CN211095171U - Eye-shade with effect of improving eyesight for myopia and presbyopia - Google Patents

Abstract

The utility model relates to an effect eye-shade for improving eyesight of myopia and presbyopia. The cold therapy gasified crystal box comprises an eye patch body, an eye patch front frame, an elastic silica gel eye patch, an elastic head sleeve belt, glasses body lenses, an elastic silica gel eye patch sticking hole, a cold therapy gasified crystal box, a cold therapy gasified crystal box fixing pin, a cold therapy gasified crystal box cover, a cold therapy gasified crystal box vision hole, a cold therapy gasified crystal box cover fumigation gasification hole, a cold therapy gasified crystal box cover vision hole, a fixing support, a replaceable lens antifogging hole and a replaceable lens cold therapy gasified crystal box cover vision hole; the cold therapy gasified crystal in the cold therapy gasified crystal box is prepared from ambergris ether, borneol and the like, has the curative effect of curing myopia, presbyopia and cataract in the early stage of vision below 0.8 for 1 to 16 treatment courses, and the recovery of normal vision is over 90 percent. The cold therapy gasified crystal eye cover is worn for myopia, presbyopia and cataract for 35 minutes, and then the person with half-check and three-check inequality vision can be promoted by taking off the eye cover, and the effective rate is 99.9%. Is especially effective in improving eyesight of myopia and presbyopia.

Description

Eye-shade with effect of improving eyesight for myopia and presbyopia

Technical Field

The utility model belongs to the technical field of medical instrument, especially an effect eye-shade of myopia and presbyopia promotion eyesight and preparation method thereof.

Background

A survey report by the world health organization shows that age-related macular degeneration is the third roughly blinding disease worldwide following cataract, glaucoma. It can cause diseases in all ages, mainly occurring in people over 45-50 years old. Global market research reports on age-related macular degeneration show that age-related macular degeneration is increasing at an annual composite growth rate of 9.62%. The latest domestic investigation on the incidence rate of the age-related macular degeneration is a research report published in 2018, and research results show that the prevalence rate of people over 45 years old in China is 7.96-25.13%. The population base of China is large, the population aging is more and more serious, and the incidence of age-related macular degeneration is higher than the statistics. To date, the pathogenesis of both age-related macular degeneration and juvenile macular degeneration is still unclear in modern medicine, no specific therapeutic drug or means is available, no good method for preventing the progress of the disease is found, and the treatment is still very difficult.

Cataracts are the clouding of the lens in the eye from transparent to opaque, which impedes the passage of light into the eye and thus affects vision. The initial opacity of a cataract has little effect on vision and then gradually worsens, eventually affecting vision to blindness. Cataract is caused by many reasons, such as congenital, traumatic, concurrent, toxic, radiation, etc., which can cause the metabolic disorder of crystalline lens, leading to the degeneration of crystalline lens protein and leading to opacity, so the cataract is called. The opacity of the crystalline lens begins to increase in density from the central part of the crystalline lens, i.e., the position of the embryonic nucleus, gradually worsens and slowly expands to the periphery, and is yellowish in early stage, and gradually deepens the color as dark yellow and dark brown yellow along with the worsening of the opacity. Cataract patients often show unilateral or bilateral nature, the onset of both eyes can be sequential, the vision is progressively declined, the refractive powers of different parts of crystalline lens are different due to the opacity of crystalline cortex, the glare is generated, or monocular diplopia, the myopia degree is increased, and the like. The incidence of cataract is more often above 45 years old, the incidence increases with the age, at present, the incidence of cataract in the aged 45-60 years old is 60-70%, 80% above 70 years old, and almost 100% in the aged above 80 years old. Cataract is one of the leading causes of blindness worldwide, about 5 million people in the world now cause blindness due to cataract, and another 1.5 hundred million patients with cataract need surgery to recover vision, in most africa and asian countries, cataract accounts for at least half of the blind, and people with cataract in the age range of 45-89 years in our country account for 95.10% of all cataract blindness. Cataract patients account for 46.7% of the visually handicapped, and senile cataract is the first of various eye diseases in the elderly with visually handicapped. Effective prevention and cure of SC in time has become a priority.

To date, the drugs for treating cataract are: bevacizumab, avastin, pegaptanib sodium injection, combisipt, aflibercept, alitame, ranibizumab, and norubicin. Also laser photocoagulation, transpupillary thermotherapy, photodynamic therapy, artificial lens re-implantation, surgery, radiotherapy, etc. Senile cataract is divided into four stages clinically, namely an initial stage, a swelling stage, a mature stage and an over mature stage. Modern medicine has had more advanced operative therapy to senile cataract of mature period, but because the operative therapy waits to the operation of the mature period or the over mature period of cataract, and the cost of the operation is expensive, but the curative effect to the early stage and the swelling period of cataract is not good, the long process from the early stage to the mature period undoubtedly brings great inconvenience to patients and families thereof, therefore, it is more important to the patients to develop the effective and convenient treatment and prevention of the early stage of cataract, and the research and the manufacture of gasified and permeated lipid glasses have significant practical significance.

The myopic eye brings much inconvenience to people, the corrective effect can be achieved by matching the glasses, but the myopic eye cannot be treated, the myopic degree is generally lower than 6 diopters (-600 degrees), and the development stops when the myopic eye is about 20 years old. However, the progress of the myopia in young years is fast, the progress is faster to 13-20 years old, and the progress is slowed later, so that the myopic eye is usually higher than 6 diopters and can reach 20 or 30 diopters, namely, the lens is from-2000 to-3000 degrees. This myopia is called severe myopia or progressive myopia, also called pathological myopia. The myopia can be degenerative and gradually reduced by the late years, and the eyes cannot be corrected by glasses fitting, so that most of the eyes finally cause blindness. Myopia is listed as one of three diseases in the world, the number of myopia people in China is nearly 4.5 hundred million, wherein teenagers are about 3.5 hundred million, and the myopia is played by the central 2 players in 6.5.6.8.8.8.8 months, and the myopia is 88.77% for college students, 88.3% for high school students, 74.4% for junior students, 45.7% for primary school students, and about 9% for newly-increased myopia every year. The prevention and treatment of myopia is an urgent need of our country and even people all over the world, and the low vision of teenagers is a serious social and medical problem.

Corneal opacities in myopic eyes manifest as a whitening of the normal clear cornea. This loss of transparency of the cornea can cause symptoms ranging from blurred vision to blindness. Current treatments for myopia and amblyopia generally include: fog vision therapy, betz therapy, wearing glasses, laser surgery, traditional chinese medicine massage, and acupuncture. The fog-vision therapy is to wear an orthophotoscope to see nearby objects at the early stage of myopia or during non-myopia, and mainly plays a role in preventing myopia; the Betz therapy adjusts the muscles around the eyes by training the visual target to look far and near, but the treatment time of the method is long and the effect is not obvious; the eyes can see things clearly when wearing the glasses, but the degree of the eyes is increased continuously, and no treatment effect is produced; the laser operation is to cut the cornea of the eye, forcibly change the angle of light entering the eye, and damage the eye, and the fact proves that sequela exists; traditional Chinese medicine massage and acupuncture therapy are limited by technology, and have the disadvantages of complex operation, strong technical performance, low efficiency and rebound.

At present, myopia prevention and treatment methods, acupuncture treatment, ear acupuncture therapy, acupoint treatment, acupoint massage methods, electromagnetic therapy, instruments, medicines and the like are diversified, myopia glasses can be used for correction, but treatment cannot be achieved, myopia cannot be delayed, prevention cannot be achieved, and only vision degrees are aggravated with data increase. The existing hundreds of medicines for treating myopia have no effect actually, and particularly have great defects on the myopia treatment effect of teenagers.

In modern medicine, western medicines for treating cataract are mainly used for cataract, while no preparation pharmacopoeia for preventing and treating cataract in the field of traditional Chinese medicines is available. The vitreous injection preparation is expensive, and the price of each preparation is different from thousands yuan to tens of thousands yuan. In addition, the vitreous injection preparation is frequently used, generally needs to be injected once every month, and is also injected once every 2-3 months, so that the tolerance of a patient is poor, certain damage to an eyeball can be caused in use, and certain risk is caused. The injection directly acts on the administration site, so that the vitreous injection preparation has obvious effect and relatively large side effect.

The Chinese medicinal treatment medicaments for preventing and treating cataract, myopia and the like by internal treatment and external treatment are reported in documents as follows: the internal treatment mainly comprises oral liquid, decoction, granules, pills, granules, tablets, capsules and the like. The internal treatment mainly comprises the oral liquid for removing obstacles, the compound ginseng fruit liquid, the soup for promoting blood circulation and removing obstacles, the granules for recovering eyesight, the pill for treating obstacles No. 1, the pill for removing nebula, the tablet for recovering eyesight, the capsule for consolidating the foundation and improving eyesight, the pill for removing obstacles and improving eyesight, the pill for golden flower and improving eyesight, the oral liquid for removing cataract, the compound granules for removing obstacles for sugar, the bear gall pill and the like. These drugs are poor or ineffective and have large side effects.

The external treatment method mainly comprises powder, eye drops and eye patches. In addition, the literature of treating cataract with traditional Chinese medicine film agent and injection is also seen. For example, she zhu ming min san, ZYM ye's solution, bai nei ting (pirenoxine sodium) eye drops, eye freeze-dried injection for eliminating cataract, xue fu ming yan ye's solution, compound leech eye drops, compound Chinese medicine eye drops, qu xue ling ye's solution, xue yi san eye drops (made into xu yi san, prepared for use) etc. The local eye drops have small drug-loading rate, and patients need to use the eye drops frequently to meet the needs; the topical eye drops are liquid preparations, which have poor bioadhesion and short retention time in the eyes, and although they are convenient to use, they are small in dosage and short in time of acting on the eyes, and thus they are easily eliminated, and their preventive and therapeutic effects are poor or ineffective. The local eye drops are extremely difficult to penetrate through the physiological structure of the eyeball to reach the posterior eye part, and have certain toxic and side effects.

In recent years, cold therapy gasified crystals for preventing and treating myopia, presbyopia and cataract at home and abroad are worn and used in eyeshades and are widely concerned by researchers, many experts and scholars want to study the cold therapy gasified crystals, but one person does not succeed in the study, so that the registration, paper report and patent registration for preventing and treating myopia, presbyopia, cataract and macular degeneration through wearing eye shade cold therapy gasification permeation are not carried in the preparation pharmacopoeias at home and abroad so far, and therefore, the eyeshade for improving the eyesight of the myopia and presbyopia has the effect. Is still blank at home and abroad.

Disclosure of Invention

In order to overcome the major defects that the existing technologies such as glasses, eyepatches, eye patches, eye drops and the like at home and abroad can not take off the glasses to cure the myopia, presbyopia and cataract at the early stage of vision (0.8), the myopia at the middle stage, presbyopia and cataract can not be relieved, the vitreous body injection cost is high, the operation is troublesome and risky, and particularly, the glasses, the eyepatches and the eye patches cannot be continuously gasified and permeate to cornea, crystalline lens, vitreous body, retina and optic nerve at room temperature, and the vision can not be relieved by using medicines, wearing glasses and wearing the eyepatches.

In order to solve the serious defects, the invention provides a cryotherapy gasified crystal which is arranged in an eye shield and can effectively prevent and cure myopia, presbyopia and cataract with less than 0.8 visual acuity in the early stage. Can be used for relieving myopia, presbyopia, and cataract. Effectively improve myopia vision, presbyopia vision and cataract vision, and can improve three consistent vision (calculated by taking the visual chart as a standard grid number) by removing the eye mask after wearing the eye mask for 35-45 minutes for early-stage myopia, presbyopia, cataract or middle-stage myopia, presbyopia and cataract. The eye patch has the effects of preventing and treating myopia and cataract without operation, effectively repairing crystalline lens, preventing vitreous opacity, effectively relieving cataract vision aggravation, macular degeneration vision aggravation, myopia vision aggravation, glaucoma vision aggravation and degenerative eye disease, has the effects of penetrating and removing nebula, is high in cure rate, remarkable in prevention and treatment effect, free of pain and irritation of eyes, convenient to use and exact in treatment effect, is not directly applied to the eyes, and does not have side effect, and the preparation method of the eye patch is high in cure rate. .

The invention aims to provide an effect eye shield for improving eyesight of myopia and presbyopia and a preparation method thereof.

The front part of the glasses body is provided with a rubber glasses frame main body and glasses body lenses, and the middle part is provided with a sponge silica gel pad nose support;

elastic head sleeve belts are arranged on two sides of the front part of the glasses body, and a head sleeve belt magic tape is arranged at one end of each elastic head sleeve belt, so that a user can adjust and fix the glasses body;

the method is characterized in that:

four fixing holes of the cold therapy gasified crystal boxes are correspondingly arranged on the lenses of the glasses body, and the fixing pins of the cold therapy gasified crystal boxes are inserted into the fixing holes for fixing;

the back of the lens of the glasses body is provided with an elastic silicon rubber eye mask pad which is curved concave, and the middle of the elastic silicon rubber eye mask pad is provided with an elastic silicon rubber eye mask pad hole;

the elastic silicon rubber eye mask pad hole is correspondingly provided with a cryotherapy gasified crystal box, the cryotherapy gasified crystal box is also in a curved concave shape, the middle part of the cryotherapy gasified crystal box is provided with a cryotherapy gasified crystal box vision hole, the bottom of the cryotherapy gasified crystal box is correspondingly provided with four cryotherapy gasified crystal box fixing pins, cryotherapy gasified crystals are arranged in the box, a cryotherapy gasified crystal box cover is arranged above the cryotherapy gasified crystals in the box, the cryotherapy gasified crystal box cover is uniformly provided with cryotherapy gasified crystal box cover fumigation gasification holes, and the middle part of the gasified crystal box cover is provided with a cryotherapy gasified crystal box vision hole;

the replaceable lens sleeve and the replaceable lens are embedded in the vision hole of the cryotherapy gasified crystal box.

Another object of the present invention is to provide a method for preparing the above gasified crystal for cryotherapy, which comprises the steps of: a preparation method of eye shield cold therapy gasified crystal with the effect of improving eyesight of myopia and presbyopia is characterized by comprising the following steps:

the cold therapy gasified crystal raw materials comprise, by weight, 3-15 g of ambergris ether, 15-32 g of borneol, 5-23 g of dextro-borneol acetate, 5-12 g of methyl cedryl ketone, 5-17 g of angelica oil and 0.3-3 g of curcumin;

the best selected raw materials comprise, by weight, 15g of ambergris ether, 32 g of borneol, 23 g of dextro-borneol acetate, 11 g of methyl cedryl ketone, 17 g of angelica oil and 3 g of curcumin;

the preparation method of the cryotherapy gasified crystal comprises the following steps: mixing 15g of ambergris ether, 30 g of borneol and 20 g of dextro-borneol acetate together → crushing, adding 11 g of methyl cedryl ketone and 17 g of angelica oil into the crushed material, heating and melting → fully stirring and mixing after melting → leading the cold therapy gasified crystal liquid to flow into an eyeshade box → cooling and crystallizing → cooling to room temperature, and sealing and packaging by using a plastic film to obtain the cold therapy gasified crystal eyeshade.

The eye patch with the effect of improving the eyesight of the myopia and the presbyopia and the preparation method thereof are characterized in that:

the preparation method of ambergris ether comprises the following steps:

stirring 0.001mol of ferric trichloride and 0.01mol of ambergris diol in 20ml of acetone for 16 hours, reacting at 22 ℃ to obtain a reacted filtrate, filtering the reacted filtrate, performing rotary evaporation treatment on the filtered filtrate, obtaining a crude ambergris ether after the rotary evaporation of the reacted filtrate is finished, and performing column chromatography purification on the crude ambergris ether to obtain an ambergris ether finished product;

the preparation method of borneol comprises the following steps:

adding 10.0g of crude borneol (commercial borneol containing 60.6 wt% of borneol), 1.0g of boron anhydride catalyst, 2.5g of metatitanic acid catalyst and 15.0g of anhydrous oxalic acid into a 250m L-opening round-bottom flask, stirring and condensing and refluxing 30.0g of n-hexane serving as a solvent, keeping the temperature at 54-56 ℃ for 24 hours, removing the solvent, camphene and tricyclene after the reaction is finished, saponifying the residual liquid to obtain a crude product, refining to obtain 3.1g of borneol product with the content of 88.1% (88.1: 8.1) and the extraction rate of the borneol of 45.1%;

the preparation method of the dextro borneol acetate comprises the following steps:

taking natural d-borneol and acetic anhydride as raw materials, feeding the acetic anhydride and the natural d-borneol into reaction solvent petroleum ether according to the mass ratio of 1-2: 1, wherein the material-liquid ratio of the natural d-borneol to the petroleum ether is 1: 10-15 g/ml, wherein the reaction solvent contains P2O5 or P2O5-H3PO4 as a catalyst, the dosage of the catalyst is 5-10% of the mass of the natural d-borneol, the reaction temperature is 55-75 ℃, the esterification reaction is carried out for 4-10H under the normal pressure condition, and the d-borneol acetate is obtained after purification;

the preparation method of the methyl cedryl ketone comprises the following steps:

adding 210 g of cedrene and 15g of niobic acid loaded aluminum chloride catalyst into a reaction kettle, stirring and heating to 55 ℃ for isomerization reaction for 2h, converting β -cedrene into α -cedrene, then starting to dropwise add 320 g of acetic anhydride, stirring and heating to 60 ℃ after 30min of dropwise addition is finished, carrying out acetylation reaction for 7 h, converting α -cedrene into methyl cedryl ketone by acetylation, converting α -terpineol into terpinyl acetate by acetylation, rectifying a product after the reaction is finished, distilling acetic anhydride and acetic acid, then adding a proper amount of crushed ice, keeping a reaction mixture at a temperature lower than 40 ℃, continuing stirring for 0.5h, standing for layering, separating an oil layer and a water layer, washing the oil layer to be alkalescent by using 10% sodium carbonate solution, washing the oil layer to be neutral by using saturated salt and deionized water, removing the water layer, rectifying the washed oil layer, collecting 140-160 ℃/0.67 kPa fraction, obtaining a methyl cedryl ketone product, wherein the yield is 82.5%, and the ketone content is 83.4%.

The use method of the effect eye mask comprises the following steps:

wearing the cold therapy gasified crystal eye mask on eyes, wearing the eye mask for fumigation therapy for 30-45 minutes once in the morning, wearing the eye mask for fumigation therapy for 30-45 minutes once in the evening, and taking 2-3 times a day for 1 month as 1 course of treatment.

Effect experiment verification;

1. the cold therapy gasified crystal eye patch has the curative effect of curing myopia, presbyopia and cataract in the early stage of below 0.8, and the lens is taken out for 1 to 16 courses of treatment, and the normal vision is recovered by more than 90 percent.

2. When wearing the cold therapy gasification crystal eye mask, people who see mobile phones, computer eyes, pains and people with eye fatigue wear the eye mask for 20-30 minutes, the cure effect is 100%.

3. The cold therapy gasified crystal eyeshade can not cure macular degeneration, cataract, glaucoma and myopia after the middle period, and can only relieve the effect that the vision is not aggravated any more, and the effective rate is more than 95 percent.

4. The cold therapy gasified crystal eye mask has the cure effect on dry eyes, pinkeye and bacterial eye diseases for 2 to 16 days, and the effective rate is 99 percent

5. The eye mask is worn for 20 minutes every day for normal eyes of people over six years old, and has the effects of efficiently preventing various eye diseases and the effective rate of 100 percent.

6. After wearing the cold therapy gasified crystal eye mask for myopia, presbyopia and cataract for 35-45 minutes, people with half-grid three-unequal vision (calculated by taking the visual chart as a standard grid number) can be promoted by taking off the eye mask, and the effective rate is 99.9%.

7. 99.9 percent of people wear the cold therapy gasified crystal eyeshade for 20 to 45 minutes, and then feel bright and comfortable.

8. The cold therapy gasified crystal eye patch has the advantages of preventing and treating myopia, preventing cataract without operation, effectively repairing crystalline lens, preventing vitreous opacity, effectively relieving cataract and non-aggravation of vision, effectively relieving macular degeneration and non-aggravation of vision, effectively relieving myopia and non-aggravation of vision, effectively relieving glaucoma and non-aggravation of vision, effectively relieving degenerative eye disease, having the effects of permeating and removing nebula, being high in cure rate, remarkable in prevention and treatment effect, not directly applied to eyes, free of pain and irritation to the eyes, free of side effects and convenient to use.

The cold therapy gasification crystal eye mask has the pharmacological treatment effects that:

1. the borneol and the angelica oil containing 70 percent of ligustilide and other medicaments are used together to play the effect of respective active factors, the molecular weight is small, the fat solubility is strong, and the cryotherapy gasified crystal has strong functions of penetrating and promoting glial cells, can cross the cornea, the crystalline lens, the vitreous body, the retina and the blood brain barrier, reaches the posterior eye part to play the roles of treating pterygium of corneal regression and inhibiting the degeneration of proteins of the crystalline lens of the eyeball to generate turbidity, and quickens the restoration of the cornea and the vitreous body;

2. the crystal of the cold therapy gasified crystal eye shield can assist active factor components to directly penetrate through an eyeball barrier to act on the posterior eye part, and the cold therapy gasified permeable crystal factors enter various cells to cross cell membranes and can smoothly reach the posterior eye part to kill virus infection so as to play a curative effect;

3. the cold therapy gasification crystal eye mask uses ambergris ether, borneol, dextro-borneol acetate, methyl cedryl ketone, angelica oil (containing ligustilide) and curcumin as indexes, and the tissue distribution result shows that the eye mask can be detected not only in the cornea, but also in the vitreous body and retina. Has a new breakthrough of penetrating cornea, vitreous body and retinal blood vessels into the interior of eye tissues.

Long-term toxicity test of cryotherapeutic gasified crystal in cryotherapeutic gasified crystal eye shield:

the cold therapy gasified crystal is taken as an object, 50 adult rats are selected and randomly divided into 5 groups, a control group and four groups of test groups, each group comprises 10 animals, and the dose of each group is 0.1 (500 m/K BW), 0.15 (750 m/K BW), 0.22 (1100 m/K BW) and 0.34 (1700 m/K BW) of L D50, the stomach is irrigated once a day for 20 days continuously, and then the observation is carried out for 7 days.

Cold therapy gasified crystal allergy test of the cold therapy gasified crystal eye cover;

the cold therapy gasified crystal is taken as an object, 30 healthy guinea pigs are taken for test, male and female ginseng halves are subjected to back removing and hair removing treatment before administration, the five groups are randomly divided into 6 groups, each group is respectively a control group, the damaged skin is 0.5mg in dosage which is 1 time higher, 1mg in dosage which is 2 times lower and 1mg in dosage which is 1 time higher, and the intact skin is 0.5mg in dosage which is 2 times lower and 1mg in dosage. After subcutaneous administration was performed once a day for 7 days, the conditions of the groups were observed, and as a result, all the guinea pigs survived, and no discomfort occurred to the skin of the guinea pigs of each group, and no significant abnormality occurred in the feeding, activity, respiration, body weight, and the like of the guinea pigs. The results show that the drug is not allergenic. Pharmacological and pharmacodynamic tests show that the medicine has no toxic effect, sensitization and adverse reaction, and is safe in clinical use.

Firstly, clinical trial for treating cataract:

324 patients with initial cataract of the same vision degree were divided into two groups according to the type of cataract, and were provided with cold therapy gasified crystal eyeshade.

Experimental method, two groups of patients all wear the cold therapy gasification crystal eyeshade for 2-16 courses of treatment, the experimental effect of treating cataract type is shown in Table 2

Clinical tests show that the effective rate for treating cataract is 100%, the effective rate is fast, the treatment course is short, the curative effect is exact, the cure rate is high, the cure speed is fast, and no side effect is generated.

Typical treatment cases:

1. for those who suffer from cataract of 0.8 in 45 years old or 45 years old in Liu, the vision gradually blurs, sometimes the eyes are not bright enough and the color of the object is not bright enough. 2 patients all had middle-aged women, and the cataract was cured completely after 3 courses of treatment with the cold therapy gasified crystal eyeshade.

2. In short-term patients with 0.8 primary cataract and vision disease in Zhangqi, male, 49 years old and Jiangxi county, the vision is blurred, and double or multiple shadows are easily produced. 3 patients in total, all of which are middle-aged and old men, are completely cured after wearing the cold therapy gasification crystal eyeshade to treat cataract for 3 courses of treatment after long-term housework.

3. Liangqi, male, 56 years old, Rejin, with cataract visual deterioration of 0.7 disease and more severe patients. The specific symptoms are blurred vision, slight darkness and abnormal color vision. The disease condition of 2 middle-aged male patients and 2 middle-aged female patients is basically controlled after wearing the cold therapy gasification crystal eyeshade for 6 treatment courses, and the cold therapy gasification crystal eyeshade needs to be continuously relieved and stabilized at 0.8 eyesight.

4. In Song Dynasty, male, age 63, patients with 0.5 percent of cataract with long-term vision deterioration in Ruik City, the specific symptoms are fixed position, unchanged shape, punctate or sheet shadow in front of eyes, and the vision is affected. The symptoms of 2 patients are relieved after 6 courses of cold therapy gasification crystal eyepatches, the cold therapy gasification crystal eyepatches are kept stable at 0.6 vision after 6 courses of cold therapy gasification crystal eyepatches, and the cold therapy gasification crystal eyepatches are required to be continued to relieve.

Secondly, clinical trial for treating myopia;

the 300 patients with myopia with the same degree were divided into three groups according to the type of myopia, and were provided with cold therapy gasified crystal eyeshades.

Experimental method, the treatment results of 1-12 courses of treatment of all cold therapy gasified crystal eyeshades of three groups of patients are shown in table 3:

clinical tests show that the effective rate of treating myopia is 100%, the effect is quick, the treatment course is short, the curative effect is exact, the cure rate is high, the cure speed is high, and no side effect is generated.

Typical cases of myopia:

roxxx, female, jiang west prefecture, 13 years old, five-year-old student, myopia at 0.8 degree of vision, astigmatism. From three years, parents run through numerous hospitals in order to prevent the parents from wearing glasses, ear acupoint massage, eye paste, acupuncture and moxibustion and the like are almost used, various myopia treatment devices bought at home are all the more available, the visual power fluctuates at 0.8 constantly, and the sight of eyes is squinted into a line. After 2 courses of cold therapy and gasification of the crystal eyeshade, the vision of both eyes is recovered to be naked vision 1.3.

Zhang XX, female, 15 years old, Jiangxi Ganzhou city, the vision of the left eye before treatment is 0.85, and no obvious curative effect exists in the national hospital for massage treatment for one year. After 2 courses of cold therapy with gasified crystal eyeshade, her left eye vision was 1.2 and her right eye vision was 1.5 and fully recovered.

Blue XX, male, 20 years old, the greater part of Jiangxi, play games on night, the physical examination eyesight is 4.8, the spectacles are worn, the degree of the lenses is 400 degrees, the hospital recognizes pseudomyopia, and no obvious improvement exists after treatment by means of the medicine eye drops and the eye massager. After 4 weeks, the lens degree is reduced to 200 degrees, and after one course of treatment, the vision is recovered to 1.2 normal, so that the patient always uses the lens eye mask, and the effect of relieving the asthenopia is very good.

XX, male 17 years old, Jiangxi Confucian for 3 years of myopia, naked eye vision is 4.1 in the left eye and 4.4 in the right eye, no glasses are used for correcting vision, people are accustomed to squinting, eyes are dry and astringent, fatigue is easy to occur, and people do eye exercises all the year round and difficultly maintain vision, but only can recover vision transiently. After the cold therapy gasification crystal eye mask is used for two weeks, the vision clarity is improved, the fatigue feeling disappears, after the cold therapy gasification crystal eye mask is continuously used for 2 treatment courses, the vision is recovered to 5, the vision of the right eye is recovered to 4.8, and the vision is still maintained until now.

Liu XX, female, 45 years old, Ganzhou, was myopic in the eyes from 17 years old, she had contact lenses with 4.3 plus degrees all the time, and had severe astigmatism. After 2 courses of cold therapy and gasification of the crystal eyeshade, the eyes can achieve the effect of relieving the vision by 4.1.

Thirdly, clinical test for treating keratitis;

255 patients with the same degree of keratitis were divided into two groups according to the type of keratitis, and cold therapy was performed to gasify the crystalline eye patches.

Experimental method, two groups of patients all cold-cure the gasified crystal eyeshade for 6-16 days to treat keratitis.

Results of the keratitis-type treatment experiment table 4:

clinical tests show that the effective rate for treating keratitis is 100%, the medicine has the advantages of quick response, short treatment course, exact curative effect, high cure rate, quick cure speed and no side effect.

In the case of a typical patient,

1. the patients with XX, women and 53 years old, Jiangxi Jiangzhou city, the right eye is scratched by branches to cause corneal ulcer for about three months, and the effects of various therapies used in a certain hospital are not obvious, and the treatment is called out in 2018, 11 and 13 days. The general condition was good. Ocular conditions, vision 0.05 right, lacrimation, photophobia, pain, ciliary hyperemia (thirty), full opacity of the cornea, a deep stripe of ulcer in the center, inability to spy on the fundus. Right corneal ulcer (pannus) was diagnosed. The cold therapy gasification crystal eye mask is worn for 45 minutes in the morning and for 30-45 minutes in the evening, the fumigation therapy is carried out 5 times a day, after 7 days, the stimulation symptom disappears, the ulcer is healed, the cornea forms slight corneal opacity, the vision is improved to 1.2, and the disease is cured.

2. The patients with XX, female and 45 years old, Jiangxi Jiangzhou city in Jiangxi province have symptoms, the right eye has corneal ulcer for nearly five months, and the patients are initially diagnosed in 2018 in 25-6 months after various treatments are ineffective. The examination was generally good, and the left eye was normal. The vision of the right eye is 0.1, the sensation of light, lacrimation, photophobia, headache and even eye pain. Mixed congestion, deep ulceration in the pupillary region of the cornea, pus accumulation in the front, level parallel to the lower edge of TONG-Kong. And diagnosing, namely, the purulent corneal ulcer (upper yellow humor) in the right anterior chamber. The cold therapy gasification crystal eye mask is worn for 40 minutes in the morning and for 30-45 minutes in the evening, the cold therapy gasification crystal eye mask is worn for 3 times a day, stimulation symptoms disappear after 13 days, the amazing symptom is absorbed, the ulcer is healed, the vision reaches 0.8, and the patient is cured.

3. The patients who suffer from symptoms of acute corneal ulcer in Jiangxi province, Ganzhou city, XX, 55 years old and Jiangxi province are complained that the left eyes are scratched by nails to cause corneal ulcer for a plurality of days, and the patients are diagnosed in 2019, 1 month and 16 days after the treatment of certain hospital is ineffective. No discomfort of the whole body is detected. The vision of the eye is 0.6 on the right, lacrimation, photophobia, pain, ciliary hyperemia (thirty), the cornea is totally turbid, and the fundus with a deep strip in the center cannot be peeped. Corneal ulcer of the right eye was diagnosed. The cold therapy gasification crystal eye mask is worn for one time of 40 minutes for fumigation therapy in the morning and is worn for 30-40 minutes for fumigation therapy in the evening, 5 times a day, after 15 days, stimulation symptoms are completely disappeared, ulcer is healed, corneal nebula is formed, and vision is improved to 1 and all symptoms are cured.

4. Liu XX, female, 40 years old, Jiangxi province Ganzhou city diseased symptoms, patients suffered from corneal ulcer in the right eye for nearly three months, and the patients were ineffectively treated by multi-party treatment, and were visited before 3 months and 12 days in 2019. The inspection is generally good. The right eye has sight, light sensation, lacrimation, photophobia, headache and even eye pain. Mixed congestion, deep ulceration in the pupillary region of the cornea, pus accumulation in the front, level parallel to the lower edge of TONG-Kong. And diagnosing, namely, the purulent corneal ulcer (upper yellow humor) in the right anterior chamber. The cold therapy gasification crystal eye mask is worn for 40 minutes in the morning and for 30-40 minutes in the evening, the cold therapy gasification crystal eye mask is used for treating, the fumigation therapy is worn for 5 times every day, after 9 days, the stimulation symptom disappears, the intracameral pus is absorbed, and the ulcer disappears and is healed.

The utility model has the advantages that:

1. during treatment, the eyes of a person do not shield the eyes of the person from seeing like the prior treatment, and the invention can wear different myopia lenses for wearing lenses, hyperopia lenses for wearing lenses and plain lenses for normal people according to different eye degrees of the patient.

2. The invention is an unexpected important breakthrough that the vision of cataract can be effectively relieved from aggravation, the vision of macular degeneration can be effectively relieved from aggravation, the vision of myopia can be effectively relieved from aggravation, the vision of glaucoma can be effectively relieved from aggravation, degenerative ophthalmopathy can be effectively relieved, and opacity caused by degeneration of eyeball lens protein can be inhibited.

3. The invention solves the key problem that the medicament can not be applied to eyes directly without operation, has the advantages of no pain, no stimulation, no side effect and convenient use, and can also exert the new creation of continuous gasification administration by natural gasification.

4. The invention breaks through the worldwide problem that the crystal eyeshade with cold therapy gasification can prevent and treat cataract, myopia and presbyopia for hundreds of years.

5. The curative effect is 1 to 16 courses of treatment, the glasses are removed, and the normal vision is recovered by more than 90 percent for the myopia, presbyopia and cataract in the early stage of vision which is less than 0.8.

6. The unexpected technical effect shows that the curative effect of the cold therapy gasified crystal eye mask for 20-30 minutes is 100 percent for the mobile phone, the computer eye pain patients and the eye fatigue patients.

7. The cold therapy gasified crystal eye mask has the effect effective rate of more than 95 percent on the macular degeneration, cataract, glaucoma, and no more aggravation of vision after the myopia middle period.

8. The cold therapy gasified crystal eye mask has the cure effect on dry eyes, pinkeye and bacterial eye diseases for 2 to 16 days, and the effective rate is 99 percent

9. The cold therapy gasified crystal eye mask is worn on normal eyes of people over six years old once a day for 20 minutes, so that the cold therapy gasified crystal eye mask has the advantages of high-efficiency prevention of various eye diseases, and obvious 100% effective rate prevention and treatment effect.

10. After the cold therapy gasified crystal eye mask for myopia, presbyopia and cataract is worn for 35-45 minutes, the unexpected technical effect that people with three different vision half-cells (calculated by taking an eye chart as a standard cell number) can be improved by taking off the eye mask, and the effective rate is newly created with 99.9%.

11. 99.9 percent of people with unexpected technical effect feel bright and comfortable after wearing the cryotherapy gasified crystal eye mask for 20-45 minutes.

12. The invention relates to a new breakthrough that ambergris ether, borneol, dextro-borneol acetate, methyl cedryl ketone, angelica oil (containing ligustilide) and curcumin are taken as indexes, the tissue distribution result shows that the ambergris ether can be detected in cornea, vitreous body and retina, and the unexpected technical effect that the medicine can penetrate through the cornea, vitreous body and retina blood vessel and enter the interior of eye tissue. The preparation has certain innovation in the aspect of selection.

Description of the drawings:

FIG. 1 is a schematic view of a three-dimensional structure of the utility model

Fig. 2 is a schematic top view of the utility model;

FIG. 3 is a schematic perspective view of the elastic rubber-silica gel eye mask pad and the cryotherapy gasified crystal box of the utility model;

FIG. 4 is a schematic cross-sectional view of the flexible silicone rubber eyeshade cushion and cryotherapy gasified crystal capsule of the present invention;

FIG. 5 is a schematic perspective view of the cryotherapy gasification crystal cover of the utility model;

FIG. 6 is a schematic structural view of the interchangeable lens cover of the present invention;

fig. 7 is a schematic sectional view of the replaceable lens of the present invention.

In the picture 1-7, 1 is eye cover body, 2 is eye cover front mirror bracket, 3 is elastic silicon rubber eye cover pad, 4 is elastic head sleeve belt, 5 is glasses body lens, 6 is head sleeve belt magic subsides, 7 is sponge silica gel pad nose support, 8 is elastic silicon rubber eye cover pad hole, 9 is cold therapy gasified crystal box, 10 is cold therapy gasified crystal, 11 is cold therapy gasified crystal box fixed pin, 12 is cold therapy gasified crystal box cover, 13 is cold therapy gasified crystal box vision hole, 14 is cold therapy gasified crystal box cover fumigation gasification hole, 15 is cold therapy gasified crystal box cover vision hole, 16 is fixed stay, 17 is interchangeable lens antifog hole, 18 is interchangeable lens, 19 is interchangeable lens cover, 20 is cold therapy gasified crystal box cover vision hole.

Detailed Description

Example 1

Referring to fig. 1-6, the embodiment of the present invention is an eye mask with effect of improving eyesight for myopia and presbyopia and a method for making the same, wherein the eye mask comprises an eye mask body 1, an eye mask front frame 2, an elastic silicone rubber eye mask pad 3, an elastic head sleeve belt 4, a glasses body lens 5, a head sleeve belt magic tape 6, a sponge silicone rubber pad nose support 7, an elastic silicone rubber pad hole 8, a cold therapy gasified crystal box 9, a cold therapy gasified crystal 10, a cold therapy gasified crystal box fixing pin 11, a cold therapy gasified crystal box cover 12, a cold therapy gasified crystal box eyesight hole 13, a cold therapy gasified crystal box cover fumigation gasification hole 14, a cold therapy gasified crystal eyesight cover hole 15, a fixing support eye mask 16, an interchangeable lens antifogging hole 17, an interchangeable lens 18, an interchangeable lens sleeve 19, and a cold therapy gasified crystal box cover eyesight hole 20.

The front part of the glasses body 1 is provided with a rubber glasses frame main body 2 and glasses body lenses 5, and the middle part is provided with a sponge silica gel pad nose support 7;

two sides of the front part of the glasses body 1 are provided with elastic head sleeve belts 4, and one end of each elastic head sleeve belt 4 is provided with a head sleeve belt magic tape 6, so that a user can adjust and fix the glasses body 1;

the method is characterized in that:

four fixing holes of the cryotherapy gasified crystal box 9 are correspondingly arranged on the lens 5 of the glasses body, and a cryotherapy gasified crystal box fixing pin 16 is inserted into the fixing holes for fixing;

the back of the lens 5 of the glasses body is provided with an elastic silicon rubber eye mask pad 3, the elastic silicon rubber eye mask pad 3 is in a curved concave shape, and the middle part of the elastic silicon rubber eye mask pad is provided with an elastic silicon rubber eye mask pad hole 8;

the elastic silicon rubber eyeshade pad hole 8 is correspondingly provided with a cryotherapy gasification crystal box 9, the cryotherapy gasification crystal box 9 is also in a curved concave shape, the middle part of the box is provided with a cryotherapy gasification crystal box vision hole 13, the bottom of the cryotherapy gasification crystal box 9 is correspondingly provided with four cryotherapy gasification crystal box fixing pins 11, a cryotherapy gasification crystal 10 is arranged in the box, a cryotherapy gasification crystal box cover 12 is arranged on the upper surface of the cryotherapy gasification crystal 10 in the box, cryotherapy gasification crystal box cover fumigation gasification holes 14 are uniformly distributed on the cryotherapy gasification crystal box cover 12, and the middle part of the gasification crystal box cover 12 is provided with a cryotherapy gasification crystal box vision hole 20;

the replaceable lens sleeve 19 and the replaceable lens 18 are embedded in the vision hole 13 of the cryotherapy gasified crystal box.

An eye patch for improving the visual effect of myopia and presbyopia and a preparation method thereof, a preparation method of a cryotherapy gasified crystal, which is characterized in that: a preparation method of eye shield cold therapy gasified crystal for improving eyesight effect of myopia and presbyopia is characterized by comprising the following steps:

the cold therapy gasified crystal raw materials comprise, by weight, 3-15 g of ambergris ether, 15-32 g of borneol, 5-23 g of dextro-borneol acetate, 5-12 g of methyl cedryl ketone, 5-17 g of angelica oil and 0.3-3 g of curcumin;

the best selected raw materials comprise, by weight, 15g of ambergris ether, 32 g of borneol, 23 g of dextro-borneol acetate, 11 g of methyl cedryl ketone, 17 g of angelica oil and 3 g of curcumin;

the preparation method of the cryotherapy gasified crystal comprises the following steps: mixing 15g of ambergris ether, 30 g of borneol and 20 g of dextro-borneol acetate together → crushing, adding 11 g of methyl cedryl ketone and 17 g of angelica oil into the crushed material, heating and melting → fully stirring and mixing after melting → flowing the cold therapy gasified osmotic crystal liquid into an eyeshade box → cooling and crystallizing → cooling to room temperature, and sealing and packaging by using a plastic film to obtain the cold therapy gasified crystal eyeshade.

The eye patch with the effect of improving the eyesight of the myopia and the presbyopia and the preparation method thereof are characterized in that:

the preparation method of ambergris ether comprises the following steps:

stirring 0.001mol of ferric trichloride and 0.01mol of ambergris glycol in 20ml of acetone for 16 hours, reacting at 22 ℃ to obtain a reacted filtrate, filtering the reacted filtrate, performing rotary evaporation treatment on the filtered filtrate, obtaining a crude ambergris ether after the rotary evaporation of the reacted filtrate is finished, and performing column chromatography purification on the crude ambergris ether to obtain an ambergris ether finished product, wherein the yield of the ambergris ether finished product is 80%;

the preparation method of borneol comprises the following steps:

adding 10.0g of crude borneol (commercial borneol containing 60.6 wt% of borneol), 1.0g of boron anhydride catalyst, 2.5g of metatitanic acid catalyst and 15.0g of anhydrous oxalic acid into a 250m L-opening round-bottom flask, stirring and condensing and refluxing 30.0g of n-hexane serving as a solvent, keeping the temperature at 54-56 ℃ for 24 hours, removing the solvent, camphene and tricyclene after the reaction is finished, saponifying the residual liquid to obtain a crude product, refining to obtain 3.1g of borneol product with the content of 88.1% (88.1: 8.1) and the extraction rate of the borneol of 45.1%;

the preparation method of the dextro borneol acetate comprises the following steps:

taking natural d-borneol and acetic anhydride as raw materials, feeding the acetic anhydride and the natural d-borneol into reaction solvent petroleum ether according to the mass ratio of 1-2: 1, wherein the material-liquid ratio of the natural d-borneol to the petroleum ether is 1: 10-15 g/ml, wherein the reaction solvent contains P2O5 or P2O5-H3PO4 as a catalyst, the dosage of the catalyst is 5-10% of the mass of the natural d-borneol, the reaction temperature is 55-75 ℃, the esterification reaction is carried out for 4-10H under the normal pressure condition, and the d-borneol acetate is obtained after purification;

the preparation method of the methyl cedryl ketone comprises the following steps:

adding 210 g of cedrene and 15g of niobic acid loaded aluminum chloride catalyst into a reaction kettle, stirring and heating to 55 ℃ for isomerization reaction for 2h, converting β -cedrene into α -cedrene, then starting to dropwise add 320 g of acetic anhydride, stirring and heating to 60 ℃ after 30min of dropwise addition is finished, carrying out acetylation reaction for 7 h, converting α -cedrene into methyl cedryl ketone by acetylation, converting α -terpineol into terpinyl acetate by acetylation, rectifying a product after the reaction is finished, distilling acetic anhydride and acetic acid, then adding a proper amount of crushed ice, keeping a reaction mixture at a temperature lower than 40 ℃, continuing stirring for 0.5h, standing for layering, separating an oil layer and a water layer, washing the oil layer to be alkalescent by using 10% sodium carbonate solution, washing the oil layer to be neutral by using saturated salt and deionized water, removing the water layer, rectifying the washed oil layer, collecting 140-160 ℃/0.67 kPa fraction, obtaining a methyl cedryl ketone product, wherein the yield is 82.5%, and the ketone content is 83.4%.

The working principle is as follows:

when the utility model is used, the interchangeable lens sleeve and the interchangeable lens of the eyeshade are selected according to the eye condition of the patient, the myopia lens is selected for the myopia eye, and the interchangeable lens of the eyeshade with the myopia degree is correspondingly selected according to the myopia degree of the patient; the hyperopia eye selects the hyperopia lens, and the eye cover replaceable lens of the hyperopia power is correspondingly selected according to the hyperopia power of the patient; the presbyopia selects presbyopic lenses, and the eyeshade replaceable lenses with presbyopic degrees are correspondingly selected according to the presbyopic degrees of the patient; the normal person selects the eyeshade of the plain lens to replace the plain lens.

And placing the selected replaceable lens sleeve and the replaceable lens of the eye shield into the central hole of the eye shield.

Placing the cavernous body sealing eye cover into the eye cover body, placing the cryotherapy gasified crystal box into the cavernous body sealing eye cover, and placing the cryotherapy gasified crystal box into the elastic silica gel eye cover pad; the eye mask body is sleeved on the head and eyes of a user after the cold therapy gasification crystal box cover is placed on the cold therapy gasification crystal box, the tightness of the head band is adjusted by the head band and the magic tape, and the eye diseases are treated by starting treatment and volatilizing the cold therapy gasification crystal.

Because the middle of the replaceable lens is provided with the antifogging hole, the lens cannot be fogged, and the visual field is clear.

Claims (1)

1. An effect eye shield for improving eyesight of myopia and presbyopia, which consists of an eye shield body, an eye shield front frame, an elastic silicon rubber eye shield pad, an elastic head sleeve belt, a spectacle body lens, a head sleeve belt magic tape, a sponge silica gel pad nose support, an elastic silicon rubber eye shield pad hole, a cold therapy gasified crystal box, a cold therapy gasified crystal box fixing pin, a cold therapy gasified crystal box cover, a cold therapy gasified crystal box eyesight hole, a cold therapy gasified crystal box cover fumigation hole, a cold therapy gasified crystal box eyesight hole, a fixed support, a replaceable lens antifogging hole, a replaceable lens sleeve and a cold therapy gasified crystal box cover eyesight hole;

the front part of the glasses body is provided with a rubber glasses frame main body and glasses body lenses, and the middle part is provided with a sponge silica gel pad nose support;

elastic head sleeve belts are arranged on two sides of the front part of the glasses body, and a head sleeve belt magic tape is arranged at one end of each elastic head sleeve belt, so that a user can adjust and fix the glasses body;

the method is characterized in that:

four fixing holes of the cold therapy gasified crystal boxes are correspondingly arranged on the lenses of the glasses body, and the fixing pins of the cold therapy gasified crystal boxes are inserted into the fixing holes for fixing;

the back of the lens of the glasses body is provided with an elastic silicon rubber eye mask pad which is curved concave, and the middle of the elastic silicon rubber eye mask pad is provided with an elastic silicon rubber eye mask pad hole;

the elastic silicon rubber eye mask pad hole is correspondingly provided with a cryotherapy gasified crystal box, the cryotherapy gasified crystal box is also in a curved concave shape, the middle part of the cryotherapy gasified crystal box is provided with a cryotherapy gasified crystal box vision hole, the bottom of the cryotherapy gasified crystal box is correspondingly provided with four cryotherapy gasified crystal box fixing pins, cryotherapy gasified crystals are arranged in the box, a cryotherapy gasified crystal box cover is arranged above the cryotherapy gasified crystals in the box, cryotherapy gasified crystal box cover fumigation gasification holes are uniformly distributed on the cryotherapy gasified crystal box cover, and the middle part of the gasified crystal box cover 12 is provided with a cryotherapy gasified crystal box vision hole;

the replaceable lens sleeve and the replaceable lens are embedded in the vision hole of the cryotherapy gasified crystal box.

Images