WO2021106210A1 - Timbre transdermique - Google Patents

Timbre transdermique Download PDF

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Publication number
WO2021106210A1
WO2021106210A1 PCT/JP2019/046844 JP2019046844W WO2021106210A1 WO 2021106210 A1 WO2021106210 A1 WO 2021106210A1 JP 2019046844 W JP2019046844 W JP 2019046844W WO 2021106210 A1 WO2021106210 A1 WO 2021106210A1
Authority
WO
WIPO (PCT)
Prior art keywords
base material
release film
patch
support base
aqueous gel
Prior art date
Application number
PCT/JP2019/046844
Other languages
English (en)
Japanese (ja)
Inventor
直礼 奥田
裕樹 堀本
立樹 小枝
彰 永松
Original Assignee
小林製薬株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 小林製薬株式会社 filed Critical 小林製薬株式会社
Priority to PCT/JP2019/046844 priority Critical patent/WO2021106210A1/fr
Publication of WO2021106210A1 publication Critical patent/WO2021106210A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/02—Compresses or poultices for effecting heating or cooling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug

Definitions

  • the present invention relates to a patch used by sticking to human skin.
  • the conventional patch 100 has a structure in which the aqueous gel 102 is laminated on the supporting base material 101 and the aqueous gel 102 is covered with the release film 103.
  • the conventional patch 100 is a strip-shaped patch sheet in which an aqueous gel is applied on a long support base material and then a long release film is laminated on the surface thereof. , Manufactured by cutting to a predetermined size with a cutting blade.
  • the cutting position of the patch sheet is pressed to extrude and eliminate the aqueous gel at the cut position. It is carried out. This prevents the aqueous gel from being exposed on the end face (cut surface) of the patch after cutting.
  • the aqueous gel 102 does not exist near the outer peripheral edge due to the above-mentioned streaking. Therefore, as shown in FIG. 7, in the patch 100, the supporting base material 101 is attached to the user's skin S due to the adhesiveness of the aqueous gel 102, but if the aqueous gel 102 is not present near the outer peripheral edge, The outer peripheral edge of the support base material 101 is rolled up, and the patch 100 is easily peeled off from the skin S.
  • the present invention has been made to solve the above problems, and an object of the present invention is to provide a patch that does not easily come off from the skin.
  • the patch of the present invention relates to a patch comprising a support base material, an aqueous gel laminated on one surface of the support base material, and a release film covering the water-based gel.
  • a patch comprising a support base material, an aqueous gel laminated on one surface of the support base material, and a release film covering the water-based gel.
  • the aqueous gel is the water-based material at least in a part of the support base material and the release film on the joint side. It is characterized in that the thickness of the gel gradually decreases toward the joint.
  • the patch of the present invention can be configured so that the outer peripheral edge of the supporting base material is bonded to the release film over the entire circumference.
  • the supporting base material and the release film have a rectangular shape in a plan view, and can be configured so that a pair of facing sides are joined by the joint portion. ..
  • the supporting base material can be configured to be a non-woven fabric.
  • the non-woven fabric can be configured to contain heat-weldable fibers and the release film is a heat-weldable film, and further, the heat-weldable fibers are polypropylene fibers and the heat. It can be configured such that the weldable film is a polypropylene film.
  • the patch of the present invention can be configured so that the water content of the aqueous gel is 60% by weight or more and 95% by weight or less.
  • the aqueous gel has the thickness of the aqueous gel in the portion near the joint portion of the outer peripheral edge of the supporting base material. Gradually becomes smaller toward the joint. Therefore, when the release film is peeled off from the support base material and the support base material is attached so that the exposed aqueous gel hits the skin of the user, the support base material wraps the water-based gel on the outer peripheral edge of the support base material. In such a shape, the outer peripheral edge of the supporting base material adheres to the skin by the adhesiveness of the aqueous gel in a state where the outer peripheral edge does not float from the user's skin. Therefore, since it is possible to prevent the outer peripheral edge of the supporting base material from rolling up, it is possible to prevent the patch from peeling off from the skin.
  • FIG. 5 is a cross-sectional view showing a schematic configuration of a vertical cross section along the line AA of FIG. 1 in a patch according to another embodiment of the present invention.
  • FIG. 5 is a cross-sectional view showing a schematic configuration of a vertical cross section along the line AA of FIG. 1 in a patch according to another embodiment of the present invention.
  • It is explanatory drawing which shows the state when the patch is attached to the skin.
  • sectional drawing which shows the schematic structure of the vertical cross section of the pasting agent of a conventional example.
  • the patch of the present invention is used by sticking it on human skin, for example, cooling the affected area during fever, headache, toothache, inflammation, etc., cooling the burning of the face, etc., or after sports.
  • a sheet-shaped cooling agent used for cooling down muscles and the like can be exemplified.
  • the patch 1 includes at least a support base material 2, an aqueous gel 3, and a release film 4, and has a layered structure in which these are laminated.
  • a plurality of patches 1 are stored in a packaging bag (not shown) in a stacked state. Further, at the time of use, the patch 1 is taken out from the packaging bag, the release film 4 is peeled off from the support base material 2, and then the exposed aqueous gel 3 is directly applied to the part to be cooled on the skin, whereby the aqueous gel 3 is formed. Due to its stickiness, it is attached to the user's skin.
  • the water contained in the aqueous gel 3 evaporates with the passage of time, and the temperature of the aqueous gel 3 is lowered by the heat of vaporization taken at that time, so that the skin in contact with the aqueous gel 3 is cooled.
  • the thickness and size of the patch 1 are not particularly limited, and the thickness and size can be appropriately set according to the purpose and the part to be cooled.
  • the outer shape of the patch 1 is not particularly limited, and in the present embodiment, it has a rectangular shape in a plan view, but it may have various other shapes such as a square shape, a circular shape, and an elliptical shape.
  • the support base material 2 supports the aqueous gel 3 on one surface thereof.
  • the support base material 2 is not formed into a fixed shape, but is in the form of a sheet that can be flexibly deformed.
  • the sheet structure of the supporting base material 2 is not particularly limited as long as it has moisture permeability and breathability and can support the water-based gel 3, and various woven fabrics, non-woven fabrics, films and the like are used. However, among them, it is preferable to use a non-woven fabric.
  • the support base material 2 is composed of a woven fabric or a non-woven fabric, the materials thereof are natural fibers such as cotton, linen and wool; cellulose fibers such as rayon and acetate; nylon, vinylon, styrene, polypropylene, polyethylene and polyethylene.
  • Examples thereof include synthetic resin fibers such as terephthalate and acrylic; and fibers (blended cotton products and mixed fiber products) in which various fibers are mixed. Further, when the support base material 2 is made of a film, polystyrene (styrene), polypropylene, polyethylene terephthalate, polyethylene and the like can be exemplified as the material thereof.
  • the support base material 2 can be formed by using various materials described above, and among them, it is preferable to use a non-woven fabric containing synthetic fibers (heat-welding fibers) having heat-welding properties such as polypropylene fibers.
  • a non-woven fabric containing synthetic fibers (heat-welding fibers) having heat-welding properties such as polypropylene fibers.
  • the details will be described later by including the heat-weldable fiber in the support base material 2, but when heat or ultrasonic vibration is applied to the support base material 2 and the release film 4, the heat-weldability in the support base material 2 is obtained.
  • the fibers are melted and integrated with the release film 4 (for example, one made of a heat-weldable film such as a polypropylene film) to form a bonding portion 5, and the supporting base material 2 and the release film 4 are bonded by the bonding portion 5 by welding. be able to.
  • the support base material 2 is not limited to one layer, and may be composed of a laminated body having two layers or three or more layers.
  • the support base material 2 is preferably a mixed fiber product of, for example, polyethylene terephthalate fiber and heat-weldable fiber.
  • the support base material 2 is preferably made of a laminate in which a layer made of heat-weldable fibers faces a side in contact with the release film 4.
  • the thickness of the support base material 2 is not particularly limited, but is preferably 0.1 mm or more and 3.0 mm or less, preferably 0.5 mm or more, from the viewpoint of usability, ease of fitting to the attachment site, and the like. It is more preferably 2.0 mm or less.
  • the support base material 2 has an appropriate elasticity so that it fits and fits in various sticking parts of the body to be stuck.
  • the degree of elasticity is not particularly limited, and the expansion / contraction direction can be expanded / contracted only in one direction (longitudinal direction) of the support base material 2 and only in the other direction (width direction) orthogonal to the one direction. It may be stretchable, or it may be stretchable in both the one direction (longitudinal direction) and the other direction (width direction), but it is preferable that it is stretchable in both directions.
  • the water-based gel 3 is formed by being laminated on one surface of the support base material 2.
  • various gels compatible with the skin can be used.
  • the thickness of the aqueous gel 3 is not particularly limited, but is preferably moderately large from the viewpoints of cooling power, feel when attached to the skin, maintenance of the attached state to the skin, and the like.
  • the thickness D C is 0.1mm or more 20mm or less in the center of the support substrate 2, and more preferably less than 1.0mm 10mm or less.
  • the thickness of the aqueous gel 3 can be measured by using the method described in "6.1 Thickness (ISO method)" of JIS L1913: 2010.
  • the thickness of the aqueous gel 3 is at least outside the support base material 2 at a portion close to the outer peripheral edge of the support base material 2 (a part on the joint portion 5 side where the release film 4 is bonded to the support base material 2 described later). It gradually becomes smaller toward the peripheral edge (joint 5). That is, in the vertical cross-sectional view of the aqueous gel 3, at least the outer peripheral edge portion near the joint portion 5 is tapered. If the thickness of the aqueous gel 3 gradually decreases toward the joint portion 5 at least in a part on the joint portion 5 side, the release film 4 side is shown in a vertical cross-sectional view thereof.
  • the central portion may have a flat or substantially flat trapezoidal shape toward the release film 4 side. It may also have a dome-shaped or substantially trapezoidal raised shape toward the supporting base material side 2, and further, a dome-shaped or substantially trapezoidal shape toward the supporting base material side 2 and the release film 4 side. It may have a raised shape.
  • Aqueous gel 3 has water-holding property, moisture-releasing property, self-retaining property or adhesiveness.
  • the "water-holding property” means a property of stably containing water inside, but more preferably a property of not exuding the contained water even when further compressed.
  • self-retaining property means a property of retaining the shape without significantly causing fluidity or disintegration.
  • a natural high molecular weight polysaccharide generally used as a gelling agent can be exemplified.
  • natural gums such as carrageenan, alginic acid, propylene glycol alginate, tara gum, locust bean gum, glucomannan, xanthan gum, gellan gum, pectin, purulan, guar gum, psyllium seed gum, sodium alginate, mannan, gelatin, and agar.
  • Glucomannan and locust bean gum can be preferably exemplified.
  • gelling agent examples include polyacrylic acid, polymethacrylic acid, salts of polyacrylic acid, salts of polymethacrylic acid, and the like, in addition to the above-mentioned natural high molecular weight polysaccharides. These can be used alone or in combination of two or more.
  • Aqueous gel 3 refreshes polyhydric alcohol, surfactant, preservative, preservative, stabilizer, fragrance, colorant, pH adjuster, limonene, camphor, peppermint oil, l-menthol and the like as other components. It may contain known additives such as agents, moisturizers, stimulants, disinfectants, antibacterial agents, pressure-imparting agents, shape-retaining agents, and thickeners.
  • the water-based gel 3 preferably contains a sufficient amount of water in order to continuously exert a desired cooling power, and the water content of the water-based gel 3 is determined in the composition constituting the water-based gel 3. , 60% by weight or more, more preferably 70% by weight or more. Further, the upper limit of the water content of the aqueous gel 3 is preferably 95% by weight or less, more preferably 90% by weight or less, from the viewpoint of self-retaining property.
  • the release film 4 covers the aqueous gel 3 before the use of the patch 1, and the release film 4 can improve the handleability and hygiene of the patch 1.
  • the material of the release film 4 is not particularly limited as long as it can coat the aqueous gel 3, and synthetic resins such as polypropylene, polyethylene, polyester, nylon, vinyl chloride, and polyethylene terephthalate can be exemplified. .. Among them, as the release film 4, it is preferable to use a film having heat welding properties (heat welding film) such as a polyolefin resin film (for example, polypropylene film, polyethylene film, etc.).
  • the support base material 2 and the release film 4 are preferably formed using the same material, and particularly preferably polypropylene, from the viewpoint of facilitating heat welding and ultrasonic welding.
  • the release film 4 has the same shape as the support base material 2 but is larger in size, or if the support base material 2 and the release film 4 have different shapes, a part of the outer peripheral edge of the support base material 2 is peeled off. It is joined at a position separated inward from the outer peripheral edge of the film 4.
  • the outer peripheral edge of the supporting base material is bonded to the release film means that the outer peripheral edge of the supporting base material is substantially bonded to the release film
  • FIGS. In addition to the state in which the outermost edge P1 of the support base material 2 is bonded to the release film 4 as shown in FIG. 3, the outermost edge P1 of the support base material 2 as shown in FIG. 4 is attached to the release film 4. It also includes a state in which a position P2 that is not bonded but is slightly separated inward from the outermost edge P1 is bonded to the release film 4.
  • the support base material 2 was used before use such as during transportation or storage of the support base material 1 after production.
  • the case where it is bonded to the release film 4 at P2 is also included.
  • the position P2 slightly distant from the outermost edge P1 of the support base material 2 is 2.0 mm or less, preferably 1.0 mm or less from the outermost edge P1 of the support base material 2.
  • the support base material 2 has the same shape but is larger than the release film 4, it is slightly separated inward from the outermost edge P1 of the support base material 2 as in the embodiment shown in FIG. It suffices that the outer peripheral edge of the release film 4 is joined at the position P2.
  • the outer peripheral edge of the support base material 2 is bonded to the release film 4 over the entire circumference. Therefore, the water-based gel 3 is enclosed inside the supporting base material 2 and the release film 4, and the end face of the water-based gel 3 is not exposed.
  • the outer peripheral edge of the support base material is bonded to the release film over the entire circumference means that the outer peripheral edge of the support base material is bonded to the release film over substantially the entire circumference, and the support group.
  • the state in which most of the outer peripheral edge of the supporting base material is bonded to the release film but a part is not bonded to the release film is also included.
  • the outer peripheral edge of the supporting base material was bonded to the release film over the entire circumference at the time of manufacturing the patch, the outer peripheral edge of the supporting base material was used before use such as during transportation or storage of the patch after manufacturing. Including the case where a part of the joint is broken.
  • the support base material 2 and the release film 4 are joined by welding.
  • the welding method is not particularly limited as long as at least one of the support base material 2 and the release film 4 is joined by melting, and for example, the support base material 2 and the release film 4 are laminated.
  • Heat welding heat sealing
  • ultrasonic welding that pressurizes both while applying ultrasonic vibration while the supporting base material 2 and the release film 4 are overlapped, etc.
  • Various known methods can be used.
  • the patch 1 having the above-described configuration is efficient by cutting a patch sheet in which a plurality of patches 1 are continuous in at least one direction along a cutting line that divides the patches 1 into individual patches 1.
  • the patch sheet is sandwiched between the ultrasonic vibrating device and the cutting device, and the horn of the ultrasonic vibrating device is brought into contact with the release film 4 at the cutting line of the patch sheet.
  • the support base material 2 and the release film 4 can be joined by ultrasonic welding and cut into individual patches 1. .. Thereby, the production efficiency of the patch 1 can be further improved.
  • the patch sheet is cut with high accuracy without the water-based gel 3 adhering to the cutting blade, and the cut surface is clean.
  • the support base material 2 is made of polyethylene terephthalate fiber and a non-woven fabric made of polypropylene fiber
  • the release film 4 is made of polypropylene film. Is preferable.
  • the formation of the patch 1 by joining the support base material 2 and the release film 4 and the division of the individual patches 1 by cutting the patch sheet do not necessarily have to be performed at the same time, and the outer peripheral edge of the patch 1 is formed. After joining the support base material 2 and the release film 4 at the portion to form the patch 1, the patch sheet may be cut at the portion serving as the outer peripheral edge of the patch 1 and divided into individual patches 1. ..
  • the joint portion 5 of the support base material 2 and the release film 4 in the patch 1 may have a band shape having a slightly large width W as shown in FIG. 2, or a streak shape having a small width W as shown in FIG.
  • the aqueous gel 3 is laminated on almost the entire area of the support base material 2, the range of the skin on which the desired cooling force can be exerted by the patch 1 can be increased, and the outer peripheral edge of the support base material 2 can be increased.
  • the adhesiveness of the aqueous gel 3 makes it adhere well to the skin, so that the outer peripheral edge of the supporting base material 2 is less likely to roll up, and thus it is possible to prevent the patch 1 from being easily peeled off from the skin.
  • the width W of the joint portion 5 is preferably 2.0 mm or less, more preferably 1.0 mm or less, and further preferably 0.5 mm or less. Further, the lower limit of the width W of the joint portion 5 is preferably 0.05 mm or more, more preferably 0.1 mm or more, and 0. It is more preferably 2 mm or more.
  • the patch 1 of the present embodiment described above at least a part of the outer peripheral edge of the support base material 2 is bonded to the release film 4, and the aqueous gel 3 is in the vicinity of the joint portion 5 of the outer peripheral edge of the support base material 2. In the portion, the thickness of the aqueous gel 3 gradually decreases toward the joint portion 5. Therefore, as shown in FIG. 5 (A), the release film 4 is peeled off from the support base material 2, the exposed aqueous gel 3 is applied to the user's skin S, and then the release film 4 is supported as shown in FIG. 5 (B).
  • the support base material 2 When the base material 2 is attached to the skin S due to the adhesiveness of the water-based gel 3, the support base material 2 wraps the water-based gel 3 on the outer peripheral edge of the support base material 2, and is outside the support base material 2.
  • the water-based gel 3 adheres to the skin S by the adhesiveness of the aqueous gel 3 in a state where the peripheral edge does not float from the user's skin and sticks to the skin. Therefore, since it is possible to prevent the outer peripheral edge of the supporting base material 2 from rolling up, it is possible to prevent the patch 1 from being peeled off from the skin.
  • the entire outer peripheral edge of the support base material 2 is less likely to be rolled up, so that the patch 1 is more difficult to be peeled off from the skin. be able to.
  • the outer peripheral edge of the release film 4 is rolled up from the support base material 2. It can be suppressed from being easily peeled off.
  • the water-based gel 3 is continuously sealed inside the support base material 2 and the release film 4, so that the water-based gel 3 It is possible to prevent drying and the like.
  • the front surface and / or the back surface of the patch 1 is pressed during transportation, storage, etc., and the aqueous gel 3 is formed. Even if it is pressed, it is possible to prevent the aqueous gel 3 from being extruded and protruding from the outer peripheral edge of the patch 1. This makes it possible to prevent the aqueous gel 3 from adhering to the user's hand when the user uses the patch 1.
  • the patch 1 since the patch 1 is stored in a packaging box (not shown) in a state of being stacked in a plurality during transportation or storage, the patch 1 is the weight of the other plurality of patches 1.
  • the aqueous gel 3 By receiving the pressure, the aqueous gel 3 is compressed. Conventionally, since the aqueous gel 3 may be pressed and protrude from the outer peripheral edge of the patch 1, a partition is set in the packaging box, and the weight of the patch 1 is received by the partition to receive the weight of the patch 1, and the aqueous gel 3 is used. Was prevented from being squeezed.
  • the patch 1 of the present embodiment is medium because the aqueous gel 3 does not protrude from the outer peripheral edge of the patch 1 even if the aqueous gel 3 is pressed by the weights of the other plurality of patches 1 in the packaging box. No partition is required, and the cost can be reduced accordingly.
  • the water-based gel 3 does not leak from the outer peripheral edge of the patch 1. Therefore, conventionally, at the time of manufacturing the patch, it was necessary to perform a treatment for solidifying the aqueous gel 3 after cutting the patch sheet into individual patches. For example, since this treatment step can be eliminated or the treatment time can be shortened, the manufacturing efficiency of the patch can be improved by shortening the process time.
  • the outer peripheral edge of the support base material 2 is bonded to the release film 4 over the entire circumference, but only a part of the outer peripheral edge may be bonded to the release film 4.
  • the support base material 2 and the release film 4 have a rectangular shape (including a square shape and a rectangular shape) in a plan view, at least a pair of opposite sides of the support base material 2 and the release film 4 are joined to each other. Just do it.
  • the support base material 2 and the release film 4 have the same shape, but if at least a part of the outer peripheral edge of the support base material 2 is bonded to the release film 4, the support base material 2 and the release film 4 are bonded to the release film 4.
  • the shape may be different from that of 4.
  • the patch 1 has a three-layer structure of the support base material 2, the aqueous gel 3, and the release film 4, but may have other layers.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Thermal Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne un timbre transdermique peu susceptible de se décoller de la peau. Plus spécifiquement, ce timbre transdermique (1) comporte: un substrat (2) de support; un gel aqueux (3) déposé en couche sur une face du substrat (2) de support; et un film détachable (4) recouvrant le gel aqueux (3). Au moins une partie du bord externe du substrat (2) de support est assemblée au film détachable (4). Dans au moins une partie côté partie (5) d'assemblage du substrat (2) de support et du film détachable (4) , l'épaisseur du gel aqueux (3) va en diminuant en direction de la partie (5) d'assemblage.
PCT/JP2019/046844 2019-11-29 2019-11-29 Timbre transdermique WO2021106210A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/JP2019/046844 WO2021106210A1 (fr) 2019-11-29 2019-11-29 Timbre transdermique

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2019/046844 WO2021106210A1 (fr) 2019-11-29 2019-11-29 Timbre transdermique

Publications (1)

Publication Number Publication Date
WO2021106210A1 true WO2021106210A1 (fr) 2021-06-03

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PCT/JP2019/046844 WO2021106210A1 (fr) 2019-11-29 2019-11-29 Timbre transdermique

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WO (1) WO2021106210A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61215321A (ja) * 1985-03-18 1986-09-25 メンレイ・アンド・ジエームス・ラボラトリース・リミテツド 局所薬および全身薬の経皮デリバリー制御組成物および該制御方法
JPH06296702A (ja) * 1992-04-21 1994-10-25 Mli Acquisition Corp Ii ヒドロゲルアプリケータおよびその製造方法
JP2003019157A (ja) * 2001-07-06 2003-01-21 Advance Co Ltd 温感材並びに冷感材
JP2003102760A (ja) * 2001-09-28 2003-04-08 Toko Yakuhin Kogyo Kk 貼付材及びその製造方法
WO2019230362A1 (fr) * 2018-05-31 2019-12-05 小林製薬株式会社 Patch adhésif

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61215321A (ja) * 1985-03-18 1986-09-25 メンレイ・アンド・ジエームス・ラボラトリース・リミテツド 局所薬および全身薬の経皮デリバリー制御組成物および該制御方法
JPH06296702A (ja) * 1992-04-21 1994-10-25 Mli Acquisition Corp Ii ヒドロゲルアプリケータおよびその製造方法
JP2003019157A (ja) * 2001-07-06 2003-01-21 Advance Co Ltd 温感材並びに冷感材
JP2003102760A (ja) * 2001-09-28 2003-04-08 Toko Yakuhin Kogyo Kk 貼付材及びその製造方法
WO2019230362A1 (fr) * 2018-05-31 2019-12-05 小林製薬株式会社 Patch adhésif

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