard object clarity improve, feeling of fatigue disappearance,
Without dry and astringent, after being continuing with 2 courses for the treatment of, uncorrected visual acuity is restored to 4.9, and right vision restores to 4.8, and eyesight still maintains so far.
Liu XX, female, 21 years old, ShenZhen,GuangDong people from city, eyes regarded nearby from 17 years old, she has on always the stealth spent 400 more
Glasses, severe astigmatism.Reach naked by binocular vision after gasification infiltration fat glasses treat 2 courses for the treatment of is worn and regard 1.2.
Rely XX, female, Jiangxi people from Yudu County, 14 years old, five classmans, 300 degree near-sighted, astigmatism.The myopia since Third school grade
It rises, parent goes around countless hospitals in order not to allowing her to wear glasses, and ear point massaging, eye sticker, acupuncture etc. are almost used time, and family is bought
The various equipment for controlling myopia be also it is complete, can eyesight fluctuated at 0.6 always, eyes make a line depending on object.By
It wears after gasification infiltration fat glasses treat 2 courses for the treatment of, binocular vision, which has been restored to, naked regards 1.5.
Lee XX, man, Jiangxi people from Nankang City, 13 years old, sixth-former, myopia more than 500 was spent, astigmatism.The eyes from senior class
With regard to myopia, ear point massaging was successively carried out 2 years, eye sticker half a year, myopia is not only good instead from 200 degree, has risen always
It being spent 600 more.By wearing after gasification infiltration fat glasses treat 2 courses for the treatment of, binocular vision, which has been restored to, naked regards 2.0.
Four, keratitis clinical test is treated;
Subjects 368 suffer from the identical patient of keratitis degree, are divided into three groups according to keratitis type, wear gasification infiltration fat eye
Mirror.
Experimental method, three groups of patients all wear gasification infiltration fat glasses, and effect is respected in 1-8 course of therapy keratitis experiment.
Treat keratitis type experimental result table 4:
The effective percentage that clinical test shows to treat keratitis is 100%, rapid-action, short treating period, curative for effect, not only cure rate
Height, and speed of fully recovering is fast, not will produce any side effect.
Model case,
1, leaf XX, female, 41 years old, Ganzhou City of Jiangxi Province illness symptom right eye causes ulcer of the cornea three months left sides after being scratched by branch
The right side is not shown through certain hospital with various therapy effects, and by the agency of is sought medical advice in September in 2017 to examine on the 17th.It checks, systemic conditions are good
It is good.Eye conditions, eyesight are the right side 0.05, are shed tears, photophobia, pain, ciliary congestion (thirty), and cornea is in full muddiness, and center has one
The deeper ulcer of shape, eyeground cannot be pried through.It is diagnosed as cornea of right eye ulcer (corneal ulcer).Gasification infiltration fat glasses, morning are worn in treatment
Smoked treatment in one time 40 minutes is worn, wears smoked treatment in one time 30-40 minutes at night, 3 times a day, after 5 days, irritation disappears, ulcer healing,
Cornea forms nubecula, and eyesight rises to 1.2, and the disease is cured.
2, Lee XX, female, 35 years old, Ganzhou City of Jiangxi Province illness symptom, right eye suffers from ulcer of the cornea nearly five months, through various treatments
In vain, in first visit on May 21 in 2017.It checks, ordinary circumstance is fair, and left eye is normal.Right vision 0.1, light sensation are shed tears, shy
Bright, headache, mesh pain is most very.Mixed congestion, cornea lesser ring of Merkel deep layer ulcer, front empyema, liquid level are parallel with the holes Pupil lower edge.It examines
It is disconnected, right eye hypopyon ulcer (upward rushing of yellow fluid, hypopyon).Treatment wears gasification infiltration fat glasses, wears morning one time 40 minutes and smoke
It treats, wears smoked treatment in one time 30-40 minutes at night, 3 times a day, irritation disappears after 7 days, and hypopyon absorbs, ulcer healing, depending on
Power is accused and is cured up to 0.9.
3, week XX, man, 56 years old, Ganzhou City of Jiangxi Province illness symptom, patient's private prosecution left eye leads to cornea after being scratched by nail
The ulcer a few days examines after certain hospitalize is invalid on March 13rd, 2018.It checks, whole body is without discomfort.Eye, eyesight are the right side
0.08, it sheds tears, photophobia, pain, ciliary congestion (thirty), cornea is in full muddiness, and center has the deeper ulcer eyeground of a strip that cannot peep
Depending on.It is diagnosed as cornea of right eye ulcer.Gasification infiltration fat glasses are worn in treatment, are worn smoked treatment in one time 40 minutes morning, are worn at night primary
Smoked treatment in 30-40 minutes, 3 times a day, after 9 days, irritation all disappears, ulcer healing, and cornea forms nubecula, and eyesight is increased to
1.1 all diseases are all removed and are cured.
4, Liu XX, female, 43 years old, Ganzhou City of Jiangxi Province illness symptom, patient's right eye suffers from ulcer of the cornea nearly three months, through multi-party
Treatment is invalid, on 2 10th, 2018 and come to see a doctor.It checks, ordinary circumstance is fair.Right vision, light sensation are shed tears, photophobia, head
Bitterly, mesh pain most very.Mixed congestion, cornea lesser ring of Merkel deep layer ulcer, front empyema, liquid level are parallel with the holes Pupil lower edge.Diagnose right eye
Hypopyon ulcer (upward rushing of yellow fluid, hypopyon).Gasification infiltration fat glasses are worn in treatment, are worn smoked treatment in one time 40 minutes morning, are worn at night
Smoked treatment in one time 30-40 minutes, 3 times a day, after 6 days, irritation disappears, and hypopyon absorbs, and ulcer disappears and is cured.
The gasification infiltration fat glasses of the present invention have the characteristics that the following aspects：
First, in treatment, no longer as previous treatment makes the eye of people cover invisible thing, the present invention can for the eyes of people
According to the different patient's eye number of degrees, to wear different lenses fitted myopia concave lens, long sight hyperopic lens, normal
People uses plano lens.
Second is that unexpected gasification infiltration fat of the invention can penetrate eye position after eyeball barrier reaches and work, with
Natural d-borneol, L-Borneol, Angelica oil are shown containing the tissue distribution results that 70% Ligustilide is index, are not only existed
It can measure in cornea, can also be measured in vitreum and retina, after illustrating that present invention gasification infiltration fat can be reached smoothly
The creativeness of eye.
Cataract eyesight can be delayed to aggravate third, the present invention is unexpected, macular degeneration eyesight is delayed to aggravate, delay blueness
Light eye vision aggravates, retarding myopia eye vision aggravates, and inhibits lens protein denaturation and muddy new breakthrough occurs.
Both do not have to operation fourth, key of the present invention solves, be not applied to eye, eye no pain, non-stimulated, nothing directly
Side effect, advantage easy to use, and spontaneous vaporization can be played and successively gasified the novel original creation of administration.
There are gasification infiltration fat glasses that can prevent cataract, macular degeneration, myopia fifth, the present invention breaches Qian Bai Lai No
Eye, global problem of the glaucoma treatment without specific medicament.
Sixth, the present invention is solved without operative treatment initial phase and intumescent cataract, macular degeneration, glaucoma, myopia
Eye cure rate is high, fireballing new creation of fully recovering.
Seventh, the gasification infiltration fat factor of the present invention directly acts on eye, maculopathy is can effectively improve, it is rapid-action, it oozes
The saturating fat factor has the function of intervention experiment retinosis, and cure rate is high, control effect is notable.
It is oozed eigth, invention is gasified made of the Chinese medicines such as Wikstroemia indica flavones, natural d-borneol, L-Borneol, Ligustilide
Saturating fat glasses, it has the effect of dispelling screen improving eyesight, for improving and treating eye-blurred and cataract of old people, and the field of Chinese medicines
The infiltration fat glasses of gasification not yet that the gasification infiltration fat glasses pharmacopeia of prevention cataract is recorded.Being prepared in the side of choosing has centainly
Novelty, the present invention have certain social economic value and practicability.
The present invention is described in further detail with reference to the accompanying drawings and detailed description.
Description of the drawings：
Fig. 1 is the dimensional structure diagram of the present invention；
Fig. 2 is the overlooking structure diagram of the present invention；
Fig. 3 is this bright lens hanger structural schematic diagram；
Fig. 4 is the lens hanger schematic cross-sectional view of the present invention；
Fig. 5 is the lenses fitted and lenses fitted frame structural schematic diagram of the present invention；
Fat Ventilation cover structure schematic diagram is permeated in the gasification of Fig. 6 present invention；
The lens body eyeglass of Fig. 7 present invention and lenses fitted hole sleeve structural schematic diagram.
In Fig. 1-7,1. lens bodies, 2. rubber glasses frame bodies, 3. rubber seal eyeshades, 4. Rubber end cuffs, 5.
Mirror ontology eyeglass, 6. Rubber end cuffs buckle, 7. rubber nose supports, 8. frame protrusion card columns, 9. frame grooves, 10. frames and rubber
Glue glasses frame body connection card hooks, 11. gasification infiltration fat, 12. gasification infiltration fat ventilating covers, 13. lenses fitted hole sleeves, and 14.
Lenses fitted hole sleeve hole, 15. lenses fitteds, 16. lenses fitted framves, 17. gasification infiltration fat gas lid centre bores, 18. gasifications are oozed
Saturating fat ventilating cover mesh, the fixing groove in 19. rubber nose supports, the fixing groove on 20. rubber glasses frame bodies.
Specific implementation mode
Embodiment 1
Referring to Fig. 1-7, fat glasses are permeated in the gasification of prevention macular degeneration cataract myopia, by lens body 1, rubber spectacle frame master
Body 2, rubber seal eyeshade 3, Rubber end cuff 4, lens body eyeglass 5, Rubber end cuff buckle 6, rubber nose support 7, eye frame are convex
Card column 8, eye frame groove 9 are played, eye frame hooks 10 with rubber glasses frame body connection card, and fat 11 is permeated in gasification, and gasification infiltration fat is ventilative
12, lenses fitted hole sleeve 13, lenses fitted hole sleeve hole 14, lenses fitted 15, lenses fitted frame 16, it is ventilative that fat is permeated in gasification
Lid centre bore 17, gasify infiltration fat ventilating cover mesh 18, the fixing groove 19 in rubber nose support, the fixation on rubber glasses frame body
Slot 20 forms.
The front of lens body 1 is rubber glasses frame body 2 and lens body eyeglass 5；
Lens body eyeglass 5 is made of organic glass, and the front is eyeglass, and there is a frame groove 9 at middle part, behind eye frame groove 9
There are a frame protrusion card column 8, eye frame protrusion card column 8 to there is a frame to hook 10 with rubber glasses frame body connection card by the side of nose support, eye
Frame protrusion card column 8 and eye frame hook 10 with rubber glasses frame body connection card and are nested in corresponding rubber on rubber glasses frame body 2
In the fixing groove 20 in fixing groove 19 and rubber glasses frame body in nose support.
The rear portion of lens body 1 is rubber seal eyeshade 3；There are Rubber end cuff 4, rubber headgear 4 in the both sides of lens body 1
Centre have Rubber end cuff buckle 6.
There is rubber nose support 7 at the middle part of lens body 1.
It is characterized in that：
The outermost interposition of lens body eyeglass 5 is equipped with lenses fitted hole sleeve hole 14, has on lenses fitted hole sleeve hole 14
Lenses fitted hole sleeve 13, lenses fitted hole sleeve 13 can be set with the lenses fitted 15 of the different number of degrees or zero diopter.
Lenses fitted 15 and lenses fitted frame 16 are integral casing, end of the lenses fitted 15 in 16 one end of lenses fitted frame
Portion.
The centre of 5 the inside of lens body eyeglass is cased with corresponding with 13 aperture of lenses fitted hole sleeve with poroid gasification
Fat 11 is permeated, corresponding gasification infiltration fat ventilating cover 12, gasification infiltration fat ventilating cover 12 are covered with behind gasification infiltration fat 11
Centre have a gasification infiltration fat ventilating cover centre bore 17, it is ventilative that the two sides of gasification infiltration fat ventilating cover 12 is evenly equipped with gasification infiltration fat
Cover net hole 18.
The gasification infiltration fat glasses of prevention macular degeneration cataract myopia and preparation method thereof, the preparation of fat is permeated in gasification
Method, it is characterised in that：The gasification infiltration fat raw material matches composition based on following parts by weight, and it includes brother to prepare raw material
3-13 parts of king's general flavone, 35-65 parts of natural d-borneol, 30-58 parts of L-Borneol, 20-50 parts of Angelica oil, lutein 1-5
Part, -2 parts of vitamin B1.
Fat preparation method is permeated in above-mentioned gasification.Include the following steps：
Wikstroemia indica general flavone extracts
Step 1 is packed into extraction after the pulverizer of dry Wikstroemia indica 300g medicinal material good leak tightness is crushed the particle for 20 mesh
In batch can, extraction batch can is placed in extraction kettle, extraction kettle is sealed, is passed through carbon dioxide in a supercritical state and is extracted
It takes, and uses 200 milliliters of absolute ethyl alcohol as entrainer and participate in extraction, wherein extraction equipment process condition range, pressure 28,000,000
Pascal, temperature are 38 degrees Celsius, and carbon dioxide flow is 18 liters per hour, and extraction time is 2 hours,
Step 2,
Step 1 the method is prepared into gained Wikstroemia indica extract and is diluted to medicinal material, solution 1:Sample liquid is crossed polyamide by 1
Column, it is to be adsorbed completely after, first use the ethanol aqueous wash of pure water and 10-30% to remove decontamination, then water-soluble with the ethyl alcohol of 40-80%
Liquid elutes, and collects eluent, is concentrated under reduced pressure, and 70 DEG C of low-temperature vacuum drying obtains Wikstroemia indica general flavone.
Prevent the gasification infiltration fat glasses and preparation method thereof of macular degeneration cataract myopia:
The preparation method of gasification infiltration fat is as follows：
Preparing the raw material weight number meter ratio range that most preferably selects of the gasification infiltration fat of the present invention is:Wikstroemia indica general flavone 3, naturally
41 parts of d-Bomeol, L-Borneol 33, part, 17 parts of Angelica oil, 2 parts of lutein, 2 parts of vitamin B;
By 3 parts of Wikstroemia indica general flavone, 41 parts of natural d-borneol, 33 parts of L-Borneol, 2 parts of lutein, the conjunction of vitamin B2 part
And 17 parts of Angelica oil is added in one → crushing, crushed material, heating melting → being thoroughly mixed after melting → is gasified infiltration
Fat flows into spectacle case → crystallisation by cooling → and after being cooled to room temperature, is packed with plastic film, and must gasify infiltration fat glasses, using each
Kind curing eye diseases and prevention.
Operation principle：
In the use of the present invention, according to the eye conditions of patient, lenses fitted, glasses for the shortsighted is selected to select concave lens, and root
Eyeglass is selected according to patient's myopia degree；Long sight eyes select hyperopic lens, and select eyeglass according to patient's myopia degree；Presbyopia
The number of degrees select eyeglass, normal person to select zero diopter lenses fitted；Lenses fitted is sleeved on prevention macular degeneration cataract myopia
In the mider hole of gasification infiltration fat glasses；The gasification infiltration fat glasses for preventing macular degeneration cataract myopia are worn into patient's head again
It is elastic to adjust headband for portion.
Claims (2)
1. fat glasses are permeated in a kind of gasification of prevention macular degeneration cataract myopia, by lens body（1）, rubber glasses frame body
（2）, rubber seal eyeshade（3）, Rubber end cuff（4）, lens body eyeglass（5）, Rubber end cuff buckle（6）, rubber nose support
（7）, eye frame protrusion card column（8）, eye frame groove（9）, eye frame and rubber glasses frame body connection card hook（10）, gasification infiltration fat
（11）Gasification infiltration fat is ventilative（12）, lenses fitted hole sleeve（13）, lenses fitted hole sleeve hole（14）, lenses fitted（15）It wears
Wear lens hanger（16）, gasification infiltration fat ventilating cover centre bore（17）, gasification infiltration fat ventilating cover mesh（18）, in rubber nose support
Fixing groove（19）Fixing groove on rubber glasses frame body（20）Composition；
Lens body（1）Front be rubber glasses frame body（2）With lens body eyeglass（5）；
Lens body eyeglass（5）It is made of organic glass, the front is eyeglass, and there is a frame groove at middle part（9）, eye frame groove（9）
Behind（10）, eye frame protrusion card column（8）It is hooked with eye frame and rubber glasses frame body connection card（10）It is nested in rubber spectacle frame
Main body（2）Fixing groove in upper corresponding rubber nose support（19）With the fixing groove on rubber glasses frame body（20）It is interior；
Lens body（1）Rear portion be rubber seal eyeshade（3）；Lens body（1）Both sides have Rubber end cuff（4）, rubber
Headgear（4）Centre have Rubber end cuff buckle（6）；
Lens body（1）Middle part have rubber nose support（7）；
It is characterized in that：
Lens body eyeglass（5）Outermost interposition be equipped with lenses fitted hole sleeve hole（14）, lenses fitted hole sleeve hole
（14）On have lenses fitted hole sleeve（13）Lenses fitted hole sleeve（13）The lenses fitted of the different number of degrees or zero diopter can be set with
（15）
Lenses fitted（15）With lenses fitted frame（16）It is integral casing, lenses fitted（15）In lenses fitted frame（16）One end
End；
Lens body eyeglass（5）The centre of the inside is cased with and lenses fitted hole sleeve（13）Aperture is corresponding to have poroid gasification
Permeate fat（11）Gasification infiltration fat（11）Behind be covered with corresponding gasification infiltration fat ventilating cover（12）, it is ventilative that fat is permeated in gasification
Lid（12）Centre have gasification infiltration fat ventilating cover centre bore（17）Gasification infiltration fat ventilating cover（12）Two sides be evenly equipped with gasification
Permeate fat ventilating cover mesh（18）.
2. a kind of preparation method of the gasification infiltration fat glasses gasification infiltration fat of prevention macular degeneration cataract myopia, feature exist
In：The gasification infiltration fat raw material matches composition based on following parts by weight, and it includes Wikstroemia indica general flavone 3-13 to prepare raw material
Part, 35-65 parts of natural d-borneol, 30-58 parts of L-Borneol, 20-50 parts of Angelica oil, 1-5 parts of lutein, vitamin B1-2
Part；
Fat preparation method is permeated in above-mentioned gasification, is included the following steps：
Wikstroemia indica general flavone extracts
Step 1 is packed into extraction after the pulverizer of dry Wikstroemia indica 300g medicinal material good leak tightness is crushed the particle for 20 mesh
In batch can, extraction batch can is placed in extraction kettle, extraction kettle is sealed, is passed through carbon dioxide in a supercritical state and is extracted
It takes, and uses 200 milliliters of absolute ethyl alcohol as entrainer and participate in extraction, wherein extraction equipment process condition range, pressure 28,000,000
Pascal, temperature are 38 degrees Celsius, and carbon dioxide flow is 18 liters per hour, and extraction time is 2 hours,
Step 2,
Step 1 the method is prepared into gained Wikstroemia indica extract and is diluted to medicinal material, solution 1:Sample liquid is crossed polyamide by 1
Column, it is to be adsorbed completely after, first use the ethanol aqueous wash of pure water and 10-30% to remove decontamination, then water-soluble with the ethyl alcohol of 40-80%
Liquid elutes, and collects eluent, is concentrated under reduced pressure, and 70 DEG C of low-temperature vacuum drying obtains Wikstroemia indica general flavone；
Prevent the gasification infiltration fat glasses and preparation method thereof of macular degeneration cataract myopia:
The preparation method of gasification infiltration fat is as follows：
Preparing the raw material weight number meter ratio range that most preferably selects of the gasification infiltration fat of the present invention is:Wikstroemia indica general flavone 3, naturally
41 parts of parts of d-Bomeol, L-Borneol 33, part, 17 parts of Angelica oil, 2 parts of lutein, 2 parts of vitamin B;
By 3 parts of Wikstroemia indica general flavone, 41 parts of natural d-borneol, 33 parts of L-Borneol, 2 parts of lutein, the conjunction of vitamin B2 part
And 17 parts of Angelica oil is added in one → crushing, crushed material, heating melting → being thoroughly mixed after melting → is gasified infiltration
Fat flows into spectacle case → crystallisation by cooling → and after being cooled to room temperature, is packed with plastic film, and must gasify infiltration fat glasses, using each
Kind curing eye diseases and prevention；
Operation principle：
In the use of the present invention, according to the eye conditions of patient, lenses fitted, glasses for the shortsighted is selected to select concave lens, and root
Eyeglass is selected according to patient's myopia degree；Long sight eyes select hyperopic lens, and select eyeglass according to patient's myopia degree；Presbyopia
The number of degrees select eyeglass, normal person to select zero diopter lenses fitted；Lenses fitted is sleeved on prevention macular degeneration cataract myopia
In the mider hole of gasification infiltration fat glasses；The gasification infiltration fat glasses for preventing macular degeneration cataract myopia are worn into patient's head again
It is elastic to adjust headband for portion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810627433.8A CN108578523A (en) | 2018-06-19 | 2018-06-19 | Prevent the gasification infiltration fat glasses and preparation method thereof of macular degeneration cataract myopia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810627433.8A CN108578523A (en) | 2018-06-19 | 2018-06-19 | Prevent the gasification infiltration fat glasses and preparation method thereof of macular degeneration cataract myopia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108578523A true CN108578523A (en) | 2018-09-28 |
Family
ID=63628133
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810627433.8A Withdrawn CN108578523A (en) | 2018-06-19 | 2018-06-19 | Prevent the gasification infiltration fat glasses and preparation method thereof of macular degeneration cataract myopia |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108578523A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110652390A (en) * | 2019-11-10 | 2020-01-07 | 赣州安宏环保科技有限公司 | Eye shield with effect of improving eyesight for myopia and presbyopia and preparation method thereof |
| CN111685934A (en) * | 2020-07-17 | 2020-09-22 | 赣州市特可环保技术有限公司 | Eye shield with plant nano crystals and function of improving eyesight and preparation method of eye shield |
| CN114053296A (en) * | 2021-11-28 | 2022-02-18 | 赣州安宏环保科技有限公司 | Eyesight improving nano gasified rubber for myopia and its prepn |
| CN114146130A (en) * | 2021-12-18 | 2022-03-08 | 赣州安宏环保科技有限公司 | Eyesight-improving lens glue for various glasses lenses and preparation method thereof |
| CN114236877A (en) * | 2021-12-26 | 2022-03-25 | 赣州安宏环保科技有限公司 | Lens patch with effect of preventing and treating pain and dizziness of eyes watching mobile phone and computer and preparation method thereof |
-
2018
- 2018-06-19 CN CN201810627433.8A patent/CN108578523A/en not_active Withdrawn
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110652390A (en) * | 2019-11-10 | 2020-01-07 | 赣州安宏环保科技有限公司 | Eye shield with effect of improving eyesight for myopia and presbyopia and preparation method thereof |
| CN111685934A (en) * | 2020-07-17 | 2020-09-22 | 赣州市特可环保技术有限公司 | Eye shield with plant nano crystals and function of improving eyesight and preparation method of eye shield |
| CN114053296A (en) * | 2021-11-28 | 2022-02-18 | 赣州安宏环保科技有限公司 | Eyesight improving nano gasified rubber for myopia and its prepn |
| CN114146130A (en) * | 2021-12-18 | 2022-03-08 | 赣州安宏环保科技有限公司 | Eyesight-improving lens glue for various glasses lenses and preparation method thereof |
| CN114236877A (en) * | 2021-12-26 | 2022-03-25 | 赣州安宏环保科技有限公司 | Lens patch with effect of preventing and treating pain and dizziness of eyes watching mobile phone and computer and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108578523A (en) | Prevent the gasification infiltration fat glasses and preparation method thereof of macular degeneration cataract myopia | |
| CN109091675A (en) | A kind of compound low concentration atropic category medicament dropping ocular fluid and preparation method thereof | |
| CN109803652A (en) | Ophthalmic pharmaceutical compositions and its associated uses | |
| CN110652390A (en) | Eye shield with effect of improving eyesight for myopia and presbyopia and preparation method thereof | |
| CN103417525B (en) | Application of zinc gluconate tablets and six vitamin pills in treating ametropic eyes | |
| CN206566238U (en) | A kind of Chinese medicine nano magnetite for treating cataract myopia is smoked to treat piece glasses | |
| CN211095171U (en) | Eye-shade with effect of improving eyesight for myopia and presbyopia | |
| CN112121104B (en) | Traditional Chinese medicine composition for relieving asthenopia and preventing and treating myopia | |
| CN107669470A (en) | A thousand li optical glasses | |
| CN212631046U (en) | Eye shield with plant nano crystal for improving eyesight | |
| CN111685934A (en) | Eye shield with plant nano crystals and function of improving eyesight and preparation method of eye shield | |
| CN109581693A (en) | A kind of plant crystal room temperature gasification glasses preventing near-sighted cataract | |
| CN104306546B (en) | A kind of Chinese medicine composition and its decoction, pill and powder for being used to treat optic atrophy | |
| CN209070254U (en) | A kind of plant crystal room temperature gasification glasses preventing near-sighted cataract | |
| Kondrot | Improvement in vision parameters for participants treated with alternative therapies in a 3-day program | |
| US6605640B2 (en) | Method of treating certain eye diseases | |
| Luo et al. | Case Report rhegmatogenous retinal detachment due to full-thickness macular hole secondary to uveitis: a case report | |
| CN103751358B (en) | A kind of Chinese medicine composition for rescuing ametropia ophthalmic | |
| CN106344733A (en) | Eye drops for treating myopia and preparation method of eye drops | |
| von Carion | Treatise on the Diseases of the Eye, Including the Anatomy of the Organ | |
| PINCUS | ANIRIDIA CONGENITA: Report of Five Cases; Genealogy; Possibilities of Treatment | |
| Tian | A review of myopia treatment methods and their research progress | |
| Ramsay | Diathesis and ocular diseases | |
| Shaw | A Comparative Clinical Study to Evaluate the Efficacy of Triphala Choorna with Krishnadi Anjana and Triphala Choorna in the Management of Timira wsr to Senile Immature Cataract | |
| CN115120650A (en) | Traditional Chinese medicine eye drop and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20180928 |
|
| WW01 | Invention patent application withdrawn after publication |