WO2019230928A1 - Procédé de production de timbres transdermiques adhésifs - Google Patents

Procédé de production de timbres transdermiques adhésifs Download PDF

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Publication number
WO2019230928A1
WO2019230928A1 PCT/JP2019/021653 JP2019021653W WO2019230928A1 WO 2019230928 A1 WO2019230928 A1 WO 2019230928A1 JP 2019021653 W JP2019021653 W JP 2019021653W WO 2019230928 A1 WO2019230928 A1 WO 2019230928A1
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WO
WIPO (PCT)
Prior art keywords
patch
sheet
cutting
base material
patch sheet
Prior art date
Application number
PCT/JP2019/021653
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English (en)
Japanese (ja)
Inventor
直礼 奥田
裕樹 堀本
立樹 小枝
彰 永松
Original Assignee
小林製薬株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 小林製薬株式会社 filed Critical 小林製薬株式会社
Publication of WO2019230928A1 publication Critical patent/WO2019230928A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B26—HAND CUTTING TOOLS; CUTTING; SEVERING
    • B26D—CUTTING; DETAILS COMMON TO MACHINES FOR PERFORATING, PUNCHING, CUTTING-OUT, STAMPING-OUT OR SEVERING
    • B26D7/00—Details of apparatus for cutting, cutting-out, stamping-out, punching, perforating, or severing by means other than cutting
    • B26D7/27—Means for performing other operations combined with cutting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B26—HAND CUTTING TOOLS; CUTTING; SEVERING
    • B26F—PERFORATING; PUNCHING; CUTTING-OUT; STAMPING-OUT; SEVERING BY MEANS OTHER THAN CUTTING
    • B26F3/00—Severing by means other than cutting; Apparatus therefor

Definitions

  • the present invention relates to a method for producing a patch to be used by being applied to human skin.
  • the conventional patch 100 generally has a structure in which an aqueous gel is laminated as a pressure-sensitive adhesive layer 102 on a support substrate 101 such as a nonwoven fabric and the pressure-sensitive adhesive layer 102 is covered with a release film 103. It has been.
  • this conventional patch 100 is a band-shaped patch sheet in which a long release film is superposed on the surface after an adhesive layer is applied on a long support substrate. It is manufactured by cutting into a predetermined size with a cutting blade.
  • the cutting position of the patch sheet before cutting a patch sheet into individual patches of a predetermined size with a cutting blade, the cutting position of the patch sheet is pressed to extrude and remove the adhesive layer at the cutting position. It is carried out. This prevents the adhesive layer from being exposed on the end surface (cut surface) of the cut patch.
  • the support substrate 101 and the release film 103 are not joined at the outer peripheral edge. Therefore, when a load is applied, for example, when the front surface and / or back surface of the patch 1 is pressed, the adhesive layer 102 may be pushed out and protrude from the outer peripheral edge of the patch 1. This is because the thickness of the adhesive layer 102 is increased. When it is large or when the fluidity of the adhesive layer 102 is high, it becomes a significant problem. In order to solve this problem, a process for promoting the solidification of the adhesive layer 102 is required, which causes an increase in manufacturing cost.
  • the present invention has been made to solve the above-described problems, and an object of the present invention is to provide a method for producing a patch capable of preventing the sticking layer from protruding.
  • the method for producing a patch of the present invention comprises a support substrate, an adhesive layer laminated on one side of the support substrate, and a patch comprising a plurality of patches each having a release film covering the adhesive layer.
  • the support base and the patch sheet are caused to act on the patch sheet from the side of the release film by an ultrasonic vibration device at the contour portion. It is preferable to bond a release film.
  • the patch sheet is sandwiched between the ultrasonic vibration device and the cutting device, and ultrasonic vibration is applied by the ultrasonic vibration device.
  • the ultrasonic vibration device includes a horn that contacts the patch sheet, and the joining step is performed on the contact surface of the horn with respect to the patch sheet. It is preferable that a cutting device cuts the patch sheet at the contour portion.
  • the support base material and the release film are joined to the patch sheet by thermocompression bonding at the contour portion.
  • the support base material is a nonwoven fabric.
  • the nonwoven fabric is made of polyethylene terephthalate resin fiber and the release film is made of polyolefin resin.
  • the adhesive layer is an aqueous gel and the water content thereof is 60 wt% or more and 95 wt% or less.
  • the coating step of applying the adhesive layer to one surface of the long support substrate to be conveyed, and the long release film wound around the outer peripheral surface of the film supply roll are unwound and unrolled.
  • the release film and the supporting base material are joined to the patch sheet at the contour portion which is the outer peripheral edge of the patch sheet before or during cutting of the patch sheet. Therefore, in the cut patch, the outer periphery of the support base and the release film are joined, so even if a load is applied such as when the front and / or back of the patch is pressed during transportation, etc. It is possible to prevent the adhesive layer from being pushed out and protruding from the outer peripheral edge of the patch. Moreover, the process for accelerating the solidification of the adhesive layer during the production of the patch can be shortened or omitted.
  • FIG. 6 is a longitudinal sectional view showing an AA section of FIG. 5 in an enlarged manner. It is a longitudinal cross-sectional view of the patch of a conventional example.
  • FIG. 1 shows a schematic configuration of a method for producing a patch according to an embodiment of the present invention.
  • the patch produced by the method for producing a patch of the present embodiment is used by being affixed to human skin, for example, cooling of the affected area during fever, headache, toothache, inflammation, etc. Examples of the sheet-like coolant used for cooling a hot flash on a face or the like, or for cooling a muscle after sports.
  • the patch 1 has at least a support substrate 2, an aqueous gel 3 as an adhesive layer, and a release film 4, and has a layer structure in which these are laminated. .
  • the patch 1 is peeled off the release film 4 from the support substrate 2, and the exposed aqueous gel 3 is directly applied to a site to be cooled of the skin, so that the adhesive of the aqueous gel 3 sticks to the user's skin. Attached. Thereby, the water
  • each step of the manufacturing method of the patch of this embodiment will be described in order. It should be noted that the thicknesses of the constituent members of the patch 1 and the patch sheet 10 are exaggerated for easy understanding.
  • the manufacturing method of the patch of this embodiment is a base material conveyance process which conveys the elongate support base material 20, and apply
  • seat 10 to each patch 1 are included.
  • Each process is provided with a processing apparatus for performing the process in each process.
  • the long support base material 20 wound around the outer peripheral surface of the base material supply roll 11 is unwound from the base material supply roll 11, and the longitudinal direction is used as a conveyance direction to the support roll 12.
  • the base material supply roll 11 supports a long support base material 20 wound in a roll shape.
  • the long support base material 20 is not particularly limited as long as it has moisture permeability and air permeability and can carry the aqueous gel 3, and various woven fabrics, nonwoven fabrics, and films can be used. Etc. can be formed.
  • woven fabric or non-woven fabric as the material for the long support base 20
  • natural fibers such as cotton, hemp and wool
  • cellulosic fibers such as rayon and acetate
  • Examples thereof include synthetic resin fibers such as polyethylene terephthalate and acrylic.
  • a film as a raw material of the support base material 2
  • a polystyrene (styrene), a polypropylene, a polyethylene terephthalate, polyethylene etc. can be illustrated.
  • the thickness of the long support base 20 is not particularly limited, but is 0.1 mm or more and 3.0 mm or less from the viewpoint of the feeling of use of the manufactured patch 1 and the familiarity with the application site. It is preferable that it is 0.5 mm or more and 2.0 mm or less.
  • the width of the long support base 20 (the length in the direction orthogonal to the longitudinal direction) is not particularly limited, but is preferably large enough to form a plurality of individual patches 1 in the width direction. .
  • the coating apparatus 6 includes a tank 13 for storing the aqueous gel 3, an application roll 14 for taking the aqueous gel 3 from the tank 13 and applying it to the long support base 20, and a long support base 20 for the application roll 14. And a support roll 12 sandwiched therebetween.
  • a part of the outer peripheral surface of the coating roll 14 is immersed in the aqueous gel 3 in the tank 13, and the aqueous gel 3 in the tank 13 adheres to the outer peripheral surface by rotating in the direction of the arrow to thereby rotate the aqueous gel 3. Is removed from the tank 13.
  • the application roll 14 apply
  • Aqueous gel 3 has water retention, moisture release, self-retaining property, etc. in addition to adhesiveness.
  • Hydrophilic means the property of stably containing water inside, but more preferably means the property of not exuding the contained water even when further compressed.
  • Self shape retention means the property of maintaining the shape without causing significant fluidity or disintegration.
  • components that can exhibit such properties including water include natural polymer polysaccharides generally used as gelling agents.
  • natural gums such as carrageenan, alginic acid, propylene glycol alginate, tara gum, locust bean gum, glucomannan, xanthan gum, gellan gum, pectin, pullulan, guar gum, psyllium gum, sodium alginate, mannan, gelatin, agar Can be illustrated. These can be used alone or in combination of two or more.
  • glucomannan and locust bean gum can be exemplified.
  • gelling agent examples include polyacrylic acid, polymethacrylic acid, a salt of polyacrylic acid, a salt of polymethacrylic acid, and the like in addition to the natural polymer polysaccharide described above. These can be used alone or in combination of two or more.
  • Aqueous gel 3 is a cooling agent such as polyhydric alcohol, surfactant, preservative, preservative, stabilizer, flavor, colorant, pH adjuster, limonene, camphor, peppermint oil or l-menthol as other components. It may contain known additives such as agents, moisturizers, stimulants, disinfectants, antibacterial agents, tackifiers, shape retainers, thickeners and the like.
  • the aqueous gel 3 preferably contains a sufficient amount of moisture in order to continuously exhibit a desired cooling power, and the water content of the aqueous gel 3 is in the composition constituting the aqueous gel 3. 60% by weight or more, more preferably 70% by weight or more.
  • the upper limit of the water content of the aqueous gel 3 is preferably 95% by weight or less, and more preferably 90% by weight or less, from the viewpoint of self-shape retention.
  • the thickness of the aqueous gel 3 is not particularly limited, but is preferably appropriately large from the viewpoints of cooling power, feel when affixed to the skin, maintenance of the affixed state to the skin, and the like.
  • the patch 1 after production it is preferable that the thickness D C of the aqueous gel 3 at the center position of the support substrate 2 is 0.1mm or more 20mm or less, and more preferably less than 1.0mm 10mm or less .
  • the thickness of the aqueous gel 3 is preferably uniform or substantially uniform over the entire area of the support substrate 2, and there is no significant difference between the thickness of the aqueous gel 3 in the central portion and the thickness of the aqueous gel 3 in the outer peripheral portion. It is preferable.
  • the ratio D E / D C of the thickness D E of 1.0mm inside position of the aqueous gel 3 of the junction 5 of the supporting substrate 2 to the thickness D C of the aqueous gel 3 at the center position of the support substrate 2 is 0. It is preferably 1 or more and 2.0 or less, more preferably 0.3 or more and 1.2 or less, and further preferably 0.5 or more and 1.0 or less.
  • the thickness of the aqueous gel 3 can be measured using the method described in “6.1 Thickness (ISO Method)” of JIS L1913: 2010.
  • the thickness of the aqueous gel 3 does not necessarily have to be uniform or substantially uniform over the entire area of the support base 2 and gradually decreases or gradually increases toward the outer peripheral edge of the support base 2 or Only the portion close to the outer peripheral edge of the support substrate 2 may gradually decrease or increase gradually toward the outer peripheral edge.
  • the long release film 40 wound around the outer peripheral surface of the film supply roll 15 is unwound and conveyed to the laminating roll 16 with the longitudinal direction as the conveying direction.
  • the film supply roll 15 is supporting the elongate peeling film 40 wound by roll shape.
  • the elongate peeling film 40 conveyed is bonded together with the elongate support base material 20 with which the aqueous gel 3 was laminated
  • the laminating device 7 is composed of a support roll 12 and a laminating roll 16, and both rolls 12 in a state where a long release film 40 is superimposed on the aqueous gel 3 of the long support base 20.
  • the patch sheet 10 is formed after adjusting the thickness of the aqueous gel 3 laminated
  • the formed patch sheet 10 is conveyed to the cutting device 8 in the next step by a conveyance roll 17 and a conveyance conveyor 18 such as a belt conveyor.
  • the material of the long release film 40 is not particularly limited as long as the aqueous gel 3 can be coated, and examples thereof include synthetic resins such as polypropylene, polyethylene, polyester, nylon, vinyl chloride, and polyethylene terephthalate. Among them, among them, polyolefin resins such as polypropylene and polyethylene can be preferably mentioned.
  • the thickness of the long release film 40 is not particularly limited, and can be, for example, 0.02 mm to 0.3 mm, and more preferably 0.03 mm to 0.2 mm.
  • the width of the long release film 40 (the length in the direction orthogonal to the longitudinal direction) is not particularly limited, but a plurality of individual patches 1 can be provided in the width direction as in the case of the long support substrate 20. A size that can be formed is preferred.
  • the support base material 20 and the release film 40 are joined to the patch sheet 10 transported by the transport conveyor 18 by the ultrasonic vibration device 9 at the contour portion serving as the outer peripheral edge of the patch 1.
  • the patch sheet 10 includes a plurality of patches 1 continuous in at least one direction (longitudinal direction) and a plurality of patches 1 in another direction (width direction) orthogonal to the one direction. Therefore, the patch sheet 10 is lined with the boundary portion (cutting line L1) of the patch 1 in the other direction (width direction), and the patch sheet 10 is lined with the patch sheet 10 in the one direction (longitudinal direction).
  • the support base material 20 and the release film 40 are joined to the boundary portion (cutting line L2).
  • the ultrasonic vibration device 9 of the present embodiment joins the support base material 20 and the release film 40 at the boundary portion (cutting line L1) of the patch 1 in which the patch sheet 10 is arranged in the other direction (width direction).
  • a vibration device 9B The first ultrasonic vibration device 9 ⁇ / b> A and the second ultrasonic vibration device 9 ⁇ / b> B are disposed on the release film 40 side with respect to the patch sheet 10.
  • Each of the first ultrasonic vibration device 9A and the second ultrasonic vibration device 9B includes horns 90 and 91 having contact surfaces 90A and 91A with respect to the patch sheet 10 as an ultrasonic transmission unit, respectively, and an oscillator (not shown).
  • the horns 90 and 91 vibrate at high speed by the AC voltage supplied from The first ultrasonic vibration device 9A and the second ultrasonic vibration device 9B approach and separate from the patch sheet 10 by a first movement mechanism (not shown) and a second movement mechanism (not shown), respectively.
  • the contact surfaces 90A and 91A of the horns 90 and 91 come into contact with the patch sheet 10 along the cutting lines L1 and L2 when approaching the patch sheet 10.
  • the patch sheet 10 is sandwiched between the ultrasonic vibration device 9 and the cutting device 8, and ultrasonic waves are applied to the patch sheet 10 by the ultrasonic vibration device 9.
  • the cutting process of cutting the patch sheet 10 by the cutting device 8 while the vibration is applied is simultaneously performed.
  • the cutting device 8 corresponds to each of the first ultrasonic vibration device 9A and the second ultrasonic vibration device 9B of the ultrasonic vibration device 9, and each of the patch 1 in which the patch sheet 10 is arranged in the other direction (width direction).
  • the 1st cutting device 8A and the 2nd cutting device 8B are arrange
  • the first cutting device 8 ⁇ / b> A includes a plurality of rotary blades 80 provided at intervals in the width direction of the patch sheet 10, and a rotary drive mechanism (Not shown).
  • 8 A of 1st cutting devices are arrange
  • Each rotary blade 80 has a disk shape, and the cutting edge has a substantially V-shaped cross-sectional view, and is disposed so as to contact or be close to the patch sheet 10 to which the cutting edge is conveyed.
  • each rotary blade 80 is arrange
  • Each rotary blade 80 sandwiches the patch sheet 10 with each horn 90 when the first ultrasonic vibration device 9A approaches the patch sheet 10, so that a wide patch is applied at each cutting line L1.
  • the agent sheet 10 is cut. Thereby, the patch sheet 10 is divided into the same width as the patch 1.
  • the second cutting device 8B includes a cutting blade 81 whose cutting edge has a substantially V shape in cross section.
  • the second cutting device 8B is arranged so that the cutting blade 81 faces the horn 91 of the second ultrasonic vibration device 9B with the patch sheet 10 interposed therebetween.
  • the cutting blade 81 is disposed so that the blade edge is in contact with or close to the patch sheet 10 to be conveyed, and the blade edge is disposed along the width direction of the patch 10.
  • the cutting blade 81 holds the patch sheet 10 with the horn 91 when the second ultrasonic vibration device 9B approaches the patch sheet 10, so that the patch is longer than the patch 1.
  • the patch sheet 10 is sequentially cut along the cutting lines L2 at predetermined intervals along the longitudinal direction with respect to the sheet 10. Thereby, the patch sheet 10 is divided into a plurality of patches 1.
  • the patch sheet 10 is sandwiched between the horns 90 and 91 and the rotary blade 80 and the cutting blade 81, and the horns 90 and 91 rotate while applying ultrasonic vibration to the patch sheet 10.
  • the aqueous gel 3 is turned into a rotating blade at the time of cutting. Since it does not adhere to 80 and the cutting blade 81, the patch sheet 10 can be cut with high accuracy.
  • the release film 40 of the patch sheet 10 by applying ultrasonic vibration to the release film 40 of the patch sheet 10 by the horns 90 and 91 along the cutting lines L1 and L2, the cutting lines L1 and L2 of the patch sheet 10 are cut.
  • the release film 40 is welded to the support substrate 20 and the release film 40 and the support substrate 20 are joined in a streak shape. Therefore, about the patch 1 after cutting, as shown in FIG.5 and FIG.6, the outer periphery of the support base material 2 and the peeling film 4 can be joined over the perimeter, and the water-based gel 3 is attached to the support base material 2 and The release film 4 can be encapsulated inside.
  • the support substrate 20 is made of a nonwoven fabric made of polyethylene terephthalate resin fibers
  • the release film 40 is a polyolefin-based material such as polypropylene or polyethylene. It is preferable to consist of resin.
  • the blade edges of the rotary blade 80 and the cutting blade 81 are easy to cut the patch sheet 10 when the blade edge angle ⁇ is small and sharp, while the support base material for the manufactured patch 1 is used. 2 and the release film 4 are weakly bonded. Moreover, when the blade edge angle ⁇ is large and the tip is blunt, the bonding of the support base 2 and the release film 4 of the manufactured patch 1 becomes strong, but the patch sheet 10 is difficult to cut. Therefore, the blade edge angle ⁇ is appropriately set in order to make it easy to cut the patch sheet 10 and the bonding strength between the support base 2 and the release film 4.
  • the patch 1 individually cut from the patch sheet 10 in the cutting process is transported to the next process by the transporting conveyor 19 arranged at a lower position in the vertical direction.
  • the patch 1 is packaged in a non-breathable storage bag manually or using a machine, and in the subsequent step, the treatment for solidifying the aqueous gel 3 is performed, whereby the patch 1 Is manufactured.
  • the method for producing a patch of the present embodiment described above by joining and cutting the patch sheet 10 in which a plurality of the patches 1 are continuous in at least one direction at the contour portion that becomes the outer peripheral edge of the patch 1,
  • the outer peripheral edges of the support base 2 and the release film 4 are joined, and the aqueous gel 3 is enclosed in the support base 2 and the release film 4. Therefore, even if the aqueous gel 3 has a high water content and high fluidity, the aqueous gel 3 can be prevented from leaking from the outer peripheral edge of the patch 1 when the patch 1 is transported in a line after cutting. .
  • the aqueous gel 3 is pressed by pressing the front surface and / or the back surface of the patch 1 when the patch 1 is transported or stored, the aqueous gel 3 is pushed out and removed from the patch 1. Protruding from the periphery can be prevented. Thereby, when a user uses the patch 1, it can prevent that the aqueous gel 3 adheres to a user's hand.
  • the patch 1 since the patch 1 is stored in a state where a plurality of patches 1 are stacked in a packaging box (not shown) at the time of transportation or storage, the patch 1 has the weight of the other plurality of patches 1.
  • the aqueous gel 3 is pressed. Conventionally, since the aqueous gel 3 may be pressed out from the outer peripheral edge of the patch 1, a partition is set in the packaging box, and the aqueous gel 3 receives the weight of the patch 1 in the partition. Was prevented from being pressed.
  • the produced patch 1 is applied even if the aqueous gel 3 is compressed by the weight of the other plurality of patches 1 in the packaging box. Since it does not protrude from the outer periphery of the agent 1, a partition is unnecessary, and the cost can be reduced accordingly.
  • the manufacturing method of the patch of this embodiment since joining and cutting
  • the horns 90 and 91 of the ultrasonic vibration devices 9A and 9B are brought into contact with the patch sheet 1, and the rotary blade 80 and the cutting blade 81 of the cutting devices 8A and 8B are contacted. Since the cutting edge is pressed against the horns 90 and 91 to cut the patch sheet 10 on the contact surfaces 90A and 91A, the rotary blades 80 and the cutting blades 81 of the cutting devices 8A and 8B are used for cutting the patch sheet 10. A backing plate for pressing the blade edge can be eliminated.
  • the method for producing a patch of the present embodiment even if the water content of the aqueous gel 3 is large and the fluidity is high, the aqueous gel 3 does not leak from the outer peripheral edge of the patch 1. Therefore, since the processing time of the processing step for hardening the aqueous gel 3 after the cutting step of the patch sheet 10 described above can be shortened or this processing step can be made unnecessary, the shortening of the processing time can reduce the length of the patch 1. Manufacturing efficiency can be improved.
  • the joining step and the cutting step are performed at the same time, but the cutting may be performed after the support base material 20 and the release film 40 are joined to the patch sheet 1.
  • a joining method is not specifically limited, Support Various known methods such as a method of joining the base material 20 and the release film 40 using a known adhesive, a method of joining the support base material 20 and the release film 40 by thermocompression bonding (heat sealing), and the like are used. it can.
  • the support base material 20 and the release film 40 are thermocompression-bonded by hot pressing the patch sheet 10 along the cutting lines L1 and L2 using a pair of upper and lower hot-pressing rolls or a press die (not shown). It can be joined by heat sealing.
  • seat 10 is a thing of the magnitude
  • the patch 1 has a rectangular shape in plan view, but may have other shapes such as a square shape or a substantially elliptical shape.
  • the patch 1 has a three-layer structure of the support base 2, the aqueous gel 3, and the release film 4, but may have other layers.
  • the coating apparatus 6 which apply
  • seat 10 are cut
  • the cutting devices 8A and 8B are not necessarily limited to the device of the above embodiment, and other known devices can be used.
  • the patch 1 is a sheet-like cooling agent and the adhesion layer is the aqueous gel 3, especially if a patch is affixed and used for a human skin.
  • the pressure-sensitive adhesive layer is not limited, and may be a pressure-sensitive adhesive other than the aqueous gel 3 as long as the pressure-sensitive adhesive layer can be attached to the human skin.

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Abstract

L'invention concerne un procédé de production de timbres transdermiques adhésifs, moyennant quoi une couche adhésive peut être empêchée de déborder. Le procédé de production de timbres transdermiques adhésifs comprend : une étape de liaison dans laquelle un matériau de base de support (20) et un film pelable (40) sont liés au niveau d'une section de contour qui est la périphérie externe des timbres transdermiques adhésifs (1), en une feuille (10) de timbres transdermiques adhésifs qui comprend une pluralité de timbres transdermiques adhésifs (1) l'un à la suite de l'autre dans au moins une direction de celle-ci qui comprennent un matériau de base de support (2), un gel aqueux (3) (couche adhésive) stratifié sur une surface du matériau de base de support (2), et un film pelable (4) recouvrant le gel aqueux (3) ; et une étape de découpe dans laquelle la feuille (10) de timbres transdermiques adhésifs est découpée au niveau de la section de contour.
PCT/JP2019/021653 2018-05-31 2019-05-31 Procédé de production de timbres transdermiques adhésifs WO2019230928A1 (fr)

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JP2018105625 2018-05-31

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JPH10235131A (ja) * 1997-02-26 1998-09-08 Toppan Printing Co Ltd シート状脱酸素剤とその切断方法
JP2004201703A (ja) * 2002-11-06 2004-07-22 Akatsuki Kinzoku Kogyo:Kk 貼付剤シートの加工ライン
WO2005087155A1 (fr) * 2004-03-16 2005-09-22 Mycoal Products Co., Ltd. Processus pour produire un adhésif de type chauffant
JP2008119837A (ja) * 2006-11-08 2008-05-29 Kiwa Kinzoku:Kk 超音波溶着装置

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