CN107334845A - A kind of acne gel containing traditional Chinese medicine ingredients and preparation method thereof - Google Patents

A kind of acne gel containing traditional Chinese medicine ingredients and preparation method thereof Download PDF

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Publication number
CN107334845A
CN107334845A CN201710563498.6A CN201710563498A CN107334845A CN 107334845 A CN107334845 A CN 107334845A CN 201710563498 A CN201710563498 A CN 201710563498A CN 107334845 A CN107334845 A CN 107334845A
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chinese medicine
acne
root
medicine extract
vitamin
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裴利红
谭庆坤
高琛
李泠玥
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Shandong Academy of Chinese Medicine
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Shandong Academy of Chinese Medicine
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718—Coptis (goldthread)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4415—Pyridoxine, i.e. Vitamin B6
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    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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Abstract

The invention provides a kind of acne gel containing traditional Chinese medicine ingredients, the active ingredient of following parts by weight is included：Treat the Chinese medicine extract 250 1000 of acne, sulphur 58, the dried venom of toads 35, vitamin B65 15, vitamin C glucoside 15, zinc chloride 5 10, allantoin 0.5 1, the 1%wt of excipient 0.5, surfactant 0.05 0.15%wt, the 1%wt of preservative 0 and the 10%wt of solvent 5；The Chinese medicine extract of the treatment acne, is made up of the raw material of following parts by weight：The coptis 30 50, radix scutellariae 40 50, the capsule of weeping forsythia 30 50, schizonepeta 40 50, windproof 40 50, cape jasmine 30 50, the dried immature fruit of citron orange 40 50, kuh-seng 50 100, dandelion 100 200, pot marigold 30 40, tribulus terrestris 20 30, the root of Dahurain angelica 40 50, the root of herbaceous peony 40 50, Poria cocos 40 50, radix glycyrrhizae 20 40.The acne gel containing traditional Chinese medicine ingredients of the present invention does not contain hormone, antibiotic, and use is safer, is discontinued after use uneasy to recur；The effect of with anti-inflammatory, antipruritic, toxin expelling, the lasting period, long toxic side effect was small；Skin-nourishing can be also supplemented, improves skin oxidation resistance, promotes skin self-healing, eliminates pockmark.

Description

A kind of acne gel containing traditional Chinese medicine ingredients and preparation method thereof
Technical field
The present invention relates to a kind of acne gel containing traditional Chinese medicine ingredients and preparation method thereof, belong to medical pharmaceutical field.
Background technology
Acne is a kind of multifactor disease, be currently known its morbidity with sex hormone level, sebaceous glands largely secrete, acne The factor such as Propionibacterium propagation, pilosebaceous duct dyskeratosis and inflammation is relevant.Generally, acne is apt to occur in Adolescent male Or women, few patients can also extend to more than 30 years old.Although acne be have self-healing be inclined to disease, acne in itself with And caused scar can have a strong impact on the quality of life of patient to acne treatment not in time, the stress and economy for causing patient are born Load, therefore the medicine for treating acne is the study hotspot of this area.
In the traditional Chinese medical science, acne is referred to as " acne " or " whelk ".The traditional Chinese medical science thinks that acne majority is eating and drinking without temperance, damage Taste, lung stomach is hot and suffocating, upper to steam face and cause, and it demonstrate,proves mostly empirical.And it is relevant with patient heart, if long-term spirit is not relaxed, heat The heresy of poison is taken advantage of a weak point, and visitor or flees in channels and collaterals between the flesh natural fibre line of meat so that qi and blood train of thought is obstructed, the long suppuration of the stasis of blood and cause purulence Sore, it is the chronic inflammatory skin of hair follicle and sebaceous glands.Western medicine thinks to remove endocrinopathy, and 3male hormone secretion is vigorous to be drawn It is also relevant with some pathogenic bacterial infections outside rising, such as pityrosporum furfur, propionibacterium acnes, staphylococcus aureus and acarid Deng.Treatment acne treats acne frequently with antibiotic, sex hormone, retinoid etc. at present, though there is certain effect, controls outside not In controlling, the internal factor for inducing acne still has, and the secondary work of larger poison be present with antibiotic and hormone medicine treatment With.
At present, it is usually clinically to be treated using antibiotic medicine for oral administration, based on anti-inflammation, but some contain The medicine of tetracycline, prolonged administration of drugs can aggravate liver, the burden of kidney, especially there is taboo to pregnant woman, and easily multiple after deactivation Hair.Treatment by Chinese herbs acne is mostly to take clearing heat and detoxicating reduce internal heat orally, it is difficult to is taken into account caused by the Different types of etiopathogenises such as various asthenic symptoms and excessive internal heat Situation, it is difficult to realize to treat both principal and secondary aspect of disease, while action effect is slow, manufacturing process is cumbersome, is not suitable for modern allegro life.Cause This, it is still desirable to the medicine that the effect of finding treatment acne is good, toxic side effect is small, easy to use.
The content of the invention
Slow to acne curative effect for current pure Chinese medicine composition externally applied drug, the easily recurrence etc. of western medicine composition externally applied drug treatment acne is asked Topic, the present invention provide a kind of safety, the good acne gel containing traditional Chinese medicine ingredients of effect.
It is a further object of the present invention to provide a kind of preparation method of easy above-mentioned gel preparation.
To achieve the above object, the present invention adopts the following technical scheme that.
A kind of acne gel containing traditional Chinese medicine ingredients, include the active ingredient of following parts by weight：Treat the traditional Chinese medicine extraction of acne Liquid 250-1000, sulphur 5-8, dried venom of toads 3-5, vitamin B65-15, vitamin C glucoside 1-5, zinc chloride 5-10, allantoin 0.5-1；
The Chinese medicine extract of the treatment acne, is made up of the raw material of following parts by weight：Coptis 30-50, radix scutellariae 40-50, the capsule of weeping forsythia 30-50, schizonepeta 40-50, windproof 40-50, cape jasmine 30-50, dried immature fruit of citron orange 40-50, kuh-seng 50-100, dandelion 100-200, pot marigold 30-40, tribulus terrestris 20-30, root of Dahurain angelica 40-50, root of herbaceous peony 40-50, Poria cocos 40-50, radix glycyrrhizae 20-40.
The sulphur fineness is 200-400 mesh.
The acne gel is also comprising 0.5-1%wt excipient, 0.05-0.15%wt surfactants, 0-1%wt preservatives With 5-10%wt solvents.
The excipient is in carbomer, PVP, polyethylene glycol, hydroxypropyl methyl cellulose and hydroxypropyl cellulose At least one；
The solvent is selected from least one of ethanol, propane diols, glycerine, ethyl oleate and water；
The surfactant be selected from Emulsifier EL-60, polysorbate 20, polysorbate 40, polyoxyethylene sorbitan monoleate, lecithin, At least one of NaTDC and F68 F-68.
Above-mentioned acne gel is external application when applied to treatment acne.
A kind of preparation method of the acne gel containing traditional Chinese medicine ingredients, comprises the following steps：
（1）By vitamin B6, vitamin C glucoside, zinc chloride and allantoin be dissolved in Chinese medicine extract；
（2）The dried venom of toads and surfactant are dissolved in appropriate solvent and stirred, addition Cosan, which stirs into, is uniformly distributed liquid；
（3）By step（1）With（2）Solution mixing, add excipient, stir into gel.
Above-mentioned preparation method, step（1）In also include preservative.
A kind of Chinese medicine extract for treating acne, is made up of the raw material of following parts by weight：Coptis 30-50, radix scutellariae 40-50, Capsule of weeping forsythia 30-50, schizonepeta 40-50, windproof 40-50, cape jasmine 30-50, dried immature fruit of citron orange 40-50, kuh-seng 50-100, dandelion 100-200, gold Small cup chrysanthemum 30-40, tribulus terrestris 20-30, root of Dahurain angelica 40-50, root of herbaceous peony 40-50, Poria cocos 40-50, radix glycyrrhizae 20-40；
Prepared using following methods：It will weigh after raw material crushes and use solvent extraction, be obtained after concentration.
Preferably, the Chinese medicine extract of above-mentioned treatment acne, is made up of the raw material of following parts by weight：The coptis 50, radix scutellariae 40th, the capsule of weeping forsythia 50, schizonepeta 40, windproof 40, cape jasmine 30, the dried immature fruit of citron orange 40, kuh-seng 50, dandelion 150, pot marigold 30, tribulus terrestris 30, the root of Dahurain angelica 50th, the root of herbaceous peony 40, Poria cocos 50, radix glycyrrhizae 30.
A kind of preparation method of above-mentioned Chinese medicine extract, comprises the following steps：
（1）Weigh each raw material and be ground into 20-200 mesh powder, obtain mixed powder；
（2）Above-mentioned mixed powder is added to the solvent of 2-3 times of weight, after 90-100 DEG C of extracting 1-5 hour, obtains extract solution；
（3）By said extracted liquid be concentrated into original volume 1/5-1/3 produce treatment acne Chinese medicine extract.
The preparation method, step（2）Middle solvent is selected from the mixing of ethanol, water or alcohol-water.
A kind of application of above-mentioned Chinese medicine extract in Retinoids, Retin-A, Renova, Accutane is prepared.
The coptis, radix scutellariae, the capsule of weeping forsythia are clearing heat and detoxicating, dispersing swelling and dissipating binds, share the heat toxin of removing summer-heat acne；Cape jasmine, the dried immature fruit of citron orange, dandelion, Pot marigold heat clearing and blood cooling；Schizonepeta, windproof, kuh-seng, the root of herbaceous peony, Poria cocos, tribulus terrestris have the work(of clearing damp；It is strong that the root of Dahurain angelica draws the up head of all medicines Dissolve the effect of poison, all medicines share can move back acne excessive noxious heat；Pot marigold, tribulus terrestris, the root of Dahurain angelica, the root of herbaceous peony, Poria cocos, radix glycyrrhizae detumescence row Purulence, it is antipruritic, also there is certain red abnormal pigmentary deposit on the skin trace of elimination；Sulphur attacks the antipruritic hygroscopic of poison, swelling and pain relieving with dried venom of toads external application；Dimension Raw plain B6, vitamin C glucoside, zinc chloride and allantoin help to recover skin itself function, create anti-oxidant environment, drop Low inflammation occurrence degree.
The present invention has advantages below：
The acne gel containing traditional Chinese medicine ingredients of the present invention does not contain hormone, antibiotic, and use is safer, and being discontinued after use is not easy Recurrence；The effect of with anti-inflammatory, antipruritic, toxin expelling, the lasting period, long toxic side effect was small；Skin-nourishing can be also supplemented, skin is improved and resists Oxidability, promote skin self-healing, eliminate pockmark.
Embodiment
With reference to embodiment, the present invention will be further described, but the present invention is not limited by following embodiments.
Embodiment 1 treats the preparation of the Chinese medicine extract of acne.
Dispensing（Parts by weight）：The coptis 50, radix scutellariae 40, the capsule of weeping forsythia 50, schizonepeta 40, windproof 40, cape jasmine 30, the dried immature fruit of citron orange 40, kuh-seng 50, Dandelion 150, pot marigold 30, tribulus terrestris 30, the root of Dahurain angelica 50, the root of herbaceous peony 40, Poria cocos 50, radix glycyrrhizae 30.
Preparation method：
（1）Weigh each raw material and be ground into 200 mesh powder, obtain mixed powder；
（2）Above-mentioned mixed powder is added to the water of 3 times of weight, after 100 DEG C extract 3 hours, obtains extract solution；
（3）Said extracted liquid is concentrated into the 1/5 of the original volume Chinese medicine extract for producing treatment acne.
The preparation of acne gel of the embodiment 2 containing traditional Chinese medicine ingredients.
Formula（g）：
Chinese medicine extract 500 in embodiment 1, sulphur 5, the dried venom of toads 3, vitamin B610, vitamin C glucoside 5, zinc chloride 5, Allantoin 0.8, ethanol 5, glycerine 50, Acritamer 940 5, polyoxyethylene sorbitan monoleate 0.5, Phenoxyethanol 0.5, triethanolamine 7.5.
Preparation method：
（1）By Phenoxyethanol, vitamin B6, vitamin C glucoside, zinc chloride and allantoin be dissolved in Chinese medicine extract；
（2）The dried venom of toads and polyoxyethylene sorbitan monoleate are stirred in ethanol, addition Cosan, which stirs into, is uniformly distributed liquid；
（3）It is swelled after Acritamer 940 is ground with glycerine in water, adds the lower addition step of triethanolamine stirring（1）With（2） Solution, it is well mixed to produce the acne gel containing traditional Chinese medicine ingredients.
The compliance test result of acne gel of the embodiment 3 containing traditional Chinese medicine ingredients.
The volunteer for participating in experiment is certain hospital dermatology department patient, face acnes be present.Test group 40, control group 10 Example.Major facial skin symptom is as follows：Skin of face especially two cheeks, have useless fellow, the sebaceous cyst to differ in size, skin be present Skin is in light red or kermesinus.
2.1 application method
Test group uses acne gel in embodiment 2 as follows, continues 60 days：Affected part, which is applied to, after night face cleaning avoids mouth Nose eye；Second day early morning, which washes one's face, to be washed away.
Control group is without using any topical agent.
2.2 using effects are evaluated
According to the using effect of following evaluation criteria evaluation acne gel, using effect data are shown in Table 1.
（1）Syndrome Scale and acne gel effective evaluation standard
Syndrome Scale quantitative criteria
The Syndrome Scale standard of table 1
Using effect evaluation criteria
Comprehensive therapeutic effect index=[（Integrated before treatment after integration-treatment）Integrated before/treatment] × 100%.
Recovery from illness：Symptom disappears after medication, and integrated value reduces >=95%.
It is effective：Symptom is obviously improved after medication, and integrated value reduces >=70%.
Take a turn for the better：Symptom improves after medication, and integrated value reduces >=30%.
It is invalid：Symptom is not improved after medication, or integrated value reduces ＜ 30%.
Recovery from illness will finally be counted as " effective " with effective.
（2）Acne gel using effect
All volunteers for participating in this experiment complete using effect experience, and test data is as follows：
The acne gel effect of table 2
According to the data of table 2, acne gel of the invention is 68.75% using 45 days effective percentage, and it is 87.50% that 60 days are efficient, with Blank control is compared, and difference has conspicuousness（P<0.05）And do not occur adverse reaction during testing.Test data shows, this hair Bright acne gel can be effectively improved the skin problem of acne initiation.
The preparation of acne gel of the embodiment 4 containing traditional Chinese medicine ingredients.
Formula（g）：
Chinese medicine extract 250 in embodiment 1, sulphur 8, the dried venom of toads 5, vitamin B65, vitamin C glucoside 1, zinc chloride 10, Allantoin 0.5, ethanol 3, glycerine 25, Acritamer 940 1.5, polyoxyethylene sorbitan monoleate 0.3, methyl-isothiazol 0.3, triethanolamine 2.3。
Preparation method：
（1）By methyl-isothiazol, vitamin B6, vitamin C glucoside, zinc chloride and allantoin be dissolved in Chinese medicine extract；
（2）The dried venom of toads and polyoxyethylene sorbitan monoleate are stirred in ethanol, addition Cosan, which stirs into, is uniformly distributed liquid；
（3）It is swelled after Acritamer 940 is ground with glycerine in water, adds the lower addition step of triethanolamine stirring（1）With（2） Solution, it is well mixed to produce the acne gel containing traditional Chinese medicine ingredients.
The preparation of acne gel of the embodiment 5 containing traditional Chinese medicine ingredients.
Formula（g）：
Chinese medicine extract 1000 in embodiment 1, sulphur 6, the dried venom of toads 4, vitamin B615, vitamin C glucoside 4, zinc chloride 8, Allantoin 1, ethanol 5, glycerine 80, Acritamer 940 10, Emulsifier EL-60 1.5, methyl-isothiazol 5, triethanolamine 15.
Preparation method：
（1）By methyl-isothiazol, vitamin B6, vitamin C glucoside, zinc chloride and allantoin be dissolved in Chinese medicine extract；
（2）The dried venom of toads and Emulsifier EL-60 are stirred in ethanol, addition Cosan, which stirs into, is uniformly distributed liquid；
（3）It is swelled after Acritamer 940 is ground with glycerine in water, adds the lower addition step of triethanolamine stirring（1）With（2） Solution, it is well mixed to produce the acne gel containing traditional Chinese medicine ingredients.

Claims (10)

1. a kind of acne gel containing traditional Chinese medicine ingredients, it is characterised in that include the active ingredient of following parts by weight：Treat acne Chinese medicine extract 250-1000, sulphur 5-8, dried venom of toads 3-5, vitamin B65-15, vitamin C glucoside 1-5, zinc chloride 5- 10, allantoin 0.5-1；
The Chinese medicine extract of the treatment acne, is made up of the raw material of following parts by weight：Coptis 30-50, radix scutellariae 40-50, the capsule of weeping forsythia 30-50, schizonepeta 40-50, windproof 40-50, cape jasmine 30-50, dried immature fruit of citron orange 40-50, kuh-seng 50-100, dandelion 100-200, pot marigold 30-40, tribulus terrestris 20-30, root of Dahurain angelica 40-50, root of herbaceous peony 40-50, Poria cocos 40-50, radix glycyrrhizae 20-40.
2. acne gel according to claim 1, it is characterised in that sulphur fineness is 200-400 mesh.
3. acne gel according to claim 1, it is characterised in that also comprising 0.5-1%wt excipient, 0.05-0.15% Wt surfactants, 0-1%wt preservatives and 5-10%wt solvents；
The excipient in carbomer, PVP, polyethylene glycol, hydroxypropyl methyl cellulose and hydroxypropyl cellulose extremely Few one kind；
The solvent is selected from least one of ethanol, propane diols, glycerine, ethyl oleate and water；
The surfactant be selected from Emulsifier EL-60, polysorbate 20, polysorbate 40, polyoxyethylene sorbitan monoleate, lecithin, At least one of NaTDC and F68 F-68.
A kind of 4. preparation method of the acne gel containing traditional Chinese medicine ingredients as described in claim 1 or 3 is any, it is characterised in that bag Include following steps：
（1）By vitamin B6, vitamin C glucoside, zinc chloride and allantoin be dissolved in the Chinese medicine extract for the treatment of acne；
（2）The dried venom of toads and surfactant are dissolved in appropriate solvent and stirred, addition Cosan, which stirs into, is uniformly distributed liquid；
（3）By step（1）With（2）Solution mixing, add excipient, stir into gel.
5. preparation method according to claim 5, it is characterised in that step（1）In also include preservative.
6. a kind of Chinese medicine extract for treating acne, it is characterised in that be made up of the raw material of following parts by weight：Coptis 30-50, Huang A kind of reed mentioned in ancient books 40-50, capsule of weeping forsythia 30-50, schizonepeta 40-50, windproof 40-50, cape jasmine 30-50, dried immature fruit of citron orange 40-50, kuh-seng 50-100, dandelion 100-200, pot marigold 30-40, tribulus terrestris 20-30, root of Dahurain angelica 40-50, root of herbaceous peony 40-50, Poria cocos 40-50, radix glycyrrhizae 20-40；
Prepared using following methods：It will weigh after raw material crushes and use solvent extraction, be obtained after concentration.
7. Chinese medicine extract according to claim 6, it is characterised in that be made up of the raw material of following parts by weight：The coptis 50, Radix scutellariae 40, the capsule of weeping forsythia 50, schizonepeta 40, windproof 40, cape jasmine 30, the dried immature fruit of citron orange 40, kuh-seng 50, dandelion 150, pot marigold 30, tribulus terrestris 30, The root of Dahurain angelica 50, the root of herbaceous peony 40, Poria cocos 50, radix glycyrrhizae 30.
8. the preparation method of a kind of Chinese medicine extract as described in claim 6 or 7 is any, it is characterised in that including following step Suddenly：
（1）Weigh each raw material and be ground into 20-200 mesh powder, obtain mixed powder；
（2）Above-mentioned mixed powder is added to the solvent of 2-3 times of weight, after 90-100 DEG C of extracting 1-5 hour, obtains extract solution；
（3）By said extracted liquid be concentrated into original volume 1/5-1/3 produce treatment acne Chinese medicine extract.
9. preparation method according to claim 8, it is characterised in that step（2）Middle solvent be selected from ethanol, water or ethanol- The mixing of water.
A kind of 10. application of Chinese medicine extract as described in claim 6 or 7 is any in Retinoids, Retin-A, Renova, Accutane is prepared.
CN201710563498.6A 2017-07-12 2017-07-12 A kind of acne gel containing traditional Chinese medicine ingredients and preparation method thereof Pending CN107334845A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108992389A (en) * 2018-10-23 2018-12-14 江苏朗沁科技有限公司 A kind of light spot dressing of anti-acne
CN109464469A (en) * 2018-10-19 2019-03-15 江苏浦金药业有限公司 A kind of extracting method of the dried venom of toads
US11517578B1 (en) * 2021-07-29 2022-12-06 Innomed Technologies, Inc. Topical formulations containing erythritol and methods of treating skin conditions

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101919793A (en) * 2009-06-15 2010-12-22 李小兵 Chinese herbal medicine mask capable of removing acne and whitening
CN106511474A (en) * 2016-11-14 2017-03-22 惠州市蕙薏美生物科技有限公司 External traditional Chinese medicine composition with function of removing skin acnes, and skin-care preparation thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101919793A (en) * 2009-06-15 2010-12-22 李小兵 Chinese herbal medicine mask capable of removing acne and whitening
CN106511474A (en) * 2016-11-14 2017-03-22 惠州市蕙薏美生物科技有限公司 External traditional Chinese medicine composition with function of removing skin acnes, and skin-care preparation thereof

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109464469A (en) * 2018-10-19 2019-03-15 江苏浦金药业有限公司 A kind of extracting method of the dried venom of toads
CN108992389A (en) * 2018-10-23 2018-12-14 江苏朗沁科技有限公司 A kind of light spot dressing of anti-acne
US11517578B1 (en) * 2021-07-29 2022-12-06 Innomed Technologies, Inc. Topical formulations containing erythritol and methods of treating skin conditions
WO2023009829A1 (en) * 2021-07-29 2023-02-02 Innomed Technologies, Inc. Topical formulations containing erythritol and methods of treating skin conditions

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