CN105726697A - Anti-asthenopia rose composition, eye drop and preparation method of anti-asthenopia rose composition - Google Patents
Anti-asthenopia rose composition, eye drop and preparation method of anti-asthenopia rose composition Download PDFInfo
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- CN105726697A CN105726697A CN201610176420.4A CN201610176420A CN105726697A CN 105726697 A CN105726697 A CN 105726697A CN 201610176420 A CN201610176420 A CN 201610176420A CN 105726697 A CN105726697 A CN 105726697A
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- rosae rugosae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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Abstract
The invention discloses an anti-asthenopia rose composition, an eye drop and a preparation method of the anti-asthenopia rose composition. The anti-asthenopia rose composition and the eye drop are prepared from the following raw materials in parts by weight: 160-230 parts of roses, 160-230 parts of honeysuckle and 1.5-4.5 parts of pearl powder. The eye drop reaches the effects of improving the eye blood microcirculation, improving eye fatigue and restoring the eyes into a normal state through compatibility of components, and has the effect which is obviously superior to that of individually used roses, honeysuckle or pearl powder. The eye drop has the characteristics of being simple to prepare and free of toxicity and irritation, and can be widely applied to various people with asthenopia.
Description
Technical field
The present invention relates to a kind of anti-asthenopic Flos Rosae Rugosae compositions, be specifically related to a kind of anti-asthenopic collyrium and preparation method thereof.
Background technology
Along with life style and the change of working condition of people, a large amount of appearance of netizen, cybraian and car owners, make regarding tired
Crowd's expanding day of labor, many people long-time in the face of computer screen or after driving, often occur eyes dry and astringent, foreign body sensation,
The asthenopia symptoms such as eyes acid is swollen, blurred vision, generally when the method such as have a rest, look in the distance cannot be alleviated, it is necessary to use specific
The collyrium of function is alleviated or treats asthenopia.Major part the most on the market, for asthenopic collyrium, contains anticorrosion more
Agent, such as life-time service, can cause preservative to cornea and the damage of conjunctiva.
In order to overcome traditional general for asthenopic collyrium action effect and containing preservative defect, the present invention is to medicament for the eyes
The formula of water is adjusted, and (has improve local nerve function anti-inflammatory, promote blood circulation with Flos Rosae Rugosae extract, rise
To eliminating asthenopic effect)；Flos Lonicerae (has the effects such as heat-clearing and toxic substances removing, dredge the meridian passage, broad-spectrum antiseptic and antiviral, has
" Chinese medicine antibiotic ", " title of antibacterial green element；Margarita powder (having the effect of improving eyesight) is raw material, prepares collyrium.
Summary of the invention
It is an object of the invention to provide one and can effectively alleviate asthenopia, antagonism visual deterioration；Moisten eye, alleviation eyes are done
Dry collyrium.
The present invention is realized by the following method:
A kind of anti-asthenopic Flos Rosae Rugosae compositions, this Flos Rosae Rugosae compositions comprises the raw material of following weight portion: Flos Rosae Rugosae 160-230 part；
Flos Lonicerae 160-230 part；Margarita powder 1.5-4.5 part.
Wherein it is preferred to, this Flos Rosae Rugosae compositions comprises the raw material of following weight portion: Flos Rosae Rugosae 160 parts；Flos Lonicerae 160 parts；Pearl
Powder Margarita powder 1.5 parts.
Wherein it is preferred to, this Flos Rosae Rugosae compositions comprises the raw material of following weight portion: Flos Rosae Rugosae 200 parts；Flos Lonicerae 200 parts；Pearl
Powder Margarita powder 2.5 parts.
Wherein it is preferred to, this Flos Rosae Rugosae compositions comprises the raw material of following weight portion: Flos Rosae Rugosae 230 parts；Flos Lonicerae 230 parts；Pearl
Powder Margarita powder 4.5 parts.
The invention also discloses the application in preparing anti-asthenopia medicine or health product of a kind of described Flos Rosae Rugosae compositions.
The invention also discloses a kind of collyrium containing described Flos Rosae Rugosae compositions.
The method that the invention also discloses described anti-asthenopic collyrium, the preparation process of described anti-asthenopic collyrium
For:
(1) take each raw material in proportion, Flos Rosae Rugosae, Flos Lonicerae are put into equipped with on the double-edged fine-toothed comb of the marmite of water, then uses on this marmite
Sealing on another marmite lid, slow fire decocts 5-8h, cools and has one layer of medicine frost on rear marmite inwall above, is collected by medicine frost；
(2) medicine of step (1) frost and the Margarita powder that weighs in proportion are put in the distilled water of 1000 parts and dissolve, after dissolving,
Boric acid adjusts pH value to be 6-7, filters, sterilizes, subpackage, sealing obtain finished product.
Detailed description of the invention
Below in conjunction with specific embodiment, technical scheme is described in further detail, but protection scope of the present invention is not limited to
Described embodiment.
Embodiment 1 alleviates the preparation of asthenopia collyrium
(1) formula 1
Flos Rosae Rugosae 160g, Flos Lonicerae 160g, Margarita powder 1.5g
(2) formula 2
Flos Rosae Rugosae 200g, Flos Lonicerae 200g；Margarita powder 2.5g.
(3) formula 3
Flos Rosae Rugosae 230g, Flos Lonicerae 230g；Margarita powder 4.5g.
Preparation method:
Weigh Flos Rosae Rugosae in proportion；Flos Lonicerae is put into equipped with on the double-edged fine-toothed comb of the marmite of water, then with on another marmite lid on this marmite
Sealing, slow fire decocts 5-8h, cools and has one layer of medicine frost on rear marmite inwall above, is collected by medicine frost；By medicine frost and in proportion
The Margarita powder weighed is put in the distilled water of 1000g and is dissolved, and after dissolving, boric acid adjusts pH value to be 6-7, filter, sterilize, point
Dress, sealing obtain finished product.
Embodiment 2 alleviates the acute eye irritation test of asthenopia collyrium
The collyrium prepared by formula in embodiment 11,2,3.
Rabbit 30, male and female half and half, by eye conjunctival sac on the right side of alleviation asthenopia collyrium 0.1ml instillation so that upper and lower eyelid
Passively closing 1s, another is surveyed eyes and does own control, instills by 1h, 24h, 48h, 72h after material object and the 4th day and the 7th day, sees
Examine by real Eye irritation response situation, and press the integration of the standards of grading record Eye irritation reaction of eye infringement.
| Animal Sex | Dosage | Number of animals | Cornea | Iris | Congested | Total mark |
| Formula 1 | 0.1ml/ is only | 10 | 0 | 0 | 0 | 0 |
| Formula 2 | 0.1ml/ is only | 10 | 0 | 0 | 0 | 0 |
| Formula 3 | 0.1ml/ is only | 10 | 0 | 0 | 0 | 0 |
Experimental result: irritative symptoms does not occurs in animal eye.Result shows that this collyrium eye irritation is little.
The alleviation asthenopia experiment of embodiment 3 anti-asthenopia collyrium
1. medicine
The collyrium prepared by formula in embodiment 11,2,3, and use Flos Lonicerae, Margarita powder, Flos Rosae Rugosae respectively as right
According to, compound method is as follows:
Flos Rosae Rugosae matched group:
Flos Rosae Rugosae 200g
Weigh Flos Rosae Rugosae in proportion to put into equipped with on the double-edged fine-toothed comb of the marmite of water, then seal with on another marmite lid on this marmite, literary composition
5-8h decocted by fire, cools and has one layer of medicine frost on rear marmite inwall above, is collected by medicine frost；Medicine frost is put into the distilled water of 1000g
In dissolve, after dissolving, boric acid adjusts pH value to be 6-7, filters, sterilizes, subpackage, sealing obtain Flos Rosae Rugosae comparison.
Flos Lonicerae matched group:
Flos Lonicerae 200g
Weigh Flos Lonicerae in proportion to put into equipped with on the double-edged fine-toothed comb of the marmite of water, then seal with on another marmite lid on this marmite, literary composition
5-8h decocted by fire, cools and has one layer of medicine frost on rear marmite inwall above, is collected by medicine frost；Medicine frost is put into the distilled water of 1000g
In dissolve, after dissolving, boric acid adjusts pH value to be 6-7, filters, sterilizes, subpackage, sealing obtain Flos Lonicerae comparison.
Margarita powder matched group:
2.5g
Preparation method:
The Margarita powder proportionally added is put in the distilled water of 1000 parts and is dissolved, and after dissolving, boric acid adjusts pH value to be 6-7, filter,
Sterilization, subpackage, sealing obtain finished product.
Judge according to the criterion in " health product function assessment assessment process and the method for inspection ".Screen 70 examples for a long time with eye,
Asthenopic volunteer, 10 examples use the anti-asthenopia collyrium of formula 1 as requested, and 10 examples use formula as requested
The anti-asthenopia collyrium of 2,10 examples use the anti-asthenopia collyrium of formula 3 as requested, and 10 examples are Flos Rosae Rugosae matched group, 10 examples
For Flos Lonicerae matched group, 10 examples are Margarita powder matched group, and 10 examples are blank.After 10 days, self compare symptom before and after experimental group total
Integration.
2. alleviate asthenopia inspection
Test basis: " health product function assessment assessment process and the method for inspection "
Result and judgement:
After Flos Rosae Rugosae comparison uses 10 days, front and back self comparing symptom total mark and decline 2.01, duration of photopic vision raises 11.97%；
Test group compares symptom total mark and declines 1.04 with blank group, and duration of photopic vision raises 6.05%；Total effective rate improves.
After Flos Lonicerae comparison uses 10 days, front and back self comparing symptom total mark and decline 1.84, duration of photopic vision raises 10.01%；
Test group compares symptom total mark and declines 0.87 with blank group, and duration of photopic vision raises 5.44%；Total effective rate improves.
After Margarita powder comparison uses 10 days, front and back self comparing symptom total mark and decline 1.38, duration of photopic vision raises 4.55%；Examination
Testing group and compare symptom total mark decline 0.41 with blank group, duration of photopic vision raises 2.57%；Total effective rate improves.
After formula 1 collyrium uses 10 days, self compare symptom total mark before and after formula 1 test group and decline 3.94, duration of photopic vision
Raise 24.22%；Test group compares symptom total mark and declines 2.97 with blank group, and duration of photopic vision raises 17.64%；Always have
Efficiency is obviously improved.
After formula 2 collyrium uses 10 days, self compare symptom total mark before and after formula 1 test group and decline 4.54, duration of photopic vision
Raise 31.25%；Test group compares symptom total mark and declines 3.57 with blank group, and duration of photopic vision raises 26.31%；Always have
Efficiency is obviously improved.
After formula 3 collyrium uses 10 days, self compare symptom total mark before and after formula 1 test group and decline 3.88, duration of photopic vision
Raise 23.75%；Test group compares symptom total mark and declines 2.91 with blank group, and duration of photopic vision raises 17.42%；Always have
Efficiency is obviously improved.
Three experimental formula indices reach effective criterion and are that t tests and composition t inspection is compared and had by self pair
Highly significant sex differernce (P ＜ 0.01): before and after test, other healthy index of correlation of experimenter the most substantially changes.According to " health care
Articles for use function assessment assessment process and the method for inspection " criterion in (DB22-T397-2004) judges: disclosed by the invention slow
Solve asthenopia collyrium and there is alleviation asthenopia effect, hence it is evident that be better than being used alone the effect of Flos Rosae Rugosae, Flos Lonicerae or Margarita powder.
Claims (7)
1. an anti-asthenopic Flos Rosae Rugosae compositions, it is characterised in that this Flos Rosae Rugosae compositions comprises the raw material of following weight portion: Flos Rosae Rugosae
160-230 part；Flos Lonicerae 160-230 part；Margarita powder 1.5-4.5 part.
2. anti-asthenopic Flos Rosae Rugosae compositions as claimed in claim 1, it is characterised in that this Flos Rosae Rugosae compositions comprises following weight portion
Raw material: Flos Rosae Rugosae 160 parts；Flos Lonicerae 160 parts；Margarita powder 1.5 parts.
3. anti-asthenopic Flos Rosae Rugosae compositions as claimed in claim 1, it is characterised in that this Flos Rosae Rugosae compositions comprises following weight portion
Raw material: Flos Rosae Rugosae 200 parts；Flos Lonicerae 200 parts；Margarita powder 2.5 parts.
4. anti-asthenopic Flos Rosae Rugosae compositions as claimed in claim 1, it is characterised in that this Flos Rosae Rugosae compositions comprises following weight portion
Raw material: Flos Rosae Rugosae 230 parts；Flos Lonicerae 230 parts；Margarita powder 4.5 parts.
5. a Flos Rosae Rugosae compositions application in preparing anti-asthenopia medicine or health product as described in any one of Claims 1-4.
6. the collyrium containing Flos Rosae Rugosae compositions described in any one of Claims 1-4.
7. the method for anti-asthenopic collyrium as claimed in claim 6, it is characterised in that described anti-asthenopic collyrium
Preparation process is:
(1) take each raw material in proportion, Flos Rosae Rugosae, Flos Lonicerae are put into equipped with on the double-edged fine-toothed comb of the marmite of water, then uses on this marmite
Sealing on another marmite lid, slow fire decocts 5-8h, cools and has one layer of medicine frost on rear marmite inwall above, is collected by medicine frost；
(2) medicine of step (1) frost and the pro rata Margarita powder that weighs are put in the distilled water of 1000 parts and dissolved, after dissolving,
Boric acid adjusts pH value to be 6-7, filters, sterilizes, subpackage, sealing obtain finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610176420.4A CN105726697B (en) | 2016-03-25 | 2016-03-25 | Anti-asthenopia rose composition, eye drop and preparation method of eye drop |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610176420.4A CN105726697B (en) | 2016-03-25 | 2016-03-25 | Anti-asthenopia rose composition, eye drop and preparation method of eye drop |
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| Publication Number | Publication Date |
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| CN105726697A true CN105726697A (en) | 2016-07-06 |
| CN105726697B CN105726697B (en) | 2020-02-28 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112168897A (en) * | 2019-07-04 | 2021-01-05 | 刘琪明 | Chinese patent medicine eye drops |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1943650A (en) * | 2006-10-30 | 2007-04-11 | 韩倩琰 | Rose liquid and its eye drops |
| CN104288334A (en) * | 2014-09-17 | 2015-01-21 | 张道敬 | Traditional Chinese medicine eye drop for relieving eyestrain and preparation method thereof |
| CN105125630A (en) * | 2015-09-08 | 2015-12-09 | 内江市药城宗玉医学研究所 | Eye drops and preparation method thereof |
-
2016
- 2016-03-25 CN CN201610176420.4A patent/CN105726697B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1943650A (en) * | 2006-10-30 | 2007-04-11 | 韩倩琰 | Rose liquid and its eye drops |
| CN104288334A (en) * | 2014-09-17 | 2015-01-21 | 张道敬 | Traditional Chinese medicine eye drop for relieving eyestrain and preparation method thereof |
| CN105125630A (en) * | 2015-09-08 | 2015-12-09 | 内江市药城宗玉医学研究所 | Eye drops and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112168897A (en) * | 2019-07-04 | 2021-01-05 | 刘琪明 | Chinese patent medicine eye drops |
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| CN105726697B (en) | 2020-02-28 |
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