CN106344733A - Eye drops for treating myopia and preparation method of eye drops - Google Patents

Eye drops for treating myopia and preparation method of eye drops Download PDF

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Publication number
CN106344733A
CN106344733A CN201610878461.8A CN201610878461A CN106344733A CN 106344733 A CN106344733 A CN 106344733A CN 201610878461 A CN201610878461 A CN 201610878461A CN 106344733 A CN106344733 A CN 106344733A
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parts
vitamin
myopia
medicine
flos
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卢海凤
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Guangxi University
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Guangxi University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/58—Reptiles
    • A61K35/583—Snakes; Lizards, e.g. chameleons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/062—Ascomycota
    • A61K36/066—Clavicipitaceae
    • A61K36/068—Cordyceps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/43—Cuscutaceae (Dodder family), e.g. Cuscuta epithymum or greater dodder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/482—Cassia, e.g. golden shower tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/64—Orobanchaceae (Broom-rape family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

Abstract

The invention relates to eye drops for treating myopia. The eye drops are prepared from the following medicines in parts by weight: 110 to 150 parts of chamomile, 100 to 140 parts of vitamin B, 90 to 110 parts of semen cassiae, 80 to 110 parts of honeysuckle flower, 80 to 120 parts of flos eriocauli, 60 to 70 parts of vitamin C, 60 to 70 parts of vitamin E, 33 to 53 parts of herba cistanches, 26 to 50 parts of herba cynomorii, 31 to 55 parts of mulberry fruit, 28 to 53 parts of red ginseng, 10 to 20 parts of semen cuscutae, 10 to 20 parts of snake gall, 5 to 15 parts of cordyceps flower, 5 to 15 parts of borneol and 5 to 15 parts of sodium chloride. The invention also discloses a preparation method of the eye drops. The eye drops disclosed by the invention have a function of general eye drops, namely a function of wetting eyes; a predominant effect of the eye drops is to treat the myopia, so that the eyesight of the eyes can almost reach that before the myopia, and people suffering from the myopia can get rid of trouble and obsession of wearing glasses; the eye drops have the advantages of simplicity in preparation, convenience in operation and suitability for popularization and use.

Description

For treating collyrium of myopia and preparation method thereof
Technical field
The present invention relates to collyrium is and in particular to be used for treating collyrium of myopia and preparation method thereof.
Background technology
Myopia is a kind of common disease of ophthalmology, and sickness rate is very high.Pathogeny mainly has:
First, mechanical compressing.Teen-age eyeball is in growth promoter peak phase, and regulating power is very strong, the stretching of ball wall Also ratio is larger for malleability, and closely during study and work, eyes adjust influx reinforcement, and sclera, eyeball are pressed in the systolic pressure effect of rectus It is under pressure, intraocular pressure also accordingly raises, is continuously increased with tired, the frequency of influx and time are also gradually increased, pressure Lasting, make eyeball congestion, intraocular pressure raises, ophthalmic volume increases, vitreous chamber increases, sclera stretches, eyeball development exceedes Normal rates, last axis oculi extends, rectus and the anatomy relationship of sclera junction point and the increase of ophthalmic volume, corneal curvature also with Change, formed myopia.
2nd, the effect of ciliary muscle, during long-time close eye, in order to regarding clear object, adjust and constantly strengthen, ciliary muscle warp Often it is in high-pressure state, technical contraction causes ciliary muscle tenses degree to increase or spasm, cause crystal convexity to change, Thus leading to bathomorphic generation.
3rd, current school is unilateral makes students' work heavy to improve " proportion of students entering schools of a higher grade ", fatigue eye, and eyes cannot be just Normal rest and the popularization of computer, radiation injury eyes of microcomputer etc..
Raising with people's living standard and the quickening of rhythm of life, each electronic product has become the required of life Product, but allow the time that eyes obtain resting fewer and feweri simultaneously.The sickness rate of all kinds of oculopathy also rises year by year, tend to becoming younger, Variation.Cataract and keratopathy are China three main blinding oculopathy greatly, therefore the love of eye health are carved Do not allow to delay.I talks about in " Classic of the Virtue of the Tao ": " five colors make us blindness；The five notes of traditional Chinese music make us deaf；The five tastes make us mouth and feel well；Galloping goes hunting hunts, Make us the heart to go mad；Rare goods, makes us capable harm ... ".The five colors make us blindness in addition to disclosing abstruse Philosophical Significance, for controlling Treat oculopathy and also there is positive directive significance, eyes are limited for various visual stimulus, excessively blindness is exactly must afterwards So result.
Chinese medicine is of long standing and well established, when treating ophthalmic, most important viewpoint seek to especially to pay attention to eye with Zang-fu differentiation, the relation of qi-blood-body fluid." the puzzled greatly opinion of Ling Shu Miraculous Pivot or Divine Axis ": " the essence of five ZANG-organs and six FU-organs gas, all on note in mesh for it essence.Essence Nest be eye, the essence of the kidney manifesting in pupil, the essence of the liver manifesting in the black part of eye, the essence of the heart replenishing in the venules of eye, its nest the essence of the lung manifesting in the white part of eye, the essence of muscle is about Bundle, wrap up in the essence picking muscles and bones vim and vigour, and with arteries and veins and be above to belong to brain, after in item." and meridians are to run whole body QI and blood, Human body plays communication the exterior and the interior up and down, the effect of contact internal organs organ." a Ling Shu Miraculous Pivot or Divine Axis pathogen cacosplanchnia shape piece ": " twelve regular channelss, 300 65 networks, its vim and vigour all goes up walks sky key in face, its vivid YANG QI walks mesh and essence for it." this all illustrate eye and internal organs it Between, it is the connection insertion by meridians, remain organic contact.It is that meridians constantly convey QI and blood, just maintain the vision of eye Function.
Treat bathomorphic therapy mainly laser at present to beat, or wear near-sighted glasses.Therefore, society eye disease patient urgently Treat that a kind of medicine treating myopia comes out.
Content of the invention
It is an object of the invention to: for above-mentioned deficiency, the invention provides a kind of eye for treating myopia Liquid medicine and preparation method thereof.In addition to having general medicament for the eyes moistening water eyes function, its outstanding role is to control to the present invention Treat myopia, the vision before making eyes nearly reach myopia, make myope break away from the trouble worn glasses and puzzlement, make simple, behaviour Facilitate, be suitable for promoting the use of.
To achieve these goals, the technical solution used in the present invention is as follows:
A kind of collyrium for treating myopia, is made up of the medicine of following weight portion: Flos Matricariae chamomillae 110-150 part, vitamin b_ 100-140 part, Semen Cassiae 90-110 part, Flos Lonicerae 80-110 part, Flos Eriocauli 80-120 part, vitamin c _ 60-70 part, dimension life Plain e_60-70 part, Herba Cistanches 33-53 part, Herba Cynomorii 26-50 part, Fructus Mori 31-55 part, Radix Ginseng Rubra 28-53 part, Semen Cuscutae 10-20 Part, Fel Serpentis 10-20 part, Cordyceps 5-15 part, Borneolum Syntheticum 5-15 part and sodium chloride 5-15 part.
Currently preferred technical scheme is, the described collyrium for treating myopia, by the medicine of following weight portion Make: 130 parts of Flos Matricariae chamomillae, vitamin b_120 part, 100 parts of Semen Cassiae, 95 parts of Flos Lonicerae, 100 parts of Flos Eriocauli, vitamin c _ 65 parts, vitamin e_65 part, 43 parts of Herba Cistanches, 38 parts of Herba Cynomorii, 43 parts of Fructus Mori, 40 parts of Radix Ginseng Rubra, 15 parts of Semen Cuscutae, Fel Serpentis 15 Part, 10 parts of Cordyceps, 10 parts of Borneolum Syntheticum and 10 parts of sodium chloride.
Further, the described collyrium for treating myopia, is made up of the medicine of following weight portion: Flos Matricariae chamomillae 120- 140 parts, vitamin b_110-130 part, Semen Cassiae 95-105 part, Flos Lonicerae 90-100 part, Flos Eriocauli 95-105 part, vitamin C_62-68 part, vitamin e_62-68 part, Herba Cistanches 41-45 part, Herba Cynomorii 31-45 part, Fructus Mori 39-47 part, Radix Ginseng Rubra 36-45 Part, Semen Cuscutae 12-18 part, Fel Serpentis 12-18 part, Cordyceps 8-12 part, Borneolum Syntheticum 8-12 part and sodium chloride 8-12 part.
Further, the described preparation method for treating Medicine for myopia, comprises the steps of:
(1) Flos Matricariae chamomillae, Semen Cassiae, Flos Lonicerae, Flos Eriocauli, Herba Cistanches, Herba Cynomorii, Fructus Mori, Radix Ginseng Rubra, Tu are weighed according to parts by weight SIZI, Cordyceps, Borneolum Syntheticum and sodium chloride, in marmite, add the water of 3-6 times of weight of Flos Lonicerae, add 2-5 times of Flos Lonicerae and weigh The dehydrated alcohol of amount, after soaking 6-8h, decocts 2-5h, filtrate is collected by filtration；
(2) filtrate that step (1) obtains is continued heating to concentrate, cooled and filtered, collect filtrate, obtain the concentrated liquid of tradition Chinese medicine；
(3) the concentrated liquid of tradition Chinese medicine that vitamin b, vitamin c, vitamin e, Fel Serpentis and step (2) obtain is mixed, stirs, Filter to clear and bright, cooling after, sterilization, detection qualified after, sterile filling, obtain final product for treat myopia collyrium.
Further, the described preparation method for treating Medicine for myopia, in step (1), described soaking technology will All of medicine is asked to submerge completely in liquid；Described filtering technique is using nylon screen natural filtration.
Further, the described preparation method for treating Medicine for myopia, in step (2), described heating technique Temperature is 80-90 DEG C.
Further, the described preparation method for treating Medicine for myopia, in step (2) and step (3), described mistake Filtering technology is to adopt microporous membrane filtration.
Further, the described preparation method for treating Medicine for myopia, in step (2) and step (3), described cold But technique is to be cooled to less than 40 DEG C.
Further, the described preparation method for treating Medicine for myopia, in step (3), described stirring technique Mixing speed is 150-200r/min；Described sterilization technique is the flowing steam sterilization with 100 DEG C.
Wherein, Fel Serpentis must be with fresh and alive it is impossible to decoct concentration, and bile is extracted by available asepsis injector.
The acting as of each medicine in the present invention:
Flos Matricariae chamomillae, another name Anthemis nobilis, Matricaria recutita, Classification system: chamomilia, the manufacture of leukocyte can be stimulated, And then resist antibacterial, strengthen immune system, there is alleviating pain, improve acne, allergy, eczema, burn and scald, can say it is skin Optimal quintessence oil it.
Vitamin b_, English name vitamin b, b vitamin is the requisite nutrient of all tissues, is The key that food releases energy, and liver has compared with substantial connection.
Semen Cassiae, Chinese medicine name.It is the dry mature seed of leguminous plant Semen Cassiae or little Cassia tora, the work(of improving eyesight is had and name with it It.Autumn harvests mature fruit, dries, and lays seed, removes impurity.Luxuriant Folium Persicae bitter in the mouth, sweet, salty, cold nature are enter liver, kidney, big Intestinal warp；Loosening bowel to relieve constipation, lipid-loweringing improving eyesight, treatment constipation and hyperlipidemia, hypertension.Liver heat removing and eyesight improving, diuretic relieving constipation, there is laxative action, Reducing blood pressure and blood fat.
Flos Lonicerae is described as the good medicine of heat-clearing and toxic substances removing from ancient times.Its property sweet cold fragrance, clearing away heat with drugs sweet in flavor and cold in nature and do not injure one's stomach, fragrance is thoroughly Reach and can eliminating evil.Flos Lonicerae can dispelling wind-heat, be also apt to removing summer-heat blood poison, for various febrile diseases, such as fever of the body, dermexanthesis, send out speckle, heat The diseases such as skin infection carbuncle, laryngopharynx swelling and pain, equal effect is significant.
Flos Eriocauli, Chinese medicine name.Head inflorescence is hemispherical, and bract close-packed arrays layer by layer are arranged at bottom, bract pistac, on The close raw white undercoat in portion edge, inflorescence top canescence.Scape is very thin, different in size, and pistac is glossy, slightly distorts, and has Crest line several.China is used as medicine as Flos Eriocauli with this kind of plant herb in most area, harvests, dry when fall flowering beads up.Have Dispelling wind and heat pathogens, effect of improving acuity of vision and removing nebula.Give birth to the diseases such as cataracta, headache due to pathogenic wind-heat, nyctalopia for wind-heat of liver channel, conjunctival congestion and swelling pain, mesh. Compendium of Material Medica: " the light property of Flos Eriocauli body is floated, can up positive bright dividing line.All control all diseases in mesh, plus and use it, very good.Improving acuity of vision and removing nebula Work(, like on Flos Chrysanthemi.”
Vitamin c _, English name: vitamin c, in vivo, vitamin c _ and it is a kind of antioxidant, plant can be helped Opposing arid, ozone and ultraviolet, protection body avoids the threat of free radical, vitamin c _ and it is also a kind of coenzyme simultaneously, have Alleviate vitiligo, the effect of reduction cancer morbidity.
Vitamin e_, English name: vitamin e, is a kind of fatsoluble vitamin, its hydrolyzate is tocopherol, can Promoting reproduction, there is protection t lymphocyte, protection erythrocyte, free radical resisting oxidation, suppression platelet aggregation thus reducing cardiac muscle Infarction and the danger of cerebral infarction.Food containing abundant vitamin and mineral can constitute meals balanced in nutrition, and Vitamin e_, then represent antioxidation and the challenge to the age of brilliance.Free radical can be effective against, suppress lipid peroxidation Matter generates, eliminating chloasma；The vitamin e_ of esterified form can also eliminate and be caused by extraneous factors such as ultraviolet, air pollutions Excessive oxygen-derived free radicals, play delay photoaging, prevention sunburn and suppression sunburn generate etc. effect.
Herba Cistanches, Classification system: cistanche deserticola ma, sweet in the mouth, salty, warm in nature, return kidney, large intestine channel.Have The good reputation of " desert Radix Ginseng ", has high medical value, is the rare Chinese medicine of Chinese tradition.Kidney tonifying and blood benefiting, defying age, increasing Strong immunity.
Herba Cynomorii, Classification system: cynomorium songaricum rupr, sweet in the mouth, warm in nature, the kidney invigorating, can the kidney invigorating, benefit essence, Moisturize, cure mainly impotence and seminal emission, soreness of the waist and knees, dry constipation of intestines, to paralysis with improve that sexual function is weak to have certain effect.
Fructus Mori, Classification system: morus alba l, another name Mulberry reality, Shen, black mulberry, civil and military real, black mulberry, Mulberry Fructus Jujubae.Sweet in the mouth, Acid, cold in nature, enter the heart, liver and kidney channel.Enrich blood YIN nourishing, antimutagenic, improving eyesight is promoted the production of body fluid, intestine moistening cures mainly weakness due to chronic disease, hepatic and renal YIN deficiency, waist and knee Aching and limp, the dark tinnitus of mesh, articular instability, dry constipation of intestines, body fluid deficiency insufficiency of blood, hectic fever is passed out semen, diabetes.
Radix Ginseng Rubra, beneficial blood and tranquilizing mind, regulation nerve, defying age, resisting fatigue, radioprotective.
Semen Cuscutae, acrid in the mouth, sweet, mild-natured, enter liver kidney channel, invigorating the liver and kidney, beneficial marrow, controlling nocturnal emission with astringent drugs improving eyesight.
Fel Serpentis, have the effect of liver heat removing and eyesight improving, suppressing the hyperactive liver to relieve the wind syndrome, can adjust immunity, slow down aging.
Cordyceps, nourishing the lung and kidney hepatoprotective, antioxidation, anti-aging, antibacterial anti-inflammatory, intraocular pressure lowering, improve immunity of organisms.
Borneolum Syntheticum: enter the heart, spleen, lung meridian, work hard and be slightly cold, inducing resuscitation of having one's ideas straightened out, clearing away heat to alleviate pain, conjunctival congestion aphtha, all keys can be led to, dissipate strongly fragrant Fire.
Sodium chloride, English name: sodium chloride, stability is relatively good, and its aqueous solution is in neutrality.It is grown up internal institute Total amount containing sodium ion is about 60g, and wherein 80% is present in extracellular fluid, and chloride ion is also primarily present in extracellular fluid.In blood Na ion concentration be directly connected to body fluid level of security regulation.The water of sodium chloride-containing 0.9% is referred to as normal saline, because It has identical osmotic pressure with blood plasma.Normal saline is main humor substitute, is widely used in treatment and prevention dehydration, also uses In intravenous medical treatment and prevention hypovolemic shock.
The resisting fatigue collyrium whole process of the present invention is all prepared by aseptic processing procedure, including medicinal liquid filling whole process all dustless Operation in aseptic environment, its step includes: blows ring, bottle blowing, filling, seals and move back the steps such as bottle, particularly, therein blows Bottle, filling, sealing step are once to complete.In addition, liquid medicine bottle and medicinal liquid are before sealing, directly connect all without with operator Touch, and filling machine has automatic cleaning (cip) and the function of automatic sterilizing (sip), therefore excellent production quality can be kept.
The mensure of collyrium ph value of the present invention: adjust ph, final products from commercially available precision test paper during adjusting ph Accurately measure ph value with commercially available numeral ph analyzer.
Using method: medicine is dripped for collyrium of the present invention and is not particularly limited interval time, patient can be according to itself feelings Condition takes the circumstances into consideration to select spraying times, generally can drip once every two hours, also can drip daily three times, only drip daily 1 time also can, every time Every eye 1-2 drips.
In sum, the present invention is due to employing such scheme, the invention has the advantages that
(1) application of compound recipe constituent of the present invention is can be fabricated to various dosage form product, especially to be fabricated to easypro eye Precerving liquid or eye Liquid medicine is optimal, user foreign sense when using, and has and can quickly absorb, and reaches eyes wettability effect and is effective against Tired is both effectiveness.
(2) in addition to having general medicament for the eyes moistening water eyes function, its outstanding role is can to treat myopia to the present invention, Vision before making eyes nearly reach myopia, makes myope break away from the trouble worn glasses and puzzlement, makes simple, easy to operate, It is suitable for promoting the use of.
Specific embodiment
The present invention is used for treat collyrium of myopia and preparation method thereof and preparation method thereof with reference to embodiment, makees Further illustrate.
Embodiment 1
A kind of collyrium for treating myopia, is made up of the medicine of following weight portion: 110 parts of Flos Matricariae chamomillae, vitamin b_100 Part, 90 parts of Semen Cassiae, 80 parts of Flos Lonicerae, 80 parts of Flos Eriocauli, vitamin c _ 60 part, vitamin e_60 part, 33 parts of Herba Cistanches, lock 26 parts of sun, 31 parts of Fructus Mori, 28 parts of Radix Ginseng Rubra, 10 parts of Semen Cuscutae, 10 parts of Fel Serpentis, 5 parts of Cordyceps, 5 parts of Borneolum Syntheticum and 5 parts of sodium chloride.
Preparation method for treating Medicine for myopia described above, comprises the steps of:
(1) Flos Matricariae chamomillae, Semen Cassiae, Flos Lonicerae, Flos Eriocauli, Herba Cistanches, Herba Cynomorii, Fructus Mori, Radix Ginseng Rubra, Tu are weighed according to parts by weight SIZI, Cordyceps, Borneolum Syntheticum and sodium chloride, in marmite, add the water of 3 times of weight of Flos Lonicerae, add 2 times of weight of Flos Lonicerae Dehydrated alcohol, all of medicine submerges after soaking 6h in liquid completely, decocts 2h, using nylon screen natural filtration, collects filter Liquid；
(2) filtrate that step (1) obtains is continued heating to concentrate, add temperature to be 80 DEG C, after being cooled to less than 40 DEG C, using micro- Hole membrane filtration, collects filtrate, obtains the concentrated liquid of tradition Chinese medicine；
(3) the concentrated liquid of tradition Chinese medicine that vitamin b, vitamin c, vitamin e, Fel Serpentis and step (2) obtain is mixed, with 150r/min Speed stir, using microporous membrane filtration to clear and bright, be cooled to less than 40 DEG C, sterilized with 100 DEG C of flowing steams and go out Bacterium, after detection is qualified, sterile filling, obtain final product the collyrium for treating myopia.
Embodiment 2
A kind of collyrium for treating myopia, is made up of the medicine of following weight portion: 150 parts of Flos Matricariae chamomillae, vitamin b_140 Part, 110 parts of Semen Cassiae, 110 parts of Flos Lonicerae, 120 parts of Flos Eriocauli, vitamin c _ 70 part, vitamin e_70 part, Herba Cistanches 53 Part, 50 parts of Herba Cynomorii, 55 parts of Fructus Mori, 53 parts of Radix Ginseng Rubra, 20 parts of Semen Cuscutae, 20 parts of Fel Serpentis, 15 parts of Cordyceps, 15 parts of Borneolum Syntheticum and chlorination 15 parts of sodium.
Preparation method for treating Medicine for myopia described above, comprises the steps of:
(1) Flos Matricariae chamomillae, Semen Cassiae, Flos Lonicerae, Flos Eriocauli, Herba Cistanches, Herba Cynomorii, Fructus Mori, Radix Ginseng Rubra, Tu are weighed according to parts by weight SIZI, Cordyceps, Borneolum Syntheticum and sodium chloride, in marmite, add the water of 6 times of weight of Flos Lonicerae, add 5 times of weight of Flos Lonicerae Dehydrated alcohol, all of medicine submerges after soaking 8h in liquid completely, decocts 5h, using nylon screen natural filtration, collects filter Liquid；
(2) filtrate that step (1) obtains is continued heating to concentrate, add temperature to be 90 DEG C, after being cooled to less than 40 DEG C, using micro- Hole membrane filtration, collects filtrate, obtains the concentrated liquid of tradition Chinese medicine；
(3) the concentrated liquid of tradition Chinese medicine that vitamin b, vitamin c, vitamin e, Fel Serpentis and step (2) obtain is mixed, with 200r/min Speed stir, using microporous membrane filtration to clear and bright, be cooled to less than 40 DEG C, sterilized with 100 DEG C of flowing steams and go out Bacterium, after detection is qualified, sterile filling, obtain final product the collyrium for treating myopia.
Embodiment 3
A kind of collyrium for treating myopia, is made up of the medicine of following weight portion: 130 parts of Flos Matricariae chamomillae, vitamin b_120 Part, 100 parts of Semen Cassiae, 95 parts of Flos Lonicerae, 100 parts of Flos Eriocauli, vitamin c _ 65 part, vitamin e_65 part, 43 parts of Herba Cistanches, 38 parts of Herba Cynomorii, 43 parts of Fructus Mori, 40 parts of Radix Ginseng Rubra, 15 parts of Semen Cuscutae, 15 parts of Fel Serpentis, 10 parts of Cordyceps, 10 parts of Borneolum Syntheticum and sodium chloride 10 parts.
Preparation method for treating Medicine for myopia described above, comprises the steps of:
(1) Flos Matricariae chamomillae, Semen Cassiae, Flos Lonicerae, Flos Eriocauli, Herba Cistanches, Herba Cynomorii, Fructus Mori, Radix Ginseng Rubra, Tu are weighed according to parts by weight SIZI, Cordyceps, Borneolum Syntheticum and sodium chloride, in marmite, add the water of 4.5 times of weight of Flos Lonicerae, add 3.5 times of weights of Flos Lonicerae The dehydrated alcohol of amount, all of medicine submerges after soaking 7h in liquid completely, decocts 3.5h, using nylon screen natural filtration, Collect filtrate；
(2) filtrate that step (1) obtains is continued heating to concentrate, add temperature to be 85 DEG C, after being cooled to less than 40 DEG C, using micro- Hole membrane filtration, collects filtrate, obtains the concentrated liquid of tradition Chinese medicine；
(3) the concentrated liquid of tradition Chinese medicine that vitamin b, vitamin c, vitamin e, Fel Serpentis and step (2) obtain is mixed, with 175r/min Speed stir, using microporous membrane filtration to clear and bright, be cooled to less than 40 DEG C, sterilized with 100 DEG C of flowing steams and go out Bacterium, after detection is qualified, sterile filling, obtain final product the collyrium for treating myopia.
Embodiment 4
A kind of collyrium for treating myopia, is made up of the medicine of following weight portion: 120 parts of Flos Matricariae chamomillae, vitamin b_110 Part, 95 parts of Semen Cassiae, 90 parts of Flos Lonicerae, 95 parts of Flos Eriocauli, vitamin c _ 62 part, vitamin e_62 part, 41 parts of Herba Cistanches, lock 31 parts of sun, 39 parts of Fructus Mori, 36 parts of Radix Ginseng Rubra, 12 parts of Semen Cuscutae, 12 parts of Fel Serpentis, 8 parts of Cordyceps, 8 parts of Borneolum Syntheticum and 8 parts of sodium chloride.
Preparation method for treating Medicine for myopia described above, comprises the steps of:
(1) Flos Matricariae chamomillae, Semen Cassiae, Flos Lonicerae, Flos Eriocauli, Herba Cistanches, Herba Cynomorii, Fructus Mori, Radix Ginseng Rubra, Tu are weighed according to parts by weight SIZI, Cordyceps, Borneolum Syntheticum and sodium chloride, in marmite, add the water of 4 times of weight of Flos Lonicerae, add 3 times of weight of Flos Lonicerae Dehydrated alcohol, all of medicine submerges after soaking 6.5h in liquid completely, decocts 3h, using nylon screen natural filtration, collects Filtrate；
(2) filtrate that step (1) obtains is continued heating to concentrate, add temperature to be 82 DEG C, after being cooled to less than 40 DEG C, using micro- Hole membrane filtration, collects filtrate, obtains the concentrated liquid of tradition Chinese medicine；
(3) the concentrated liquid of tradition Chinese medicine that vitamin b, vitamin c, vitamin e, Fel Serpentis and step (2) obtain is mixed, with 160r/min Speed stir, using microporous membrane filtration to clear and bright, be cooled to less than 40 DEG C, sterilized with 100 DEG C of flowing steams and go out Bacterium, after detection is qualified, sterile filling, obtain final product the collyrium for treating myopia.
Embodiment 5
A kind of collyrium for treating myopia, is made up of the medicine of following weight portion: 140 parts of Flos Matricariae chamomillae, vitamin b_130 Part, 105 parts of Semen Cassiae, 100 parts of Flos Lonicerae, 105 parts of Flos Eriocauli, vitamin c _ 68 part, vitamin e_68 part, Herba Cistanches 45 Part, 45 parts of Herba Cynomorii, 47 parts of Fructus Mori, 45 parts of Radix Ginseng Rubra, 18 parts of Semen Cuscutae, 18 parts of Fel Serpentis, 12 parts of Cordyceps, 12 parts of Borneolum Syntheticum and chlorination 12 parts of sodium.
Preparation method for treating Medicine for myopia described above, comprises the steps of:
(1) Flos Matricariae chamomillae, Semen Cassiae, Flos Lonicerae, Flos Eriocauli, Herba Cistanches, Herba Cynomorii, Fructus Mori, Radix Ginseng Rubra, Tu are weighed according to parts by weight SIZI, Cordyceps, Borneolum Syntheticum and sodium chloride, in marmite, add the water of 5 times of weight of Flos Lonicerae, add 4 times of weight of Flos Lonicerae Dehydrated alcohol, all of medicine submerges after soaking 7.5h in liquid completely, decocts 4h, using nylon screen natural filtration, collects Filtrate；
(2) filtrate that step (1) obtains is continued heating to concentrate, add temperature to be 88 DEG C, after being cooled to less than 40 DEG C, using micro- Hole membrane filtration, collects filtrate, obtains the concentrated liquid of tradition Chinese medicine；
(3) the concentrated liquid of tradition Chinese medicine that vitamin b, vitamin c, vitamin e, Fel Serpentis and step (2) obtain is mixed, with 190r/min Speed stir, using microporous membrane filtration to clear and bright, be cooled to less than 40 DEG C, sterilized with 100 DEG C of flowing steams and go out Bacterium, after detection is qualified, sterile filling, obtain final product the collyrium for treating myopia.
The collyrium of the present invention is on the basis of handed down from one's ancestors, and the clinical practice for many years through inventor, continuously improves Perfect, total effective rate more than 93% evident in efficacy for treating myopia, cure rate is more than 78%, and the recurrence after healing can be avoided.
Application example 1: 5 certain, man, 45 years old, be high myopia during 18 years old student, left eye: 450 °, right eye: 525 °, wear Glasses, touch, after graduation in 26 years old, the myope being cured with this invention medicine, that is, visit to require treatment, using the use of the present invention After the collyrium 30d for the treatment of myopia, left eye: 250 °, right eye: 325 °, after 90d, binocular recovers twenty-twenty vision, removes Glasses, now do not recur, reach clinical cure purpose for 19 years.
Application example 2: Zhu, man, 30 years old, be high myopia during 16 years old student, left eye: 425 °, right eye: 425 °, wear Glasses, touch, after graduation in 23 years old, the myope being cured with this invention medicine, that is, visit to require treatment, using the use of the present invention After the collyrium 30d for the treatment of myopia, left eye: 250 °, right eye: 250 °, after 90d, binocular recovers twenty-twenty vision, removes Glasses, now do not recur, reach clinical cure purpose for 7 years.
In sum, the application of compound recipe constituent of the present invention is can be fabricated to various dosage form product, especially to be fabricated to easypro eye Precerving liquid or collyrium are optimal, user foreign sense when using, and have and can quickly absorb, except having general collyrium Eyes wettability effect and be effective against fatigue both effectiveness outside, its outstanding role is can to treat myopia, makes eyes several Reach the vision before myopia, make myope break away from the trouble worn glasses and puzzlement, make simple, easy to operate, it is suitable for promoting Use.
The foregoing is only the preferred embodiment of invention, not in order to limit the present invention, all spirit in the present invention Within principle, any modification, equivalent substitution and improvement made etc., should be included within the scope of the present invention.

Claims (9)

1. a kind of collyrium for treating myopia is it is characterised in that be made up of the medicine of following weight portion: Flos Matricariae chamomillae 110- 150 parts, vitamin b_100-140 part, Semen Cassiae 90-110 part, Flos Lonicerae 80-110 part, Flos Eriocauli 80-120 part, vitamin C_60-70 part, vitamin e__60-70 part, Herba Cistanches 33-53 part, Herba Cynomorii 26-50 part, Fructus Mori 31-55 part, Radix Ginseng Rubra 28- 53 parts, Semen Cuscutae 10-20 part, Fel Serpentis 10-20 part, Cordyceps 5-15 part, Borneolum Syntheticum 5-15 part and sodium chloride 5-15 part.
2. the collyrium for treating myopia according to claim 1 is it is characterised in that medicine system by following weight portion Become: 130 parts of Flos Matricariae chamomillae, vitamin b_120 part, 100 parts of Semen Cassiae, 95 parts of Flos Lonicerae, 100 parts of Flos Eriocauli, vitamin c _ 65 Part, vitamin e_65 part, 43 parts of Herba Cistanches, 38 parts of Herba Cynomorii, 43 parts of Fructus Mori, 40 parts of Radix Ginseng Rubra, 15 parts of Semen Cuscutae, 15 parts of Fel Serpentis, 10 parts of Cordyceps, 10 parts of Borneolum Syntheticum and 10 parts of sodium chloride.
3. the collyrium for treating myopia according to claim 1 is it is characterised in that medicine system by following weight portion Become: Flos Matricariae chamomillae 120-140 part, vitamin b_110-130 part, Semen Cassiae 95-105 part, Flos Lonicerae 90-100 part, Flos Eriocauli 95- 105 parts, vitamin c _ 62-68 part, vitamin e_62-68 part, Herba Cistanches 41-45 part, Herba Cynomorii 31-45 part, Fructus Mori 39-47 Part, Radix Ginseng Rubra 36-45 part, Semen Cuscutae 12-18 part, Fel Serpentis 12-18 part, Cordyceps 8-12 part, Borneolum Syntheticum 8-12 part and sodium chloride 8-12 Part.
4. the preparation method for treating Medicine for myopia according to any one of claims 1 to 3 it is characterised in that by Following steps form:
(1) Flos Matricariae chamomillae, Semen Cassiae, Flos Lonicerae, Flos Eriocauli, Herba Cistanches, Herba Cynomorii, Fructus Mori, Radix Ginseng Rubra, Tu are weighed according to parts by weight SIZI, Cordyceps, Borneolum Syntheticum and sodium chloride, in marmite, add the water of 3-6 times of weight of Flos Lonicerae, add 2-5 times of Flos Lonicerae and weigh The dehydrated alcohol of amount, after soaking 6-8h, decocts 2-5h, filtrate is collected by filtration；
(2) filtrate that step (1) obtains is continued heating to concentrate, cooled and filtered, collect filtrate, obtain the concentrated liquid of tradition Chinese medicine；
(3) the concentrated liquid of tradition Chinese medicine that vitamin b, vitamin c, vitamin e, Fel Serpentis and step (2) obtain is mixed, stirs, Filter to clear and bright, cooling after, sterilization, detection qualified after, sterile filling, obtain final product for treat myopia collyrium.
5. the preparation method for treating Medicine for myopia according to claim 4 it is characterised in that: in step (1), institute State all of medicine of soaking technology requirement to submerge completely in liquid；Described filtering technique is using nylon screen natural filtration.
6. the preparation method for treating Medicine for myopia according to claim 4 it is characterised in that: in step (2), institute The temperature stating heating technique is 80-90 DEG C.
7. the preparation method for treating Medicine for myopia according to claim 4 it is characterised in that: in step (2) and Step (3), described filtering technique is to adopt microporous membrane filtration.
8. the preparation method for treating Medicine for myopia according to claim 4 it is characterised in that: in step (2) and Step (3), described cooling technique is to be cooled to less than 40 DEG C.
9. the preparation method for treating Medicine for myopia according to claim 4 it is characterised in that: in step (3), institute The mixing speed stating stirring technique is 150-200r/min；Described sterilization technique is the flowing steam sterilization with 100 DEG C.
CN201610878461.8A 2016-10-09 2016-10-09 Eye drops for treating myopia and preparation method of eye drops Pending CN106344733A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107184643A (en) * 2017-05-24 2017-09-22 深圳市欧斯特尔实业有限公司 A kind of eyesight-improving health care function liquid containing snake gall and preparation method thereof

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CN1162454A (en) * 1996-04-16 1997-10-22 郭良才 Green bamboo liquid for fumigation of eyes and preparation thereof
CN101455684A (en) * 2009-01-06 2009-06-17 河北科技大学 Zhenshiming eye drops without bacteria inhibitor and preparation method thereof
CN102188604A (en) * 2010-03-09 2011-09-21 贺光民 Medicament for treating myopia and presbyopia
CN104587250A (en) * 2015-01-13 2015-05-06 青岛市中心医院 Traditional Chinese medicine eye drops for treating liver and kidney deficiency type myopia and preparation method thereof

Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
CN1162454A (en) * 1996-04-16 1997-10-22 郭良才 Green bamboo liquid for fumigation of eyes and preparation thereof
CN101455684A (en) * 2009-01-06 2009-06-17 河北科技大学 Zhenshiming eye drops without bacteria inhibitor and preparation method thereof
CN102188604A (en) * 2010-03-09 2011-09-21 贺光民 Medicament for treating myopia and presbyopia
CN104587250A (en) * 2015-01-13 2015-05-06 青岛市中心医院 Traditional Chinese medicine eye drops for treating liver and kidney deficiency type myopia and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107184643A (en) * 2017-05-24 2017-09-22 深圳市欧斯特尔实业有限公司 A kind of eyesight-improving health care function liquid containing snake gall and preparation method thereof

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