CN108653202B - Eye cleaning composition, eye liquid containing same and preparation method thereof - Google Patents
Eye cleaning composition, eye liquid containing same and preparation method thereof Download PDFInfo
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- CN108653202B CN108653202B CN201810674690.7A CN201810674690A CN108653202B CN 108653202 B CN108653202 B CN 108653202B CN 201810674690 A CN201810674690 A CN 201810674690A CN 108653202 B CN108653202 B CN 108653202B
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Abstract
The invention provides an eye cleaning composition, an eye cleaning liquid containing the same and a preparation method thereof. The borneol water and borneol camphor extract in the eye clearing composition contains active ingredients of borneol, eucalyptol, camphor, borneol acetate, alpha-pinene, limonene, beta-myrcene, alpha-terpineol, linalool, beta-pinene and alpha-caryophyllene, and the active ingredients can open channels of skin at eyes, promote effective ingredients in ginkgo leaf extract, lily extract, mint extract, chrysanthemum flavum extract and blueberry extract to permeate into skin at the bottom layer of eyes, promote metabolism of skin, relieve fatigue of eyes, clear free radicals, prevent wrinkles and resist aging. The preparation method provided by the invention fully extracts the active ingredients in the branches and leaves of borneol camphor trees, fully extracts the active ingredients of total flavonoids and ginkgolides in the ginkgo leaves, and fully extracts the active substance of phenolic acid glyceride glycoside compounds in lily; the preparation method provided by the invention can fully extract the target active substance and has high extraction efficiency.
Description
Technical Field
The invention belongs to the field of eye care, and particularly relates to an eye cleaning composition, eye liquid containing the same and a preparation method thereof.
Background
With the change of social environment and the change of production relation, most workers need to use electronic products such as computers, mobile phones and the like, and the eyes are uncomfortable after long-term use of eyes, such as dry eyes, eye marks increase and the like. Although dry eyes generally do not cause serious ocular disease, they can cause eye damage and even corneal inflammation if left unattended or mishandled. For the people who have low vision help such as cataract, glaucoma and xerophthalmia and the people who use computers or electronic display equipment for a long time, the eye drop is seriously caused by the symptoms of dry eyes, fatigue, lacrimation, much eye droppings and the like, and the vision is gradually reduced. The use of eye care solutions can alleviate the above-mentioned symptoms of eye discomfort. However, the eye care solution has uneven quality, and many active ingredients in the eye care solution have certain toxicity, so that other damages to eyes can be caused after long-term use, and the eye care solution is not paid.
The eye drops for relieving eye discomfort symptoms mostly contain chemically synthesized components, while traditional Chinese medicine components with high safety performance are more and more concerned by people in recent years, but different medicine combinations have different effects, the eye drops are mixed in the market of fish and dragon, target products cannot be obtained in the process of extracting effective components of the medicines, and the absorption is the largest problem.
Disclosure of Invention
In order to solve the technical problems, the invention provides an eye cleaning composition which has high permeability and penetrability, can be absorbed by eye skin and has the advantages of well relieving asthenopia, improving symptoms such as dry eyes and dry eyes, an eye lotion containing the eye cleaning composition and a preparation method of the eye cleaning composition.
The invention aims to provide an eye cleaning composition.
It is another object of the present invention to provide an eye cleaning liquid comprising the above-mentioned eye cleaning composition.
The invention further aims to provide a preparation method of the eye cleaning liquid.
The eye cleaning composition comprises the following components in parts by weight: 40-70 parts of borneol water, 0.5-6 parts of borneol camphor extract, 0.5-4 parts of ginkgo leaf extract, 0.2-5 parts of lily extract, 0.2-4 parts of mint extract, 0.2-4 parts of chrysanthemum extract and 0.5-5 parts of blueberry extract.
The eyesight cleaning composition comprises borneol water and borneol camphor extract, wherein the borneol water contains about 10-30% of borneol essential oil components, part of borneol essential oil cannot be completely extracted in the borneol camphor extraction process, and the effective components are usually wasted, the eyesight cleaning composition comprises the borneol water and the borneol camphor extract, the borneol, eucalyptol, camphor, borneol acetate, alpha-pinene, limonene, beta-myrcene, alpha-terpineol, linalool, beta-pinene and alpha-caryophyllene are contained in the two components, the active components can be transdermally absorbed, have the effects of resisting bacteria, diminishing inflammation and inducing resuscitation, can promote the eyes to absorb other nutritional components, so that the effective components in the ginkgo leaf extract, the lily extract, the mint extract, the yellow chrysanthemum extract and the blueberry extract can permeate into the eye bottom layer, promoting skin metabolism, and relieving eye fatigue.
The effective components of the eye cleaning liquid according to the specific embodiment of the invention comprise the following components in parts by weight: 40-70 parts of borneol water, 0.5-6 parts of borneol camphor extract, 0.5-4 parts of ginkgo leaf extract, 0.2-5 parts of lily extract, 0.2-4 parts of mint extract, 0.2-4 parts of chrysanthemum extract and 0.5-5 parts of blueberry extract.
The eye cleaning liquid according to the embodiment of the invention preferably further comprises 5-15 parts of 1-3 butanediol, 5-15 parts of propylene glycol and 0.2-4 parts of sodium hyaluronate. The eye cleaning liquid also comprises 1-3 butanediol, propylene glycol and sodium hyaluronate, has the moisturizing effect and can retain moisture of eye skin; meanwhile, the sodium hyaluronate can keep the eye skin moist, smooth, fine and tender, so that the eye skin is elastic and has the effects of resisting wrinkles and preventing wrinkles.
The eye cleaning liquid according to the embodiment of the invention preferably comprises the following components in parts by weight: 60 parts of borneol water, 5 parts of borneol camphor extract, 3.5 parts of ginkgo leaf extract, 2.5 parts of lily extract, 3 parts of mint extract, 2.5 parts of chrysanthemum extract, 2.5 parts of bilberry extract, 10 parts of 1-3 butanediol, 8 parts of propylene glycol and 2 parts of sodium hyaluronate.
The invention also provides eye cleaning liquid with remarkable effect, and the components are compatible through the components and the contents, so that the components can be mutually matched, and the effect of cleaning eyes and resisting fatigue is achieved.
The preparation method of the eye cleaning liquid according to the embodiment of the invention comprises the following steps: (1) preparing borneol water and borneol camphor extract: drying, crushing and sieving branches and leaves of borneol camphor trees to obtain branches and leaves powder of the borneol camphor trees, adding water, carrying out ultrasonic treatment, distilling to obtain distillate, and carrying out water-oil separation on the distillate to obtain borneol camphor essential oil and borneol crude extract water; cooling and crystallizing the borneol crude extract to obtain borneol camphor crystal and borneol water, wherein the borneol extract comprises borneol camphor essential oil and borneol camphor crystal;
(2) preparing a ginkgo leaf extract: drying folium Ginkgo, pulverizing, sieving, extracting with 75-80% ethanol under reflux, adding sodium hydroxide to adjust pH to 8-10, filtering to obtain extractive solution, and concentrating to obtain soft extract; adding 30-35% ethanol into the soft extract, stirring, reflux extracting, adjusting pH to 5-6, filtering to obtain filtrate, recovering ethanol, adding water, heating to obtain water extractive solution, cooling the water extractive solution, filtering, desalting the filtrate with macroporous resin column, eluting with gradient ethanol, recovering ethanol to obtain folium Ginkgo extractive solution, and drying to obtain folium Ginkgo extract;
(3) preparing a lily extract: taking dried lily, crushing, adding 5-10 times by weight of 30-75% ethanol in volume percentage, heating and leaching in water bath for 2-4 times, combining filtrates, concentrating the obtained filtrate under reduced pressure until no alcohol smell exists to obtain an extract, passing the extract through a macroporous adsorption resin chromatographic column, washing with distilled water to remove impurities, eluting with 75-85% ethanol in volume fraction, concentrating, and drying to obtain the lily extract;
(4) uniformly mixing a mint extract, a yellow chrysanthemum extract, a bilberry extract, a borneol camphor extract and borneol water obtained in the step (1), a ginkgo leaf extract obtained in the step (2) and a lily extract obtained in the step (3), adding 1-3 butanediol, propylene glycol and sodium hyaluronate, and fully mixing to obtain the eye clearing liquid.
According to the preparation method of the liquid for clearing eyes, provided by the invention, the cell structure of branches and leaves of borneol camphor is destroyed by ultrasonic treatment, so that the active ingredients in the branches and leaves of borneol camphor are easy to dissolve out, then borneol essential oil and borneol crude extract are obtained by a distillation method, borneol dissolved in borneol crude water is separated out, and borneol water is obtained, and at the moment, the borneol water also contains part of water-soluble active ingredients and part of essential oil; the method comprises the steps of firstly, carrying out crude extraction by adopting high-concentration ethanol, carrying out crude extraction under the alkaline condition that the pH value is 8-10, precipitating chlorophyll components in ginkgo leaves, then carrying out reflux extraction by adopting low-concentration ethanol, adding water, heating, extracting, cooling, desalting by using a macroporous resin column, and finally carrying out gradient washing by using ethanol to obtain a ginkgo leaf extracting solution, wherein the obtained ginkgo leaf extract contains high-purity active substance total flavonoids and ginkgolides; according to the preparation method of the lily extract, active substances in lily are fully extracted, the obtained extract contains phenolic acid glyceride glycoside compounds which are active substances, and the active substances can effectively remove free radicals and have the effects of resisting oxidation and preventing aging. The preparation method provided by the invention fully extracts active substances in the effective components, and the obtained eye cleaning liquid can be absorbed by eye skin, and has good effects of relieving asthenopia, improving dry eye, removing free radicals, preventing wrinkles and resisting wrinkles.
According to the preparation method of the eye cleaning liquid according to the embodiment of the invention, preferably, in the step (1), the particle size of the borneol camphor branch and leaf powder is 20-100 meshes. The cells can be dissolved out only by destroying active substances in the extraction process of the branches and leaves of the borneol camphor wood, when the branches and leaves of the borneol camphor wood are completely extracted, the extraction efficiency is low, the crushed particle size is too small, the resource waste can be caused, the extraction efficiency can not be improved, and through the research of an inventor, when the particle size of powder is 20-100 meshes, the extraction efficiency is highest, and the comprehensive benefit is optimal.
According to the preparation method of the eye cleaning solution according to the embodiment of the invention, preferably, in the step (1), water is added to the borneol camphor branch and leaf powder, and the weight ratio of the borneol camphor branch and leaf powder to the water is 1: 10-15.
According to the method for preparing the eye cleaning liquid according to the embodiment of the present invention, preferably, in the step (2), the heating temperature is 55-85 ℃.
According to the preparation method of the eye cleaning solution, in the step (3), the water bath heating temperature is 55-65 ℃, and the leaching time is 0.5-1.5 h.
The invention has the beneficial effects that:
the invention provides an eye cleaning composition, an eye cleaning liquid containing the same and a preparation method thereof. The eyesight cleaning composition provided by the invention takes borneol water and borneol camphor extract as main active ingredients, wherein the borneol water contains water-soluble active ingredients and part of essential oil, and the borneol water and the borneol camphor extract contain active ingredients such as borneol, eucalyptol, camphor, borneol acetate, alpha-pinene, limonene, beta-myrcene, alpha-terpineol, linalool, beta-pinene and alpha-caryophyllene.
The preparation method provided by the invention fully extracts the active ingredients in the branches and leaves of borneol camphor trees; the ginkgo leaf extraction method fully extracts the active ingredients of total flavonoids and ginkgolides, and has high extraction efficiency and high purity; fully extracting phenolic acid glyceride glycoside compounds as active substances in the lily extract in the extraction method; the preparation method provided by the invention has the advantages that the target active substances are fully extracted, the extraction efficiency is high, the obtained eye cleaning liquid can be well absorbed by eye skin, and the eye cleaning liquid has good effects of relieving asthenopia, improving dry eye, removing free radicals, preventing wrinkles and resisting wrinkles.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention.
Example 1
An eye cleaning composition comprising the following components by weight: 40g of borneol water, 0.5g of borneol camphor extract, 0.5g of ginkgo leaf extract, 5g of lily extract, 0.2g of mint extract, 4g of chrysanthemum extract and 5g of blueberry extract.
Example 2
An eye cleaning composition comprising the following components by weight: 70g of borneol water, 6g of borneol camphor extract, 4g of ginkgo leaf extract, 0.2g of lily extract, 4g of mint extract, 0.2g of chrysanthemum extract and 0.5g of bilberry extract.
Example 3
The eye cleaning solution comprises the following components in parts by weight: an eye cleaning composition comprising the following components by weight: 40g of borneol water, 0.5g of borneol camphor extract, 0.5g of ginkgo leaf extract, 5g of lily extract, 0.2g of mint extract, 4g of chrysanthemum extract, 5g of bilberry extract, 5g of 1-3 butanediol, 5g of propylene glycol and 4g of sodium hyaluronate.
The preparation method of the eye cleaning solution comprises the following steps:
(1) preparing borneol water and borneol camphor extract: taking branches and leaves of borneol camphor trees, drying, crushing and sieving to obtain branches and leaves powder of the borneol camphor trees, wherein the grain size of the branches and leaves powder of the borneol camphor trees is 20-40 meshes, adding 10 times of water by weight, carrying out ultrasonic treatment for 20min, then carrying out distillation to obtain distillate, and carrying out water-oil separation on the distillate to obtain borneol camphor essential oil and borneol crude extract water; cooling and crystallizing the borneol crude extract to obtain borneol camphor crystal and borneol water, wherein the borneol extract comprises borneol camphor essential oil and borneol camphor crystal;
(2) preparing a ginkgo leaf extract: drying folium Ginkgo, pulverizing, sieving, extracting with 75% ethanol under reflux, adding sodium hydroxide to adjust pH to 8, filtering to obtain extractive solution, and concentrating to obtain soft extract; adding 30% ethanol into the soft extract, stirring, reflux extracting, adjusting pH to 5, filtering to obtain filtrate, recovering ethanol, adding water, heating to 55 deg.C to obtain water extractive solution, cooling the water extractive solution, filtering, desalting the filtrate with macroporous resin column, gradient ethanol eluting, recovering ethanol to obtain folium Ginkgo extractive solution, and drying to obtain folium Ginkgo extract;
(3) preparing a lily extract: taking dried lily, crushing, adding 5 times of ethanol with the volume percentage of 30% in 5 times of the weight of the dried lily, heating in a water bath to 55 ℃, leaching for 2 times, wherein the leaching time is 1.5 hours each time, merging the filtrates, concentrating the obtained filtrate under reduced pressure until no alcohol smell exists to obtain an extracting solution, passing the extracting solution through a macroporous adsorption resin chromatographic column, washing with distilled water to remove impurities, eluting with 75% ethanol in volume fraction, concentrating, and drying to obtain the lily extract;
(4) uniformly mixing a mint extract, a yellow chrysanthemum extract, a bilberry extract, a borneol camphor extract and borneol water obtained in the step (1), a ginkgo leaf extract obtained in the step (2) and a lily extract obtained in the step (3), adding 1-3 butanediol, propylene glycol and sodium hyaluronate, and fully mixing to obtain the eye clearing liquid.
Example 4
The eye cleaning solution comprises the following components in parts by weight: 70g of borneol water, 6g of borneol camphor extract, 4g of ginkgo leaf extract, 0.2g of lily extract, 4g of mint extract, 0.2g of chrysanthemum extract, 0.5g of bilberry extract, 15g of 1-3 butanediol, 5g of propylene glycol and 4g of sodium hyaluronate.
The preparation method of the eye cleaning solution comprises the following steps:
(1) preparing borneol water and borneol camphor extract: taking branches and leaves of borneol camphor trees, drying, crushing and sieving to obtain branches and leaves powder of the borneol camphor trees, wherein the grain size of the branches and leaves powder of the borneol camphor trees is 80-100 meshes, adding 15 times of water by weight, carrying out ultrasonic treatment for 15min, then carrying out distillation to obtain distillate, and carrying out water-oil separation on the distillate to obtain borneol camphor essential oil and borneol crude extract water; cooling and crystallizing the borneol crude extract to obtain borneol camphor crystal and borneol water, wherein the borneol extract comprises borneol camphor essential oil and borneol camphor crystal;
(2) preparing a ginkgo leaf extract: drying folium Ginkgo, pulverizing, sieving, extracting with 80 vol% ethanol under reflux, adding sodium hydroxide to adjust pH to 10, filtering to obtain extractive solution, and concentrating to obtain soft extract; adding 35% ethanol into the soft extract, stirring, reflux extracting, adjusting pH to 6, filtering to obtain filtrate, recovering ethanol, adding water, heating to 85 deg.C to obtain water extractive solution, cooling the water extractive solution, filtering, desalting the filtrate with macroporous resin column, gradient ethanol eluting, recovering ethanol to obtain folium Ginkgo extractive solution, and drying to obtain folium Ginkgo extract;
(3) preparing a lily extract: taking dried lily, crushing, adding 10 times of ethanol with volume percentage of 75% in weight, heating in water bath to 65 ℃, leaching for 4 times, wherein the leaching time is 0.5h each time, combining filtrates, concentrating the obtained filtrate under reduced pressure until no alcohol smell exists to obtain an extracting solution, passing the extracting solution through a macroporous adsorption resin chromatographic column, washing with distilled water to remove impurities, eluting with 85% ethanol in volume fraction, concentrating, and drying to obtain the lily extract;
(4) uniformly mixing a mint extract, a yellow chrysanthemum extract, a bilberry extract, a borneol camphor extract and borneol water obtained in the step (1), a ginkgo leaf extract obtained in the step (2) and a lily extract obtained in the step (3), adding 1-3 butanediol, propylene glycol and sodium hyaluronate, and fully mixing to obtain the eye clearing liquid.
Example 5
The eye cleaning solution comprises the following components in parts by weight: 60g of borneol water, 5g of borneol camphor extract, 3.5g of ginkgo leaf extract, 2.5g of lily extract, 3g of mint extract, 2.5g of chrysanthemum extract, 2.5g of bilberry extract, 10g of 1-3 butanediol, 8g of propylene glycol and 2g of sodium hyaluronate.
The preparation method of the eye cleaning solution comprises the following steps:
(1) preparing borneol water and borneol camphor extract: taking branches and leaves of borneol camphor trees, drying, crushing and sieving to obtain branches and leaves powder of the borneol camphor trees, wherein the grain size of the branches and leaves powder of the borneol camphor trees is 80-100 meshes, then adding 12 times of water by weight, carrying out ultrasonic treatment for 18min, then carrying out distillation to obtain distillate, and carrying out water-oil separation on the distillate to obtain borneol camphor essential oil and borneol crude extract water; cooling and crystallizing the borneol crude extract to obtain borneol camphor crystal and borneol water, wherein the borneol extract comprises borneol camphor essential oil and borneol camphor crystal;
(2) preparing a ginkgo leaf extract: drying folium Ginkgo, pulverizing, sieving, extracting with 75% ethanol under reflux, adding sodium hydroxide to adjust pH to 8, filtering to obtain extractive solution, and concentrating to obtain soft extract; adding 30% ethanol into the soft extract, stirring, reflux extracting, adjusting pH to 5.5, filtering to obtain filtrate, recovering ethanol, adding water, heating to 65 deg.C to obtain water extractive solution, cooling the water extractive solution, filtering, desalting the filtrate with macroporous resin column, gradient ethanol eluting, recovering ethanol to obtain folium Ginkgo extractive solution, and drying to obtain folium Ginkgo extract;
(3) preparing a lily extract: taking dried lily, crushing, adding 8 times of 60% ethanol in percentage by volume by weight, heating in a water bath to 60 ℃, leaching for 3 times, wherein the leaching time is 1 hour each time, combining filtrates, concentrating the obtained filtrate under reduced pressure until no alcohol smell exists to obtain an extracting solution, passing the extracting solution through a macroporous adsorption resin chromatographic column, washing with distilled water to remove impurities, eluting with 80% ethanol in percentage by volume, concentrating, and drying to obtain the lily extract;
(4) uniformly mixing a mint extract, a yellow chrysanthemum extract, a bilberry extract, a borneol camphor extract and borneol water obtained in the step (1), a ginkgo leaf extract obtained in the step (2) and a lily extract obtained in the step (3), adding 1-3 butanediol, propylene glycol and sodium hyaluronate, and fully mixing to obtain the eye clearing liquid.
The eye cleaning liquid is sprayed for 2-3 times per day and can be used for a long time. According to the use feedback of consumers of the product, after most of people with symptoms of dry eyes, dry eyes and asthenopia use the eye drop cream, the problems of dry eyes, dry eyes and asthenopia can be effectively improved, the effective rate reaches more than 95%, and fine lines of the people with fine lines of eyes obviously fade after more than 2 months of use; and the eye cleaning liquid provided by the invention is not dependent when being frequently used, can be frequently used when eyes are frequently used, but can be stopped when the eye frequency is reduced, and uncomfortable symptoms can not be caused. The eye cleaning liquid provided by the invention is high in safety performance and remarkable in effect.
The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.
Claims (9)
1. An eye cleaning composition is characterized by comprising the following components in parts by weight: 40-70 parts of borneol water, 0.5-6 parts of borneol camphor extract, 0.5-4 parts of ginkgo leaf extract, 0.2-5 parts of lily extract, 0.2-4 parts of mint extract, 0.2-4 parts of chrysanthemum extract and 0.5-5 parts of cowberry fruit extract;
the borneol water, the borneol camphor extract, the ginkgo leaf extract and the lily bulb extract in the clear eye composition are extracted by the following methods:
preparing borneol water and borneol camphor extract: drying, crushing and sieving branches and leaves of borneol camphor trees to obtain branches and leaves powder of the borneol camphor trees, adding water, carrying out ultrasonic treatment, distilling to obtain distillate, and carrying out water-oil separation on the distillate to obtain borneol camphor essential oil and borneol crude extract water; cooling and crystallizing the borneol crude extract to obtain borneol camphor crystal and borneol water, wherein the borneol extract comprises borneol camphor essential oil and borneol camphor crystal;
preparing a ginkgo leaf extract: drying folium Ginkgo, pulverizing, sieving, extracting with 75-80% ethanol under reflux, adding sodium hydroxide to adjust pH to 8-10, filtering to obtain extractive solution, and concentrating to obtain soft extract; adding 30-35% ethanol into the soft extract, stirring, reflux extracting, adjusting pH to 5-6, filtering to obtain filtrate, recovering ethanol, adding water, heating to obtain water extractive solution, cooling the water extractive solution, filtering, desalting the filtrate with macroporous resin column, eluting with gradient ethanol, recovering ethanol to obtain folium Ginkgo extractive solution, and drying to obtain folium Ginkgo extract;
preparing a lily extract: taking dried lily, crushing, adding 5-10 times of ethanol with volume percentage of 30-75% by weight, heating and leaching in water bath for 2-4 times, combining filtrates, concentrating the obtained filtrate under reduced pressure until no alcohol smell exists to obtain an extracting solution, passing the extracting solution through a macroporous adsorption resin chromatographic column, washing with distilled water to remove impurities, eluting with 75-85% ethanol by volume fraction, concentrating, and drying to obtain the lily extract.
2. An eye-cleaning liquid, characterized in that the effective ingredient thereof comprises the eye-cleaning composition according to claim 1.
3. The eye cleaning solution according to claim 2, further comprising 5-15 parts of 1-3 butylene glycol, 5-15 parts of propylene glycol and 0.2-4 parts of sodium hyaluronate.
4. The eye cleaning solution according to claim 3, comprising the following components in parts by weight: 60 parts of borneol water, 5 parts of borneol camphor extract, 3.5 parts of ginkgo leaf extract, 2.5 parts of lily extract, 3 parts of mint extract, 2.5 parts of chrysanthemum extract, 2.5 parts of bilberry extract, 10 parts of 1-3 butanediol, 8 parts of propylene glycol and 2 parts of sodium hyaluronate.
5. The method for preparing an eye cleaning solution according to claim 4, comprising the steps of:
(1) preparing borneol water and borneol camphor extract: drying, crushing and sieving branches and leaves of borneol camphor trees to obtain branches and leaves powder of the borneol camphor trees, adding water, carrying out ultrasonic treatment, distilling to obtain distillate, and carrying out water-oil separation on the distillate to obtain borneol camphor essential oil and borneol crude extract water; cooling and crystallizing the borneol crude extract to obtain borneol camphor crystal and borneol water, wherein the borneol extract comprises borneol camphor essential oil and borneol camphor crystal;
(2) preparing a ginkgo leaf extract: drying folium Ginkgo, pulverizing, sieving, extracting with 75-80% ethanol under reflux, adding sodium hydroxide to adjust pH to 8-10, filtering to obtain extractive solution, and concentrating to obtain soft extract; adding 30-35% ethanol into the soft extract, stirring, reflux extracting, adjusting pH to 5-6, filtering to obtain filtrate, recovering ethanol, adding water, heating to obtain water extractive solution, cooling the water extractive solution, filtering, desalting the filtrate with macroporous resin column, eluting with gradient ethanol, recovering ethanol to obtain folium Ginkgo extractive solution, and drying to obtain folium Ginkgo extract;
(3) preparing a lily extract: taking dried lily, crushing, adding 5-10 times by weight of 30-75% ethanol in volume percentage, heating and leaching in water bath for 2-4 times, combining filtrates, concentrating the obtained filtrate under reduced pressure until no alcohol smell exists to obtain an extract, passing the extract through a macroporous adsorption resin chromatographic column, washing with distilled water to remove impurities, eluting with 75-85% ethanol in volume fraction, concentrating, and drying to obtain the lily extract;
(4) uniformly mixing a mint extract, a yellow chrysanthemum extract, a bilberry extract, a borneol camphor extract and borneol water obtained in the step (1), a ginkgo leaf extract obtained in the step (2) and a lily extract obtained in the step (3), adding 1-3 butanediol, propylene glycol and sodium hyaluronate, and fully mixing to obtain the eye clearing liquid.
6. The method for preparing eye cleaning solution according to claim 5, wherein in the step (1), the particle size of the borneol camphor branch and leaf powder is 20-100 meshes.
7. The preparation method of eye cleaning solution according to claim 5, wherein in step (1), water is added to the borneol camphor branch and leaf powder, and the weight ratio of the borneol camphor branch and leaf powder to the water is 1: 10-15.
8. The method for preparing an eye cleaning solution according to claim 5, wherein in step (2), the temperature of the heating is 55-85 ℃.
9. The method for preparing the eye cleaning solution according to claim 5, wherein in the step (3), the temperature of the water bath heating is 55-65 ℃, and the time of each leaching is 0.5-1.5 h.
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| CN112262857B (en) * | 2020-10-23 | 2021-10-08 | 珍田(泉州)生物科技有限公司 | Soil purifying agent for preventing and treating root-knot nematode |
| CN114288230A (en) * | 2022-02-10 | 2022-04-08 | 杜伊斯堡生物科技有限公司 | Acne-removing and tissue regeneration-promoting liquid containing borneol camphor extract |
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