CN110269850A - A kind of preparation for treating rhinitis and preparation method thereof of the active constituent of CBD containing cannabidiol - Google Patents
A kind of preparation for treating rhinitis and preparation method thereof of the active constituent of CBD containing cannabidiol Download PDFInfo
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Abstract
The present invention discloses a kind of preparation for treating rhinitis and preparation method thereof of active constituent of CBD containing cannabidiol, it is made of the raw material of following mass ratio: cannabidiol CBD 2-20%, Rhizoma Gastrodiae extract 0.2-1%, Notogineng Extract 0.1-0.5%, Rhizoma Polygonati extract 0.1-0.6%, Crodaret: 2-10%, 1.2- propylene glycol: 1-5%, glycerol 1-10%, rapeseed oil 1-10%, sorbic acid 0.2-1%, surplus are water, and the summation of above-mentioned each component is 100%.The different Rhinitis Symptoms such as acute, rhinitis chronic, nasosinusitis can be treated.Effective component of the present invention is cannabidiol CBD, in conjunction with nano-emulsion booster action, its effect is increased, its stability is improved, then is acted synergistically with Rhizoma Gastrodiae extract, Notogineng Extract, Rhizoma Polygonati extract cooperation, drug is not only enable uniformly to play maximum drug effect, drug absorption is rapid, and onset time is fast after being administered, and medication is convenient, is easy to be absorbed by affected part or lesions position.The present invention is externally applied drug.
Description
Technical field
The present invention relates to a kind of sprays for treating rhinitis, and in particular to a kind of nose of the active constituent of CBD containing cannabidiol
Scorching spray and preparation method thereof, belongs to field of biotechnology.
Background technique
Rhinitis, that is, nasal cavity inflammatory disease is virus, bacterium, allergen, various physical and chemical factors and certain systemic diseases
The inflammation of caused bronchia mucosal.The main pathological change of rhinitis is bronchia mucosal hyperemia, swelling, exudation, hyperplasia, atrophy or bad
It waits indefinitely.And common Rhinitis Symptoms have: acute rhinitis, rhinitis chronic, nasosinusitis, allergic rhinitis, rhinitis medicamentosa etc., morbidity
When cardinal symptom be the more tears of having a stuffy nose, rhiocnesmus, sneezing, smell decline, giddy headache etc..The drug of previous treatment rhinitis has anti-group
Knit amine medicine such as chlorpheniramine, Acrivastine etc.；Decongestant such as ephedrine, FUMA HEJI etc..Drug therapy is usually no more than 7 days, long
Phase is using can cause rhinitis medicamentosa；Hormone medicine such as primary gram of sodium, Rhinocort etc..Though the curative effect of Western medicine is good, side effect
Greatly, and it is unable to long-term administration, the disease easily sent out this to rhinitis is often palliative, in addition treats the drug sucking of rhinitis
Afterwards can also be by liver metabolism, once being metabolized can inactivate, drug effect is not lasting, and effect is undesirable.
Cannabidiol CBD is the effective component extracted from natural cannabis plants, and there is no literature reported on to treatment nose at present
It is scorching effective.
Summary of the invention
The first purpose of this invention be to provide it is a kind of can effectively treat acute, rhinitis chronic and nasosinusitis containing hemp
The preparation for treating rhinitis of diphenol CBD active constituent.
Second object of the present invention is to provide a kind of preparation side of the preparation for treating rhinitis of active constituent of CBD containing cannabidiol
Method.
In order to realize that above-mentioned first purpose, the present invention are achieved through the following technical solutions: one kind CBD containing cannabidiol is living
The preparation for treating rhinitis of property ingredient, it is characterised in that be made of the raw material of following mass percent:
The summation of above-mentioned each component is 100%.
The cannabidiol CBD extract is commercial products, is the effective component extracted from natural hemp, belongs to non-
Additive active material, cannabidiol CBD have analgesia, the vomiting of antitumor, nausea, treatment spirit and cerebral disorders, it is anti-inflammatory,
The effects of antibacterial.
Rhizoma Gastrodiae is herbaceos perennial, is conventional Chinese medicine simply, property is pungent, warm, nontoxic, there is calmness, antispastic, analgesic
Effect.Radix Notoginseng is Araliaceae, there is detumescence ding-tong effect.Rhizoma polygonati is HUANGJING ZANYU CAPSULE, has tonifying spleen, the effect of moistening lung and producing body fluid
The Rhizoma Gastrodiae extract, Notogineng Extract, Rhizoma Polygonati extract are commercial products.
Further, the Rhizoma Gastrodiae extract passes through following operation: the concentration of 5 times of Rhizoma Gastrodiae powder quality being added in Rhizoma Gastrodiae powder
It is stirred 60min for the ethyl alcohol of 95v/v%, adds same concentrations, the ethyl alcohol of 10 times of Rhizoma Gastrodiae powder quality impregnates 12h, through seeping
It filters, collects filtrate, medicinal extract is concentrated under reduced pressure into get Rhizoma Gastrodiae extract is arrived in filtrate.
Further, the Notogineng Extract is through following operation: the concentration of 10 times of Radix Notoginseng powder quality being added in Radix Notoginseng powder
Extracted 2 times, each 20min for the EtOH Sonicate of 95v/v%, filtering merges 2 filtrates, filtrate decompression be condensed into medicinal extract to get
To Notogineng Extract.
Further, the Rhizoma Polygonati extract is made by following operation: it dries, then is crushed into powder after rhizoma polygonati is sliced,
It is 1:8 by solid-liquid ratio g/ml, impregnates 12h with the ethyl alcohol that mass concentration is 95%, after filtering, collect rhizoma polygonati alcohol extract, alcohol extracting
Medicinal extract shape is concentrated under reduced pressure into get Rhizoma Polygonati extract is arrived in liquid.
The Crodaret is regular market purchase product, is a kind of faint yellow to orange-yellow thick liquid,
It is used as the solubilizer or emulsifier of spray.
The glycerol, 1.2- propylene glycol are commercially available moisturizer.
The rapeseed oil is commercially available edible oil.
The sorbic acid is commercially available antisepsis antistaling agent.
Second object of the present invention is realized by following technical proposal: a kind of nose of the active constituent of CBD containing cannabidiol
The preparation method of scorching preparation, it is characterised in that pass through following each step:
(1) material preparation of following mass percent is pressed:
The summation of above-mentioned each component is 100%；
(2) Rhizoma Gastrodiae extract, Notogineng Extract, Rhizoma Polygonati extract are mixed, suitable quantity of water is added and stirs evenly, obtains material
A；
(3) after mixing by Crodaret, glycerol, rapeseed oil, it is heated to 30-50 DEG C, it later will be big
Numb diphenol CBD extract is added in the miscella, and low whipping speed is to keep cannabidiol CBD extract complete under 10-30r/s
At being dissolved in miscella, then plus suitable quantity of water is stirred to the molten object of oil and is completely dissolved in water under the speed of 10-40r/s,
Obtain material B；
(4) after mixing by the material A of the material B of step (3) and step (2), 10-15h, mistake are refrigerated at 3-5 DEG C
Filter collects filtrate, obtains material C；
(5) sorb acid for adjusting pH value is added in material C to 5-6, adds 1.2- propylene glycol and the stirring of remaining water is mixed
It is even to get arrive the active constituent of CBD containing cannabidiol preparation for treating rhinitis.
The preparation for treating rhinitis of the active constituent of CBD containing cannabidiol is spray, is perhaps liniment or is drops.
The present invention has following advantages and effect: the nose of the active constituent of CBD containing cannabidiol obtained using the above scheme
Scorching preparation is mainly used for treating the different rhinitis such as acute or chronic rhinitis, nasosinusitis.Its effective component is cannabidiol CBD,
Especially by preparation for treating rhinitis made from the method for the present invention, effect can be increased to the maximum extent, improve its stability, then with Rhizoma Gastrodiae
The cooperation synergistic effect of extract, Notogineng Extract, Rhizoma Polygonati extract, not only enables drug uniformly play maximum medicine
Effect, drug absorption is rapid, and onset time is fast after administration, and medication is convenient, is easy to be absorbed by affected part or lesions position.
Specific implementation method
Below with reference to embodiment, the present invention will be further described.
Embodiment 1
(1) material preparation of following mass percent is pressed
The Rhizoma Gastrodiae extract passes through following operation: the concentration that 5 times of Rhizoma Gastrodiae powder quality are added in Rhizoma Gastrodiae powder is 95v/v%
Ethyl alcohol be stirred 60min, add same concentrations, the ethyl alcohol of 10 times of Rhizoma Gastrodiae powder quality impregnates 12h, through diacolation, collect filter
Medicinal extract is concentrated under reduced pressure into get Rhizoma Gastrodiae extract is arrived in liquid, filtrate；
The Notogineng Extract passes through following operation: the concentration that 10 times of Radix Notoginseng powder quality are added in Radix Notoginseng powder is 95v/
The EtOH Sonicate of v% extracts 2 times, each 20min, filtering, merges 2 filtrates, and filtrate decompression is condensed into medicinal extract to get Radix Notoginseng is arrived
Extract；
The Rhizoma Polygonati extract is by following operation: drying, then is crushed into powder after rhizoma polygonati is sliced, is by solid-liquid ratio g/ml
1:8 impregnates 12h with the ethyl alcohol that mass concentration is 95%, after filtering, collects rhizoma polygonati alcohol extract, alcohol extract is concentrated under reduced pressure
At medicinal extract shape to get arrive Rhizoma Polygonati extract；
(2) Rhizoma Gastrodiae extract, Notogineng Extract, Rhizoma Polygonati extract are uniformly mixed with suitable quantity of water together, obtain material A；
(3) by Crodaret, glycerol, rapeseed oil is mixed, and 30 DEG C is heated to, later by cannabidiol CBD
Extract is added in the miscella, and low whipping speed is so that the completion of cannabidiol CBD extract is dissolved in mixing under 10r/s
In oil, then plus suitable quantity of water stirs to the molten object of oil and is completely dissolved in water, obtain material B under the speed of 40r/s；
(4) after mixing by the material A of the material B of step (3) and step (2), 12h, mistake are refrigerated under the conditions of 4 DEG C
Filter collects filtrate, obtains material C；
(5) sorb acid for adjusting pH value is added in material C to 5, adds 1.2- propylene glycol and remaining water stirs and evenly mixs,
Obtain the spray for treating rhinitis of the active constituent of CBD containing cannabidiol.
Embodiment 2
(1) material preparation of following mass percent is pressed:
The preparation of the Rhizoma Gastrodiae extract, Notogineng Extract, Rhizoma Polygonati extract is the same as embodiment 1；
(2) by Rhizoma Gastrodiae extract, Notogineng Extract, Rhizoma Polygonati extract is mixed, and suitable quantity of water is added and is uniformly mixed, obtains material
A；
(3) by Crodaret, glycerol, rapeseed oil is mixed, and 50 DEG C is heated to, later by cannabidiol CBD
Extract is added in the miscella, and low whipping speed is so that the completion of cannabidiol CBD extract is dissolved in mixing under 10r/s
In oil, then plus suitable quantity of water stirs to the molten object of oil and completely dissolves in water, obtain material B under the speed of 10r/s；
(4) after mixing by the material A of the material B of step (3) and step (2), 12h, mistake are refrigerated under the conditions of 4 DEG C
Filter collects filtrate, obtains material C；
(5) sorb acid for adjusting pH value is added in material C to 6, adds 1.2- propylene glycol and remaining water stirs and evenly mixs,
Obtain the spray for treating rhinitis of the active constituent of CBD containing cannabidiol.
Embodiment 3
(1) material preparation of following mass percent is pressed:
The Rhizoma Gastrodiae extract, Notogineng Extract, Rhizoma Polygonati extract are commercial products；
(2) by Rhizoma Gastrodiae extract, Notogineng Extract, Rhizoma Polygonati extract is mixed, and suitable quantity of water is added and is uniformly mixed, obtains material
A；
(3) by Crodaret, glycerol, rapeseed oil is mixed, and 40 DEG C is heated to, later by cannabidiol CBD
Extract is added in the miscella, and low whipping speed is so that the completion of cannabidiol CBD extract is dissolved in mixing under 20r/s
In oil, then plus suitable quantity of water stirs to the molten object of oil and is completely dissolved in water, obtain material A under the speed of 20r/s；
(4) after mixing by the material A of the material B of step (3) and step (2), 12h, mistake are refrigerated under the conditions of 4 DEG C
Filter collects filtrate, obtains material C；
(5) sorb acid for adjusting pH value is added in material C to 6, adds 1.2- propylene glycol and remaining water stirs and evenly mixs,
Obtain the rhinitis liniment of the active constituent of CBD containing cannabidiol.
Embodiment 4
(1) material preparation of following mass percent is pressed:
The Rhizoma Gastrodiae extract, Notogineng Extract, Rhizoma Polygonati extract are commercial products；
(2) Rhizoma Gastrodiae extract, Notogineng Extract, Rhizoma Polygonati extract are mixed, suitable quantity of water is added and is uniformly mixed, obtains material
A；
(Crodaret, glycerol, rapeseed oil after mixing, are heated to 38 DEG C by (3), later by hemp
Diphenol CBD extract is added in the miscella, and low whipping speed is so that cannabidiol CBD extract is completed dissolution under 25r/s
In miscella, then plus suitable quantity of water stirs to the molten object of oil and is completely dissolved in water, obtain material B under the speed of 30r/s；
(4) after mixing by the material A of the material B of step (3) and step (2), 10h is refrigerated at 5 DEG C, filtered, receive
Collect filtrate, obtains material C；
(5) sorb acid for adjusting pH value is added in material C to 5, adds 1.2- propylene glycol and remaining water stirs and evenly mixs,
Obtain the rhinitis liniment of the active constituent of CBD containing cannabidiol.
Embodiment 5
(1) material preparation of following mass percent is pressed:
The preparation of the Rhizoma Gastrodiae extract, Notogineng Extract, Rhizoma Polygonati extract is the same as embodiment 1；
(2) Rhizoma Gastrodiae extract, Notogineng Extract, Rhizoma Polygonati extract are mixed, suitable quantity of water is added and is uniformly mixed, obtains material
A；
(Crodaret, glycerol, rapeseed oil after mixing, are heated to 40 DEG C by (3), later by hemp
Diphenol CBD extract is added in the miscella, and low whipping speed is so that cannabidiol CBD extract is completed dissolution under 30r/s
In miscella, then plus suitable quantity of water stirs to the molten object of oil and is completely dissolved in water, obtain material B under the speed of 40r/s；
(4) after mixing by the material A of the material B of step (3) and step (2), 15h is refrigerated at 3 DEG C, filtered, receive
Collect filtrate, obtains material C；
(5) sorb acid for adjusting pH value is added in material C to 6, adds 1.2- propylene glycol and remaining water stirs and evenly mixs,
Obtain the rhinitis liniment of the active constituent of CBD containing cannabidiol.
The present invention detects its security performance through following test example:
Experimental example one, Detection of Stability
Detection method: referring to " disinfection technology standard " version in 2002
Stability test method: Acceleration study: the sample of embodiment 1-5 is placed in 55 DEG C of insulating boxs respectively, is examined respectively
0d, 15d, 30d, 45d are surveyed, the sample index of 60d different number of days keeps relative humidity > 75%, and sampling carries out antibacterial or bactericidal properties
It can test.
1.1.2 Testing index are as follows:
1. appearance detects: color, smell is muddy, is layered, precipitating
2. ultraviolet spectrogram is stablized
3. inhibitory effect: detection is to Escherichia coli, staphylococcus aureus bacteriostasis
1.1.3 testing result
Evaluation criterion:
55 DEG C of accelerated stability testing results: sterilizing rate or bacteriostasis rate reach defined standard value, determine embodiment 1-5's
The sterilization of the preparation for treating rhinitis of the nano-emulsion of CBD containing cannabidiol or bacteriostasis be it is effective, room temperature preservation at least 2 years.
Experimental example two, Skin and mucosa irritation experiment
Main agents:
The preparation for treating rhinitis of the nano-emulsion of CBD containing cannabidiol of embodiment 1-5, physiological saline, 75% alcohol；
Main material: scissors, dropper；
Experimental animal: each embodiment is with 3 rabbits, and eyeball is normal, average weight: 2.5kg；
Specific experiment method:
Each embodiment does three repeated experiments with 3 rabbits, and rabbit left eye is test group, and right eye is control group, Gu
It is fixed, check that the eyes of every rabbit, eye are normal.Eyelid is gently pulled down, after eyeball, physiological saline is taken to be respectively dropped into
In eye conjunctiva capsule (1-2 drop), eyelid is then closed about 2~3 seconds.Normal saline flushing is used after 30s, and images of left and right eyes is administered later,
And in 0h, 1h, for 24 hours, 48h, 72h, 7d, 14d observed.If not occurring stimulate the reaction in 72h, or to 7d or 14d, eye thorn
Swash and restore completely, experiment can be terminated in advance.
Testing index:
1. there is the irritative responses such as corneal injury, injury of iris, hyperemia, oedema.
Evaluation index:
In (for 24 hours, 48h, 72h) observing time point, according to following table to horn membrane damage, iris damage, conjunctival congestion,
It scores in terms of chemosis four, and temporally puts be added the scoring of animal respectively, divided by number of animals, respectively with animal horn
Film, iris, conjunctival congestion, the average score of oedema, recovery time carry out, and according to the form below is evaluated the tested material and stimulated animal skin
Intensity.
Daily every animal average integral (stimulus index) is calculated according to the following formula, and following list deciding skin irritatin is strong
Degree.
Note: restore the Eye irritation reaction scoring for referring to animal: cornea, iris damage=0, conjunctival congestion, oedema=0 completely
Or 1.
Note: recovery time: restoring for the scoring of animal stimulate the reaction to corneal injury 0, iris damage 0, conjunctival congestion 0 or 1,
The time of chemosis 0 or 1.
Corrosivity: at least 1 animal still has cornea adhesion or pannus in 21d, can also be judged to corrosivity.
Experimental result:
1 preparation stimulation test appraisal result of embodiment
2 preparation stimulation test appraisal result of embodiment
3 preparation stimulation test appraisal result of embodiment
4 preparation stimulation test appraisal result of embodiment
5 preparation stimulation test appraisal result of embodiment
Summarize: tri- rabbits of A, B, C of each embodiment for 24 hours, in 48h, 72h period generate corneal injury < 1, rainbow
Membrane damage < 1, conjunctival congestion < 1, chemosis < 1, recovery time < 7d, be expressed as it is nonirritant, illustrate embodiment 1-5 containing big
The preparation for treating rhinitis of numb diphenol CBD nano-emulsion can be used safely.
Experimental example three, intact skin stimulation test
Main agents:
The preparation for treating rhinitis of the nano-emulsion of CBD containing cannabidiol of embodiment 1-5, physiological saline, 75% alcohol；
Main material: scissors, dropper；
Experimental animal: each embodiment three rabbits, skin no marking, no wound, average weight: 2.5kg
Concrete operation step
Next day, (concentration was generally 5 times of skin degerming application liquid or stoste 0.5ml (g) is coated in side skin by tested material
On, the other side applies solvent as control, and the 4h after smearing is cleaned with water or non-stimulated suitable solvent, removes residue.Daily
It smears 1 time, continuously smears 14d.Result is observed for 24 hours after each smear, and is scored by table 2.For the ease of tested material smearing and
As a result it observes, answers cropping when necessary.The same test block of the processing method of check plot.
2. evaluation regulation
1. intact skin stimulation test
Daily every animal average integral (stimulus index) is calculated according to the following formula, and determines that skin irritatin is strong with table two
Degree.
Average integral=∑ (total mark of every animal 14 days erythema and oedema)/animal subject of daily every animal
Number * 14
Table one:
The standards of grading of skin wound repair
Table two:
Skin irritatin strength grading
Experimental result
The multiple stimulation test appraisal result of 1 preparation of embodiment
1 Multiple skin irritation test appraisal result of embodiment
Administration group 14d erythema and oedema total mark: 55 skin irritation index: 1.3
Control group 14d erythema and oedema total mark: 3 skin irritation index: 0.07
The multiple stimulation test appraisal result of 2 preparation of embodiment
2 Multiple skin irritation test appraisal result of embodiment
Administration group 14d erythema and oedema total mark: 55 skin irritation index: 1.3
Control group 14d erythema and oedema total mark: 3 skin irritation index: 0.07
The multiple stimulation test appraisal result of 3 preparation of embodiment
3 Multiple skin irritation test appraisal result of embodiment
51 skin irritation index of administration group 14d erythema and oedema total mark: 0.9
Control group 14d erythema and oedema total mark: 3 skin irritation index: 0.07
The multiple stimulation test appraisal result of 4 preparation of embodiment
4 Multiple skin irritation test appraisal result of embodiment
Administration group 14d erythema and oedema total mark: 54 skin irritation index: 1.2
Control group 14d erythema and oedema total mark: 3 skin irritation index: 0.07
The multiple stimulation test appraisal result of 5 preparation of embodiment
5 Multiple skin irritation test appraisal result of embodiment
Administration group 14d erythema and oedema total mark: 48 skin irritation index: 0.5
Control group 14d erythema and oedema total mark: 3 skin irritation index: 0.07
Summarize: tri- rabbits of A, B, C of each embodiment in continuous 14 days multiple dosing stimulation tests, see through medicine by eye
Group and control group physiological saline are given a mark and are classified according to reaction standards of grading, and administration group skin irritation index range exists
0.5-1.3；Physiological saline group skin irritation index is 0.07, and rhinitis belongs within the scope of slight stimulation by spraying, and skin after 2 days
Restore normal, illustrates that the preparation for treating rhinitis of the nano-emulsion of CBD containing cannabidiol of embodiment 1-5 has been inferred as slight stimulation, it can be with
Safe handling.
Experimental example four
The therapeutic efficiency of preparation for treating rhinitis of the invention to rhinitis chronic, acute rhinitis, nasosinusitis:
300 men and women patients are selected to carry out experience on probation, wherein rhinitis chronic 100, acute rhinitis 100, nasosinusitis
100,300 patient symptoms are mostly more tears of having a stuffy nose, and rhiocnesmus is sneezed, smell decline, the various diseases such as giddy headache, at random
It is divided into treatment group and control group, treatment group 200 is 100, female 100, control group 100 male: male 100, female 100,
Two groups of genders, age severity extent are statistically analyzed that there was no significant difference (P > 0.05).
1, treatment method, treatment group 200 are divided into male, female each 10, and 20 one group, totally five groups, five groups make respectively
It is a kind of obtained by embodiment 1-5 to contain cannabidiol (CBD) active constituent nanometer preparation for treating rhinitis, it uses 7 days, carries out 3 times a day
It is spraying；Control group 100 were sprayed using Rhinocort spray for treating rhinitis on the market using 7 days three times a day.
2, efficacy evaluation: effective: other symptoms disappear, and dizzy headache syndromes disappear substantially, and nose ventilation is obviously improved, and have
Effect: other symptoms disappear, and dizzy headache syndromes have improvement, and nose ventilation is preferably, invalid: more tears of having a stuffy nose, rhiocnesmus, sneezing, smell
Decline, dizzy headache syndromes are not improved.
Experimental result
| Group | Case load/example | Effective example (%) | Effective example (%) | Invalid example (%) | Efficient (%) |
| Treatment group | 200 | 160 | 30 | 10 | 95% |
| Control group | 100 | 50 | 10 | 40 | 60% |
Experiment conclusion: the effective percentage for the treatment of group is significantly better than control group, illustrates spray of the invention to rhinitis chronic, urgency
Property rhinitis, nasosinusitis have conspicuousness therapeutic effect.
Claims (6)
1. a kind of preparation for treating rhinitis of the active constituent of CBD containing cannabidiol, it is characterised in that by the raw material system of following mass percent
At:
Cannabidiol CBD 2-20%,
Rhizoma Gastrodiae extract 0.2-1%,
Notogineng Extract 0.1-0.5%,
Rhizoma Polygonati extract 0.1-0.6%,
Crodaret 2-10%,
1.2- propylene glycol 1-5%,
Glycerol 1-10%,
Rapeseed oil 1-10%,
Sorbic acid 0.2-1%,
Water surplus,
The summation of above-mentioned each component is 100%.
2. the preparation for treating rhinitis of the active constituent of CBD containing cannabidiol as described in claim 1, it is characterised in that the cannabidiol
CBD extract, Rhizoma Gastrodiae extract, Notogineng Extract, Rhizoma Polygonati extract are commercial products.
3. the preparation for treating rhinitis of the active constituent of CBD containing cannabidiol as described in claim 1, it is characterised in that the Rhizoma Gastrodiae extracts
Object passes through following operation: the ethyl alcohol that the concentration that 5 times of Rhizoma Gastrodiae powder quality are added in Rhizoma Gastrodiae powder is 95v/v% is stirred 60min,
Add same concentrations, the ethyl alcohol of 10 times of Rhizoma Gastrodiae powder quality impregnates 12h, through diacolation, collect filtrate, leaching is concentrated under reduced pressure into filtrate
Cream to get arrive Rhizoma Gastrodiae extract.
4. the preparation for treating rhinitis of the active constituent of CBD containing cannabidiol as described in claim 1, it is characterised in that the Radix Notoginseng is extracted
Object is through following operation: EtOH Sonicate extraction 2 times that the concentration that 10 times of Radix Notoginseng powder quality are added in Radix Notoginseng powder is 95v/v%, every time
20min, filtering merge 2 filtrates, and filtrate decompression is condensed into medicinal extract to get Notogineng Extract is arrived.
5. the preparation for treating rhinitis of the active constituent of CBD containing cannabidiol as described in claim 1, it is characterised in that the rhizoma polygonati extracts
Object is made by following operation: drying, then is crushed into powder after rhizoma polygonati is sliced, is 1:8 by solid-liquid ratio g/ml, is with mass concentration
95% ethyl alcohol impregnates 12h, after filtering, collects rhizoma polygonati alcohol extract, medicinal extract shape is concentrated under reduced pressure into get Huang is arrived in alcohol extract
Essence extract.
6. a kind of preparation method of the preparation for treating rhinitis of the active constituent of CBD containing cannabidiol, it is characterised in that pass through following each step:
(1) material preparation of following mass percent is pressed:
Cannabidiol CBD 2-20%,
Rhizoma Gastrodiae extract 0.2-1%,
Notogineng Extract 0.1-0.5%,
Rhizoma Polygonati extract 0.1-0.6%,
Crodaret 2-10%,
1.2- propylene glycol 1-5%,
Glycerol 1-10%,
Rapeseed oil 1-10%,
Sorbic acid 0.2-1%,
Water surplus,
The summation of above-mentioned each component is 100%；
(2) Rhizoma Gastrodiae extract, Notogineng Extract, Rhizoma Polygonati extract are mixed, suitable quantity of water is added and stirs evenly, obtains material A；
(3) after mixing by Crodaret, glycerol, rapeseed oil, it is heated to 30-50 DEG C, later by hemp two
Phenol CBD extract is added in the miscella, and low whipping speed is to complete cannabidiol CBD extract molten under 10-30r/s
Solution is in miscella, and then plus suitable quantity of water is stirred to the molten object of oil and is completely dissolved in water, obtain under the speed of 10-40r/s
Material B；
(4) after mixing by the material A of the material B of step (3) and step (2), 10-15h is refrigerated at 3-5 DEG C, filtered, receive
Collect filtrate, obtains material C；
(5) sorb acid for adjusting pH value is added in material C to 5-6, adds 1.2- propylene glycol and remaining water stirs and evenly mixs, i.e.,
Obtain the preparation for treating rhinitis of the active constituent of CBD containing cannabidiol.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021158714A1 (en) * | 2020-02-07 | 2021-08-12 | Natural Extraction Systems, LLC | Compositions and methods related to cannabinoid anions |
| CN113633717A (en) * | 2021-09-17 | 2021-11-12 | 云南根之然生物科技有限公司 | Electronic atomized liquid composition for nasal cavity care, application thereof and obtained care product |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1253806A (en) * | 1999-10-26 | 2000-05-24 | 王克廷 | Medicine for external application for curing rhinitis and its preparation method |
-
2019
- 2019-06-15 CN CN201910518296.9A patent/CN110269850A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1253806A (en) * | 1999-10-26 | 2000-05-24 | 王克廷 | Medicine for external application for curing rhinitis and its preparation method |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021158714A1 (en) * | 2020-02-07 | 2021-08-12 | Natural Extraction Systems, LLC | Compositions and methods related to cannabinoid anions |
| CN113633717A (en) * | 2021-09-17 | 2021-11-12 | 云南根之然生物科技有限公司 | Electronic atomized liquid composition for nasal cavity care, application thereof and obtained care product |
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