CN107929580A - It is a kind of that there is novel compound preparation for alleviating eye strain and its preparation method and application - Google Patents
It is a kind of that there is novel compound preparation for alleviating eye strain and its preparation method and application Download PDFInfo
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Abstract
It is more particularly to a kind of that there is novel compound preparation for alleviating eye strain and its preparation method and application the present invention relates to a kind of compound preparation technical field, there is the novel compound preparation for alleviating eye strain to include：Peppermint oil, menthol, borneol, honeysuckle flower extract, phllostachys pubescens leaf ext, corn flower extract, Egyptian blue water lily flower extract, little Cassia tora seed extract, cetostearyl alcohol olive oleate, the smooth olive oleate of sorb.The effect of employing appropriate each material rate, having given full play to each component, effect are better than each single dose effect, not only possess good relieving eye strain, eye skin conditioning, eye antibacterial anti-inflammatory multi-efficiency, but also non-stimulated to eyes.
Description
Technical field
It is more particularly to a kind of that there is the novel compound for alleviating eye strain the present invention relates to a kind of compound preparation technical field
Preparation and its preparation method and application.
Background technology
With the continuous development of modern science and technology, various electronic products are maked rapid progress, and many people are daily in life and work
It can all be used in work to products such as computer, TV, mobile phones, excessively can cause visual impairment with eye, while also with easy regarding thing
Fatigue, the symptom such as discomfort that eyes acid is swollen.Simultaneously as the continuous development of industry, the environment of people's life, air etc. all receive
Certain pollution, does not pay attention to health etc., it is easy to cause inflammatory eye with eye sometimes in addition.Therefore, have and alleviate asthenopia, resist
The medicine of bacterium anti-inflammatory and other effects becomes people's Daily Level Readiness medicine.
Current market sales of eye drops contains preservative, and the easy corneal epithelial of long-time service causes damage, causes to do
Eye disease, often contains antibiotic for treating the eyedrops of eye infection, and bacterium infection easily occurs, and glaucoma occurs for abuse potential
Cause to blind, the eyedrops containing steroids is over a long time using that can cause intraocular pressure to raise, moreover, most of eye drops has necessarily
Irritation, long-time service have eye certain side effect.Resist at present for relieving eye strain, eye skin conditioning, eye
Bacterium anti-inflammatory curative effect is good and non-stimulated compound preparation has the good market demand.
The content of the invention
To overcome disadvantages mentioned above, present invention aims at provide it is a kind of have alleviate eye strain novel compound preparation and
Its preparation method and application.
The technical solution adopted by the present invention is：It is a kind of have alleviate eye strain novel compound preparation include peppermint oil,
Menthol, borneol, honeysuckle flower extract, phllostachys pubescens leaf ext, corn flower extract, Egyptian blue water lily flower extract, little Cassia tora
Seed extract, cetostearyl alcohol olive oleate, the smooth olive oleate of sorb.
Peppermint oil：Main component is menthol, menthones, menthyl acetate, limonene, in addition also contains a variety of trips
From amino acid threonine, glutamic acid, asparagine, alanine etc. and resin, tannin, Rosmarinic acid and a variety of flavonoids
Compound, has antibacterial and bactericidal effect, can make antiinflammatory.
Menthol：Organic compound, colorless needle crystals or granular, levorotatory menthol have peppermint fragrance and have refrigerant
Effect, racemization menthol also have refrigerant effect, have effects that antipruritic, analgesic, anti-corrosion, stimulation, anesthesia, refrigerant and inflammation-resisting itch-stopping.
Borneol：It is to be obtained by composite family Blumea balsamifera cauline leaf or canella borneol camphor tree branches and leaves through steam distillation and recrystallization,
Also useful turpentine oil is obtained through a series of chemical method techniques, it can be used for closing card coma, for red eye, swell pain, larynx numbness aphtha,
For sore swell and ache curative, do not held back after bursting, possess anti-inflammatory anti-itch effect.
Honeysuckle flower extract：Anti-irritant, it is anti-oxidant, effectively suppress inflammatory mediator il-1（IL-1）And prostaglandin
（PEG2）, improve scytitis, resist bacterium, promote pore convergence, make skin more moist.
Phllostachys pubescens leaf ext：The leaf of bamboo is containing based on phenolic compound, to there is polyphenol components and chromocor compound.But it can use
Make only triein and the p-Coumaric Acid of quality standard, the former is a chromocor compound, and the latter is a phenolic compound, and the leaf of bamboo carries
Thing efficacy performance is taken in antibiotic property, antioxidant, moisture retention and anti-inflammatory.First, in water extract antibiotic property, bamboo extractive
There is preferable antibiotic property to staphylococcus aureus, Escherichia coli and Bacillus subtilis, their minimal inhibitory concentration is respectively
0.25%th, 0.125% and 0.125%, but effect of the bamboo extractive to mould, saccharomycete and unobvious.Second, Moso Bamboo Leaves water
Extract has certain antioxidant, and elimination factor of the concentration in 1mg/mL that disappear to free radical DPPH is 35%, to hydroxyl radical free radical
65% and 71% are respectively reached with the elimination factor of superoxide radical.3rd, Moso Bamboo Leaves water extract causes rat toes to swell carrageenan
Swollen to have suppression, when concentration is in 30mg/Kg, inhibiting rate is 22 ± 7%（3 measure when small）, there is certain anti-inflammatory.
Corn flower extract：Active ingredient Chrysanthemin, energy skin maintenance, loosen mood, be antifatigue, helping digest, and has
Help treatment stomachache, prevention gastritis, upset,gastro-intestinal, bronchitis.
Egyptian blue water lily flower extract：The extract of Egyptian blue nymphaea tetragona, by increasing capacitance it is possible to increase the natural moisture preserving component NMF of skin
（Natural moisturizing factor）, skin moisture content is kept, in addition it plays the role of relaxing wrinkle, glabrous skin and mitigates trace tired out, and
And there is good moisturizing effect.
Little Cassia tora seed extract：Clearing heat and detoxicating, traditional Chinese medicine ingredients have a conditioning skin, and calmness is releived effect.
The smooth olive oleate of sorb：Playing increases the hold-up of effective effective component in skin, improves local biologic profit
The effect of expenditure.
Cetostearyl alcohol olive oleate：Moisturizing.
The present invention by peppermint oil, menthol, borneol, honeysuckle flower extract, phllostachys pubescens leaf ext, corn flower extract, angstrom
And the smooth olive oleate of Nymphaea caerulea flower extract, little Cassia tora seed extract, sorb, cetostearyl alcohol olive oleate are applied in combination
Afterwards, there is obvious relieving eye strain, eye skin conditioning, eye antibacterial anti-inflammatory multi-efficiency, its positive effect is better than respectively
The effect of single dose, and it is non-stimulated to eyes.
Preferably, in parts by weight, the percentage by weight of feed components is：Peppermint oil 1-10%, menthol 0.1-
10%th, borneol 0.1-10%, honeysuckle flower extract 1-30%, phllostachys pubescens leaf ext 1-30%, corn flower extract 1-30%, Egyptian blue
Water lily flower extract 1-30%, little Cassia tora seed extract 1-30%, the smooth olive oleate 1-20% of sorb, cetostearyl alcohol olive oil
Acid esters 1-20%.
Preferably, in parts by weight, the percentage by weight of feed components is：Peppermint oil 1-5%, menthol 1-5%, ice
Piece 1-5%, honeysuckle flower extract 10-20%, phllostachys pubescens leaf ext 10-20%, corn flower extract 10-20%, Egyptian blue nymphaea tetragona
Extract 10-20%, little Cassia tora seed extract 10-20%, cetostearyl alcohol olive oleate 5-10%, the smooth olive oleate of sorb
5-10%。
Further, dry Moso Bamboo Leaves are crushed, using supercritical carbon dioxide extraction method, and by the use of absolute ethyl alcohol as
Agent is carried, the extract parsed is dispersed in water, molten with ethanol after the completion of absorption using macroporous absorbent resin Dynamic Adsorption
Liquid elutes, and eluent is concentrated under reduced pressure, and concentrate is adsorbed using polyamide again, is eluted, washed with ethanol solution after the completion of absorption
De- liquid is concentrated under reduced pressure, and obtains phllostachys pubescens leaf ext in raw material.
Further, crystallization is separated out after peppermint oil is freezed, centrifugation gained crystallization is obtained pure left-handed thin with low boiling solvent recrystallization
Lotus alcohol, it is hydrogenated to be changed into left-handed peppermint also containing larger amount of menthones except the mother liquor after decrystallizing contains menthol 40%~50%
The mixture of alcohol and dextrorotation neomenthol, it is crystallized, distill or be made after its borate and point remove peppermint oil by the partly-hydrolysed of ester
In other parts, obtain menthol in raw material.
Present invention also offers a kind of preparation method for the novel compound preparation for having and alleviating eye strain, including following step
Suddenly：
（1）According to the required weight content of novel compound preparation for alleviating eye strain, peppermint oil, peppermint are weighed respectively
Alcohol, borneol are simultaneously added into a container；
（2）According to the required weight content of novel compound preparation for alleviating eye strain, the smooth olive oleic acid of sorb is weighed
Ester and cetostearyl alcohol olive oleate, then add the smooth olive oleate of sorb and cetostearyl alcohol olive oleate to step
Suddenly（1）In the container, in this process controlled at 70~85 DEG C, and 0.5~1h is stirred；
（3）According to alleviate eye strain the required weight content of novel compound preparation, weigh by honeysuckle flower extract,
Phllostachys pubescens leaf ext, corn flower extract, Egyptian blue water lily flower extract and little Cassia tora seed extract are put into step（1）And step
Suddenly（2）In the container；In this process controlled at 40~50 DEG C, and 0.5~1h is stirred, stop heating, then side is stirred
Side cooling is mixed, 2~6h of stirring is down to room temperature, obtains finished product.
Preferably, the step（2）Mixing speed during middle stirring is 100~250r/min.
Preferably, the step（3）Mixing speed during middle stirring is 50~100r/min.
Present invention also offers a kind of there is the novel compound preparation for alleviating eye strain to be used for relieving eye strain, conditioning
Application in eye skin and/or the preparation of eye antibacterial-anti-inflammatory drug.
The present invention is beneficial to be had technical effect that：
1. the compound preparation employs appropriate each material rate, the effect of having given full play to each component, effect is better than each single dose
Effect, not only possesses relieving eye strain, eye skin conditioning, eye antibacterial anti-inflammatory multi-efficiency, but also non-stimulated to eyes.
2. for eye crowd is used for a long time, the cuticula of eye skin is partially thin, is easily stimulated be subject to the external world, for a long time
It is more and more the problem of causing eye skin with eye, designed present invention is specifically directed to eye skin, have moisturizing, moisturizing imitate
Fruit, it is non-stimulated to eyes.
Embodiment
The content that the present invention is furture elucidated with reference to embodiments, but the present invention is not restricted to the model of following examples
Enclose.
Embodiment 1
A kind of novel compound preparation with alleviation eye strain provided by the invention, raw materials used medicine or auxiliary material include peppermint
The smooth olive oleate of oil, menthol, borneol, sorb, cetostearyl alcohol olive oleate can be bought by market, honeysuckle flowers extraction
Thing, phllostachys pubescens leaf ext, corn flower extract, Egyptian blue water lily flower extract, little Cassia tora seed extract preparation method are：Using
Honeysuckle flowers, Moso Bamboo Leaves, corn flower, Egyptian blue nymphaea tetragona, little Cassia tora seed raw material, then will be each respectively with 95% ethanol derect seething
Extract is condensed into medicinal extract, obtains honeysuckle flower extract, phllostachys pubescens leaf ext, corn flower extract, Egyptian blue nymphaea tetragona respectively
Extract, little Cassia tora seed extract.
Wherein, menthol and phllostachys pubescens leaf ext can also be made using the following method of the present embodiment：
Dry Moso Bamboo Leaves are crushed, using supercritical carbon dioxide extraction method, and by the use of absolute ethyl alcohol as agent is carried, are parsed
Obtained extract is dispersed in water, and using macroporous absorbent resin Dynamic Adsorption, is eluted after the completion of absorption with ethanol solution, elution
Liquid is concentrated under reduced pressure, and concentrate is adsorbed using polyamide again, is eluted after the completion of absorption with ethanol solution, and eluent decompression is dense
Contracting, obtains phllostachys pubescens leaf ext in raw material.
Crystallization is separated out after peppermint oil is freezed, centrifugation gained crystallization obtains pure levorotatory menthol with low boiling solvent recrystallization, removes
Mother liquor after decrystallizing contains menthol 40%~50%, hydrogenated to be changed into levorotatory menthol and the right side also containing larger amount of menthones
The mixture of neomenthol is revolved, it is crystallized, distill or be made after its borate and point remove its in peppermint oil by the partly-hydrolysed of ester
His part, obtains menthol in raw material.
A kind of to have the novel compound preparation for alleviating eye strain, the percentage by weight of feed components is：Peppermint oil 1%,
Menthol 0.1%, borneol 0.1%, honeysuckle flower extract 16.8%, phllostachys pubescens leaf ext 20%, corn flower extract 20%, Egyptian blue
The smooth olive oleate 1% of water lily flower extract 20%, little Cassia tora seed extract 20%, sorb, cetostearyl alcohol olive oleate 1%.
A kind of preparation method with the novel compound preparation for alleviating eye strain, includes the following steps：
（1）According to the required weight content of novel compound preparation for alleviating eye strain, peppermint oil, peppermint are weighed respectively
Alcohol, borneol are simultaneously added into a container；
（2）According to the required weight content of novel compound preparation for alleviating eye strain, the smooth olive oleic acid of sorb is weighed
Ester and cetostearyl alcohol olive oleate, then add the smooth olive oleate of sorb and cetostearyl alcohol olive oleate to step
Suddenly（1）In the container, in this process controlled at 70~85 DEG C, and 0.5~1h is stirred, wherein mixing speed is 100
~250r/min；
（3）According to alleviate eye strain the required weight content of novel compound preparation, weigh by honeysuckle flower extract,
Phllostachys pubescens leaf ext, corn flower extract, Egyptian blue water lily flower extract and little Cassia tora seed extract are put into step（1）And step
Suddenly（2）In the container；In this process controlled at 40~50 DEG C, and 0.5~1h is stirred, stop heating, then side is stirred
Side cooling is mixed, 2~6h of stirring is down to room temperature, obtains finished product, wherein mixing speed is 50~100r/min.
Embodiment 2
A kind of novel compound preparation with alleviation eye strain provided by the invention, raw materials used medicine or auxiliary material include peppermint
The smooth olive oleate of oil, menthol, borneol, sorb, cetostearyl alcohol olive oleate can be bought by market, honeysuckle flowers extraction
Thing, phllostachys pubescens leaf ext, corn flower extract, Egyptian blue water lily flower extract, little Cassia tora seed extract preparation method are：Using
Honeysuckle flowers, Moso Bamboo Leaves, corn flower, Egyptian blue nymphaea tetragona, little Cassia tora seed raw material, then will be each respectively with 95% ethanol derect seething
Extract is condensed into medicinal extract, obtains honeysuckle flower extract, phllostachys pubescens leaf ext, corn flower extract, Egyptian blue nymphaea tetragona respectively
Extract, little Cassia tora seed extract.
Wherein, menthol and phllostachys pubescens leaf ext can also be made using the following method of the present embodiment：
Dry Moso Bamboo Leaves are crushed, using supercritical carbon dioxide extraction method, and by the use of absolute ethyl alcohol as agent is carried, are parsed
Obtained extract is dispersed in water, and using macroporous absorbent resin Dynamic Adsorption, is eluted after the completion of absorption with ethanol solution, elution
Liquid is concentrated under reduced pressure, and concentrate is adsorbed using polyamide again, is eluted after the completion of absorption with ethanol solution, and eluent decompression is dense
Contracting, obtains phllostachys pubescens leaf ext in raw material.
Crystallization is separated out after peppermint oil is freezed, centrifugation gained crystallization obtains pure levorotatory menthol with low boiling solvent recrystallization, removes
Mother liquor after decrystallizing contains menthol 40%~50%, hydrogenated to be changed into levorotatory menthol and the right side also containing larger amount of menthones
The mixture of neomenthol is revolved, it is crystallized, distill or be made after its borate and point remove its in peppermint oil by the partly-hydrolysed of ester
His part, obtains menthol in raw material.
A kind of to have the novel compound preparation for alleviating eye strain, the percentage by weight of feed components is：Peppermint oil
10%th, menthol 10%, borneol 10%, honeysuckle flower extract 10%, phllostachys pubescens leaf ext 10%, corn flower extract 10%, Egyptian blue
The smooth olive oleate 10% of water lily flower extract 10%, little Cassia tora seed extract 10%, sorb, the smooth olive oleate 10% of sorb.
A kind of preparation method with the novel compound preparation for alleviating eye strain, includes the following steps：
（1）According to the required weight content of novel compound preparation for alleviating eye strain, peppermint oil, thin is weighed respectively
Lotus alcohol, borneol are simultaneously added into a container；
（2）According to the required weight content of novel compound preparation for alleviating eye strain, the smooth olive oleic acid of sorb is weighed
Ester and cetostearyl alcohol olive oleate, then add the smooth olive oleate of sorb and cetostearyl alcohol olive oleate to step
Suddenly（1）In the container, in this process controlled at 70~85 DEG C, and 0.5~1h is stirred, wherein mixing speed is 100
~250r/min；
（3）According to alleviate eye strain the required weight content of novel compound preparation, weigh by honeysuckle flower extract,
Phllostachys pubescens leaf ext, corn flower extract, Egyptian blue water lily flower extract and little Cassia tora seed extract are put into step（1）And step
Suddenly（2）In the container；In this process controlled at 40~50 DEG C, and 0.5~1h is stirred, stop heating, then side is stirred
Side cooling is mixed, 2~6h of stirring is down to room temperature, obtains finished product, wherein mixing speed is 50~100r/min.
Embodiment 3
A kind of novel compound preparation with alleviation eye strain provided by the invention, raw materials used medicine or auxiliary material include peppermint
The smooth olive oleate of oil, menthol, borneol, sorb, cetostearyl alcohol olive oleate can be bought by market, honeysuckle flowers extraction
Thing, phllostachys pubescens leaf ext, corn flower extract, Egyptian blue water lily flower extract, little Cassia tora seed extract preparation method are：Using
Honeysuckle flowers, Moso Bamboo Leaves, corn flower, Egyptian blue nymphaea tetragona, little Cassia tora seed raw material, then will be each respectively with 95% ethanol derect seething
Extract is condensed into medicinal extract, obtains honeysuckle flower extract, phllostachys pubescens leaf ext, corn flower extract, Egyptian blue nymphaea tetragona respectively
Extract, little Cassia tora seed extract.
Wherein, menthol and phllostachys pubescens leaf ext can also be made using the following method of the present embodiment：
Dry Moso Bamboo Leaves are crushed, using supercritical carbon dioxide extraction method, and by the use of absolute ethyl alcohol as agent is carried, are parsed
Obtained extract is dispersed in water, and using macroporous absorbent resin Dynamic Adsorption, is eluted after the completion of absorption with ethanol solution, elution
Liquid is concentrated under reduced pressure, and concentrate is adsorbed using polyamide again, is eluted after the completion of absorption with ethanol solution, and eluent decompression is dense
Contracting, obtains phllostachys pubescens leaf ext in raw material.
Crystallization is separated out after peppermint oil is freezed, centrifugation gained crystallization obtains pure levorotatory menthol with low boiling solvent recrystallization, removes
Mother liquor after decrystallizing contains menthol 40%~50%, hydrogenated to be changed into levorotatory menthol and the right side also containing larger amount of menthones
The mixture of neomenthol is revolved, it is crystallized, distill or be made after its borate and point remove its in peppermint oil by the partly-hydrolysed of ester
His part, obtains menthol in raw material.
A kind of to have the novel compound preparation for alleviating eye strain, the percentage by weight of feed components is：Peppermint oil 1%,
Menthol 1%, borneol 1%, honeysuckle flower extract 1%, phllostachys pubescens leaf ext 1%, corn flower extract 30%, Egyptian blue nymphaea tetragona carry
Take the smooth olive oleate 20% of thing 15%, little Cassia tora seed extract 10%, sorb, cetostearyl alcohol olive oleate 20%.
A kind of preparation method with the novel compound preparation for alleviating eye strain, includes the following steps：
（1）According to the required weight content of novel compound preparation for alleviating eye strain, peppermint oil, thin is weighed respectively
Lotus alcohol, borneol are simultaneously added into a container；
（2）According to the required weight content of novel compound preparation for alleviating eye strain, the smooth olive oleic acid of sorb is weighed
Ester and cetostearyl alcohol olive oleate, then add the smooth olive oleate of sorb and cetostearyl alcohol olive oleate to step
Suddenly（1）In the container, in this process controlled at 70~85 DEG C, and 0.5~1h is stirred, wherein mixing speed is 100
~250r/min；
（3）According to alleviate eye strain the required weight content of novel compound preparation, weigh by honeysuckle flower extract,
Phllostachys pubescens leaf ext, corn flower extract, Egyptian blue water lily flower extract and little Cassia tora seed extract are put into step（1）And step
Suddenly（2）In the container；In this process controlled at 40~50 DEG C, and 0.5~1h is stirred, stop heating, then side is stirred
Side cooling is mixed, 2~6h of stirring is down to room temperature, obtains finished product, wherein mixing speed is 50~100r/min.
Embodiment 4
A kind of novel compound preparation with alleviation eye strain provided by the invention, raw materials used medicine or auxiliary material include peppermint
The smooth olive oleate of oil, menthol, borneol, sorb, cetostearyl alcohol olive oleate can be bought by market, honeysuckle flowers extraction
Thing, phllostachys pubescens leaf ext, corn flower extract, Egyptian blue water lily flower extract, little Cassia tora seed extract preparation method are：Using
Honeysuckle flowers, Moso Bamboo Leaves, corn flower, Egyptian blue nymphaea tetragona, little Cassia tora seed raw material, then will be each respectively with 95% ethanol derect seething
Extract is condensed into medicinal extract, obtains honeysuckle flower extract, phllostachys pubescens leaf ext, corn flower extract, Egyptian blue nymphaea tetragona respectively
Extract, little Cassia tora seed extract.
Wherein, menthol and phllostachys pubescens leaf ext can also be made using the following method of the present embodiment：
Dry Moso Bamboo Leaves are crushed, using supercritical carbon dioxide extraction method, and by the use of absolute ethyl alcohol as agent is carried, are parsed
Obtained extract is dispersed in water, and using macroporous absorbent resin Dynamic Adsorption, is eluted after the completion of absorption with ethanol solution, elution
Liquid is concentrated under reduced pressure, and concentrate is adsorbed using polyamide again, is eluted after the completion of absorption with ethanol solution, and eluent decompression is dense
Contracting, obtains phllostachys pubescens leaf ext in raw material.
Crystallization is separated out after peppermint oil is freezed, centrifugation gained crystallization obtains pure levorotatory menthol with low boiling solvent recrystallization, removes
Mother liquor after decrystallizing contains menthol 40%~50%, hydrogenated to be changed into levorotatory menthol and the right side also containing larger amount of menthones
The mixture of neomenthol is revolved, it is crystallized, distill or be made after its borate and point remove its in peppermint oil by the partly-hydrolysed of ester
His part, obtains menthol in raw material.
A kind of to have the novel compound preparation for alleviating eye strain, the percentage by weight of feed components is：Peppermint oil 5%,
Menthol 5%, borneol 5%, honeysuckle flower extract 20%, phllostachys pubescens leaf ext 30%, corn flower extract 1%, Egyptian blue nymphaea tetragona carry
Take the smooth olive oleate 1% of thing 1%, little Cassia tora seed extract 30%, sorb, cetostearyl alcohol olive oleate 2%.
A kind of preparation method with the novel compound preparation for alleviating eye strain, includes the following steps：
（1）According to the required weight content of novel compound preparation for alleviating eye strain, peppermint oil, peppermint are weighed respectively
Alcohol, borneol are simultaneously added into a container；
（2）According to the required weight content of novel compound preparation for alleviating eye strain, the smooth olive oleic acid of sorb is weighed
Ester and cetostearyl alcohol olive oleate, then add the smooth olive oleate of sorb and cetostearyl alcohol olive oleate to step
Suddenly（1）In the container, in this process controlled at 70~85 DEG C, and 0.5~1h is stirred, wherein mixing speed is 100
~250r/min；
（3）According to alleviate eye strain the required weight content of novel compound preparation, weigh by honeysuckle flower extract,
Phllostachys pubescens leaf ext, corn flower extract, Egyptian blue water lily flower extract and little Cassia tora seed extract are put into step（1）And step
Suddenly（2）In the container；In this process controlled at 40~50 DEG C, and 0.5~1h is stirred, stop heating, then side is stirred
Side cooling is mixed, 2~6h of stirring is down to room temperature, obtains finished product, wherein mixing speed is 50~100r/min.
Embodiment 5
A kind of novel compound preparation with alleviation eye strain provided by the invention, raw materials used medicine or auxiliary material include peppermint
The smooth olive oleate of oil, menthol, borneol, sorb, cetostearyl alcohol olive oleate can be bought by market, honeysuckle flowers extraction
Thing, phllostachys pubescens leaf ext, corn flower extract, Egyptian blue water lily flower extract, little Cassia tora seed extract preparation method are：Using
Honeysuckle flowers, Moso Bamboo Leaves, corn flower, Egyptian blue nymphaea tetragona, little Cassia tora seed raw material, then will be each respectively with 95% ethanol derect seething
Extract is condensed into medicinal extract, obtains honeysuckle flower extract, phllostachys pubescens leaf ext, corn flower extract, Egyptian blue nymphaea tetragona respectively
Extract, little Cassia tora seed extract.
Wherein, menthol and phllostachys pubescens leaf ext can also be made using the following method of the present embodiment：
Dry Moso Bamboo Leaves are crushed, using supercritical carbon dioxide extraction method, and by the use of absolute ethyl alcohol as agent is carried, are parsed
Obtained extract is dispersed in water, and using macroporous absorbent resin Dynamic Adsorption, is eluted after the completion of absorption with ethanol solution, elution
Liquid is concentrated under reduced pressure, and concentrate is adsorbed using polyamide again, is eluted after the completion of absorption with ethanol solution, and eluent decompression is dense
Contracting, obtains phllostachys pubescens leaf ext in raw material.
Crystallization is separated out after peppermint oil is freezed, centrifugation gained crystallization obtains pure levorotatory menthol with low boiling solvent recrystallization, removes
Mother liquor after decrystallizing contains menthol 40%~50%, hydrogenated to be changed into levorotatory menthol and the right side also containing larger amount of menthones
The mixture of neomenthol is revolved, it is crystallized, distill or be made after its borate and point remove its in peppermint oil by the partly-hydrolysed of ester
His part, obtains menthol in raw material.
A kind of to have the novel compound preparation for alleviating eye strain, the percentage by weight of feed components is：Peppermint oil 5%,
Menthol 5%, borneol 5%, honeysuckle flower extract 30%, phllostachys pubescens leaf ext 10%, corn flower extract 1%, Egyptian blue nymphaea tetragona carry
Take the smooth olive oleate 6% of thing 30%, little Cassia tora seed extract 1%, sorb, cetostearyl alcohol olive oleate 7%.
A kind of preparation method with the novel compound preparation for alleviating eye strain, includes the following steps：
（1）According to the required weight content of novel compound preparation for alleviating eye strain, peppermint oil, peppermint are weighed respectively
Alcohol, borneol are simultaneously added into a container；
（2）According to the required weight content of novel compound preparation for alleviating eye strain, the smooth olive oleic acid of sorb is weighed
Ester and cetostearyl alcohol olive oleate, then add the smooth olive oleate of sorb and cetostearyl alcohol olive oleate to step
Suddenly（1）In the container, in this process controlled at 70~85 DEG C, and 0.5~1h is stirred, wherein mixing speed is 100
~250r/min；
（3）According to alleviate eye strain the required weight content of novel compound preparation, weigh by honeysuckle flower extract,
Phllostachys pubescens leaf ext, corn flower extract, Egyptian blue water lily flower extract and little Cassia tora seed extract are put into step（1）And step
Suddenly（2）In the container；In this process controlled at 40~50 DEG C, and 0.5~1h is stirred, stop heating, then side is stirred
Side cooling is mixed, 2~6h of stirring is down to room temperature, obtains finished product, wherein mixing speed is 50~100r/min.
Respectively according to the formula of above-described embodiment, it is made with the novel compound preparation for alleviating eye strain, through overtesting
Proof has given full play to the effect of each component, possesses good relieving eye strain, eye skin is nursed one's health, eye antibacterial anti-inflammatory is more
Weight effect, and for eye crowd is used for a long time, the cuticula of eye skin is partially thin, is easily stimulated be subject to the external world, the present invention
It is non-stimulated to eyes with good moisturizing, moisturizing effect.
The technical concepts and features of embodiment of above only to illustrate the invention, its object is to allow be familiar with technique
People understands present disclosure and is carried out, and it is not intended to limit the scope of the present invention, all spiritual according to the present invention
The equivalent change or modification that essence is done, should all cover within the scope of the present invention.
Claims (9)
1. a kind of have the novel compound preparation for alleviating eye strain, it is characterised in that：Including peppermint oil, menthol, borneol, bear
Coltsfoot extract, phllostachys pubescens leaf ext, corn flower extract, Egyptian blue water lily flower extract, little Cassia tora seed extract, spermaceti are hard
The smooth olive oleate of lipidol olive oleate, sorb.
2. according to claim 1 have the novel compound preparation for alleviating eye strain, it is characterised in that：Feed components
Percentage by weight be：Peppermint oil 1-10%, menthol 0.1-10%, borneol 0.1-10%, honeysuckle flower extract 1-30%, Moso Bamboo Leaves
Extract 1-30%, corn flower extract 1-30%, Egyptian blue water lily flower extract 1-30%, little Cassia tora seed extract 1-30%, mountain
The smooth olive oleate 1-20% of pears, cetostearyl alcohol olive oleate 1-20%.
3. according to claim 1 have the novel compound preparation for alleviating eye strain, it is characterised in that：Feed components
Percentage by weight be：Peppermint oil 1-5%, menthol 1-5%, borneol 1-5%, honeysuckle flower extract 10-20%, phllostachys pubescens leaf ext
10-20%, corn flower extract 10-20%, Egyptian blue water lily flower extract 10-20%, little Cassia tora seed extract 10-20%, spermaceti
Stearyl alcohol olive oleate 5-10%, the smooth olive oleate 5-10% of sorb.
4. having the novel compound preparation for alleviating eye strain according to any one in claim 1-3, its feature exists
In：Dry Moso Bamboo Leaves are crushed, using supercritical carbon dioxide extraction method, and by the use of absolute ethyl alcohol as agent is carried, are parsed
To extract be dispersed in water, using macroporous absorbent resin Dynamic Adsorption, eluted after the completion of absorption with ethanol solution, eluent
It is concentrated under reduced pressure, concentrate is adsorbed using polyamide again, is eluted after the completion of absorption with ethanol solution, and eluent is concentrated under reduced pressure,
Obtain phllostachys pubescens leaf ext in raw material.
5. having the novel compound preparation for alleviating eye strain according to any one in claim 1-3, its feature exists
In：Crystallization is separated out after peppermint oil is freezed, centrifugation gained crystallization obtains pure levorotatory menthol with low boiling solvent recrystallization, except decrystallizing
Mother liquor afterwards contains menthol 40%~50%, hydrogenated to be changed into levorotatory menthol and dextrorotation is newly thin also containing larger amount of menthones
The mixture of lotus alcohol, it is crystallized, distill or be made after its borate and point go to other portions in peppermint oil by the partly-hydrolysed of ester
Point, obtain menthol in raw material.
A kind of 6. preparation method with the novel compound preparation for alleviating eye strain described in claim 1, it is characterised in that：
Include the following steps：
（1）According to the required weight content of novel compound preparation for alleviating eye strain, peppermint oil, peppermint are weighed respectively
Alcohol, borneol are simultaneously added into a container；
（2）According to the required weight content of novel compound preparation for alleviating eye strain, the smooth olive oleic acid of sorb is weighed
Ester and cetostearyl alcohol olive oleate, then add the smooth olive oleate of sorb and cetostearyl alcohol olive oleate to step
Suddenly（1）In the container, in this process controlled at 70~85 DEG C, and 0.5~1h is stirred；
（3）According to alleviate eye strain the required weight content of novel compound preparation, weigh by honeysuckle flower extract,
Phllostachys pubescens leaf ext, corn flower extract, Egyptian blue water lily flower extract and little Cassia tora seed extract are put into step（1）And step
Suddenly（2）In the container；In this process controlled at 40~50 DEG C, and 0.5~1h is stirred, stop heating, then side is stirred
Side cooling is mixed, 2~6h of stirring is down to room temperature, obtains finished product.
7. the preparation method with the novel compound preparation for alleviating eye strain according to claim 6, it is characterised in that：
The step（2）Mixing speed during middle stirring is 100~250r/min.
8. the preparation method with the novel compound preparation for alleviating eye strain according to claim 6, it is characterised in that：
The step（3）Mixing speed during middle stirring is 50~100r/min.
9. the application with the novel compound preparation for alleviating eye strain in a kind of claim 1-3 described in any one, its
It is characterized in that：The application prepared for relieving eye strain, conditioning eye skin and/or eye antibacterial-anti-inflammatory drug.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104288334A (en) * | 2014-09-17 | 2015-01-21 | 张道敬 | Traditional Chinese medicine eye drop for relieving eyestrain and preparation method thereof |
| CN105055184A (en) * | 2015-09-09 | 2015-11-18 | 广东轻工职业技术学院 | Composition with effect of removing eyelid pouches and application of composition |
| CN106580798A (en) * | 2016-12-30 | 2017-04-26 | 广州科盈化妆品有限公司 | All-in-one eye cream and preparation method |
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2017
- 2017-11-20 CN CN201711154409.9A patent/CN107929580A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104288334A (en) * | 2014-09-17 | 2015-01-21 | 张道敬 | Traditional Chinese medicine eye drop for relieving eyestrain and preparation method thereof |
| CN105055184A (en) * | 2015-09-09 | 2015-11-18 | 广东轻工职业技术学院 | Composition with effect of removing eyelid pouches and application of composition |
| CN106580798A (en) * | 2016-12-30 | 2017-04-26 | 广州科盈化妆品有限公司 | All-in-one eye cream and preparation method |
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